• YAKHAK HOEJI
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• v.37 no.5
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• pp.427-436
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• 1993

The pharmacokinetics and relationship between in vitro dissolution and in vivo fraction absorbed were investigated after intravenous(iv) injection of omeprazole(OMZ), oral administration of OMZ capsules and rectal administration of 8 types of suppositories. The plasma concentration of OMZ (C$_{p}$)-time (t) curve after iv. administration fitted a two-compartment open model and the equation which best fitted the pharmacokinetics of OMZ was $C_{p}$ = 13.936 $e^{-8.78t}$+2.973 $e^{-0.716t}$. The bioavailabilities of OMZ in Witepsol H15 base (Supp-2) and PEG 4000 base (Supp-6) suppositories were 40.7% and 33.4%, respectively, which are higher(p<0.001) than 13% of oral administration of capsule. The avoidance fractions of the first-pass metabolism for Supp-2 and Supp-6 suppositiories were 31.8% and 23.4%, respectively, suggesting that the rectal application of OMZ may be a more adequate route of administration than oral one.

• Journal of Pharmaceutical Investigation
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• v.21 no.1
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• pp.11-22
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• 1991

The purpose of this study was for the enhancement of dissolution rate of ketoprofen. The solid dispersions composed of ketoprofen(KP) and polyethylene glycol(PEG) 4000 or 6000 were prepared by fusion method at various ratios of KP to PEG (0.5 : 10, 1 : 10, 2 : 10, 3 : 10 and 4 : 10(w/w)) and their physical mixtures were also prepared at the above ratios. Dissolution tests, X-ray diffraction study and differential scanning calorimetry study were carried out. It was found that the dissolution rates of solid dispersion and physical mixture at any ratio of the two components discribed above were greater than that of the pure ketoprofen. X-ray diffraction studies of ketoprofen suggested that less than 1 to 10 ratio of ketoprofen to PEG4000 (or 6000) was required to dispersion amorphous state in the carrier. In addition, the studies of DSC showed that ketoprofen had a sharp endothermic peak at $94^{\circ}C$ but not for the solid dispersion at the same temperature.

• Journal of the Korean Wood Science and Technology
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• v.30 no.1
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• pp.40-47
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• 2002

This study was carried out to investigate the dimensional stability of three softwoods (Pinus densiflora S. et Z., Pinus koraiensis S. et Z., Larix kaempferi C_ARR.) and two hardwoods(Quercus mongolica F., Quercus variabilis B_L.) treated with polyethylene glycol(PEG). Existence of PEG in wood was examined by an X-ray diffraction method. Shrinkage of the sample woods decreased with increasing concentration of PEG. The dimensional stability of five species had improved highly in thirty percent solutions of PEG with molecular weight 1000~4000, and the dimension of PEG-treated softwoods was more stable than that of PEG-treated hardwoods. Weight gain and bulking effect of the woods treated with PEG increased with increasing concentration of PEG. X-ray diffractograms of Pinus koraiensis wood treated with PEG showed two peaks derived from PEG crystal at 2𝜃 = 19° and 2𝜃 = 23°. However, the diffractograms of Quercus mongolica wood did not present any peaks caused by PEG crystal. From the result of X-ray diffraction, it was revealed that the content of PEG in Pinus koraiensis wood was higher than that in Quercus mongolica wood.

• Microbiology and Biotechnology Letters
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• v.21 no.2
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• pp.107-112
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• 1993

The optimal conditions for protoplast fusion between the cells of kanamycin resistant Lactobacillus bulgaricus IFO 13593 and those of lincomycin resistant Lactobacillus helveticus IAM 12090 were investigated in this study. The highest fusion frequency of 9.1*10-4 was obtained when protoplast fusion was carried out for 0.5 min using 40% PEG 4000 solution as a cell fusion stimulant and subsequent post-PEG-incubation was undergone at 30 for 30 min in the PPI medium.

• Korean Journal of Microbiology
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• v.27 no.3
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• pp.216-220
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• 1989

As the bsic study about protoplast fusion of amylolytic fungus Aspergillus oryze and nonamyloytic sugar fermenter, Saccaromyces cerevsisae, the intraspecific protoplast fusion of A. oryzae was carried out and the properties of the obtained fusants were investigated. For protoplast fomation from mycellia of auxotrophs, Novozyme 234 as lytic enzyme was the most effective and optimal pH was determined to be pH 5.5-6.0. When the two types of protoplasts were treated with a fusogen including 30% PEG4000, they fused effectively and most of fusants were heterokaryons. Protoplasts aggregated with 30% PEG4000 after fusion treatment were observed by the microscope. Protoplast regeneration frequency was 1.46 to 13.8% and complementation frequency of fusion was 0.12 to 0.16. Fusant strains had a 1.5-fold DNA content compared to that of parent strain. And amylase activity was intermediate between those of parent strains.

• Journal of Conservation Science
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• v.8 no.1 s.11
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• pp.28-32
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• 1999

The performance of dimensional stabilization of lactitol, PEG (Mw, 4000), and sucrose was evaluated for thin sections of oak wood (Quercus sp.) that had been buried in underground for presumably 1500 years. Thin wood sections of the specimen were soaked for three and seven days in each stabilizing agent with wide concentration ranges of 10, 30, 50, and $70\%$ by weight. Sucrose showed the largest weight gain among three agents, and the shrinkage of cross sections were found to be $1\%\;and\;4\%$ for three and seven days soaking, respectively. The result showed that sucrose among three stabilizing agents used was the best for the dimensional stabilization of the oak wood.

