• 대한약학회:학술대회논문집
• /
• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
• /
• pp.413.1-413.1
• /
• 2002

Purpose To investigate the physico-chemical properties of CB-ph ［2-benzoyloxycinnamaldehyde］, an anticancer drug obtained from Cinnamomum cassia using methylenechloride. and its stability in various aqueous solutions. Results CB-ph was rarely soluble in water but soluble in methanol and very soluble in ether. Kinetic salt effect on degradation of CB-ph in buffer solutions at pH 4.0 and 6$0^{\circ}C$ showed a linear relationship having a positive slope that means reactions between hydronium ions and protonated substrates. (omitted)

• 대한본초학회지
• /
• 제31권1호
• /
• pp.61-67
• /
• 2016

Objectives : The present study aimed to investigate the anti-inflammatory effects of the water extracts of Portulacae Herba (PH).Methods : We measured the effects of the water extracts of Portulacae Herba (PH) on the cell viability of mouse macrophage RAW 264.7 cells, the intracellular calcium production, and the proinflammatory mediators including nitric oxide (NO), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF)-BB, which are induced by the lipopolysaccharides (LPS), and obtained the results shown below.Results : After the cultivation of the PH extracts along with the mouse macrophages, the cell survival rate did not decrease with the MTT assay. However, the PH extracts did significantly suppress the production of NO by the mouse macrophages induced by LPS at the concentrations of 25, 50 and 100 ㎍/mL. The PH extract also significantly suppressed the VEGF, PDGF-BB and intracellular calcium production of the mouse macrophages by LPS at concentrations of 25, 50 and 100 ㎍/mL. As shown in the results above, the PH extracts do not have a toxic effect on the macrophages, but still have an anti-inflammatory effect that significantly reduces the intracellular calcium production as well as the production of NO, VEGF and PDGF-BB at concentrations above 25 ㎍/mL.Conclusions : In conclusion, the inhibitory anti-inflammatory effects of the PH extract can be used for a new treatment of anti-inflammatory diseases.

• 한국식품영양과학회지
• /
• 제32권8호
• /
• pp.1377-1384
• /
• 2003

본 실험에서는 Sprague-Dawley계 수컷 흰쥐의 간장 및 혈청 지질 농도와 임상생화학적 지표에 미치는 식이지방원 및 식이섬유원을 달리한 식이를 급여한 영향을 검토하였다. 실험 식이군은 5% corn oil +5% cellulose 함유 CO군, 10% corn oil +10% 차전자피 함유 CO +PH군 및 10% lard+10% 차전자피 함유 LA+PH군인 3군으로 나누었으며 실험식이와 물은 6주간 자유급여 시켰다. 체중 증가량 및 식이효율은 CO군에 비해 LA+PH군에서 유의적으로 증가하였고, CO+PH군에서는 유의적인 증가경향을 보였다. 식이 섭취량 및 장기 중량은 실험군간에 차이가 없었다. 혈청총 콜레스테롤 농도는 CO군에 비해 CO+PH군에서 유의적으로 감소하였으나, LA + PH군과는 차이가 없었다. 혈청 중성지방 및 인지질 농도는 CO군에 비해 CO +PH군 및 LA+ PH군에서 유의적으로 감소하였다. 간장 콜레스테롤 농도는 LA +PH군에서 유의적으로 감소하였다. 혈청 임상생화학적 지표 중 glutamic pyruvic transaminase 활성 은 LA+PH군에서 유의적으로 높았으며, lactate dehydrogenase 활성 및 blood urea nitrogen은 오히려 LA + PH군에서 유의적으로 감소하였다. 다른 혈청 임상생화학적 지표중 총 단백질, 알부민, 포도당, glutamic oxaloacetic transaminase 및 lactate dehydrogenase활성은 각 실험군 간에 차이가 없었다. 이상의 결과로부터 식이 차전자피에 의한 혈중 지질 농도의 저하효과는 식이지방원 lard 첨가군에 비해 corn oil 첨가군에서 더욱 현저하였다.

• 한국식품위생안전성학회지
• /
• 제26권4호
• /
• pp.398-402
• /
• 2011

십자화과 채소는 Diindolylmethane (DIM)을 포함한 Isothiocyanates계 화합물을 함유하고 있는데, 이들이 암을 예방하는 효과가 있는 것으로 알려져 있다. 특히 이번 연구에 사용되어진 DIM-C-pPhBr과 DIM-C-pPhF를 기존에 알려진 DIM보다 독성은 최소화되고, 효능은 높은 물질로 보고되어져 있다 하지만, 아직까지 구강편평상피세포암종에서의 세포증식 및 세포사멸에 대한 효능연구는 보고된 바 가 없다. 따라서, 이번 연구에서는 C-DIM 중에 DIM-pPhBr과 DIM-pPhF의 구강편평상피세포암종 세포주인 KB세포에서의 세포증식 및 세포사멸유도효능을 확인함으로써 C-DIM 의 항종양능력을 확인하고자 하였다. 결과를 분석해보면, DIM-C-pPhBr과 DIM-C-pPhF은 구강편평상피세포암종 세포주인 KB의 세포증식을 감소시키고 Western blot분석법, DAPI염색법, 및 Sub-$G_1$축적분석결과에서 알수 있듯이 세포증식을 억제하기 위해 세포사멸을 유도하는 것으로 나타났다. 따라서, DIM-C-pPhBr과 DIM-C-pPhF에 의해 유도되는 세포사멸 및 세포증식억제는 구강암 예방 및 치료를 위한 좋은 전략이 될 수 있을 것으로 사료된다.

