• Journal of the Korean Institute of Telematics and Electronics S
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• v.34S no.2
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• pp.11-20
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• 1997

It is a recent trend that mobile communications and PCS are intergrated into the broadband network. Broadband mutlimedia traffic will be transported over the integrated network. In this paper, we propose a connection re-routing method for fast inter-switch hadoffs and dynamic resurce reservation scheme, which is based on the proposed re-routing method, for the ATM-based personal communications network. To reduce the delay for re-routing method, for the ATM-based personal communications network. To reduce the delay for re-routing, the proposed re-routing method is to reserve VPI/VCIs for possible inter-swich handoff calls in advance. Our reservation scheme is to statistically reserve the fixed resources for possible inter-switch handoff calls, according to the QoS of the handoff calls. The simmulation reslts show that our proposed scheme satisfies the required QoS of handoff calls and keep the dropping probability of handoff calls lower than other schemes.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.33A no.7
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• pp.55-63
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• 1996

In this paper, a multiple-access algorithm for PCN is proposed. The proposed algorithm provides th integrated service of information soruces and can be operated stably in high load state. Given bandwidth is efficiently used for it in the microcell environment. And system performance can be improved through the statistical-multiplexing technque. In order to process the speech signal usually requiring real-tiem processing, we adopt a random access of AlOHA type for th ebasic protocol sturcture and assume the form of ALOHA-reservation. We have analyzed the performance of the proposed algorithm through system throughput and packet delay in the microcell environment.

• Journal of Korean Institute of Industrial Engineers
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• v.22 no.3
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• pp.427-440
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• 1996

Constraint networks are a major approach to knowledge representation in Concurrent Engineering (CE) systems. The networks model various factors in CE as constraints linked by shared variables. Many systems have been developed to assist constraint network processing. While these systems can be useful, their underlying assumption that a solution must simultaneously satisfy all the constraints is often unrealistic and hard to achieve. Proposed in this paper is a hierarchical representation of constraint networks using priorities, namely Prioritized Constraint Network (PCN). A mechanism to propagate priorities is developed, and a new satisfiability definition taking into account the priorities is described. Strength of constraint supporters can be derived from the propagated priorities. Several properties useful for investigating PCN's and finding effective solving strategies ore developed.

• Journal of Aerospace System Engineering
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• v.4 no.3
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• pp.34-38
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• 2010

ACN(Aircraft Classification Number) is allocated by marketing group during early stage of aircraft design phase and is a critical parameter to decide whether the designed aircraft can be landed or not in a certain airport. The loading on the main landing gear wheels, selection of main landing gear tire and estimation of ACNs for flexible and rigid pavements were done for the proposed medium-class aircraft. The estimated ACN values are compared with the similar class aircraft. And PCN(Pavement Classification Number) values of airport in Korea are surmmarized. Results showed that the currently proposed medium-class aircraft can land any airport in Korea.

• Archives of Pharmacal Research
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• v.27 no.4
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• pp.415-421
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• 2004

Cytochrome P450 3A4 (CYP3A4) is the most abundant CYPs in human liver, comprising approximately $30\%$ of the total liver CYPs contents and is involved in the metabolism of more than $60\%$ of currently used therapeutic drugs. However, the molecular mechanisms underly-ing regulation of CYP3A4 gene expression have not been understood. Thus, this study has been carried out to gain the insight of the molecular mechanism of CYP3A4 gene expression, investigating if the histone deacetylation is involved in the regulation of CYP3A4 gene expression by proximal promoter. Also SXR was investigated to see if they were involved in the regulation of CYP3A4 proximal promoter activity. Hepa-1 cells were transfected with a plasmid containing ${\~}1kb$ of the human CYP3A4 proximal promoter region (863 to +64 bp) cloned in front of a reporter gene, luciferase, in the presence or absence of SXR. Transfected cells were treated with CYP3A4 inducers such as rifampicin, PCN and RU 486, in order to examine the regulation of CYP3A4 gene expression in the presence or absence of trichostatin A (TSA). In Hepa-1 cells, CYP3A4 inducers increased modestly the luciferase activity when TSA was co-treated, but this increment was not enhanced by SXR cotransfection. Taken together, these results indicated that the inhibition of histone deacetylation was required to SXR-mediated increase in CYP3A4 proximal promoter region when rifampicin, or PCN was treated. Further a trans-activation by SXR may demand other species-specific transcription factors.

• Environmental Mutagens and Carcinogens
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• v.24 no.4
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• pp.171-179
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• 2004

Cytochrome P4503A4(CYP3A4) is the most abundnat CYPs in human liver, comparising approximately 30% of the total liver CYPs contents ans is involbed in the metabolism of more than 60% of currently used therapeutic drugs. The expression of CYP3A4 is induced by a variety of structurally unrelated xonobiotics including the antibiotic rifampicin and endogenous hormones, and might be mediated through steroid and xenobiotic receptor(SXR) system. The molecular mechanisms underlying regulation of CYP3A4 gene expression hae not been understood. In order to gain the insight of the molecular mechanism of CYP3A4 gene expression, study has been undertaken to investigate if the histone deacelylation is involved in the regulation of CYP3A4 gene expression by proximal promoter or not. Also SXR was investigated to see if they were involved in the regulation of CYP3A4 proximal promoter activity. HepG2 or Hena-I cells were transfected with a plasmid containing~1kb of the CYP3A4 proximal promoter region (-863 to +64bp) cloned in front of a reporter gene, luciferase, in the presence or absence of SXR or hER. Transfected cells were treated with CYP3A4 inducers such as rifampicin, PCN and RU 486, or with estradiol, in order to exmine to regulation of CYP3A4 gene expression in the presence or absence of trichostatin A (TSA). In HepG2 cells, CYP3A4 inducers and estradiol increased significantly the luciferase activity by CYP3A4 proximal promoter, only when TSA was co-treated after SXR cotransfection. In the case of Hepa-I cells CYP3A4 inducers and estradiol incressed modestly the luciferase activity when TSA was co-treated, but this increment was not enhanced by SXR cotransfection in contrast to HepG2 cells. Taken together, these results indicated that the inhibition of histone deacetylation was required to SXR-mediated increase in CYP3A4 proximal promoter region when rifampicin, or PCN was treated. Futher a trans-activation by SXR may demand other species-specific transcription factors.

