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Anti-tumorigenic Effect of DIM-pPhBr and DIM-pPhF Originating from Cruciferous Vegetables in KB Human Oral Squamous Cell Carcinoma Through Apoptotic Cell Death  

Cho, Hyun-Tai (Department of Oral Pathology, School of Dentistry, Chonbuk National University)
Choi, Eun-Sun (Department of Oral Pathology, School of Dentistry, Chonbuk National University)
Cho, Nam-Pyo (Department of Oral Pathology, School of Dentistry, Chonbuk National University)
Cho, Sung-Dae (Department of Oral Pathology, School of Dentistry, Chonbuk National University)
Publication Information
Journal of Food Hygiene and Safety / v.26, no.4, 2011 , pp. 398-402 More about this Journal
Abstract
Cruciferous vegetables including diindolylmethane (DIM) have been shown to have anticancer activity. Especially, DIM-pPhBr and DIM-pPhF used in this study was reported to have more effective and less toxic effects than DIM. However, there is no report presenting their anti-tumorigenic activity in oral cancer. In the present study, we examined the effects of DIM-pPhBr and DIM-pPhF on the cell proliferation and apoptosis in KB human oral cancer cells. DIM-pPhBr and DIM-pPhF decreased cell proliferation and induced apoptosis evidenced by western blot analysis, DAPI staining and sub-$G_1$ population. This provides the first evidence that DIM-pPhBr and DIM-pPhF originating from Cruciferous vegetables induce apoptotic cell death in human oral cancer cells to inhibit cancer cell proliferation.
Keywords
DIM-C-pPhBr; DIM-C-pPhF; Oral Squamous Cell Carcinoma; Apoptosis;
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