• BMB Reports
• /
• 제54권2호
• /
• pp.112-117
• /
• 2021

Phospholipase D2 (PLD2) has been implicated in the tyrosine kinase-mediated signaling pathways, but the regulation events are yet to be identified. Herein, we demonstrate that pleckstrin homology (PH) domain of PLD2 (PLD2-PH) exerts an antitumorigenic effect via the suppression of PLD2 and focal adhesion kinase (FAK). The kinase domain of FAK interacts with PLD2-PH and induces tyrosine phosphorylation and activation of PLD2. Furthermore, PLD2 increased tyrosine phosphorylation of FAK. However, ectopic expression of the PLD2-PH competes for binding to FAK and reduces the interaction between PLD2 and FAK, thereby suppressing FAK-induced PLD activation and tyrosine phosphorylation of FAK. The PLD2-PH suppressed the migration and invasion of glioblastoma cells, as well as tumor formation in a xenograft mouse model. This study uncovers a novel role of PLD2-PH as a negative regulator of PLD2 and FAK.

• 통합자연과학논문집
• /
• 제10권3호
• /
• pp.131-136
• /
• 2017

The chemical shifts in the $^{13}C$ NMR spectra of 2,3,4,5-tetraphenyl-1-silacyclopentdienide dianion $[SiC_4Ph_4]^{2-}{\cdot}2[K^+]$ (3) and 2,3,4,5-tetraphenyl-1-germacyclopentdienide dianion $[GeC_4Ph_4]^{2-}{\cdot}2[K^+]$ (4) were compared to those of $[SiC_4Ph_4]^{2-}{\cdot}2[Li^+]$ (5), $[SiC_4Ph_4]^{2-}{\cdot}2[Na^+]$ (6), and $[GeC_4Ph_4]^{2-}{\cdot}2[Li^+]$ (7). The average polarizations in two phenyl groups of two potassium salts are decreased over 15% to 20% comparing to those of the lithium salts and sodium salt {$[EC_4Ph_4]^{2-}{\cdot}2[M^+]$ (E=Si, Ge, M=Li, Na) due to the effect of the counter potassium cation.

• 대한용접접합학회:학술대회논문집
• /
• 대한용접접합학회 1996년도 특별강연 및 추계학술발표 개요집
• /
• pp.89-91
• /
• 1996

• 한국분말재료학회지
• /
• 제29권4호
• /
• pp.314-319
• /
• 2022

The effect of the laser beam diameter on the microstructure and hardness of 17-4 PH stainless steel manufactured via the directed energy deposition process is investigated. The pore size and area fraction are much lower using a laser beam diameter of 1.0 mm compared with those observed using a laser beam diameter of 1.8 mm. Additionally, using a relatively larger beam diameter results in pores in the form of incomplete melting. Martensite and retained austenite are observed under both conditions. A smaller width of the weld track and overlapping area are observed in the sample fabricated with a 1.0 mm beam diameter. This difference appears to be mainly caused by the energy density based on the variation in the beam diameter. The sample prepared with a beam diameter of 1.0 mm had a higher hardness near the substrate than that prepared with a 1.8 mm beam diameter, which may be influenced by the degree of melt mixing between the 17-4 PH metal powder and carbon steel substrate.

• 한국기계가공학회지
• /
• 제12권6호
• /
• pp.23-29
• /
• 2013

In this paper, pure $I_{ph}$ and hybrid carbon nanotube reinforced $I_{ph}$ were sintered using the SPS(spark plasma sintering) method for high densification. A nanosecond laser (${\lambda}=1063nm$, ${\tau}P=10ns$) and a femtosecond laser (${\lambda}=1027nm$, ${\tau}P=380fs$) were installed on an optical system for the micromachining test. The ablation characteristics of the pure $I_{ph}$ and CNT/$I_{ph}$ composites, such as thermal effect and ablation depth, were investigated using FE-SEM and a confocal microscope device. Laser machining results for the two mating materials showed improved performances: CNT/$I_{ph}$ composites showed good surface morphology of hole drilling without a melting zone due to the composites' high thermal properties; also, the ablated depth of CNT/$I_{ph}$ was higher than that of pure $I_{ph}$.

• Elastomers and Composites
• /
• 제40권4호
• /
• pp.258-265
• /
• 2005

스포츠화 중창용으로 사용되는 PU, IP 및 PH 등 세가지 종류의 발포체를 일정한 응력으로 반복압축한 후, 반복압축에 따른 발포체의 압축력, 영구변형, 회복력 등에 미치는 영향을 고찰하였다. 발포체의 반복압축에 따른 최대압축력은 PU의 경우는 거의 변화하지 않는 것으로 나타났으나 IP의 경우 최대 압축력은 크게 저하되었다. PU는 반복압축에 따른 발포체의 영구변형은 미소하였으나 PH의 경우 반복압축횟수가 증가함에 따라 현저하게 증가하는 경향을 나타내었다. 경도 45인 발포체를 5만회 반복압축 한 경우 발포체의 영구변형은 PU