• Title/Summary/Keyword: P-delta effects

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A Clinical Study on the Effect of Ginseng to Control Superficial Body Temperature (인삼 복용 전후 체표온도의 변화에 관한 임상적 연구)

  • Choi, Ga-Ya;Cho, Jung-Hun;Jang, Jun-Bock;Lee, Kyung-Sub
    • Journal of Oriental Medical Thermology
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    • v.2 no.1
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    • pp.49-55
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    • 2003
  • In Oriental medicine, Ginseng had been used for many diseases widely. It's main effects are suppling Qi and Promoting metastasis. The objective of this study is to examine the effect of Ginseng on control of body temperature. We conducted this study with 24 volunteers who had no problem in their health from November 2002 to January 2003. The body temperature were measured by DITI and thermometer before taking Ginseng and after 30minutes of the taking Ginseng extract 15g. We observed the difference of temperature among face chest and upper abdomen. All data were coded for computer analysis and significance were tested by Paired t-test and independent-t-test. According to our study, the axillary temperature show no signifiant change between two groups. The difference of temperature$({\Delta}T)$ between face and upper abdomen significantly increase after taking Ginseng extract(p<0.01). The difference of temperature$({\Delta}T)$ between face and chest significantly increase after taking Ginseng extract(p<0.05).

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Human Glutathione S-Transferase P1 Suppresses MEKK1-mediated Apoptosis by Regulating MEKK1 Kinase Activity in HEK293 Cells

  • Zhao, Xin;Fan, Yumei;Shen, Jiayin;Wu, Yifan;Yin, Zhimin
    • Molecules and Cells
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    • v.21 no.3
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    • pp.395-400
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    • 2006
  • Glutathione S-transferase P1 (GSTP1) plays an important role in detoxification and the metabolism of xenobiotics. Here we show that GSTP1 also regulates the MEKK1-MKK7 signaling pathway. Over-expression of GSTP1 in HEK293 cells inhibited both ${\Delta}MEKK1$- and etoposide-induced apoptosis, and inhibited procaspase-3 activation and PARP cleavage. MEKK1- induced apoptosis requires both its kinase activity and proteolytic cleavage. ${\Delta}MEKK1$ activity was inhibited by over-expression of GSTP1 in vivo and MEKK1 kinase activity was also inhibited by GSTP1 in vitro when assayed with bacterially-expressed MKK7(KM) protein as substrate. GSTP1 inhibition of etoposide-induced cell apoptosis was mainly due to its ability to suppress MEKK1 kinase activity. The glutathione-conjugating activity of GSTP1 was essential for the above effects. These findings provide insight into the mechanism by which GSTP1 protects cells from genotoxin-induced apoptosis.

A Study on the Analysis of Steel Bracing Behaviour Subjected to Cyclic Loads (반복하중을 받는 강재 브레이싱의 거동에 관한 해석적 연구)

  • 구민세;김병석;김일곤
    • Computational Structural Engineering
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    • v.2 no.3
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    • pp.69-75
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    • 1989
  • The primary purpose of using bracings is to improve the lateral rigidity of main structural system, i.e., columns and beams, by reinforciing them with much smaller members. In conventional design methods brackings are considered as tension-only members, since difficulties arise in the analysis when the P-.DELTA. effects and post-buckling behaviour of the bracing members are taken into account. This is particulary true fox X-bracings. Recently, however, both analytical and experimental studies have been conducted to investigate the more precise and real behaviour of bracing members, especially for the nonlinear and plastic behaviour under cyclic loads. In this study, an analytical model is proposed to investigate the nonlinear behavior of steel bracing members subjected to cyclic loads. Results of the analysis were compared with previous experimental results, and good agreements were obtained between these results.

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The Stability of Steel Unbraced Frames Considering Nonlinear Behavior of Connections (접합부 비선형 거동을 고려한 강구조 비가새 골조의 안정성)

  • Kim, Hee Dong
    • Journal of Korean Society of Steel Construction
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    • v.17 no.4 s.77
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    • pp.469-479
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    • 2005
  • The nonlinear behavior of a connection has an influence on the behavior (the $P-\Delta$ effect) and the stability of a steel unbraced frame when a semi-rigid connection is applied as a beam-to-column connection. Therefore, the effects of a connection's non-linear behavior on the behavior and stability of a steel unbraced frame were investigated using second-order inelastic analysis, after which the main influence factors and their behavioral tendencies were studied. The study results showed that the nonlinear behavior of a connection directly affects the stability of a steel unbraced frame, and that the main influence factors are the rotational stiffness of the connection and the location of a semi-rigid connection.

