• Title/Summary/Keyword: PCT

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Prediction of Treatment Outcome of Chemotherapy Using Perfusion Computed Tomography in Patients with Unresectable Advanced Gastric Cancer

  • Dong Ho Lee;Se Hyung Kim;Sang Min Lee;Joon Koo Han
    • Korean Journal of Radiology
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    • v.20 no.4
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    • pp.589-598
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    • 2019
  • Objective: To evaluate whether data acquired from perfusion computed tomography (PCT) parameters can aid in the prediction of treatment outcome after palliative chemotherapy in patients with unresectable advanced gastric cancer (AGC). Materials and Methods: Twenty-one patients with unresectable AGCs, who underwent both PCT and palliative chemotherapy, were prospectively included. Treatment response was assessed according to Response Evaluation Criteria in Solid Tumors version 1.1 (i.e., patients who achieved complete or partial response were classified as responders). The relationship between tumor response and PCT parameters was evaluated using the Mann-Whitney test and receiver operating characteristic analysis. One-year survival was estimated using the Kaplan-Meier method. Results: After chemotherapy, six patients exhibited partial response and were allocated to the responder group while the remaining 15 patients were allocated to the non-responder group. Permeability surface (PS) value was shown to be significantly different between the responder and non-responder groups (51.0 mL/100 g/min vs. 23.4 mL/100 g/min, respectively; p = 0.002), whereas other PCT parameters did not demonstrate a significant difference. The area under the curve for prediction in responders was 0.911 (p = 0.004) for PS value, with a sensitivity of 100% (6/6) and specificity of 80% (12/15) at a cut-off value of 29.7 mL/100 g/min. One-year survival in nine patients with PS value > 29.7 mL/100 g/min was 66.7%, which was significantly higher than that in the 12 patients (33.3%) with PS value ≤ 29.7 mL/100 g/min (p = 0.019). Conclusion: Perfusion parameter data acquired from PCT demonstrated predictive value for treatment outcome after palliative chemotherapy, reflected by the significantly higher PS value in the responder group compared with the non-responder group.

Dynamic Contrast-Enhanced Ultrasound of Gastric Cancer: Correlation with Perfusion CT and Histopathology

  • Ijin Joo;Se Hyung Kim;Dong Ho Lee;Joon Koo Han
    • Korean Journal of Radiology
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    • v.20 no.5
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    • pp.781-790
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    • 2019
  • Objective: To assess the relationship between contrast-enhanced ultrasound (CEUS) parameters and perfusion CT (PCT) parameters of gastric cancers and their correlation with histologic features. Materials and Methods: This prospective study was approved by our Institutional Review Board. We included 43 patients with pathologically-proven gastric cancers undergoing CEUS using SonoVue® (Bracco) and PCT on the same day. Correlation between the CEUS parameters (peak intensity [PI], area under the curve [AUC], rise time [RT] from 10% to 90% of PI, time to peak [TTPUS], and mean transit time [MTTUS]) and PCT parameters (blood flow, blood volume, TTPCT, MTTCT, and permeability surface product) of gastric cancers were analyzed using Spearman's rank correlation test. In cases of surgical resection, the CEUS and PCT parameters were compared according to histologic features using Mann-Whitney test. Results: CEUS studies were of diagnostic quality in 88.4% (38/43) of patients. Among the CEUS parameters of gastric cancers, RT and TTPUS showed significant positive correlations with TTPCT (rho = 0.327 and 0.374, p = 0.045 and 0.021, respectively); PI and AUC were significantly higher in well-differentiated or moderately-differentiated tumors (n = 4) than poorly-differentiated tumors (n = 18) (p = 0.026 and 0.033, respectively), whereas MTTCT showed significant differences according to histologic types (poorly cohesive carcinoma [PCC] vs. non-PCC), T-staging (≤ T2 vs. ≥ T3), N-staging (N0 vs. N-positive), and epidermal growth factor receptor expression (≤ faint vs. ≥ moderate staining) (p values < 0.05). Conclusion: In patients with gastric cancers, CEUS is technically feasible for the quantification of tumor perfusion and may provide correlative and complementary information to that of PCT, which may allow prediction of histologic features.

