• The Korean Journal of Nuclear Medicine
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• v.36 no.2
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• pp.102-109
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• 2002

Purpose : In gene therapy, tumor cells expressing the herpes simplex virus thymidine kinase are sensitive to prodrugs. Potential prodrugs IVDU and IVFRU were synthesized and radiolabeled with radioiodine for noninvasive imaging of herpes simplex virus type 1 gene expression. Material and Methods : 5-(2-trimethysilyl) vinyl-2'-deoxyuridine and 5-(2-trimethylsilyl)vinyl-2'-fluoro-2'-deoxyuridine, precursors of 5-(2--iodo)viny l-2'-deoxy uridine(IVDU) and 5-(2-iodo)-2'-vinyl-2'-deoxy-2'-fluororibofuranosyl uracil(IVFRU), were synthesized from reaction of trans-1-trimethylsillyl-2-tri-n-butylstannylethylene with 5-iodo-2'-deoxyuridine and 5-iodo-2'-fluoro-2'-deoxyuridine, respectively, on the condition of Pd catalyst. These precursors were separated from reaction mixture by silica gel column chromatography method. Each precursor was radioiodinated with radioiodine by mixing with ICI oxidizing agent. These radioiodinated compounds were purified with HPLC. Radiohalogen exchange has been shown to be effective for the synthesis of products with lower specific activity. Similarly, carrier-added and high specific activity products have been isolated in respectable radiochemical yields using ICI method. Results : Synthetic yield of precursors, IVDU and IVFRU were 43% and 18%, respectively. Radiochemical purity of both compunds was over 98%. Conclusion : We synthesized precursors of IVDU and IVFRU for monitoring of HSV1-tk gene expression. Radiotracers were radioiodinated with high radiolabeling yield by ICI method.

• Journal of Veterinary Clinics
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• v.32 no.5
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• pp.399-403
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• 2015

Peritoneal dialysis (PD) is a treatment for renal failure and acute poisoning, and uses the patient's peritoneum in the abdomen as a membrane across which fluids and dissolved substances are exchanged from the blood. In this study, we evaluated the therapeutic efficacy and complications of automated peritoneal dialyzer (APD) in dogs with renal failure. PD was performed in 10 dogs using a swan neck catheter (Neonatal, Coviden) and automatic APD. The efficacy for each dog was assessed by calculating urea reduction ratio (URR) and creatinine reduction ratio (CRR). Mean concentrations of pre-dialysis creatinine and blood urea (BUN) were $7.09{\pm}3.84$ and $145.8{\pm}48.5$, respectively. The mean number of peritoneal dialysis cycles applied was $6{\pm}1$ cycles. Peritoneal dialysis resulted in a significant decrease in BUN concentration in 7/10 dogs, while a significant decrease in creatinine concentration in 9/10 dogs. The mean of URR was higher than that of CRR ($0.39{\pm}0.16$ vs $0.38{\pm}0.13$). The mean CRR and URR per dialysis cycles were $0.064{\pm}0.023$ and $0.065{\pm}0.023$, respectively. Complications found in this study were catheter occlusion, subcutaneous dialysate leakage, septic peritonitis, hypoalbuminemia and overhydration. This study found PD using a swan neck catheter and APD machine showed acceptable efficacy for successful peritoneal dialysis in dogs. However, close monitoring is required to minimize the risk of complication.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.26 no.12
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• pp.882-887
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• 2013

We investigated a SiC-based hydrogen gas sensor with metal-insulator-semiconductor (MIS) structure for high temperature process monitoring and leak detection applications. The sensor was fabricated by Pd/$Ta_2O_5$/SiC structure, and a thin tantalum oxide ($Ta_2O_5$) layer was exploited with the purpose of sensitivity improvement, because tantalum oxide has good stability at high temperature as well as high permeability for hydrogen gas. In the experiment, dependence of I-V characteristics and capacitance response properties on hydrogen gas concentrations from 0 to 2,000 ppm was analyzed at room temperature to $500^{\circ}C$. As the result, our sensor exploiting a $Ta_2O_5$ dielectric layer showed possibilities with regard to use in hydrogen gas sensors for high-temperature applications.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4925-4928
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• 2014

Background: This study aimed to evaluate the methylation of RASSF1A and CDH13 gene promoter regions as a marker for monitoring chemotherapeutic efficacy with personalized medicine for patients with NSCLC, in the hope of providing a new direction for NSCLC individualized chemotherapy. Materials and Methods: 42 NSCLC patients and 40 healthy controls were included. Patient blood samples were collected in the whole process of chemotherapy. Methylation of RASSF1A and CDH13 gene promoter regions was detected by the methylation specific polymerase chain reaction (MSP). Results: The rate of RASSF1A and CDH13 gene methylation in 42 cases of NSCLC patients was significantly higher than in 40 healthy controls (52.4% to 0.0%, 54.8% to 0.0%, p<0.05). After the chemotherapy, the hyper-methylation of RASSF1A and CDH13 genes in PR group and SD group decreased significantly (p<0.05), and was significantly different from that in PD group (p<0.05), but not as compared with healthy controls (P>0.05). With chemotherapy, RASSF1A and CDH13 promoter region methylation rate in 42 cases of patients showed a declining trend. Conclusions: The methylation level of RASSF1A and CDH13 gene promoter region can reflect drug sensitivity of tumors to individualized treatment.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.20 no.5
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• pp.64-71
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• 2006

We developed a fiber-optic temperature sensor system, with 10 fiber Bragg gratings, for abnormal high-temperature monitoring in power systems. We used Gaussian line-fitting algorithm to compensate the spectrum distortion in the wavelength-scanned Farby-Perot filter demodulation scheme. Compared with highest-peak-detection method, the proposed algorithm substantially reduced measurement errors. The overall measurement error was less than 1[%] compared with the reference thermocouple and the linearity error was 0.37[%].