• Archives of Pharmacal Research
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• v.27 no.4
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• pp.407-414
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• 2004

The expression of CYP3A4 gene is induced by a variety of structurally unrelated xenobiotics including the antibiotic rifampicin, pregnenolone 16-carbonitrile (PCN), and endogenous hormones, that might mediate through steroid and xenobiotic receptor (SXR) system. The molecular mechanisms underlying regulation of CYP3A4 gene expression have not been understood. In order to gain the insight of the molecular mechanism of CYP3A4 gene expression, study has been undertaken to investigate if the histone deacetylation is involved in the regulation of CYP3A4 gene expression by proximal promoter in human hepatoma HepG2 cells. Also we have investigated to see if SXR is involved in the regulation of CYP3A4 proximal promoter activity in human hepatoma HepG2 cells. HepG2 cells were transfected with a plasmid PCYP3A4-Luc containing ${\~}1kb$ of the CYP3A4 proximal promoter region (-863 to +64 bp) in front of a reporter gene, luciferase, in the presence or absence of pSAP-SXR. In HepG2 cells, CYP3A4 inducers, such as rifampicin, PCN and RU486 showed minimal stimulation of CYP3A4 proximal promoter activity in the absence of SXR and histone deacetylase (HDAC) inhibitors. 4-Dimethylamino-H-[4-(2-hydroxycarbamoylvinyl)benzyl]benzamide (IN2001), a new class HDAC inhibitor significantly increased CYP3A4 proximal promoter activity over untreated control cells and rifampicin concomitant treatment with IN2001 increased further CYP3A4 proximal promoter activity that was stimulated by IN2001 The results of this study demon-strated that both HDAC inhibitors and SXR are essential to increase of CYP3A4 proximal promoter activity by CYP3A4 inducers such as PCN, rifampicin, and RU486. Especially SXR seems to be important for the dose dependent response of CYP3A4 inducing chemicals to stimulate CYP3A4 proximal promoter activity. Also this data suggested that HDAC inhibitors seemed to facilitate the CYP3A4 proximal promoter to be activated by chemicals.

• Proceedings of the Korean Information Science Society Conference
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• 1999.10c
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• pp.748-750
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• 1999

본 논문에서 우리는 통신 비용과 데이터베이스 비용을 감소시키기 위해 사용자 프로파일 복제본을 이용한 동적 위치 관리 기법을 제안한다. 이 기법에서는 위치등록과 호 설정 과정이 통신비용을 감소시킬 수 있는 복제본이 있는 VLR에서 수행되고, 복제본이 있는 VLR에서 호의 빈도커서 데이터베이스 비용을 감소시킨다. 제안한 기법의 성능을 분석하기 위해 분석 모델을 작성하고 제안 기법, IS-41 기법, 복제 기법의 성능 분석을 한다. 사용된 비교 척도는 통신 비용, 데이터 베이스 비용, 총비용 그리고 호 설정 지연이다. 이 척도들에 대해서 제안 기법이 IS-41 기법, 복제 기법보다 더 좋은 성능을 보인다.

• Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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• 1995.11a
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• pp.331-337
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• 1995

In this paper, We present that protocols have already proposed an applicable key distribution and authentication protocol based discrete logarithm and prime-factorization problem in PCN(Personal Communication Network) is anaysised. We newly propose identiity-based protocol using smart card. This proposed potocol is that Fiat-Shamir identification scheme and a new key distribution scheme based on Fiat-Shamir identification scheme are joined. Proposed protocol is compared with suiting protocols with respect to security and efficiency to evalate performance, so its calculation is reduced in key distribution and authentication to evaluate performance.

• Journal of Environmental Science International
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• v.21 no.8
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• pp.891-899
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• 2012

The chlorination pattern of naphthalene vapor when passed through a 1 cm particle bed of 0.5% (mass) copper (II) chloride ($CuCl_2$) mixed with silicon dioxide ($SiO_2$) was studied. Gas streams consisting of 92% (molar) $N_2$, 8% $O_2$ and 0.1% naphthalene vapor were introduced to an isothermal flow reactor containing the $CuCl_2/SiO_2$ particle bed. Chlorination of naphthalene was studied from 100 to $400^{\circ}C$ at a gas velocity of 2.7 cm/s. Mono through hexachlorinated naphthalene congeners were observed at $250^{\circ}C$ whereas a broader distribution of polychlorinated naphthalenes (PCNs) including hepta and octachlorinated naphthalenes was observed at $300^{\circ}C$. PCN production was peak at $250^{\circ}C$ with 3.07% (molar) yield, and monochloronaphthalene (MCN) congeners were the major products at two different temperatures. In order to assess the effect of a residence time on naphthalene chlorination, an experiment was also conducted at $300^{\circ}C$ with a gas velocity of 0.32 cm/s. The degree of naphthalene chlorination increased as a gas velocity decreased.