Diagnostic Value of Serum Procalcitonin in Febrile Infants Under 6 Months of Age for the Detection of Bacterial Infections (발열이 있는 6개월 미만의 영아에서 세균성 감염에 대한 procalcitonin의 진단적 가치)

  • Kim, Nam Hyo;Kim, Ji Hee;Lee, Taek Jin
    • Pediatric Infection and Vaccine
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    • v.16 no.2
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    • pp.142-149
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    • 2009
  • Purpose : The aim of this study was to determine the diagnostic value of serum procalcitonin (PCT) compared with that of C-reactive protein (CRP) and the total white blood cell count (WBC) in predicting bacterial infections in febrile infants<6 months of age. Methods : A prospective study was performed with infants <6 months of age who were admitted to the Department of Pediatrics with a fever of uncertain source between July and September 2008. Spinal taps were performed according to clinical symptoms and physical examination. Serum PCT levels were measured using an enzyme-linked fluorescent assay. Results : Seventy-one infants (mean age, 2.62 months) were studied. Twenty-six infants (36.6%) had urinary tract infections (UTIs), and 22 infants (31.0%) had viral meningitis. The remaining infants had acute pharyngitis (n=1), herpangina (n=1), upper respiratory tract infections (n=7), acute bronchiolitis (n=8), acute gastroenteritis (n=4), and bacteremia (n=2). The median WBC and CRP levels were significantly higher in infants with UTIs than in infants with viral meningitis. However, there were no differences in the median PCT levels between the groups (0.14 ng/mL vs. 0.11 ng/mL, P=0.419). The area under the receiver operating characteristic curve was 0.792 (95% CI, 0.65-0.896) for WBC, 0.77 (95% CI, 0.626-0.879) for CRP, and 0.568 (95% CI, 0.417-0.710) for PCT. An elevated WBC count (>11,920/${\mu}L$) and an increased CRP level (>1.06mg/dL) were significant predictors of UTIs based on multiple logistic regression analysis. Conclusion : Serum PCT concentrations should be interpreted with caution in infants <6 months of age with a fever of uncertain source.

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Acceleration Aging System for the Large Capacity Thyristor with Voltage and Heat (대용량 사이리스터의 전압/열에 의한 가속열화 시스템)

  • Seo, K.S.;Lee, Yang-Jae;Kim, H.W.;Kim, S.C.;Bahng, W.;Kim, N.K.;Kim, E.D.;Shin, E.C.
    • Proceedings of the KIEE Conference
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    • 2004.07c
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    • pp.1918-1920
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    • 2004
  • 본 고에서는 해남-제주간에 사용되는 Phase Control Thyristor의 구입비용을 고려하여, 해남-제주간 PCT와 동일 구조를 갖지만 전압/전류용량이 작은 A, B사의 PCT를 각각 40개씩 확보하였다. PCT의 가속열화를 위한 스트레스 인자는 전압/열이며, 이를 동시에 인가할 수 있도록 가속열화 시험장치를 구성하였다. 또한 가속열화에 의해 열화정도를 파악하기 위해 초기 특성을 측정하였으며, 이에 대한 결과를 기술하였다.

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Forward Adaptive Prediction on Modified Integer Transform Coefficients for Lossless Image Compression (무손실 영상 압축을 위한 변형된 정수 변환 계수에 대한 순방향 적응 예측 기법)

  • Kim, Hui-Gyeong;Yoo, Hoon
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.62 no.7
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    • pp.1003-1008
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    • 2013
  • This paper proposes a compression scheme based on the modified reversible integer transform (MRIT) and forward adaptive prediction for lossless image compression. JPEG XR is the newest image coding standard with high compression ratio and that composed of the Photo Core Transform (PCT) and backward adaptive prediction. To improve the efficiency and quality of compression, we substitutes the PCT and backward adaptive prediction for the modified reversible integer transform (MRIT) and forward adaptive prediction, respectively. Experimental results indicate that the proposed method are superior to the previous method of JPEG XR in terms of lossless compression efficiency and computational complexity.

