• 동의신경정신과학회지
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• 제17권2호
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• pp.75-89
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• 2006

Objective : This experiment was designed to investigate the effect of Rhododendron simsii Planch(RSP) on the Alzheimer's disease. Method : The effects of RSP on amyloid precursor proteins(APP), acetylcholinesterase (AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell treated by amyloid ${\beta}$ protein$(A{\beta})$ and $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ mRNA of THP-1 cell treated by lipopolysaccharide(LPS), AChE activity of PC-12 cell lysate treated by $A{\beta}$ and behavior of the memory deficit mice induced by scopolamine, and glucose, AChE in serum of the memory deficit mice induced by scopolamine were investigated, respectively. Result : 1. RSP suppressed APP, AChE, GFAP mRNA in PC-12 celt treated by $A{\beta}$. 2. RSP suppressed $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ mRNA in THP-1 cell treated by LPS. 3. RSP suppressed AChE activity in cell lysate of PC-12 cell treated by $A{\beta}$. 4. RSP increased glucose and decreased AChE significantly in the serum of the memory deficit mice induced by scopolamine. 5. RSP group showed significantly inhibitory effect on the scopolamine-induced impairment of teaming and. memory in the experiment of Morris water maze. Conclusion : According to the above results, it is suggested that RSP might be usefully applied for prevention and treatment of Alzheimer's disease and memory deficit symptom.

• 마이크로전자및패키징학회지
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• 제10권1호
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• pp.1-5
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• 2003

본 연구에서는 ITO (indium tin oxide)/glass 투명기판 위에 다층구조의 OELD (organic electroluminescent devices) 소자를 진공 열증착법으로 제작하였다. 발광층 재료로서 Alq$_3$(tris-(8-hydroxyquinoline)aluminum)물질을 사용하였고, 정공수송층으로는 TPD (triphenyl-diamine) 및 $\alpha-NPD$를 사용하였다. 정공주입층 재료로서 CuPc (Copper phthalocyanine)를 사용하였다. 또한 QD2(quinacridone2) 물질을 $Alq_3$ 발광층내에 약 $10\AA$ 두께로 증착하여 발광효율 향상을 시도하였다. 제작된 모든 소자의 발광개시전압은 약 7 V 이었으며, 정공수송층으로 TPD 물질대신에 열적안정성이 우수한 $\alpha-NPD$를 사용한 경우 휘도값과 발광효율이 개선되었다. $Alq_3$ 발광층 사이에 QD2 물질을 적층한 소자에서 발광효율은 1.55 lm/W 값을 나타내어 $Alq_3$ 발광층만을 사용한 경우에 비해 약 8배 발광효율이 향상되었다.

• 한국산업정보학회논문지
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• 제12권3호
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• pp.86-94
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• 2007

본 논문에서는 수치해석적 소자 모델링 기법을 이용하여 다층박막형 OLED(multilayer oraganic light emitting diode)에서의 전기적 특성을 연구하였다. 모델링을 위한 다층박막형 OLED 소자 구조로는 수치해석 결과에 대한 명확한 검증을 위해서 연구문헌들에 널리 적용되어진 ITO/CuPC/${\alpha}-NPD$/Alq3/ LiF/Al 구조를 채택하여 모델링하였다. 금회의 전류-전압 특성에 대한 수치해석 결과는 이전의 참고문헌들에 실험적으로 제시되어 있는 결과들과 일치되어짐을 확인하였다. 본 연구는 다층박막 OLED의 동작 메카니즘에 대한 완벽한 이해와 실제 소자에의 적용 가능성 검토를 목적으로 하였다.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2003년도 생물공학의 동향(XII)
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• pp.145-148
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• 2003

DHA의 산화를 방지하기 위하여 vitamin C/alginate 리포솜에 병합시켰다. TEM을 통하여 제조된 AVDLs를 확인할 수 있었고, TLC를 통하여 각각의 AVDLs는 초기 첨가량의 15 ${\sim}$ 18 % DHA를 함유하고 있음을 확인하였다. TBARS assay에 의해$40^{\circ}C$에서 AVDLs에 포함된 DHA의 산화정도를 분석한 결과 vitamin C를 포함한 리포솜이 DHA의 산화를 억제하는 것으로 확인되었으며 0.2 % vitamin C를 포함한 AVDLs가 항산화 효과가 가장 큼을 알 수 있었다. AVDLs는 실험에서와 같은 산화조건에서 DHA의 산화를 초기 3일까지는 억제시킴을 알 수있었다.