Effect of the Injection Parameters on Diesel Spray Characteristics

  • Song Kyu Keun;Sim Sang Cherl;Jung Byong Koog;Kim Hyung Gon;Kim Jang Heon
    • Journal of Mechanical Science and Technology
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    • v.19 no.6
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    • pp.1321-1328
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    • 2005
  • The characteristics of the diesel spray have affected certain aspects of engine performance, such as the power, fuel consumption, and emissions. Therefore, this study was performed to investigate the effects of various injection parameters. In order to obtain the effect of injection parameters on diesel spray characteristics, the experiment is performed by using a high temperature and pressure chamber. The behaviors of the spray are visualized by using a high speed video camera, spray angle, penetration, and various other things. The results of the experiment are summarized as follows. (1) The correlation of the spray penetration can be expressed as follows. $$0< t $$t_{b} (2) The correlation of the spray angle can be expressed as follows $$T_a=293K\;tan({\theta}/2)=0.59({\rho}a/{\rho}f)^{0.437}$$ $$T_a=473K\;tan({\theta}/2)=0.588({\rho}a/{\rho}f)^{0.404}$$ (3) The measured macro characteristics that include the spray tip penetration and spray angle corresponded with the established correlations.

Effects of electroacupuncture stimulation at Xingjian(LR2) on the facial thermal change by D.I.T.I (행간(行間)(LR2) 전침자극(電鍼刺戟)이 적외선(赤外線) 체열진단상(體熱診斷上) 안면부(顔面部) 온도변화(溫度變化)에 미치는 영향(影響))

  • Kim, Jong-uk;Choi, Sung-yong;Jin, Kyong-son;Hwang, Woo-jun;Min, Sang-jun;Lee, Sun-ho;Lee, Sang-ryong
    • Journal of Acupuncture Research
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    • v.21 no.1
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    • pp.226-239
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    • 2004
  • Objective: Purpose of this study was to examine the effect of electroacupuncture(EA) at Xingjian(LR2) as 'Fire(火)' point of The Leg Absolute Um Liver Meridan(足厥陰肝經 : Chok-Kworum-Kan-Kyong) on the facial thermal change. Methods: Subjects of this study were 15 patients with upperpart(includes head and facial part) fever of human body and two examinations were carried out in each other day. We divided cases of two examinations into two groups. One is experimental group(N=15) that was carried out electroacupuncture stimulation at Xingjian(LR2), the other is control group(N=15) which was carried out electroacupuncture stimulation at optional point(in space between 1st and 2nd fingers) except acupuncture points of 12 meridians. We took the temperature of fixed areas on face by digital infrared thermal image(D.I.T.I.) before and after electroacupuncture stimulation. Those fixed areas on face that was taken temperature are Jingming(BL1), Sibai(ST2), Dicang(ST4), Indang, Shuigou(GV26), Chengjiang(CV24) areas. In cases of temperature of Jingming(BL1), Sibai(ST2), Dicang(ST4) areas, we applied each mean of left and right temperature to statical analysis. Results: In the group of electroacupuncture stimulation at Xingjian(LR2), temperature of every fixed areas on face fell: Jingming(BL1) area's ${\Delta}T=-0.7007{\pm}0.78642$, Sibai(ST2) area's ${\Delta}T=-0.6280{\pm}0.56439$, Dicang(ST4) area's ${\Delta}T=-0.5940{\pm}0.60179$, Indang area's ${\Delta}T=-0.7200{\pm}0.64515$, Shuigou(GV26) area's ${\Delta}T=-0.6160{\pm}0.80487$, Chengjiang(CV24) area's ${\Delta}T=-0.5627{\pm}0.72615$. In Xingjian(LR2) electroacupuncture group, each temperature of Jingming(BL1), Sibai(ST2), Indang areas showed a drop significantly in comparison with control group (p<0.05). But each temperature of Dicang(ST4), Shuigou(GV26), Chengjiang(CV24) areas did not showed a drop significantly in comparison with control group(p>0.05). Conclusions: The results mentioned above showed that electroacupuncture stimulation at Xingjian(LR2) significantly decreased the temperature on face of patients with upperpart fever of human body. In Xingjian(LR2) electroacupuncture group, especially temperature of upper part of face includes eye, cheekbone, forehead regions showed a drop significantly in comparison with control group.