Evaluation of Platelet Indices in Lung Cancer Patients

  • Oncel, Mufide;Kiyici, Aysel;Oncel, Murat;Sunam, Guven Sadi;Sahin, Emel;Adam, Bahattin
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.17
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    • pp.7599-7602
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    • 2015
  • Background: In this study, we aimed to determine platelet indices such as platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), Plateletcrit (PCT) platelet count (PLT) in lung cancer cases, and evaluate any relationships between these parameters and stage or histologic types. Materials and Methods: This retrospective study covered 44 lung cancer patients and 47 healthy subjects. Platelet indices including PLT, PCT, MPV, PDW were estimated and compared with normal subjects. The results were evaluated statistically. Results: The PDW value was significantly higher in the cancer group compared to the control group; however, the values for PCT and MPV were lower. Conclusions: We suggest potential use of platelet indices in diagnosis of lung cancer.

Validation of 3D crack propagation in plain concrete -Part II: Computational modeling and predictions of the PCT3D test

  • Gasser, T.Christian
    • Computers and Concrete
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    • v.4 no.1
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    • pp.67-82
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    • 2007
  • The discrete crack-concept is applied to study the 3D propagation of tensile-dominated failure in plain concrete. To this end the Partition of Unity Finite Element Method (PUFEM) is utilized and the strong discontinuity approach is followed. A consistent linearized implementation of the PUFEM is combined with a predictor-corrector algorithm to track the crack path, which leads to a robust numerical description of concrete cracking. The proposed concept is applied to study concrete failure during the PCT3D test and the predicted numerical results are compared to experimental data. The proposed numerical concept provides a clear interface for constitutive models and allows an investigation of their impact on concrete cracking under 3D conditions, which is of significant scientific interests to interpret results from 3D experiments.

Effect of Electrodes on the Electrical Properties of Piezoelectric Ceramic Transformer (장방형 압전세라믹변압기의 전극형상이 전기적특성에 미치는 영향)

  • 정수태;최상수;조상희
    • Electrical & Electronic Materials
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    • v.10 no.6
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    • pp.562-569
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    • 1997
  • The resonance characteristics on vibration mode of a transverse type ceramic resonator and the output voltage characteristics of a piezoelectric ceramic transformer are discussed in the effects of partial electrode arrangement (one sided, centered and both sided). A resonance characteristics of resonator depended strongly on both a vibration mode and a electrode structure because of a strain distribution. The maximum resonance current of a piezoelectric ceramic transformer [PCT] with partial centered electrode appeared in λ/2 mode, and that of a PCT with partial both sided electrode appeared in 3λ/2 mode. But the maximum output voltage of those samples appeared in λ/2 mode. In the PCT with partial both sided electrode, the ration of output voltage to input current was highest out of all samples and the poling voltage was a half times of 깬두 type transformer.

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ESTIMATION RAIN RATE FROM MICROWAVE RADIOMETER

  • Park K. W.;Kim Y. S.
    • Proceedings of the KSRS Conference
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    • 2004.10a
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    • pp.201-203
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    • 2004
  • We present here, some of the studies carried for estimation of rainfall over land and oceanic regions in and around South Korea. We use active and passive microwave measurements from TRMM - TMI and Precipitation Radar (PR) respectively during a typhoon even named - RUSA that took place during 30 Aug. 2002. We have followed due approach by Yao at. all (2002) and examined the performance of their algorithm using two main predictor variable, named as Scattering Index (SI) and Polarization Corrected Brightness Temperature (PCT) while using TMI data. The rainfall rate estimated using PCT and SI shows some under-estimation as compared to the AWS rainfall products from the PR in common area of overlap. A larger database thus would be used in future. To establish a new rain rate algorithm over Korean region based on the present case study.

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