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Association between Interferon-Inducible Protein 6 (IFI6) Polymorphisms and Hepatitis B Virus Clearance

  • Park, Geun-Hee;Kim, Kyoung-Yeon;Cho, Sung Won;Cheong, Jae Youn;Yu, Gyeong Im;Shin, Dong Hoon;Kwack, Kyu Bum
    • Genomics & Informatics
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    • v.11 no.1
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    • pp.15-23
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    • 2013
  • CD8+T cells are key factors mediating hepatitis B virus (HBV) clearance. However, these cells are killed through HBV-induced apoptosis during the antigen-presenting period in HBV-induced chronic liver disease (CLD) patients. Interferon-inducible protein 6 (IFI6) delays type I interferon-induced apoptosis in cells. We hypothesized that single nucleotide polymorphisms (SNPs) in the IFI6 could affect the chronicity of CLD. The present study included a discovery stage, in which 195 CLD patients, including chronic hepatitis B (HEP) and cirrhosis patients and 107 spontaneous recovery (SR) controls, were analyzed. The genotype distributions of rs2808426 (C > T) and rs10902662 (C > T) were significantly different between the SR and HEP groups (odds ratio [OR], 6.60; 95% confidence interval [CI], 1.64 to 26.52, p = 0.008 for both SNPs) and between the SR and CLD groups (OR, 4.38; 95% CI, 1.25 to 15.26; p = 0.021 and OR, 4.12; 95% CI, 1.18 to 14.44; p = 0.027, respectively). The distribution of diplotypes that contained these SNPs was significantly different between the SR and HEP groups (OR, 6.58; 95% CI, 1.63 to 25.59; p = 0.008 and OR, 0.15; 95% CI, 0.04 to 0.61; p = 0.008, respectively) and between the SR and CLD groups (OR, 4.38; 95% CI, 1.25 to 15.26; p = 0.021 and OR, 4.12; 95% CI, 1.18 to 14.44; p = 0.027, respectively). We were unable to replicate the association shown by secondary enrolled samples. A large-scale validation study should be performed to confirm the association between IFI6 and HBV clearance.

Redescription of Two Species of Triconia (Copepoda, Cyclopoida, Oncaeidae) Based on Their First Records in the Tropical Pacific

  • Cho, Kyuhee;Kim, Woong-Seo;Lee, Wonchoel
    • Korean Journal of Environmental Biology
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    • v.35 no.1
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    • pp.64-82
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    • 2017
  • Two species of the minuta-subgroup within the oncaeid copepod genus Triconia $B{\ddot{o}}ttger$-Schnack, 1999 collected in the equatorial Pacific Ocean are newly recorded. A female T. minuta (Giesbrecht, 1893 ["1892"]) and both male and female T. umerus ($B{\ddot{o}}ttger$-Schnack and Boxshall, 1990) from the northeast equatorial Pacific are redescribed with the comparison of its morphological details, which differs from previous studies, in terms of the larger body size, the length to width ratio of the genital double-somite, the relative length of the outer basal seta on P5, and the ornamentation of the appendages. The characters, which are used for identification, such as the length ratio of the outer subdistal and outer spine versus the distal spine on P3-P4, and the outer spine length of the middle exopodal segment on P3 and P4 are reported for the first time. Information on the variations in the endopodal spine lengths of swimming legs 2-4 is also provided for T. minuta and T. umerus, with the summary of the wide zoogeographical distribution of these two species.

A study on the small sewerage system using SBR process (SBR을 이용한 소규모 오수처리시설에 관한 연구)

