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The Effect of Water in Four Adenine-Thymine and Three Guanine-Cytosine Pairs: Combining Quantum and Statistical Mechanics

  • Lee, Jinkeong;Ham, Sihyun
    • Proceeding of EDISON Challenge
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    • 2015.03a
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    • pp.151-155
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    • 2015
  • The molecular interactions between the nucleic acid bases and water molecules are important in organism. Despite Adenine-Thymine Hoogsteen base pair and Guanine-Cytosine Watson-Crick base pair have been demonstrated to be most stable in a gas phase, the effect of water on the stability of these base pairs remains elusive. Here we report the structural and thermodynamic characteristics on possible Adenine-Thymine and Guanine-Cytosine base pairs in a gas phase as well as in an aqueous phase by using quantum mechanical method and statistical mechanical calculations. First, we optimized the direct base-pair interaction energies of four Adenine-Thymine base pairs (Hoogsteen base pair, reverse Hoogsteen base pair, Watson-Crick base pair, and reverse Watson-Crick base pair) and three Guanine-Cytosine base pairs (GC1 base pair, GC2 base pair, and Watson Crick base pair) in a gas phase at the $B3LYP/6-31+G^{**}$ level. Then, the effect of solvent was quantified by the electronic reorganization energy and the solvation free energy by statistical mechanical calculations. Thereby, we discuss the effect of water on the stability of Adenine-Thymine and Guanine-Cytosine base pairs, and argue why Adenine-Thymine Watson-Crick base pair and Guanine-Cytosine Watson-Crick base pair are most stable in an aqueous environment.

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The Odd Pair Family's Dietary management in rural, Korea - Comparison with the Pair Family - (농촌거주 외짝가족의 식생활관리 -부부가족과의 비교-)

  • Rhie Seung Gyo;Chung Kum Ju;Won Hyang Rye
    • The Korean Journal of Community Living Science
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    • v.16 no.1
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    • pp.89-103
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    • 2005
  • Recently the rural Korea has been remarkedly changed of family and social value in accordance with the development of industry. The lower economic class made by social economic growth is widespread with increasing aged, specially odd pair family in rural. The purpose of this study was to investigate to help and keep improve health of rural lower economic class, family system by comparing and analyzing the dietary management, between pair and odd pair family, and to get the data helpful the right guidance for rural. The subjects 1870 collected in 9 provinces by sampling with probability proportional to size (PPS). Questionnaire about dietary habit, food cultivation, production and preservation survey was conducted by trained interviewers. The main results were as follows : 1) The characteristics of odd pair families, head of household was female(77%), over 65 years(84.9%), small family(1.76 persons) and lower education(male 7.5 years, female 3.1 years) status. 2) As the states of diets of odd pair family, having breakfast(87.1 %) but one or two kinds of side dishes(31.3 %) only possible to guess lower status of food intake balance. Nutritional supplements(21. 7 %) was lower than that of paired family. 3) The aspects of dietary habit of odd pair family, no instant foods(70.7%), no snack(38.4%) no dine out(69.2%) were common. 4) Dietary habit scores were 7.78 points of odd pair family compared 8.34 points of paired family. 5) Food purchase place of odd pair family was market(44.2%) but super-market(42.7%) of paired family. 6)In odd pair family, seldom traditional dish preparation(62.0%) but prepared winter kimchi(81.9%), comparing seldom traditional dish(38.6%) and winter kimchi(96.4%) in paired family. 7)The food cultivation state was surveyed, pepper( 42.2 %) and chinese cabbage( 43.9 %) were consumed after cultivation, but sesame(59.4%), bean sprout(90.2%), tofu(92.8%) and egg(93.3%) were consumed by purchase in odd pair family.8) Food cultivation score of odd pair family was 2.98/12points significantly lower than 4.50/12 points of paired family(p<0.01). 9) At the status of fermentation food production in odd pair family, Duenjang(72.1 %) and Gochujang(69.7%) Kanjang(68.3%) Kimchi(82.1 %) and Meju(68.3%) were high rate of production, but more frequently producted in pair family. 10) The score of fermentation food production of odd pair family was 8.57/12points but significantly lower than 10.24/12 points of pair family(p<0.0001). 11) Food preservation score 0.48/6 points in odd pair family was not significantly different than that of pair family(1.07/6points).

