• Journal of the Korean Society of Propulsion Engineers
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• v.15 no.4
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• pp.57-64
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• 2011

It has been suggested that turbulent effect should be considered for the study of highly unstable detonation of hydrocarbon fuels, as in the case of pulse detonation engine (PDE). A series of numerical study are carried out to understand the characteristics of the highly unstable detonation by considering viscosity, turbulence model and turbulence-combustion interaction model. Through studies of the different levels of modeling, it is understood that the viscosity and turbulence have negligible effects on low frequency characteristics, but tend to enhance the high frequency characteristics. It is also considered that the turbulence-chemistry interaction model should be taken the influence of the activation energy into account for detonation studies.

• Archives of Pharmacal Research
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• v.13 no.2
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• pp.136-141
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• 1990

The vasorelaxant effects of KR-30075 in guinea-pig pulmonary, bovine coronary and renal arterial strips contracted by either$K^+$depolarization, phenylephrine, or prostaglandin $F_{2a}$($PGF_{2a}$) were evaluated. KR-30075 was more potent than imazodan as a vasorelaxant against $PGF_{2a}$-induced contractions in bovine coronary and renal arteries, whereas against$K^+$induced contractions KR-30075 was less potent than imazodan in guieapig pulmonary arteries and more potent in bovine coronary arteries. KR-30075 was more potent against contractions induced by phenylephrine or $PGF_{2a}$ than the contractions induced by $K^+$ This profile of activity for KR-30075 was similar to that of imazodan and dissimilar from the calcium entry blocking agent nifedipine. There was no vascular selectivity of KR-30075 between bovine coronary and renal arterial strip preparations. In conclusion, this study shows that KR-30075 represents the vasorelaxant effects on guinea-pig pulmonary, bovine coronary and renal arteries without specific vascular selectivity. The vasorelaxant profile of KR-30075, with different sources of vascular smooth muscle, is unlike that of calcium entry blocking agent and more similar to the profile of the agent that inhibit cyclic nucleotide phosphodiesterase.

• Clean Technology
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• v.18 no.3
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• pp.320-324
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• 2012

In the present study, the discharge characteristics of a lithium-ion battery was evaluated to calculate the rate of heat generation under various discharge rates by mathematical modeling. The modeling and simulation of a pseudo-two dimensional ionic transport system for governing Butler-Volmer equation were carried out by using FEMLAB as a PDE (partial differential equation) solver, where the discharge rate was changed from 5 $A/m^2$ to 25 $A/m^2$. The computational results showed that the concentration of consumed solid-phase lithium at the surface of electrode was increased with increasing discharge rates. While the resulting diffusion limitation occurred shortly, it increased the rate of heat generation even more rapidly for the internal voltage to approach the cutoff voltage of the lithium-ion battery.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2007.04a
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• pp.157-162
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• 2007

A new level set based topology optimization employing inner-front creation algorithm is presented. In the conventional level set based topology optimization, the optimum topology strongly depends on the initial level set distribution due to the incapability of inner-front creation during optimization process. In the present work, in this regard, an inner-front creation algorithm is proposed. in which the sizes. shapes. positions, and number of new inner-fronts during the optimization process can be globally and consistently identified by considering both the value of a given criterion for inner-front creation and the occupied volume (area) of material domain. To facilitate the inner-front creation process, the inner-front creation map which corresponds to the discrete valued criterion of inner-front creation is applied to the level set function. In order to regularize the design domain during the optimization process, the edge smoothing is carried out by solving the edge smoothing partial differential equation (PDE). Updating the level set function during the optimization process, in the present work, the least-squares finite element method (LSFEM) is employed. As demonstrative examples for the flexibility and usefulness of the proposed method. the level set based topology optimization considering lightweight design of 3D shell structure is carried out.

• Proceedings of the Korea Information Processing Society Conference
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• 2017.11a
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• pp.781-784
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• 2017

Face recognition systems are characterized by low invasiveness of acquisition, and increasingly better reliability. Such systems may not be applied effectively, when the images are in low resolution (LR) as in the case that photos are taken from long distances, typically public surveillance. In theory, the high resolution (HR) image reconstructed from an LR face image, applying a super resolution (SR) method, can be used for face recognition. However, existing face SR algorithms may not give satisfactory results in face recognition. This article investigates the very low resolution face recognition problem and introduces a partial differential equation (PDE)-based SR method for a face recognition system of convolutional neural network (CNN).

• Bulletin of the Korean Chemical Society
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• v.33 no.11
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• pp.3607-3617
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• 2012

In this paper, the study of various ortho- and meta-substituted Magnolol derivatives is presented. The reaction enthalpies related to three antioxidant action mechanisms HAT, SET-PT and SPLET for substituted Magnolols have been calculated using DFT/B3LYP method in gas-phase and water. Calculated results show that electron-withdrawing substituents increase the bond dissociation enthalpy (BDE), ionization potential (IP) and oxidation/reduction enthalpy (O/RE), while electron-donating ones cause a rise in the proton dissociation enthalpy (PDE) and proton affinity (PA). In ortho- position, substituents show larger effect on reaction enthalpies than in meta-position. In comparison to gas-phase, water attenuates the substituent effect on all reaction enthalpies. In gas-phase, BDEs are lower than PAs and IPs, i.e. HAT represents the thermodynamically preferred pathway. On the other hand, SPLET mechanism represents the thermodynamically favored process in water. Results show that calculated enthalpies can be successfully correlated with Hammett constants (${\sigma}_m$) of the substituted Magnolols. Furthermore, calculated IP and PA values for substituted Magnolols show linear dependence on the energy of the highest occupied molecular orbital ($E_{HOMO}$).