  • 박민정;김동석
    • Journal of Environmental Science International
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    • v.12 no.4
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    • pp.427-437
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    • 2003
  • An evaluation of the application of SBR and biofilm en small sewerage system was conducted. A newly developed small sewerage system, using SBR, was successfully applied to the nutrient treatment using municipal wastewater. The system was consisted of 6 compartments. Two systems, with SBR (A type) or without SBR (B type), were compared by several parameters (COD, SS, T-N, NH$_4$$\^$+/-N, NO$_3$$\^$-/-N, NO$_2$$\^$ -/-N, alkalinity, pH, DO) in all experimental periods. Also, the time variation of several parameters (DO, pH, NH$_4$$\^$+/-N, NO$_3$$\^$-/-N NO$_2$$\^$-/-N) was examined in a SBR applied sewerage system. T-N removal efficiency of B type Was higher than that Of A type by the effect of nitrification and denitrification even though the COD removal efficiencies were similar. In aeration stage, the pH was decreased from 6.4 to 6.3 within 1 h and increased to 6.65 at the end of aerobic stage, and pH was decreased to 6.2 in non-aeration stage, and these phenomena were explained. The effects of nitrification and denitrification were compared in A type and B type sewerage system, and the typical nitrification and denitrification were observed in B type sewerage system.

Effect of Zizyphus vulgaris Supplementation on Growth Performance, Blood Cortisol and Meat Quality Characteristics in Finishing Pig (비육돈 사료내 산조인(Zizyphus vulgaris)의 급여가 성장 혈액내 Cortisol 및 육질 특성에 미치는 영향)

  • Cho Jin-Ho;Han Young-Geun;Kwon Oh-Suk;Min Byoung-Joon;Son Kyoung-Seung;Chen Ying-Jie;Kim In-Ho
    • Food Science of Animal Resources
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    • v.25 no.1
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    • pp.20-25
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    • 2005
  • This study was conducted to evaluate the effects of Zizyphus vulgaris supplementation on growth performance, blood cortisol and meat quality characteristics in finishing pigs. The total of thirty-six [Duroc${\times}$Yorkshir${\times}$Landrace] pigs ($91{\pm}2.11$ kg average initial body weight) were used in a 30-days assay. Dietary treatments included 1) CON (basal diet), 2) T1 (basal diet for 15 days and 0.1 % Zizyphus vulgaris for 15 days) and 3) T2 (0.1 % Zizyphus vulgaris for 30 days). The ADG (Average daily gain), ADFI (Average daily feed intake) and ADG/ADFI during the feeding period were not significantly differences among the treatments (p>0.05). Backfat thickness of pigs fed CON was higher than those of T1 and T2 (p<0.05). The appearance rate of A or B carcass grade was in T1 (74%) and T2 (84%) was significantly higher than that in CON (58%) (p<0.05). Pigs fed Zizyphus vulgaris 0.1 % for 30 days tended to decrease on blood cortisol compared with pigs fed CON and T1. But, there was not significantly difference among the treatments (p>0.05). The Hunter's L/sup */ (lightness) value of loin in the pork fed CON was higher than that of loin in the pork fed T1 and T2 (p<0.05). After 7 days, the L/sup */ value of loin in the pigs fed T2 was higher increased than that of pigs fed T1 and CON (p<0.05). However, a/sup */ and b/sup */ values were not affected by dietary Zizyphus vulgaris (p>0.05). There were not found remarkable differences in sensory properties (marbling, firmness and color) among the treatments. The results from the present study suggest that Zizyphus vulgaris could be a effective feed additive to improve meat quality of pigs. However, further research is needed to investigate effects of carcass characteristics.

Seasonal Changes of Chemical Components in Winter Buds of Several Mulberry Varieties (뽕나무 품종별 동아의 화학성분의 경시적 변화에 관한 연구)