• 동의신경정신과학회지
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• 제18권2호
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• pp.101-132
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• 2007

Objective : This research investigates the effect of the NogYongDaeBoTang,(NYDBT) on Alzheimer's disease. Method : The effects of the NYDBT extract on (1) $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ mRNA of PC-12 cells treated with LPS; (2) acetylcholinesterase(AChE), amyloid precursor proteins(APP), and glial fibrillary acidic protein(GFAP) mRNA the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, $IL-1{\beta}$ mRNA, and $TNF-{\alpha}$ mRNA; (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer‘s diseased mice induced with ${\beta}A$ were investigated. Results : 1. The NYDBT extract suppressed the expression of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ mRNA in BV2 microglia cell line treated with LPS. 2. The NYDBT extract suppressed the expression of $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ protein production in BV2 microglia cell line treated with LPS. 3. For the NYDBT extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by $A{\beta}$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 4. The NYDBT extract suppressed the over-expression of $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, and CD68/CD11b, in the mice with Alzheimer's disease induced by $A{\beta}$. 5. The NYDBT extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by $A{\beta}$. 6. The NYDBT extract reduced the Tau protein, GFAP protein, and presenilin1/2 protein (immunohistochemistry) of hippocampus in the mice with Alzheimer's disease induced by $A{\beta}$. Conclusions : These results suggest that the NYDBT extract may be effective for the prevention and treatment of Alzheimer's disease.

• 동서간호학연구지
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• 제11권2호
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• pp.101-109
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• 2005

Purpose: This study was to examine the correlation among interpersonal relationship, self-esteem, and self-efficacy. Method: Design was descriptive correlative study, and subjects of this study were 353 persons who are students in nursing college. Measures were interpersonal relationship measurement (Cronbach's alpha=.720), self-esteem measurement (Cronbach's alpha=.731), and self-efficacy measurement (Cronbach's alpha=.810). Data were collected from October, 2004 to January, 2005. Data were analyzed with SPSS PC+ on each aim of this study. Result: Findings were as followings. 1. In relationships among interpersonal relationship(1), self-esteem(2), and self-efficacy(3) there were significant positive correlations ((1)(2)r=.526, p=000; (1)(3)r=.443, p=000; (2)(3)r=.556, p=000). 2. In differences of interpersonal relationship, self-esteem, and self-efficacy according to general characteristics there were significant differences in age, grade, satisfaction on credit, satisfied life in the University. Conclusion: Further needs nursing intervention to improve positively the interpersonal relationship that may effect on self-esteem and self-efficacy.

• 천문학회보
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• 제36권1호
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• pp.82.1-82.1
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• 2011

We present a new code for solving non-LTE radiative transfer problems in a general grid (RIG). RIG develops from RATRAN code (Hogerheijde & van der Tak 2000) using the Accelerated Monte-Carlo method, and it can cope with line overlap effect among multiple molecular and atomic species. In this algorithm we make grids in arbitrary coordinates adequate to the problem, but, on the other hand, photons propagate in the Cartesian coordinates. For spherical, cylindrical and other well defined coordinate, the problem of tracing photon's path reduces to solving simple quadratic equations. For example, the outflow in the star formation have high dynamic range in scales from a few AU to ~ 0.1 pc and have also cylindrical symmetry. So, we have used (r, ${\alpha}$) coordinate system, where r is the distance from the origin and ${\alpha}$ is z/ R2 in the cylindrical coordinate of (R,z). The (r, ${\alpha}$) coordinate realizes the density - power function of r - and temperature distributions of the problems with smaller numbers of grid than the cylindrical coordinate does, and the former consumes less time to solve the problems than the latter.

