• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1895-1903
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• 2013

Background: It is well established that a healthy lifestyle is of benefit in the prevention of diseases such as cancer and promotion of well-being. Therefore, the objective of this study was to determine lifestyle practice and associated factors among university students in Malaysia. Materials and Methods: A cross sectional study was conducted over six months from November 2011 until May 2012 among the students from the Management and Science University. This study was approved by its ethical committee, the students being explained the objective and invited to participate. A consent form was signed by all study participants. Questionnaire was distributed randomly to the students of the five faculties through their lecturers in different faculty. For univariate analysis t-test and ANOVA test were performed. Multiple linear regression used for multivariate analysis using SPSS 13.0. Results: A total number of 1100 students participated with a mean age of $22.1{\pm}2.21$ (SD) years. The majority were 22 years or younger (56.3%), female (54%), Malay (61.5%), single (92.3%), with family monthly income ${\geq}5000$ Ringgit Malaysia (41.2%). Regarding lifestyle, about were 31.6% smokers, 75.6% never drank alcohol and 53.7% never exercised. Multivariate analysis showed that age, sex, race, parent marital status, participant marital status, type of faculty, living status, smoking status, exercise, residency, brushing teeth, fiber intake and avoid fatty food significantly influenced the practice of drinking alcohol among university students (p=0.006, p=0.042, p<0.001, p=0.003, p=0.002, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p=0.003, p<0.001; respectively). It similarly showed that sex, race, parent marital status, participant marital status, monthly family income, exercise, residency, brushing teeth and fiber intake significantly influenced the practice of sun protection (p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p=0.017, p<0.001, p<0.001, p<0.001; respectively) and that age, sex, parent marital status, participant marital status, type of faculty, living status, exercise, taking non-prescribed medication, brushing the teeth, coffee consumption and fiber intake were significantly influenced the practice of fruits consumption (p=0.008, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p=0.002, p<0.001, P<0.001; respectively). Conclusions: This study showed a poor practice of healthy lifestyle among university students. Therefore universities should emphasize a healthy lifestyle in all faculties as a required subject. Socio-demographic characteristics significantly influenced practice and thus should be considered when planning preventive measures among university students. Frequent campaigns and educational seminars are to be encouraged.

• 미생물학회지
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• 제39권2호
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• pp.118-122
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• 2003

바이러스 조립 과정 기작 연구를 위한 좋은 재료인 박데리오파아지 P2-P4시스템에 이용될 벡터 플라스미드를 개발하기 위하여, P4 ash8 sid71을 출발 물질로 삼아 새로운 P4 유도체 벡터를 조성하였다. 유전자 재조합 기법을 써서 쉽게 선택 가능한 tetracyclin내성 유전자(tetR)를 도입하고 플라스미드P 4의 크기를 조절하였다. 이를 통해 얻어진 P4 ash8(sid7l) tetR은 12.09 kb의 크기를 가지며, 필요할 때 P2로 induction하면 생물학적 활성을 가지는 박데리오파아지로 전환 가능하였다. 전환된 파아지의 burst size를 결정하고, CsCi 부양균등밀도 편차실험을 수행하였다. 균등밀도 실험 분포도에서 P2크기 파아지 머리의 packaging 상한을 추정할 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4315-4320
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• 2012

Background: The P53 tumor suppressor gene plays a pivotal role in maintaining cellular homeostasis by preventing the propagation of genome mutations. P53 in its transcriptionally active form is capable of activating distinct target genes that contribute to either apoptosis or growth arrest, like P21. However, the MDM2 gene is a major negative regulator of P53. Single nucleotide polymorphisms (SNP) in codon Arg72Pro of P53 results in impairment of the tumor suppressor activity of the gene. A similar effect is caused by a SNP in codon 31 of P21. In contrast, a SNP in position 309 of MDM2 results in increased expression due to substitution of thymine by guanine. All three polymorphisms have been associated with increased risk of tumorigenesis. Aim of the study: We aimed to study the prevalence of SNPs in the P53 pathway involving the three genes, P53, P21 and MDM2, among acute myeloid leukemia (AML) patients and to compare it to apparently normal healthy controls for assessment of impact on risk. Results: We found that the P21 ser31arg heterozygous polymorphism increases the risk of AML (P value=0.017, OR=2.946, 95% CI=1.216-7.134). Although the MDM2 309G allele was itself without affect, it showed a synergistic effect with P21 ser/arg polymorphism (P value=0.003, OR=6.807, 95% CI=1.909-24.629). However, the MDM2 309T allele abolish risk effect of the P21 polymorphic allele (P value=0.71). There is no significant association of P53 arg72pro polymorphism on the risk of AML. Conclusion: We suggest that SNPs in the P53 pathway, especially the P21 ser31arg polymorphism and combined polymorphisms especially the P21/MDM2 might be genetic susceptibility factors in the pathogenesis of AML.

