• 대한핵의학회지
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• 제36권2호
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• pp.102-109
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• 2002

목적: 유전자 치료에서, 종양세포에 herpes simplex virus thymidine kinase 유전자를 발현시키고 이에 민감한 prodrug을 전신투여하여 발현된 종양세포에 특이적으로 집적되는 방법은 매우 효율적인 방법이다. 대표적인 prodrug인, IVDU, IVFRU는 herpes simplex virus type 1의 비침습적 영상화 방법에 응용되는 방사옥소 표지가능 화합물이다. 재료 및 방법: Trans-l-trimethylsilyl-2-tri-n-butylstannylethylene과 uridine 변형체상의 iodo-uracil을 Pd촉매하에서 반응시켜 표지전구체인 5-trimethylvinyl-deoxy-uridine과 5-trimethylsilylvinyl-deoxy-fluororibofuranosyl uracil을 합성하였다. 이것을 column chromatography의 방법으로 분리 정제하였다. 합성한 각 전구체를 ICI 담체를 이용하여 높은 수율로 표지하였고, HPLC를 사용하여 분리하였다. Radiohalogen exchange 방법은 비방사능을 낮게 할수록 표지에 효율적으로 알려져 있다. 이 방법으로 ICI 방법을 사용하여 담체를 포함하는 높은 방사능의 화합물을 얻을 수 있다. 결과: IVDU와 IVFRU 표지를 위한 전구체 합성수율은 각각 43, 72% 였다. ICl로 담체를 이용한 표지방법을 사용하여 IVDU와 IVFRU 표지수율은 98% 이상이었다. 결론: HSV1-tk를 이용한 유전자 영상용 기질의 전구체를 성공적으로 합성하였고. 95% 이상의 높은 표지수율의 유전자 영상용 방사성 추적자를 성공적으로 제조하였다.

• 한국임상수의학회지
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• 제32권5호
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• pp.399-403
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• 2015

복막투석은 혈액에서부터 오는 체액과 노폐물을 교환하는 복강내의 막인 복막을 이용한 투석방법으로, 신부전과 중독증 환자에서의 치료법이다. 본 연구에서는 신부전증 개에서 자동투석기를 이용한 복막투석의 치료효율과 합병증에 대해 평가하였다. 10마리의 개를 대상으로 Swan neck 카테터(Neonatal, Coviden)와 자동 복막투석기를 사용하여 복막투석을 실시하였고, 그 효과는 요소감소율(urea reduction ratio)로 평가하였다. 평균 크레아틴닌 감소율과 평균 요소감소율은 $7.09{\pm}3.84$과 $145.8{\pm}48.5$였다. 평균 투석횟수는 $6{\pm}1$회 였다. 투석치료후 유의성 있는 요소의 감소가 7/10 개에서 관찰되었고, 유의성 있는 크레아틴의 감소가 9/10 개에서 관찰되었다. 요소의 감소율이 크레아틴 감소율보다 더 높게 관찰되었다. 1회 투석당 요소와 크레아틴닌의 감소율은 $0.064{\pm}0.023$과 $0.065{\pm}0.023$이 였다. 본 연구에서의 복막투석에 따른 합병증은 카테터 막힘, 투석액의 피하누출, 패혈성 복막염, 저알부민혈증, 과수화 등이었다. Swan neck 카테터와 자동 복막투석기를 이용한 복막투석은 임상에서 적용 가능하였으며 본 연구를 통하여 성공적인 복막투석의 가능성을 보여주었다. 하지만 합병증을 최소화하기 위해서는 주의 깊은 모니터링이 필요할 것으로 판단된다.

• 한국전기전자재료학회논문지
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• 제26권12호
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• pp.882-887
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• 2013

We investigated a SiC-based hydrogen gas sensor with metal-insulator-semiconductor (MIS) structure for high temperature process monitoring and leak detection applications. The sensor was fabricated by Pd/$Ta_2O_5$/SiC structure, and a thin tantalum oxide ($Ta_2O_5$) layer was exploited with the purpose of sensitivity improvement, because tantalum oxide has good stability at high temperature as well as high permeability for hydrogen gas. In the experiment, dependence of I-V characteristics and capacitance response properties on hydrogen gas concentrations from 0 to 2,000 ppm was analyzed at room temperature to $500^{\circ}C$. As the result, our sensor exploiting a $Ta_2O_5$ dielectric layer showed possibilities with regard to use in hydrogen gas sensors for high-temperature applications.

• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4925-4928
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• 2014

Background: This study aimed to evaluate the methylation of RASSF1A and CDH13 gene promoter regions as a marker for monitoring chemotherapeutic efficacy with personalized medicine for patients with NSCLC, in the hope of providing a new direction for NSCLC individualized chemotherapy. Materials and Methods: 42 NSCLC patients and 40 healthy controls were included. Patient blood samples were collected in the whole process of chemotherapy. Methylation of RASSF1A and CDH13 gene promoter regions was detected by the methylation specific polymerase chain reaction (MSP). Results: The rate of RASSF1A and CDH13 gene methylation in 42 cases of NSCLC patients was significantly higher than in 40 healthy controls (52.4% to 0.0%, 54.8% to 0.0%, p<0.05). After the chemotherapy, the hyper-methylation of RASSF1A and CDH13 genes in PR group and SD group decreased significantly (p<0.05), and was significantly different from that in PD group (p<0.05), but not as compared with healthy controls (P>0.05). With chemotherapy, RASSF1A and CDH13 promoter region methylation rate in 42 cases of patients showed a declining trend. Conclusions: The methylation level of RASSF1A and CDH13 gene promoter region can reflect drug sensitivity of tumors to individualized treatment.