  • 이원주;진순덕
    • Journal of Sericultural and Entomological Science
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    • v.29 no.1
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    • pp.1-6
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    • 1987
  • Changes in water content, dry weight, total nitrogen (T-N), P, K, Ca, Mg, B, Fe, Cu, Zn and Mn and death rate were studied in winter buds of mulberry trees. Winter buds of the early season varieties, Hongolbbong and Chongolbbong, (Morus Lhou Koioz) and midseason varieties, Kaeryangbbong and Chongilbbong, (Morus alba L.) were sampled every 7 days from February 28 to April 28, 1986. The result were as follow : 1. Water content was increased by 20% over the level of 45% in late February. The water content in Chongolbbing was the highest, whereas that in the rest of the varieties was nearly equal. 2. Dry weights of winter buds of the early varieties were always greater than those of midseason varieties. The dry weight of buds of early season varieties began to increase in late February and increased rapidly after April 18. There was no weight gain until April 12 in buds of midseason varieties, followed by a slow increase thereafter. 3. T-N and P, K, B, Fe, Cu and Zn concentration increased with time, Mn decreased, and Ca and Mg levels were constant. 4. T-N and Mn levels were higher and P, Ca, Fe and Cu lower in Hongolbbong than in the other varieties. T-N, Mg and Cu levels were lower in Chongolbbong. 5. The death rate of winter buds increased with the approach of the budding season. The rate was highest in Chongolbbong and lowest in Hongolbbong.

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수세법과 pH 조절법에 의한 닭가슴살 surimi의 품질 특성

  • Park, Gi-Hun;Kim, In-Jin;Ha, Ji-Hui;Gang, Seok-Mo;Kim, Il-Seok;Jin, Sang-Geun
    • Proceedings of the Korean Society for Food Science of Animal Resources Conference
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    • 2005.05a
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    • pp.155-158
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    • 2005
  • 닭가슴살을 이용해서 수리미 제조 시 4회 수세한 대조구, pH 3.0으로 산 처리한 T1, pH 11.0으로 알카리 처리한 T2로 하여 그 품질 특성을 비교한 결과 일반성분에서 수분, 조단백질과 염용성단백질 및 수율은 대조구에 비하여 pH 조절법으로 한 두 구가 높았으며, 조지방은 T2가 다른 두 구에 비하여 높았다. pH, 보수력, 파괴강도, 변형값은 처리 간에 유의적인 차이를 보이지 않았다. 전단가는 T2가 가장 높고, T1, 대조구 순이었다. $L{\ast}$값은 T2가 다른 두 구보다 낮았으며, $a{\ast}$값은 T1이 다른 두 구에 비하여 낮았다. $b{\ast}$값은 대조구가 가장 높고, T2가 가장 낮았다. 조직감에서 파쇄성 및 경도는 처리 간에 유의적인 차이를 보이지 않았으며, 응집성은 T1이 다른 두 구보다 낮았으며, 탄력성과 부착성은 대조구에 비하여 T1과 T2가 높았다. 검성은 대조구와 T1에 비하여 T2가 높았다. 조직감의 전 항목에서 T2 가 가장 높았다. 관능검사 결과 외관과 맛은 T1이 가장 높고, 대조구가 가장 낮았다. 색, 향, 다즙성, 연도 및 전체적인 기호도는 처리 간에 유의적인 차이가 없었다.

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AN EXTENSION OF SCHNEIDER'S CHARACTERIZATION THEOREM FOR ELLIPSOIDS

  • Dong-Soo Kim;Young Ho Kim
    • Bulletin of the Korean Mathematical Society
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    • v.60 no.4
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    • pp.905-913
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    • 2023
  • Suppose that M is a strictly convex hypersurface in the (n + 1)-dimensional Euclidean space 𝔼n+1 with the origin o in its convex side and with the outward unit normal N. For a fixed point p ∈ M and a positive constant t, we put 𝚽t the hyperplane parallel to the tangent hyperplane 𝚽 at p and passing through the point q = p - tN(p). We consider the region cut from M by the parallel hyperplane 𝚽t, and denote by Ip(t) the (n + 1)-dimensional volume of the convex hull of the region and the origin o. Then Schneider's characterization theorem for ellipsoids states that among centrally symmetric, strictly convex and closed surfaces in the 3-dimensional Euclidean space 𝔼3, the ellipsoids are the only ones satisfying Ip(t) = 𝜙(p)t, where 𝜙 is a function defined on M. Recently, the characterization theorem was extended to centrally symmetric, strictly convex and closed hypersurfaces in 𝔼n+1 satisfying for a constant 𝛽, Ip(t) = 𝜙(p)t𝛽. In this paper, we study the volume Ip(t) of a strictly convex and complete hypersurface in 𝔼n+1 with the origin o in its convex side. As a result, first of all we extend the characterization theorem to strictly convex and closed (not necessarily centrally symmetric) hypersurfaces in 𝔼n+1 satisfying Ip(t) = 𝜙(p)t𝛽. After that we generalize the characterization theorem to strictly convex and complete (not necessarily closed) hypersurfaces in 𝔼n+1 satisfying Ip(t) = 𝜙(p)t𝛽.

