• Title/Summary/Keyword: PD-1/PD-L1

Search Result 308, Processing Time 0.026 seconds

NOTE ON THE OPERATOR ${\hat{P}}$ ON Lp(∂D)

  • Choi, Ki Seong
    • Journal of the Chungcheong Mathematical Society
    • /
    • v.21 no.2
    • /
    • pp.269-278
    • /
    • 2008
  • Let ${\partial}D$ be the boundary of the open unit disk D in the complex plane and $L^p({\partial}D)$ the class of all complex, Lebesgue measurable function f for which $\{\frac{1}{2\pi}{\int}_{-\pi}^{\pi}{\mid}f(\theta){\mid}^pd\theta\}^{1/p}<{\infty}$. Let P be the orthogonal projection from $L^p({\partial}D)$ onto ${\cap}_{n<0}$ ker $a_n$. For $f{\in}L^1({\partial}D)$, ${\hat{f}}(z)=\frac{1}{2\pi}{\int}_{-\pi}^{\pi}P_r(t-\theta)f(\theta)d{\theta}$ is the harmonic extension of f. Let ${\hat{P}}$ be the composition of P with the harmonic extension. In this paper, we will show that if $1, then ${\hat{P}}:L^p({\partial}D){\rightarrow}H^p(D)$ is bounded. In particular, we will show that ${\hat{P}}$ is unbounded on $L^{\infty}({\partial}D)$.

  • PDF

Effect of Processing Methods on the Saponin Contents of Panax ginseng Leaf-Tea (고려인삼엽차의 제조방법에 따른 사포닌 성분의 함량 및 조성)

  • 장현기
    • The Korean Journal of Food And Nutrition
    • /
    • v.16 no.1
    • /
    • pp.46-53
    • /
    • 2003
  • Panax ginseng leaf tea was developed for the functional benefit of health, preference and convenience. The leaves of 4-year-old ginseng were selected in July and August. The ginseng leaf was treated by three methods : heat processed tea(HPT), aged tea(AGT) and hot-air dried tea(DRT). The contents and compositions of their crude saponin of ginseng leaves were measured. 1. The content of crude saponin of HPT was the higher than other treatments. The content of HPT was 18.72∼18.82%, ACT 18.24∼18.29% and DRT 17.02∼17.17%. 2. The harvest time and treatment methods were not affect the composition of ginsenoside in ginseng leaf tea. The ginsenoside-Re was shown the highest value as 1.97∼2.15. And ginsenoside-Rd was 1.48∼1.79, -Rg$_1$ 1.33∼1.58 and -Rb, -Rb$_2$, -Rc in the order. 3. The content of protopanaxadiol(PD) and protopanaxatriol(PT) was shown that DRT was 1.11∼1.13, HPT 1.09~l.12 and AGT 0.92∼1.02. The content of PD and PT were shown similar result at any harvest time. 4. The contents of crude saponin extracted by hot-water at 5 min was the higher ratios in HPT and harvested in July than other treatments. The content of crude saponin of ginseng leaf harvested in July was 15.88% and HPT was 16.88%. The order of contents of ginsenoside were -Re, -Rd, -Rg$_1$, -Rb$_1$, -Rb$_2$, and - Rc. The extraction ratio of crude saponin extracted by the circulated extraction method in 8 hours and 5 min extraction were 81.74∼84.38%. And HPT of ginseng leaf harvested in July was the highest value 84.3% but the extraction ratio of ginsenoside was 78.00~88.13%. But the extraction ratio of ginsenoside was similar trend in all treatments.