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.29 no.2
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• pp.114-119
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• 2016

This paper dealt with the propagation characteristics of acoustic signal in insulation oil for the purpose of improving the reliability of AE (acoustic emission) method used for condition monitoring of oil-immersed transformers. A discharge source was placed in insulation oil and AE sensors ($f_c$ :140 kHz) were attached on the oil tank to study the changes of velocity and propagation path with the depth and distance. The average velocity was 1,436 m/s and the velocity decreased with the increase of depth from the oil surface to 430 mm. The propagation paths were classified into three sections by the shortest reflection path of the detected signal. The minimum distinguishable distance in each section was 70 mm. It was also verified that PD (partial discharge) with a magnitude over than 500 pC can be detected by the AE sensors.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.3
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• pp.485-491
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• 2015

This paper shows the design improvement and test model of FAU (Frequency Analysis Unit) in PDD (Partial Discharge Diagnosis system) for 800kV GIS (Gas Insulated Switchgear). We found some problems during operation of previous FAU, such as the aging of fiber-optic converter that can cause communication error, the malfunction of signal analysis circuit etc. And then we solved those problems by design improvement and verified the performance through type test. To monitor partial discharge, the performance of UHF sensor is important but the performance of frequency analysis unit is also very important. So we solved communication error, the malfunction of signal analysis circuit and then increased the operation reliability of FAU by improving fiber-optic converter and signal analysis circuit. Accredited testing laboratory carried out the performance verification test according to performance test criteria and procedure of reliability test standards, IEC-60225, 61000 and 60068 etc. We confirmed the test results which correspond with the performance test criteria.

• Journal of Ocean Engineering and Technology
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• v.11 no.3
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• pp.200-211
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• 1997

Most recently, offshore Engineering & Construction field is concerned about integration management technology such as CIM(Computer Integrated Manufacturing), PDM(Product Data Management) and Enterprise Information Engineering in order to cope with the rapid change of engineering and manufacturer specification as per owner's requirement during construction stage of the project. System integration and integrated data modeling with relational database in integration management technology improve the quality of product and reduce the period of the construction project by reason of owing design information jointly. This paper represents the design methodology of system integration using Business Process Reengineering by the case study. The case study is about the offshore plant material information process from front end engineering design to detail engineering for the construction and the basis of monitoring system by integrating and sharing the design information between the 2D intelligent P&ID and 3D plant modeling using relational database. As a result of the integrated data modeling and system integration, it is possible to maintain the consistency of design process in point of view of the material balancing and reduce the design assumption/duration. Near future, this system will be expanded and connected with the MRP(Material Requirement Planing) and the POR (Purchase Order Requisition) system.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.33 no.12
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• pp.3-11
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• 2017

The non-mandatory guidance and illogical ordinance of local government generate complicated and vague regulations and procedures. These cause inconvenience in building administration, and give rise to unnecessary social and administrative expenses. The purpose of this study is to suggest the improvement of building administration by local government from an institutional point of view through the literature review and the specialist survey focusing on the problems arising from the building ordinances and non-mandatory guidance. The results of this study are as follows; In the first place, the connection between law and ordinance should be improved in a systematic, definitude manner and high-degree of completion. Second, the monitoring management system should be arranged in order to excavate and improve the non-mandatory guidance. Third, the effort should go into improving ability and disposition of building official. Fourth, it is necessary to materialize and clarify the regulatory contents and adjust them to fit the legal system. Lastly, it is important to reinforce incentives and procedures of verification in order to manage building ordinances of legal government's own free will. In order to improve of building administration by local government, it is necessary to make the structure of sustainable improvement and discuss not only institutional aspect but also elements of building administration in later study.

• Korean Journal of Materials Research
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• v.34 no.5
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• pp.235-241
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• 2024

Gas identification techniques using pattern recognition methods were developed from four micro-electronic gas sensors for noxious gas mixture analysis. The target gases for the air quality monitoring inside vehicles were two exhaust gases, carbon monoxide (CO) and nitrogen oxides (NO_x), and two odor gases, ammonia (NH₃) and formaldehyde (HCHO). Four MEMS gas sensors with sensing materials of Pd-SnO₂ for CO, In₂O₃ for NO_X, Ru-WO₃ for NH₃, and hybridized SnO₂-ZnO material for HCHO were fabricated. In six binary mixed gas systems with oxidizing and reducing gases, the gas sensing behaviors and the sensor responses of these methods were examined for the discrimination of gas species. The gas sensitivity data was extracted and their patterns were determined using principal component analysis (PCA) techniques. The PCA plot results showed good separation among the mixed gas systems, suggesting that the gas mixture tests for noxious gases and their mixtures could be well classified and discriminated changes.