Studies on the Styrenic Polymers(1), Imidization of Poly(styrene-co-maleic anhydrides) and Their Thermal Properties (Styrenic Polymers연구(1), Poly(styrene-co-maleic anhydride)의 이미드화와 열적 성질)

  • Ahn, Tae-Oan;Park, Lee-Soon;Lee, Sang-Soo;Kim, Gi-Heon
    • Applied Chemistry for Engineering
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    • v.3 no.1
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    • pp.179-187
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    • 1992
  • Poly(styrene-co-maliec anhydride) was reacted with aromatic amines such as aniline, p-toluidine, and p-chloroaniline in 10% (w/w) DMF solution to convert maleic anhydride units into maleimides. Optimum reaction conditions for cyclodehydration step of imide ring formation were : (a) reaction temp. of $80^{\circ}C$ (b) mole ratios of cyclodehydration agents : anhydride units in SMA/acetic anhydride/sodium acetate/triethyl amine= 1.0/2.0/0.2/1.1. $T_g$of SMI(imide modified SMA) was increased with increasing degree of imidization, but $T_g$leveled off in the early stage of imide content. And $T_g$of SMI was increased with the following order of amines used for imidization reagents : aniline < p-toluidine < p-chloroaniline.

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GENERALIZED ANALYTIC FOURIER-FEYNMAN TRANSFORMS AND CONVOLUTIONS ON A FRESNEL TYPE CLASS

  • Chang, Seung-Jun;Lee, Il-Yong
    • Bulletin of the Korean Mathematical Society
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    • v.48 no.2
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    • pp.223-245
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    • 2011
  • In this paper, we de ne an $L_p$ analytic generalized Fourier Feynman transform and a convolution product of functionals in a Ba-nach algebra $\cal{F}$($C_{a,b}$[0, T]) which is called the Fresnel type class, and in more general class $\cal{F}_{A_1;A_2}$ of functionals de ned on general functio space $C_{a,b}$[0, T] rather than on classical Wiener space. Also we obtain some relationships between the $L_p$ analytic generalized Fourier-Feynman transform and convolution product for functionals in $\cal{F}$($C_{a,b}$[0, T]) and in $\cal{F}_{A_1,A_2}$.

Effects of Boheo-tang and Boheo-tang plus Cervi Pantotrichum Cornu : on Immune Response in Postpartum mice (보허탕(補虛湯)과 보허탕가녹용(補虛湯加鹿茸)이 산후 생쥐의 면역반응에 미치는 영향)

  • Lee, Eun-Hee;Kim, Tae-Hee
    • The Journal of Korean Obstetrics and Gynecology
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    • v.22 no.3
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    • pp.25-35
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    • 2009
  • Purpose: The purpose of this study is to investigate the effect of Boheo-tang (B) and Boheo-tang plus cervi pantotrichum cornu (B+CP) on immune response in postpartum C57BL/6N mice. Methods: Normal saline(control), B and B+CP (8${\mu}{\ell}$/g) were administerd p.o. twice a day for 20 days. Subpopulation of T and B lymphocyte were accessed by flow cytometric analysis. Results: Splenic T and B lymphocytes were increased by the treatment of B. Subpopulation of cytotoxic T lymphocytes in the spleen, were significantly increased by both treatment of B and B+CP. Subpopulation of cytotoxic T lymphcytes in the thymus, were significantly increased by both treatment of B and B+CP. IL-4 production was significantly increased by the treatment of B+CP. Conclusion: This study shows that treatment of Boheo-tang and Boheo-tang plus cervi pantotrichum cornu can improve postpartum immune response in C57BL/6N mice.