• KSBB Journal
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• v.31 no.4
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• pp.291-299
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• 2016

In this study, Indomethacin, the poorly water soluble drug, was selected and prepared dispersing oral disintegrating films according to the molecular weight of polyethylene glycol (PEG) which are sort of dispersing agents. Also the molecular weight and content of PEG were evaluated effect on the degree of dispersion, physical property and dissolution when making oral dispersing film containing indomethacin to find appropriate condition and suggested guidelines of making oral dispersing film. The appropriate dispersing ratio of the amount of surfactants and dispersing agent were 1% and 4%, also the stability dropped in the PEG molecular weight of 4000 or more. Drying time of oral dispersing film was $90^{\circ}C$ for 10 minutes to 12 minutes that dispersing film's property about flexibility, detachability were very good. The oral dispersion film's content used PEG 400 was $98.6{\pm}0.5%$ and the most uniform. As the molecular weight of PEG increased, dissolution time also increased. On the basis of evaluation parameter, PEG with 400~600 of molecular weight was selected as good dispersing agent in oral dispersing film. Therefore, it can be suggested guideline of preparation application study in oral dispersing film.

• The Korean Journal of Food And Nutrition
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• v.12 no.6
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• pp.582-587
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• 1999

감자절편을 고농도용액에 침지하여 탈수시킨 결과 침지용액을 구성하는 용질의 분자량에 따라 탈수형태가 다르게 나타났다. 저분자 용액인 NaCl, PEG 400 용액에 침지한 경우 조직의 뒤틀림현상(cytorrhysis) 은 나타나지 않고 부피의 감소와 수분의 탈수현상이 나타난 반면 고분자 용액인 PEG 4000, PEG 6000용액에 침지한 경우 cytorrhysis 현상을 동반한 부피의 감소와 탈수현상이 나타났다. 초기 탈수속도는 저분자 용액에 침지시 더 빨랐으나 최종 탈수량은 고분자 용액에 침지시 더 컸다 고장성 용액에 감자절편을 침지시켜 탈수되는 기작이 두가지 압력(삼투압 분자압착력)에 의해 진행된다고 가정하고 모델을 제안하여 감정한 결과 제안된 모델은 고분자 용액에 침지시의 탈수현항을 설명하는데 적합하였다. 모델에서 구해진 압력인자(ΔP)와 농도인자(a)는 온도(T)와 농도(C) 의 함수로 표현되며 계수의 탄력성 검정결과 농도에 대한 의존성이 더 큰 것으로 나타났다.

• Journal of Korean Society of Forest Science
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• v.71 no.1
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• pp.14-21
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• 1985

This study was carried out in order to prevent the devaluation of wood itself and wood products causing by anisotropy, hygroscopicity, shrinkage and swelling - properties that wood itself only have, in order to improve utility of wood, by emphasizing the natural beautiful figures of wood, to develop the dimensional stabilization techniques of wood with PEG that it is a cheap, non-toxic and the impregnation treatment is not difficult, on the effects of PEG molecular weights (200, 400, 600, 1000, 1500, 2000, 4000, 6000) and species (Pinus densiflora S. et Z., Larix leptolepis Gordon., Cryptomeria japonica D. Don., Cornus controversa Hemsl., Quercus variabilis Blume., Prunus sargentii Rehder.). The results were as follows; 1) PEG loading showed the maximum value (137.22%, Pinus densiflora, in PEG 400), the others showed that relatively slow decrease. The lower specific gravity, the more polymer loading. 2) Bulking coefficient didn't particularly show the correlation with specific gravity, for the most part, indicated the maximum values in PEG 600, except that the bulking coefficient of Quercus variabilis distributed between the range of 12-18% in PEG 400-2000. In general, the bulking coefficient of hardwood was higher than that of softwood. 3) Although there was more or less an exception according to species, volumetric swelling reduction was the greatest in PEG 400. That is, its value of Cryptomeria japonica was the greatest value with 95.0%, the others indicated more than 80% except for Prunus sargentii, while volumetric swelling reduction was decreased less than 70% as the molecular weight increase more than 1000. 4) The relative effectiveness of hardwood with high specific gravity was outstandingly higher than softwood. In general, the relative effectiveness of low molecular weight PEG was superior to those of high molecular weight PEG except that Quercus variabilis showed more than 1.6 to the total molecular weight range, while it was no significant difference as the molecular weight increase more than 4000. 5) According to the analysis of the results mentioned above, the dimensional stabilization of hardwood was more effective than softwood. Although volumetric swelling reduction was the greatest at a molecular weight of 400. In the view of polymer loading, bulking coefficiency reduction of swelling and relative effectiveness, it is desirable to use the mixture of PEG of molecular weight in the range of 200-1500. To practical use, it is recommended to study about the effects on the mixed ratio on the bulking coefficient, reduction of swelling and relative effectiveness.

• Conservation Science in Museum
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• v.5
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• pp.37-41
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• 2004

The immersed ancient wood relics excavated from the low swampy area of historic site in Shinchangdong, Gwangju are extremely weak. Since they are quickly dried inducing shrinkage when exposed to air, special preservative treatment is required to exhibit and preserve such items. In the case of the heavily varnished lacquerware such as the lacquered sheaths, in particular, it is extremely difficult to preserve them because chemicals are not easily penetrated and the coating might swell or come off during the process of coating. The lacquer sheaths have been preserved by carrying out freeze-drying after impregnating them in aqueous solution with low concentration of PEG#4000 40%.