Treatment of central diabetes insipidus with anemia in a dog

  • Kim, Sol;Lee, Han Joon;Seo, Kyoung Won;Song, Kun-Ho
    • Korean Journal of Veterinary Service
    • /
    • v.45 no.2
    • /
    • pp.139-143
    • /
    • 2022
  • A 10-year-old, spayed female miniature schnauzer was referred to the Veterinary Medical Teaching Hospital of Chungnam National University due to evaluation of sudden polyuria (PU) and, polydipsia (PD) (540 mL/kg/day) with severe anemia and weight loss. Blood examination results were normal except for severe anemia (hematocrit, [HCT]: 11.8%). Urinalysis revealed a urine specific gravity (USG) of 1.003, whereas urine sediment was not specific. Urine osmolality was 90 mOsm (reference range: 800~2500 mOsm), and plasma osmolality was 303 mOsm. No specific lesions were found using diagnostic imaging including radiography, ultrasonography and magnetic resonance imaging (MRI). The serum cortisol level was normal in cosyntropin stimulation test. Plasma arginine vasopressin (AVP) concentration was <0.4 pg/mL (reference range: 3.49~5.45 pg/mL). Blood transfusion was initiated in addition to an oral prescription of desmopressin acetate (DDAVP, 0.1 mg/head) thrice a day for one week. The patient was rechecked for clinical signs, urine osmolality, and USG; the clinical signs of PU/PD were resolved, urine osmolality increased to 1106 mOsm, and, USG increased to 1.021. Considering the improved clinical signs, and increased urine osmolality, and USG after DDAVP treatment, the dog was diagnosed with central diabetes insipidus. USG and urine osmolality increased to >1.030 and 2200 mOsm, respectively. Anemia also gradually improved and HCT increased to >37%. DDAVP was tapered to 0.1 mg/head twice a day and all clinical signs in the patient have completely resolved.

Effect of surfactants on reductive degradation of Endosurfan I and II by ZVM (영가금속에 의한 Endosulfan I과 II의 환원분해에 미치는 계면활성제의 영향)

  • 김진영;김영훈;신원식;전영웅;송동익;최상준
    • Proceedings of the Korean Society of Soil and Groundwater Environment Conference
    • /
    • 2002.09a
    • /
    • pp.187-190
    • /
    • 2002
  • Reductive dechlorination of endosulfans was studied with zero valent metals (ZVMs) and bimetals in aqueous batch reactors. The effect of surfactants was evaluated. Endosulfan was successfully dechlorinated with zero valent iron. However, a bimetal, palladium coated iron (Pd/Fe) showed a highly enhanced reactivity for both endosulfan I and II indicating palladium act as a dechlorination catalyst on the iron. The effect of surfactants on degradation with ZVM has been very controvertible. Variable concentration of a nonionic surfactant, Triton X-100 and an anionic surfactant, SDS were added into the reactor with ZVM. The reaction rates of endosulfan were increased with both surfactants. In the case of Triton X-100, the reaction rate was increased with the increasing surfactant concentration up to 400 mg/L. Addition of small amount of surfactant under the CMC, the reaction rate was increased. However, the enhancing effect was diminished when a higher concentration of surfactant (1,000 mg/L) was used. Current study implicate that the surfactant adsorbed on the metal surface might increase the surface concentration of endosulfan resulting in the increased reaction rate. However, partitioning of endosulfan into the micelle formed at the high concentration of surfactant diminish the enhancing effect by reducing the contact chance between target compound and the metal surface.

  • PDF

Submicrospheres as Both a Template and the Catalyst Source. Silica Submicro-reactor Dotted with Palladium Nanoparticles as Catalysts

  • Kim, Sung Min;Noh, Tae Hwan;Jung, Ok-Sang
    • Bulletin of the Korean Chemical Society
    • /
    • v.34 no.4
    • /
    • pp.1127-1130
    • /
    • 2013
  • Formation of the monodisperse submicrospheres consisting of ionic palladium(II) complexes, $[(Me_4en)Pd(L)]_2(X)_4$($Me_4en$ = N,N,N',N'-tetramethylethylenediamine; L = bis(4-(4-pyridylcarboxyl)phenyl)methane; $X^-=BF_4{^-}$ and $ClO_4{^-}$), has been carried out without any templates or additives. The submicrospheres were coated with silicates, and then calcined in air at $550^{\circ}C$ for 1 h, to efficiently form hollow-spherical $SiO_2$ submicro-reactors dotted with palladium(0) nanoparticles (PdNPs). That is, the submicrospheres act as both a template and a source of the palladium metal nanoparticles. The submicro-reactors containing nano-catalysts have been characterized by means of SEM, TEM, and XPS. Notably, the reactors were proved to be very effective for Suzuki-Miyaura cross-coupling and hydrogenation reactions.