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Effects of Irradiation and Fumigation on Color and Sensory Properties in the Parts of Dried Red Pepper during Storage (방사선과 훈증 처리된 건고추의 저장 중 부위별 색도 및 관능적 특성)

  • Kim Byeong-Keun;Kwon Youngju;Noh Jungeun;Kim Jeong-Sook;Kim Dong-Ho;Kwon Joong-Ho
    • Food Science and Preservation
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    • v.11 no.4
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    • pp.431-436
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    • 2004
  • Associated with microbial decontamination and quarantine treatment of dried red pepper, the samples was gamma-irradiated (5, 10 kGy) and fumigated (methyl bromide/MeBr, phosphine/$PH_3$) to compare their Hunter's color (L, a, b, ${\Delta}E$) and sensory properties by types (whole, powder, pericarp, seed) during storage under room conditions($18{\pm}12^{\circ}C$). Whole pepper maintained higher lightness (L value) than other groups, while powdered pepper showed higher redness (a value) during storage. Immediately after treatments there was little difference in the overall color difference (${\Delta}E$) among the groups. After 8 months, a higher redness was observed in $PH_3$ group of whole pepper and 5 kGy group of powdered pepper, respectively(p<0.05). Redness of irradiated pericarps was apparently reduced following 8 months of storage and a similar pattern was found in fumigated samples. The yellowness (b value) of pepper seed was lowest in 10 kGy sample (p<0.05), but insignificant difference was observed among treatment groups with storage time. Sensory properties of whole and powdered peppery were little changed by both treatments under commercial conditions. Sensory scores of irradiated or fumigated samples were higher than that of non-treated control with storage time, which was more significant in the powdered than in the whole samples.

The Effect of Auricular Acupuncture at the Shinmun on the Electroencephalogram(EEG) in patients with dementia (이침(耳鍼)의 신문혈(神門穴) 자극(刺戟)이 치매환자(痴呆患者)의 뇌파(腦波)에 미치는 영향(影響))

  • Kim, Mi-Ra;Lee, Go-Eun;Lee, Sang-Eon;Park, In-Sook;Park, Jang-Ho;No, Dong-Jin;Kim, Ji-Young;Park, Bo-Ra;Lyu, Yeoung-Su;Kang, Hyung-Won
    • Journal of Oriental Neuropsychiatry
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    • v.21 no.3
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    • pp.45-64
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    • 2010
  • Objectives : The purpose of this study was to examine the effects of auricular acupuncture at the Shinmun on patients with dementia by using power spectrum analysis. Electroencephalogram(EEG) power spectrum show site-specific and state-related differences in various frequency bands. Methods : Study was carried out in 38 subjects.(31 patients with dementia and 7 normal people, 27 females and 11 males ; mean age=75.9 years old). To know the effect of auricular acupuncture at the Shinmun in patients with dementia, we measured electroencephalogram(EEG) of normal people and patients with dementia about 'before', 'after' and 'after 15 minutes' giving auricular acupuncture at the Shinmun, and compared the brain wave($\alpha$, $\beta$, $\delta$, $\theta$) of EEG 30 channels. Results : In the case of patients with dementia, in the power values of $\alpha$(alpha) band at F4, FP2, FCZ, F8, FC4 channels (p<0.05) during the Shinmun-auricular acupuncture treatment increased significantly. In $\beta$(beta) band, the power values at T8 channel(p<0.05) during the Shinmun-auricular acupuncture treatment increased significantly. In $\delta$(delta) band, the power values at F7, FP1, FZ, FP2, FCZ, C4, FC4, CP4, T8, P7, P3, O1, OZ, O2, P4, P8 channels(p<0.05) during the Shinmun-auricular acupuncture treatment decreased significantly. In $\Theta$(theta) band, the power values at O1, OZ, O2channel(p<0.05) during the Shinmun-auricular acupuncture treatment decreased significantly. Conclusions : Through these results, we concluded that auricular acupuncture at the Shinmun on patients with dementia could have effect the functional mechanism of the cerebral cortex.