• 대한수학회논문집
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• 제27권3호
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• pp.483-488
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• 2012

In this paper we introduce the notion of P-strongly regular near-ring. We have shown that a zero-symmetric near-ring N is P-strongly regular if and only if N is P-regular and P is a completely semiprime ideal. We have also shown that in a P-strongly regular near-ring N, the following holds: (i) $Na$ + P is an ideal of N for any $a{\in}N$. (ii) Every P-prime ideal of N containing P is maximal. (iii) Every ideal I of N fulfills I + P = $I^2$ + P.

• 한국멀티미디어학회논문지
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• 제22권12호
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• pp.1466-1480
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• 2019

This paper addresses the efficient processing of all-farthest-neighbors (AFN) queries in spatial network databases. Given a set of data points P={p₁,p₂,…,p_|p|} in a spatial network, where the distance between two data points p and s, denoted by dist (p,s), is the length of the shortest path between them, an AFN query is defined as follows: find the farthest neighbor ω(p)∈P of each data point p such that dist(p,ω(p)) ≥ dist(p,s) for all s∈P. In this paper, we propose a shared execution algorithm called FAST (for All-Farthest-neighbors Search in spatial neTworks). Extensive experiments on real-world roadmaps confirm the efficiency and scalability of the FAST algorithm, while demonstrating a speedup of up to two orders of magnitude over a conventional solution.

• 한국생활과학회지
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• 제22권4호
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• pp.693-705
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• 2013

This study was conducted to identify adults' knowledge, dietary behavior related to sodium, the attitude towards a low-salt diet, and to examine the relation between these variables. The participants were 366 adults in Jeonbuk area. The data were analyzed using Pearson correlation coefficients, ANOVA and Duncan test with SPSS v. 12.0. The score for participants' knowledge about sodium was 12.32 points of a possible 16, the score for dietary behavior related to sodium was 45.74 points of a possible 70, and their score for attitude towards a low-salt diet was 30.35 points of a possible 50. The knowledge showed significant differences by gender (p<.05), and concern about health (p<.05). The dietary behavior of sodium use showed significant differences by gender (p<.001), age (p<.001), educational level (p<.05), job (p<.001), income (p<.05), BMI (p<.05), smoking (p<.01), drinking (p<.01), exercise (p<.05), regularity of health checkup (p<.001), and concern about health (p<.01). The attitude towards a low-salt diet showed significant differences by gender (p<.001), age (p<.001), job (p<.001), income (p<.001), smoking (p<.05), regularity of health checkup (p<.001), and concern about health (p<.001). There was a significant positive correlation between knowledge about sodium, dietary behavior related to sodium, attitude towards a low-salt diet. Dietary behavior related to sodium showed a positive correlation with attitudes towards a low-salt diet. In conclusion, it is necessary to consider the related factors for the development and implementation of systematic education programs that can encourage and promote preventive dietary behavior for disease, e.g. stomach cancer, and hypertension among adults.

• Korean Chemical Engineering Research
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• 제47권4호
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• pp.453-458
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• 2009

최근 환경문제가 크게 대두됨에 따라 고분자 합성과 가공 공정에서도 유기용매를 사용하지 않는 새로운 친환경적 공정의 개발이 요구되고 있다. 초임계 이산화탄소는 고분자 합성에서 용매로 사용될 경우, 기존의 유기용매와 비교하여 불연성이고 독성이 없으며 생성물과의 분리가 용이하다는 장점을 가지고 있다. 본 연구에서는 초임계 이산화탄소를 이용하여 의약학 및 화장품 분야에서 지능형 약물전달체로 사용할 수 있는 pH 감응형 하이드로젤인 P(MAA-co-EGMA) 하이드로젤을 수 백 nm 수준의 입자 형태로 합성하는 방법을 개발하였다. 그리고 중합과정에서 사용하는 분산안정제인 PtBuMA-PEO와 중합개시제인 AIBN이 하이드로젤 입자의 합성에 미치는 영향을 살펴보았다. 입자의 합성에서 PtBuMA-PEO의 함량이 증가할수록 입자 크기는 감소하였으나 AIBN의 함량에 따른 입자 크기의 변화는 관찰할 수 없었다. 합성된 P(MAA-co-EGMA) 하이드로젤 입자의 pH에 따른 팽윤 실험결과, PMAA의 $pK_a$인 pH 5를 전후하여 급격한 하이드로젤의 평형 질량팽윤비의 변화를 관찰할 수 있었다. 즉, pH 5보다 낮은 pH에서는 낮은 팽윤비를, 반면에 pH 5보다 높은 pH에서는 매우 높은 팽윤비를 나타내었다. 그리고 Rh-B를 이용한 방출실험에서는 높은 pH에서는 다량의 Rh-B가 하이드로젤 입자로부터 방출되었으나 낮은 pH에서는 Rh-B가 거의 방출되지 않는 pH에 따른 선택적 방출 특성을 나타내었다.