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The Odd Pair Family's Health management in rural, Korea -Comparison with the Pair Family- (농촌거주 외짝가족의 건강관리-부부가족과의 비교)

  • Rhie Seung Gyo;Cho Young Sook;Won Hyang Rye
    • The Korean Journal of Community Living Science
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    • v.16 no.1
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    • pp.149-163
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    • 2005
  • Family has emerged as a key concept for health, and it has been identified as one of the most important conditions. The relationship between health habit and its management is different depending on family. The odd pair family, mostly rural lower income class, worry to have poor health because of no spouse and small family size. One thousand eight hundred and seventy(1870) subjects were collected in 9 provinces through the sampling of Probability Proportional to Size (PPS). Questionnaire method was conducted on health checking, bath states, alcohol consumption, cigarette smoking, and the prevalence of farmer's health related problems. The main results were as follows: 1) The characteristics of odd pair families are that the head of household is female(77% ), the size of family is small(1.76 persons), the education level is low(7.5 years for male, 3.1 years for female) and the age group is old (male: 89.78 year old, female: 73.69 year old). 2) For the odd pair family, the frequency of health checking is quite low with one or two times per year(l0.2%) and the rate of no-health checking is much higher(35.8%) .3) Bathing utility is not available 29.6% of the odd pair family and only cold water is supplied at home for the 11.5 % of them. However, for the paired family, 9.8 % of them has no bathing utility and the rate of the family supplied with only cold water is just 7.9%. 4) The bathing frequency score of odd pair family is l.74points for male and 1.25 points for female. 5) The rate of smoking habits for odd pair family is 68.5 % and specially it is 7.6% for female, which is higher comparing with that of pair family. 6) The smoking frequency score of odd pair family is 1.57 points. 7) Alcohol drinking frequency score of odd pair family is 1.79 points for male, and 3.24points for female. 8) Farmers' syndrome(FS) revealed 38.7% of odd pair family and it is lower than that of pair family(57.3%). Special pain of FS was huckle bone and muscle(28.4%) and articular pain(24.l %). The pain rate of huckle bone and muscle(43.l %) and articular pain(33.5%) were higher in a year in odd pair family were lower than those of pair family: farming machine caused accidents(6.5%) and pesticide poisoning(5.7%). l0) The odd pair family use more frequently medical clinic or public health center for the treatment of FS(74.7%) and pesticide poisoning(62.5%) than the pair family for FS(69.0%) and for pesticide poisoning(.53.6%). The score of FS treatment is 5.70 points for odd pair family and it is not significantly different from 5.62 points of the paired family. The result of pesticide poisoning treatment score is as same as that of FS.

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Solvent Effect on the Dynamics of Radical Ion Pair Separation

  • Han, Chul-Hee
    • Journal of Photoscience
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    • v.8 no.1
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    • pp.33-37
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    • 2001
  • Picosecond absorption spectroscopy has been employed in the study of the solvent dynamics of 1, 2, 4, 5-tetracyanobenzene/biphenyl derivative radical ion pairs, and the resulting rates of radical ion pair separation are faster in acetonitrile than in dichloromethane. In an effort to account quantitatively for such solvent effect on the rate of radical ion pair separation, an equation for the rate of radical ion pair separation is introduced, in which the rate depends exponentially on the electrostatic interaction energy in the radical ion pair. In our analysis of the types of electrostatic interaction energy based on the conducting spheres in dielectric continuum was chosen, and the rate equation employing this electrostatic energy provided information on the distance on the distance of radical ion pair separation and solvation energy of the radical ion pair, thereby providing quantitative explanation for the observed solvent effect on the rate of radical ion pair sepaaration.

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Clustering-driven Pair Trading Portfolio Investment in Korean Stock Market (한국 주식시장에서의 군집화 기반 페어트레이딩 포트폴리오 투자 연구)

  • Cho, Poongjin;Lee, Minhyuk;Song, Jae Wook
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.45 no.3
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    • pp.123-130
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    • 2022
  • Pair trading is a statistical arbitrage investment strategy. Traditionally, cointegration has been utilized in the pair exploring step to discover a pair with a similar price movement. Recently, the clustering analysis has attracted many researchers' attention, replacing the cointegration method. This study tests a clustering-driven pair trading investment strategy in the Korean stock market. If a pair detected through clustering has a large spread during the spread exploring period, the pair is included in the portfolio for backtesting. The profitability of the clustering-driven pair trading strategies is investigated based on various profitability measures such as the distribution of returns, cumulative returns, profitability by period, and sensitivity analysis on different parameters. The backtesting results show that the pair trading investment strategy is valid in the Korean stock market. More interestingly, the clustering-driven portfolio investments show higher performance compared to benchmarks. Note that the hierarchical clustering shows the best portfolio performance.

An Experimental Study on Effects of Pair Programming on Task Performance : Focus on SQL Query Programming Performance (페어 프로그래밍이 직무 성과에 미치는 영향에 관한 연구 : SQL 질의 프로그래밍 성과를 중심으로)

  • Yoon, Seong-No;Kim, Jong-Heon;Park, Sang-Hyun
    • Journal of Information Technology Applications and Management
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    • v.14 no.4
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    • pp.17-30
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    • 2007
  • In recent years, pair programming has become a widely used approach for development of information systems. According to a worldwide survey, 35 percent of 104 development projects reported using pair programming. However, previous studies have shown rather mixed results in terms of the effectiveness of pair programming, comparing to individual or independent programming. This paper, therefore, uses a lab setting to control some of the variables that appear to have caused conflicting results in earlier studies. Writing SQL Queries for given problem statements is selected as the task the subjects to solve. One key issue addressed is the distribution of work load among the pair programmers and the independent programmers. Another is communication among co-workers as would occur in a real-world system development environment. The results of this study indicate there is no significant difference in task performance pair programming and independent programming.