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.10
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• pp.2011-2015
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• 2009

In an insulating dielectric liquid such as transformer oil, space charge injection and propagation were analyzed under the Fowler-Nordheim and Richardson-Dushman's thermal emission charge injection conditions for blade-plane electrodes stressed by a step voltage. The governing equations were composed of all five equations such as the Poisson's equation for electric fields, three continuity equations for electrons, negative, and positive ions, and energy balanced equation for temperature distributions. The governing equations for each carrier, the continuity equations, belong to the hyperbolic-type PDE of which the solution has a step change at the space charge front resulting in numerical instabilities. To decrease these instabilities, the governing equations were solved simultaneously by the Finite Element Method (FEM) employing the artificial diffusion scheme as a stabilization technique. Additionally, the terminal current was calculated by using the generalized energy method which is based on the Poynting's theorem, and represents more reliable and stable approach for evaluating discharge current. To verify the proposed method, the discharge phenomena were successfully applied to the blade~plane electrodes, where the radius of blade cap was $50{\mu}m$.

• Steel and Composite Structures
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• v.17 no.5
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• pp.753-776
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• 2014

In this paper, nonlinear vibration and post-buckling analysis of beams made of functionally graded materials (FGMs) resting on nonlinear elastic foundation subjected to thermo-mechanical loading are studied. The thermo-mechanical material properties of the beams are assumed to be graded in the thickness direction according to a simple power law distribution in terms of the volume fractions of the constituents, and to be temperature-dependent. The assumption of a small strain, moderate deformation is used. Based on Euler-Bernoulli beam theory and von-Karman geometric nonlinearity, the integral partial differential equation of motion is derived. Then this PDE problem which has quadratic and cubic nonlinearities is simplified into an ODE problem by using the Galerkin method. Finally, the governing equation is solved analytically using the variational iteration method (VIM). Some new results for the nonlinear natural frequencies and buckling load of the FG beams such as the influences of thermal effect, the effect of vibration amplitude, elastic coefficients of foundation, axial force, end supports and material inhomogenity are presented for future references. Results show that the thermal loading has a significant effect on the vibration and post-buckling response of FG beams.

• Archives of Pharmacal Research
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• v.26 no.8
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• pp.612-619
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• 2003

In this study, we evaluated the effects of oral administration of DA-8159, a selective phosphodiesterase-5 inhibitor, on the development of pulmonary hypertension (PH) induced by monocrotaline (MCT). Rats were administered either MCT (60 mg/kg) or saline. MCT-treated rats were divided into three groups and received orally administered vehicle, or 1 mg/kg or 5 mg/kg of DA-8159, twice a day for twenty-one days. The MCT group demonstrated increased right ventricular weights, medial wall thickening in the pulmonary arteries, myocardial fibrosis and the level of plasma cyclic guanosine monophosphate (cGMP), along with decreased body weight gains. However, DA-8159 markedly and dose-dependently reduced the development of right ventricular hypertrophy and medial wall thickening. DA-8159 also amplified the increase in plasma cGMP level and significantly increased the level of lung cGMP, compared with the MCT group. Although the body weight gain was still lower from the saline-treated control group, DA-8159 demonstrated a significant increase in body weight gains, in both 1 mg/kg and 5 mg/kg groups, when compared with the MCT group. In myocardial morphology, MCT-induced myocardial fibrosis was markedly prevented by DA-8159. These results suggest that DA-8159 may be a useful oral treatment option for PH.

• Microbiology and Biotechnology Letters
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• v.47 no.2
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• pp.278-288
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• 2019

In the present investigation, we attempted to design a protocol to develop a hybrid protein with better bioremediation capacity. Using in silico approaches, a Hybrid Open Reading Frame (Hybrid ORF) is developed targeting the genes of microorganisms known for degradation of organophosphates. Out of 21 genes identified through BLAST search, 8 structurally similar genes (opdA, opd, opaA, pte RO, pdeA, parC, mpd and phnE) involved in biodegradation were screened. Gene conservational analysis categorizes these organophosphates degrading 8 genes into 4 super families i.e., Metallo-dependent hydrolases, Lactamase B, MPP and TM_PBP2 superfamily. Hybrid protein structure was modeled using multi-template homology modeling (3S07_A; 99%, 1P9E_A; 98%, 2ZO9_B; 33%, 2DXL_A; 33%) by $Schr{\ddot{o}}dinger$ software suit version 10.4.018. Structural verification of protein models was done using Ramachandran plot, it was showing 96.0% residue in the favored region, which was verified using RAMPAGE. The phosphotriesterase protein was showing the highest structural similarity with hybrid protein having raw score 984. The 5 binding sites of hybrid protein were identified through binding site prediction. The docking study shows that hybrid protein potentially interacts with 10 different organophosphates. The study results indicate that the hybrid protein designed has the capability of degrading a wide range of organophosphate compounds.