• 수산해양기술연구
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• 제39권4호
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• pp.337-346
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• 2003

레이더 정보의 수록 및 정량적 해석을 위한 시도로써 타선의 위치정보를 자선의 전자해도 및 radar 화변상에 모니터링하여 두 선박의 간격을 측정할 수 있는 양선거리측정시스템과 ARPA radar가 탐지한 표적의 추적정보를 자선의 전자해도 화면상에 실시간으로 모니터링하기 위한 시스템을 구축함과 동시에 이들 레이더 정보를 필요에 따라 수록 및 재생할 수 있는 레이더 정보수록 및 해석 시스템을 개발하고, 실용화 실험을 행한 결과를 요약하면 다음과 같다. (1) 목포 인근해역에서 레이더 신호를 수록하고, 이 레이더 영상에 위치발생시뮬레이터에 의해 생성한 타선 위치를 RS232C interface를 통해 전송 및 중첩시켜 타선의 위치를 추적하면서 실시간으로 본선과 타선의 양선 간격을 산출한 결과, 양선 거리 및 방위의 실시간 측정이 가능하여 이 시스템을 양선 거리계로써 활용할 수 있음이 입증되었다. (2) 타선의 레이더 신호를 수신한 후, $\alpha$-$\beta$ tracker를 이용하여 타선 영상의 중심 위치를 실시간으로 추적하면서 침로, 속력, 방위, 거리 등을 예측한 결과, 매우 안정된 평활화 추정치를 얻을 수 있었다. (3) ARPA 시뮬레이터를 이용하여 표적의 추적정보를 TTM sentence 등으로써 생성한 후, 이 코드를 전자해도상에 전송 및 중첩 표시시킨 결과, 추적표적의 위치, 속력, 침로, 방위, 거리 등의 추적정보의 실시간 모니터링이 안정적으로 실현된 바, 선내의 여러 장소에서 ARPA 정보를 공유하기 위한 멀티 모니터링 장치의 개발이 기대된다.

• 한국수정란이식학회:학술대회논문집
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• 한국수정란이식학회 2002년도 국제심포지엄
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• pp.74-74
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• 2002

Production of u 1-antitrypsin ($\alpha$AT) in transgenic cows has a great value in the field of medicine. The present study was conducted to determine the effect of chemically defined KSOM media on in vitro development of bovine transgenic nuclear transfer (NT) embryos. An expression plasmid for human $\alpha$AT was constructed by inserting a bovine beta-casein promoter, a green fluorescent protein (GFP) marker gene, and a human $\alpha$AT target gene into a pcDNA3 plasmid. Cumulus cells as donor nuclei in NT were collected from a Holstein cow and transfected by lipid-mediated method using FuGene6 (Roche Molecular Biochemicals, USA) as reagent. GFP expressed cumulus cells were introduced into recipient oocytes under DIC microscopy equipped with FITC filter set. After electrical fusion and chemical activation, reconstructed embryos were cultured in 1) SOF + 0.8% BSA, 2) KSOM + 0.8% BSA, 3) KSOM + 10% FBS and 4) KSOM +0.01% PVA for 192 h at 39$^{\circ}C$ with 5% $CO_2$, 5% $O_2$ and 90% $N_2$in humidified condition. The development of the embryos was recorded and the GFP expression in blastocyst was determined under FITC filter. The average fusion rate was 73.8% (251/340; n=8). The development rates to 2-4 cells, morula, blastocysts and expression rates in blastocysts varied from 70.3 to 76.5%, 30.2 to 33.8%, 25.4 to 33.8% and 11.8 to 15.6%, respectively. The difference in development and expression rates of embryos among 4 culture groups was not significant (P>0.05). This study indicates that chemically defined KSOM medium is also able to support development of bovine transgenic NT embryos at similar rate of SOF or KSOM supplemented with BSA or serum.

• 동서간호학연구지
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• 제11권1호
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• pp.51-57
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• 2005

Purpose: This study was to examine the correlation between self-efficacy and satisfaction with college life of nursing students. Method: Design was descriptive correlative study, and subjects of this study were 352 persons who are students on 3 and 4 grade in nursing college. Measures were satisfaction with college life measurement (Cronbach's alpha=.673) and self-efficacy measurement (Cronbach's alpha=.810). Data were collected from September, 2004 to January, 2005. Data were analyzed with SPSS PC+ on each aim of this study. Result: Findings were as followings. 1. In relationship between self-efficacy and satisfaction with college life, there was significant positive correlation (r=.760, p=000). 2. In difference of self-efficacy and satisfaction with college life according to general characteristics there were significant differences in grade and consultor (p<.05). Conclusion: Further needs nursing intervention to improve positively the self-efficacy that may effect on satisfaction with college life.