Culture Conditions for Mycelial Growth and Anti-Cancer Properties of Termitomyces

  • Suphachai Tharavecharak;Corina N. D'Alessandro-Gabazza;Masaaki Toda;Taro Yasuma;Taku Tsuyama;Ichiro Kamei;Esteban C. Gabazza
    • Mycobiology
    • /
    • v.51 no.2
    • /
    • pp.94-108
    • /
    • 2023
  • Termitomyces sp. that grow in symbiosis with fungus-farming Termites have medicinal properties. However, they are rare in nature, and their artificial culture is challenging. The expression of AXL receptor tyrosine kinase and immune checkpoint molecules favor the growth of cancer cells. The study evaluated the optimal conditions for the artificial culture of Termitomyces and their inhibitory activity on AXL and immune checkpoint molecules in lung adenocarcinoma and melanoma cell lines. The culture of 45 strains of Termitomyces was compared. Five strains with marked growth rates were selected. Four of the selected strains form a single cluster by sequence analysis. The mycelium of 4 selected strains produces more fungal mass in potato dextrose broth than in a mixed media. The bark was the most appropriate solid substrate for Termitomyces mycelia culture. The mycelium of all five selected strains showed a higher growth rate under normal CO2 conditions. The culture broth, methanol, and ethyl acetate of one selected strain (T-120) inhibited the mRNA relative expression of AXL receptor tyrosine kinase and immune checkpoint molecules in cancer cell lines. Overall, these results suggest the potential usefulness of Termitomyces extracts as a coadjuvant therapy in malignant diseases.

Reaction Characteristics of Oxidation Catalysts for HCCI Engine (HCCI 엔진용 산화촉매의 반응특성)

  • Park, Sung-Yong;Kim, Hwa-Nam;Choi, Byung-Chul
    • Transactions of the Korean Society of Mechanical Engineers B
    • /
    • v.34 no.2
    • /
    • pp.165-171
    • /
    • 2010
  • The Homogeneous Charge Compression Ignition (HCCI) engine concept allows for both NOx and particulate matter to be reduced simultaneously, and it is a promising way to meet the next environmental challenges. Unfortunately, HCCI combustion often increases CO and HC emissions. The development of oxidation catalyst (OC) requires high conversion efficiency for CO and HC at low temperature. Conventional oxidation catalyst technologies may not be able to convert these emissions because of the saturation of active catalytic sites. The OC used in this study was 600 cpsi cordierite. Three kinds of OC with different amounts of Pt and Pd were used. The influence of the space velocity (SV), $H_2O$ and $O_2$ concentration was also studied. All types of OCs were found to have over 90% CO conversion efficiencies at $170^{\circ}C$. When in the presence of water vapor, CO conversion was increased, but $C_3H_8$ conversion was decreased. The performance of the OC was not influenced by initial the HC concentration. The 2Pt/Pd catalyst was better in terms of thermal aging than the Pt-only catalyst. The $LOT_{50}$ of both fresh and aged OC was increased with increasing SV and with the presence of $H_2O$.