Effects of different surface finishing procedures on the change in surface roughness and color of a polymer infiltrated ceramic network material

  • Ozarslan, Mehmet Mustafa;Buyukaplan, Ulviye Sbnem;Barutcigil, Cagtay;Arslan, Merve;Tuker, Nurullah;Barutcigil, Kubilay
    • The Journal of Advanced Prosthodontics
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    • v.8 no.1
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    • pp.16-20
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    • 2016
  • PURPOSE. Polymer infiltrated ceramic network (PICN) materials, also called hybrid ceramics, are new materials in dental market. The manufacturer of the PICN material VITA Enamic suggests 3 different finishing procedures for this new material. In the present study, surface roughness and color differences caused from different finishing procedures of VITA Enamic were investigated. MATERIALS AND METHODS. 120 specimens were prepared in dimensions $2{\times}10{\times}12mm$ from VITA Enamic hybrid ceramic blocks with 'high translucency' and 'translucency 2M2' shades. The specimens were divided into 8 groups. For each group, different finishing procedures suggested by the manufacturer were performed. Surface roughness values were determined by a tactile portable profilometer. Color changes were evaluated using a clinical spectrophotometer. The data were analyzed using one-way ANOVA and Tukey's post-hoc comparison. The significance level was set at ${\alpha}=0.05$. RESULTS. The roughest surfaces were observed in Glaze Groups. Their surface roughness values were similar to that of the control group. Clinical Kit and Technical Kit groups did not show a statistically significant difference regarding surface roughness (P>.05). The largest color difference regarding ${\Delta}E_{00}$ was observed in Clinical Kit finishing groups. There were also statistically significant color changes between the groups (P<.05). However, all the groups showed clinically acceptable color change (${\Delta}E_{00}$<2.25) except Clinical Kit Groups (${\Delta}E_{00}$>2.25). CONCLUSION. Within the limitations of the present study, it may be suggested that finishing the VITA Enamic restorations by Technical Kit instead of Glaze and Clinical Kit gives better clinical performance in regard to surface roughness and shade matching.

Adsorption Analysis of Fluorescent Whitening Agent on Cellulosic Fibers by Zeta Potential Measurement (지료의 제타전위 측정을 통한 형광증백제의 흡착 평가)

  • Lee, Ji Young;Kim, Eun Hea;Kim, Chul Hwan;Park, Jong Hye
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.47 no.6
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    • pp.106-112
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    • 2015
  • Many researchers have proposed analytical methods to measure the adsorption of di-sulpho fluorescent whitening agents (D-FWAs), but practical methods for D-FWA utilization in an actual paper mill have not been established. In particular, the D-FWA adsorption behavior must be monitored in paper mills to ensure the effective use of D-FWAs. This study used the zeta-potential of pulps as an indicator of the adsorption behavior of a D-FWA. We identified the relationship between the actual adsorption of the D-FWA and the zeta-potential of the pulps as a function of D-FWA addition. zeta-potential measurements were then used to analyze the D-FWA adsorption behavior under different conditions of pulp type, conductivity, and pH. The actual adsorption of a D-FWA was proportional to the ${\Delta}zeta-potential$ of the pulps (i.e., the difference between the zeta-potential of a pulp containing no D-FWA and one containing the D-FWA). The ${\Delta}zeta-potential$ of the pulps was therefore adopted for adsorption analysis. A higher adsorption of the D-FWA was observed onto Hw-BKP than onto Sw-BKP because of the shorter fiber length and higher fines content of Hw-BKP. A high conductivity and an acidic pH decreased the D-FWA adsorption because of direct effects of high ion concentrations and low pH on the D-FWA solubility. Therefore, a D-FWA must be added to Hw-BKP under low conductivity conditions and at neutral or alkaline pH to optimize the D-FWA adsorption.