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P-Triple Barrier Labeling: Unifying Pair Trading Strategies and Triple Barrier Labeling Through Genetic Algorithm Optimization

  • Ning Fu;Suntae Kim
    • International journal of advanced smart convergence
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    • v.12 no.4
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    • pp.111-118
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    • 2023
  • In the ever-changing landscape of finance, the fusion of artificial intelligence (AI)and pair trading strategies has captured the interest of investors and institutions alike. In the context of supervised machine learning, crafting precise and accurate labels is crucial, as it remains a top priority to empower AI models to surpass traditional pair trading methods. However, prevailing labeling techniques in the financial sector predominantly concentrate on individual assets, posing a challenge in aligning with pair trading strategies. To address this issue, we propose an inventive approach that melds the Triple Barrier Labeling technique with pair trading, optimizing the resultant labels through genetic algorithms. Rigorous backtesting on cryptocurrency datasets illustrates that our proposed labeling method excels over traditional pair trading methods and corresponding buy-and-hold strategies in both profitability and risk control. This pioneering method offers a novel perspective on trading strategies and risk management within the financial domain, laying a robust groundwork for further enhancing the precision and reliability of pair trading strategies utilizing AI models.

Accuracy of the Position Fix and Local Fluctuation of Omega Signals in the South Coast of Korea (한국남해안에 있어서의 오메가신호의 지역적인 변화와 측위의 정도)

  • 안장영
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.17 no.2
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    • pp.59-63
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    • 1981
  • For the purpose of surveying accuracy of the position fix and local fluctuation of Omega signals in south coast of Korea, the author observe continuously the phase difference of the A-C pair and A-E pair form December 1, 1980, to February 28, 1981, at Cheju(33$^{\circ}$31'.0N, 126$^{\circ}$31.9E) and Busan(35$^{\circ}$7'.9 N, 129$^{\circ}$6'. 3 E). The analyzed results are as follows: 1. Omega signals at Cheju and Busan are positive correlation. Mean value of coefficients during all measured time is 0.70 with A-C pair and 0.75 with A-E pair. 2. Range of mean value of difference between the measured PPC at Cheju and Busan is 17.7~21.3 cels with A-C pair and -2.9~2.0 cels with A-E pair. 3. In case of using the differential Omega at Cheju and Busan, mean value of total errors of the position fix is 1.52 miles and its standard deviation is 0.21 miles.

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Effects of Pair Programming in an Introductory Programming Course for College Students: Academic Performance and Student Satisfaction (대학 프로그래밍 입문 수업에서 짝 프로그래밍의 효과: 학습성과와 학생 만족도 측면에서)

  • Jeong, Choongkyo
    • Journal of The Korean Association of Information Education
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    • v.21 no.5
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    • pp.537-545
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    • 2017
  • This paper presents the results of adopting pair programming practices in an introductory university programming course. The effectiveness of pair programming is analyzed by comparing the performance and survey data gathered from the experimental class that adopted the practice to those from the control class that did not. An analysis of the performance data found that pair programming improved student performance; however, not all students in the pair programming class benefited from the practice as only some students showed clear improvements in learning outcomes. The survey showed that the specific method for matching students into pairs is a critical factor affecting their performance and satisfaction. Based on the lessons learned from this pair programming class, I propose some suggestions and guidelines for applying pair programming to programming classes including 'pair matching'.

The Effects of Pair Programming on Achievement and Motivated Strategies in Programming Course (Pair Programming이 학업성취도와 학습동기전략에 미치는 영향)

  • Han, Keun-Woo;Lee, Eun-Kyoung;Lee, YoungJun
    • The Journal of Korean Association of Computer Education
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    • v.9 no.6
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    • pp.19-28
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    • 2006
  • A programming language is very important subject in computer science. But it is difficult for many students to learn programming language. New pedagogical methods and techniques to help students to learn programming are needed. In this paper, we investigated the effects of Pair Programming, and we proposed a Pair programming strategy to improve programming skills. This paper examined the proposed Pair programming strategy. A empirical study showed the proposed teaching and learning strategy has positive effects on achievement and motivated strategies in programming course. Four factors - critical thinking, metacognitive reflection, effort regulation, and peer learning - have positive effects in learning strategies. The proposed Pair Programming strategy improves programming learning and motivated strategies.

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