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Some Positive Dependent Orderings

  • Tae-Sung Kim;Song-Ho Kim
    • Journal of the Korean Statistical Society
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    • v.25 no.2
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    • pp.243-253
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    • 1996
  • Let X and Y be random vectors in R$^{n}$ . A random vector X is 'more associated' than Y if and only if P(X $\in$ A ∩ B) - P(X $\in$ A)P(X $\in$ B) $\geq$ P(Y $\in$ A ∩ B)-P(Y $\in$ A)P(Y $\in$ B) for all open upper sets A and B. By requiring the above inequality to hold for some open upper sets A and B various notions of positive dependence orderings which are weaker than 'more associated' ordering are obtained. First a general theory is given and then the results are specialized to some concepts of a particular interest. Various properties and interrelationships are derived.

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Predictive Value of the Pattern of β-Catenin Expression for Pathological Response to Neoadjuvant Chemotherapy in Breast Cancer Patients

  • Elsamany, S;Elemam, O;Elmorsy, S;Alzahrani, A;Abbas, MM
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.8
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    • pp.4089-4093
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    • 2016
  • Purpose: This study aimed to explore the association of ${\beta}-catenin$ expression pattern with pathological response after neoadjuvant chemotherapy in breast cancer (BC) patients. Materials and Methods: In this retrospective exploratory study, data for 50 BC patients who received neoadjuvant chemotherapy were recorded. ${\beta}-catenin$ expression in tumours was assessed using immunohistochemistry and classified as either membranous or cytoplasmic according to the pattern of staining. Distributions of different clinico-pathological parameters according to ${\beta}-catenin$ expression were assessed using the Chi-square test. Logistic regression analysis was used to assess any relation of the pattern of ${\beta}-catenin$ expression with the pathological response. Results: Cytoplasmic ${\beta}-catenin$ expression was detected in 34% of BCs. Among our cases, 52% were hormonal receptor (HR)-positive, 24% were HER2-positive, 74% were clinical stage III and 74% received both anthracycline and taxane-based chemotherapy. Patients with cytoplasmic expression were more commonly younger than 40 years at diagnosis (cytoplasmic, 41.2% vs. no cytoplasmic expression, 12.1%, p=0.03). By doing t-test, cytoplasmic ${\beta}-catenin$ expression was linked with a higher body mass index compared to membranous-only expression ($mean{\pm}SD$ $33.0{\pm}4.47$ vs. $29.6{\pm}6.01$, respectively, p=0.046). No significant associations were found between ${\beta}-catenin$ expression and other parameters such as HR and HER2 status, or clinical stage. Complete pathological response (pCR) rate was twice as great in patients with membranous expression but without statistical significance (membranous-only, 33.3% vs. cytoplasmic, 17.6%, OR= 2.3, 95% CI= 0.55-9.87, p=0.24). Conclusions: This study suggests that cytoplasmic ${\beta}-catenin$ expression may be linked with lower probability of achieving pCR after neoadjuvant chemotherapy. These data need to be validated in a larger cohort of patients.

Kinetics of Cell Growth and Cyclosporin A Production by Tolypocladium inflatum when Scaling Up from Shake Flask to Bioreactor

  • El Enshasy, H.;Fattah, Y. Abdel;Atta, A.;Anwar, M.;Omar, H.;Magd, S. Abou El;Zahra, R. Abou
    • Journal of Microbiology and Biotechnology
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    • v.18 no.1
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    • pp.128-134
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    • 2008
  • The kinetics of cell growth and Cyclosporin A (Cyc A) production by Tolypocladium inflatum were studied in shake flasks and bioreactors under controlled and uncontrolled pH conditions. In the case of the shake flask, the production time was extended to 226 h and the maximal antibiotic concentration was 76 mg/l. When scaling up the cultivation process to a bioreactor level, the production time was reduced to only 70h with a significant increase in both the cell growth and the antibiotic production. The maximal dry cell weights in the case of the controlled pH and uncontrolled pH cultures in the bioreactor were 22.4g/l and 14.2g/l, respectively. The corresponding maximal dry cell weight values did not exceed 7.25g/l with the shake flask cultures. The maximal values for Cyc A production were 144.72 and 131.4 mg/l for the controlled and uncontrolled pH cultures, respectively. It is also worth noting that a significant reduction was observed in both the dry cell mass and the antibiotic concentration after the Cyc A production phase, whereas the highest rate of antibiotic degradation was observed in the stirred tank bioreactor with an uncontrolled pH. Morphological characterization of the micromorphological cell growth (mycelial/pellet forms) was also performed during cultivation in the bioreactor.