• 조명전기설비학회논문지
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• 제20권5호
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• pp.64-71
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• 2006

전력설비의 비정상적인 온도변화를 감시할 목적으로 10개의 광섬유격자를 이용하여 $1[^{\circ}C]$ 이내의 온도분해능을 가지는 준분배형 광섬유 온도센서를 제작하였다. 파장가변 FP 필터를 스캔하여 얻어지는 PD 출력파형의 피크위치를 검색하여 광섬유격자 센서의 출력변화를 읽어내었고, 가우시안 line-fitting 알고리즘으로 광섬유격자의 반사스펙트럼 왜곡에 의한 영향을 보상하고 정밀도를 향상시켰다. 제작한 센서시스템과 기준 온도계로 사용한 thermocouple 간의 측정값 오차는 1[%] 이내이며, 선형화 오차는 약 0.37[%]으로 측정되었다.

• 한국전기전자재료학회논문지
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• 제29권2호
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• pp.114-119
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• 2016

This paper dealt with the propagation characteristics of acoustic signal in insulation oil for the purpose of improving the reliability of AE (acoustic emission) method used for condition monitoring of oil-immersed transformers. A discharge source was placed in insulation oil and AE sensors ($f_c$ :140 kHz) were attached on the oil tank to study the changes of velocity and propagation path with the depth and distance. The average velocity was 1,436 m/s and the velocity decreased with the increase of depth from the oil surface to 430 mm. The propagation paths were classified into three sections by the shortest reflection path of the detected signal. The minimum distinguishable distance in each section was 70 mm. It was also verified that PD (partial discharge) with a magnitude over than 500 pC can be detected by the AE sensors.

• 전기학회논문지
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• 제64권3호
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• pp.485-491
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• 2015

This paper shows the design improvement and test model of FAU (Frequency Analysis Unit) in PDD (Partial Discharge Diagnosis system) for 800kV GIS (Gas Insulated Switchgear). We found some problems during operation of previous FAU, such as the aging of fiber-optic converter that can cause communication error, the malfunction of signal analysis circuit etc. And then we solved those problems by design improvement and verified the performance through type test. To monitor partial discharge, the performance of UHF sensor is important but the performance of frequency analysis unit is also very important. So we solved communication error, the malfunction of signal analysis circuit and then increased the operation reliability of FAU by improving fiber-optic converter and signal analysis circuit. Accredited testing laboratory carried out the performance verification test according to performance test criteria and procedure of reliability test standards, IEC-60225, 61000 and 60068 etc. We confirmed the test results which correspond with the performance test criteria.

• 한국해양공학회지
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• 제11권3호
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• pp.200-211
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• 1997

Most recently, offshore Engineering & Construction field is concerned about integration management technology such as CIM(Computer Integrated Manufacturing), PDM(Product Data Management) and Enterprise Information Engineering in order to cope with the rapid change of engineering and manufacturer specification as per owner's requirement during construction stage of the project. System integration and integrated data modeling with relational database in integration management technology improve the quality of product and reduce the period of the construction project by reason of owing design information jointly. This paper represents the design methodology of system integration using Business Process Reengineering by the case study. The case study is about the offshore plant material information process from front end engineering design to detail engineering for the construction and the basis of monitoring system by integrating and sharing the design information between the 2D intelligent P&ID and 3D plant modeling using relational database. As a result of the integrated data modeling and system integration, it is possible to maintain the consistency of design process in point of view of the material balancing and reduce the design assumption/duration. Near future, this system will be expanded and connected with the MRP(Material Requirement Planing) and the POR (Purchase Order Requisition) system.

• 대한건축학회논문집:계획계
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• 제33권12호
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• pp.3-11
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• 2017

The non-mandatory guidance and illogical ordinance of local government generate complicated and vague regulations and procedures. These cause inconvenience in building administration, and give rise to unnecessary social and administrative expenses. The purpose of this study is to suggest the improvement of building administration by local government from an institutional point of view through the literature review and the specialist survey focusing on the problems arising from the building ordinances and non-mandatory guidance. The results of this study are as follows; In the first place, the connection between law and ordinance should be improved in a systematic, definitude manner and high-degree of completion. Second, the monitoring management system should be arranged in order to excavate and improve the non-mandatory guidance. Third, the effort should go into improving ability and disposition of building official. Fourth, it is necessary to materialize and clarify the regulatory contents and adjust them to fit the legal system. Lastly, it is important to reinforce incentives and procedures of verification in order to manage building ordinances of legal government's own free will. In order to improve of building administration by local government, it is necessary to make the structure of sustainable improvement and discuss not only institutional aspect but also elements of building administration in later study.

• 한국재료학회지
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• 제34권5호
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• pp.235-241
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• 2024

Gas identification techniques using pattern recognition methods were developed from four micro-electronic gas sensors for noxious gas mixture analysis. The target gases for the air quality monitoring inside vehicles were two exhaust gases, carbon monoxide (CO) and nitrogen oxides (NO_x), and two odor gases, ammonia (NH₃) and formaldehyde (HCHO). Four MEMS gas sensors with sensing materials of Pd-SnO₂ for CO, In₂O₃ for NO_X, Ru-WO₃ for NH₃, and hybridized SnO₂-ZnO material for HCHO were fabricated. In six binary mixed gas systems with oxidizing and reducing gases, the gas sensing behaviors and the sensor responses of these methods were examined for the discrimination of gas species. The gas sensitivity data was extracted and their patterns were determined using principal component analysis (PCA) techniques. The PCA plot results showed good separation among the mixed gas systems, suggesting that the gas mixture tests for noxious gases and their mixtures could be well classified and discriminated changes.