Convergence Study on Natural Preservatives from Various Native Plant Species in Jiri Mountain Area (지리산 지역 자생식물 활용 천연보존제 융합 연구)

  • Jeong, Ji-Suk
    • Journal of the Korea Convergence Society
    • /
    • v.8 no.12
    • /
    • pp.109-117
    • /
    • 2017
  • The purpose of the study aimed to explore the possibility for natural preservative convergence materials by examining the antioxidant activity and antimicrobial effect of 19 wild plants in Jiri Mountain. Total polyphenols were higher in the order of CS(Camellia sinensis L., 87.9 mg GAE/ g), MP(Mentha piperascens Holmes., 85.1 mg), NN(Nelumbo nucifera Gaertn., 65.0 mg) and PD(Pinus densiflora Siebold & Zucc., 52.8 mg). Total flavonoids were high in NN(25.7 mg QUE / g) and MP (25.4 mg QUE / g). CS(58.1%), NN(47.9%), and MP(40.6%) showed high ABTS radical scavenging ability and the result was similar in DPPH radical scavenging ability. The extracts of HC(Hemerocallis coreana Nakai.), PD, and CO(Cornus officinalis Siebold et Zucc.) showed the highest inhibitory effect on the growth of E. coli. The extracts of PK(Pulsatilla koreana Nakai ex Nakai.), SC(Saururus chinensis Baill.), and MC(Smilax china L.) completely inhibited the proliferation of S. aureus, showing the possibility to be developed as natural preservatives and disinfectants.

Oxidative Modification of Neurofilament-L Induced by Endogenous Neurotoxin, Salsolinol

  • Kang, Jung-Hoon
    • Bulletin of the Korean Chemical Society
    • /
    • v.32 no.9
    • /
    • pp.3421-3424
    • /
    • 2011
  • The endogenous neurotoxin, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol), has been considered a potential causative factor for the pathogenesis of Parkinson's disease (PD). In this study, we examined oxidative modification of neurofilament-L (NF-L) induced by salsolinol. When disassembled NF-L was incubated with salsolinol, the aggregation of protein was increased with the concentration of sasolinol. The formation of carbonyl compound was obtained in salsolinol-mediated NF-L aggregates. This process was protected by free radical scavengers, such as N-acetyl-L-cysteine and glutathione. These results suggest that the aggregation of NF-L is mediated by salsolinol via the generation of free radicals. We also investigated the effects of copper ion on salsolinol-mediated NF-L modification. In the presence of copper ions, salsolinol enhanced the modification of NF-L. We suggest that salsolinol might be related to abnormal aggregation of NF-L which may be involved in the pathogenesis of neurodegenerative diseases and related disorders.

Hydrogen separation of $V_{99.8}B_{0.2}$ Alloy Membrane in Water-gas shift Reaction (수성 가스 전이반응에서 $V_{99.8}B_{0.2}$ 합금 분리막의 수소분리)

  • Jeon, Sung-Il;Jung, Yeong-Min;Park, Jung-Hoon;Lee, Yong-Taek
    • Membrane Journal
    • /
    • v.22 no.1
    • /
    • pp.16-22
    • /
    • 2012
  • The influence of co-existing gases on the hydrogen permeation without sweep gas was studied through a Pd-coated $V_{99.8}B_{0.2}$ alloy membrane. Membranes have been investigated in the pressure range 1.5-8.0 bar under pure hydrogen, hydrogen-carbon dioxide and hydrogen-carbon monoxide gas mixture without sweep gas at $400^{\circ}C$. Preliminary hydrogen permeation experiments without sweep gas have been confirmed that hydrogen flux was $40.7mL/min/cm^2$ for a Pd-coated $V_{99.8}B_{0.2}$ alloy membrane (thick : 0.5 mm) using pure hydrogen as the feed gas. In addition, hydrogen flux was $21.4mL/min/cm^2$ for $V_{99.8}B_{0.2}$ alloy membrane using $H_2/CO_2$ as the feed gas. The hydrogen permeation flux decreased with decrease of hydrogen partial pressure irrespective of pressure when $H_2/CO_2$and $H_2/CO$mixture applied as feed gas respectively and permeation fluxes were satisfied with Sievert's law in different feed conditions. It was found from XRD, SEM/EDX results after permeation test that the Pd-coated $V_{99.8}B_{0.2}$ alloy membrane had good stability and durability for various mixtures feeding condition.