• 한국미생물·생명공학회지
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• 제23권2호
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• pp.164-169
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• 1995

An endogenous cryptic plasmid, pBL1, which has been used to construct plasmid vectors for coryneform bacteria producing amino acids, was eliminated from Brevibacterium lactofermentum. The pBL1 was partially digested with Sau3AI and the resulting DNA fragments were subcloned into a suicide vector pEM1 which contains a kanamycin-resistant (km$^{r}$) gene. KM$^{r}$ B. lactofermentum transconjugants were obtained by conjugal transfer of the pEM1 derivatives containing pBL1 DNA fragments from Escherichia coli into B. lactofermentum. A km$^{r}$ transconjugant was analyzed to contain a plasmid pEB14, which occurred in vivo by homologous recombination between pBL1 and the conjugal-transferred plasmid. The pEB14 including the pEM1-derived km$^{r}$ gene was found to be lost concomitantly with km$^{r}$ phenotype, resulting in the construction of a pBL1-free strain of B lactofermentum. Based on transformation efficiencies and plasmid stability, the resultant pBL1- free strain is more useful than wild strain as a host cell for genetic manipulation. It could be concluded that foreign plasmid DNAs are efficiently isolated and analyzed from the pBL1-free strain because of the absence of endogenous pBL1 plasmid.

• 한국유기농업학회지
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• 제21권1호
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• pp.105-113
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• 2013

Antibacterial activity is an important feature for the development of antibiotics alternatives. Plant extract is considered as a promising alternative for organic farming. In this study, a total of 11 plants were extracted using ethanol to determine their antibacterial activities against to Staphylococcus aureus, Listeria monocytogens, Mannheimia haemolytica and Salmonella gallinarum. The synergistic interaction among plant extracts was also investigated. Plants used in this study were Carthamus nctoricus L. (pA), Poncirus trifollata Raf. (pB), Scutellaria balcalensis Georgi (pC) Prunus sargentii (pD), Cucurbita moschata $D_{UCH}$ Leaf (pE), Allium cepa L. peel (pF) Portulaca oleracea L. (pG), Xanthium strumarium L. (pH), Duchesnea chrysantha (pI), Cudrania tricuspidata (pJ) and Juniperus chinensis L. (pK). The pB and pA had the most broad antibacterial spectrum and the highest activity against to Staph. aureus among plant extract, respectively. In the synergistic interaction, the mixtures of pA and pC as well as pA and pF had batter antibacterial activity against to Staph. Aureus compared with other mixtures.

• 한국항행학회논문지
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• 제15권6호
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• pp.1015-1024
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• 2011

최근 애드혹 네트워크에서의 모바일 P2P에 대한 관심이 높아지고 있다. 비록 유선 네트워크에서 P2P 알고리즘에 대한 많은 연구가 있었지만, 기존 P2P 프로토콜들은 장치의 이동성을 고려하지 않아 모바일 애드혹 네트워크(MANET, Mobile Ad-hoc Network)에 적합하지 않다. 본 연구에서는 애드혹 네트워크에서 장치의 이동성을 고려하여 클러스터 기반의 새로운 P2P 프로토콜을 제안한다. 기존의 클러스터 기반의 P2P 알고리즘에서 각 클러스터는 슈퍼피어와 슈퍼피어에 자신이 갖고 있는 파일 목록을 등록한 피어들로 구성된다. 이동성이 높은 피어들은 클러스터 간에 자주 핸드오프가 발생하고, 이로 인하여 슈퍼피어에 파일 목록을 등록하기 위한 트래픽이 많이 발생한다. 제안하는 알고리즘에서 이동성이 낮은 피어들은 기존의 클러스터 기반 P2P의 피어들과 동일하게 동작하고, 이동성이 높은 피어들은 다르게 동작한다. 즉 이동성이 높은 피어들은 새로운 클러스터에 참여시, 자신의 존재를 슈퍼피어에게 알리지만 파일 목록을 등록하지는 않으며 파일을 찾고자 할 때 우선 슈퍼피어에 등록된 파일 목록을 검색하고 만약 찾지 못하였을 경우 검색 메시지를 클러스터 내에 전파(broadcast)한다. 본 논문에서 제안 알고리즘을 수학적으로 모델링하고 P2P 트래픽과 라우팅 트래픽에 대한 분석과 최적화를 수행하였고 수학적 모델링 결과에서 제안 알고리즘의 성능이 기존의 클러스터 기반 P2P 알고리즘과 Gnutella 알고리즘에 비해 비슷하거나 더 좋음을 보였다.