Factors Related with the Intention of Smoking Abstinence among Elementary Students in a Large City (일부 대도시 초등학생의 금연의지와의 관련 요인)

  • Park, Soon-Woo
    • Journal of the Korean Society of School Health
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    • v.22 no.1
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    • pp.49-59
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    • 2009
  • Purpose: The aim of this study was to identify the factors related with the intention of smoking abstinence among elementary students in a metropolitan city in Korea. Methods: All the elementary schools in the city were stratified by region, and then schools as a primary sampling units (PSU) were selected by probability proportional to size (PPS) sampling. One class per grade was sampled randomly from 5th and 6th grade in the sampled schools from October to December in 2004. The students completed a standardized self-administered questionnaire anonymously. A total number of 1,712 respondents who did not smoke was included in the final analysis. The dependent variable was an intention of smoking in the future, and it was dichotomized into 'absolutely confident in smoking abstinence' and 'others'. The risk of non-absolute confidence in smoking abstinence was calculated with simple and multiple logistic regression, which were conducted with STATA 9.0 by a design-based analysis considering strata variable, PSU, and sampling weight. Results: In the final model of multiple logistic regression analysis, those who were more likely to have non-absolute confidence in smoking abstinence were male students (OR=2.66, p<0.001); barely attending religious services (OR=3.32, p=0.002) or having no religion (OR=1.95, p=0.027); exposure to environmental tobacco smoke outside home 1${\sim}$2 days per week (OR=1.60, p=0.013); having friends who smoked (OR=1.93, p=0.011); non-absolute confidence in refusing to smoke (OR=5.35, p<0.001); having relatively less negative attitude (OR=2.88, p<0.001), positive attitude (OR=2.35, p<0.001), and indifference (OR=4.05, p=0.034) toward peer smoking; not good relationship with mother (OR=1.52, p=0.016). Conclusion: The factors related with non-absolute confidence in smoking abstinence were coincided with those of smoking among children. The results of this study suggest the smoking prevention education should be applied to the children more actively, especially who are not confident in smoking abstinence in the future.

Runoff Characteristics of Non-point Pollutants Source in Suwon City (수원시 비점오염물질의 유출 특성)

  • Chi, Hong-Jin;Lee, Sang-Eun;Lee, Jae-Dong
    • Journal of Environmental Science International
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    • v.22 no.4
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    • pp.493-505
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    • 2013
  • This study was to investigate the runoff characteristics of non-point pollutants source at the urban area in Suwon city. The highest T-N and T-P concentration of rainfall runoff observed in agricultural area. In residential area, the highest $BOD_5$ and SS concentration of rainfall runoff was investigated. During rainfall events, the peak concentrations of SS and $BOD_5$ were observed after 1~2 hours of rainfall in urban area. Whereas, the peak concentrations occurred within 1~2 hours after rainfall and then the highest concentrations of SS and $BOD_5$ sharply decreased, showing strong first flush effect in urban area. The EMC results indicated that the highest value of T-N and T-P in agricultural area was observed. While residential area was shown the lowest EMC value as T-N and T-P. Non-point pollutant loads on the land use types in urban area were investigated in the order of residential>industrial>agricultural>highway. $BOD_5$ and SS loads on urban watershed were investigated in the order of Suwon>Hwangguji>Seoho>Wonchunri. Whereas, T-N and T-P loads on urban watershed were investigated in the order of Hwangguji>Suwon>Wonchunri>Seho.

The Water Pollution of Yocheon, Uppermost Stream of the Sumjin River (섬진강 최상류인 요천의 수질오염)

  • Ahn, Kun-Sang
    • Journal of the Korean earth science society
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    • v.26 no.8
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    • pp.821-827
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    • 2005
  • The Yocheon is an upper stream of Sumjin river, passing through Namwon city. The water temperature of the stream increases from upper stream to downstream. The amount of COD, T-P, T-N, EC, TDS abruptly increases at measuring site 8. Whereas, the pH and DO level abruptly decreases at this site. At this point, the Yocheon river joins another small stream passing through the central part of Namwon city. At a further downstream pass site 8, the amount of COD on April and June (a dry season) is on third grade of water quality for lacustrine. This contamination suggests that sewage from the Namwon city provide COD, T-N, T-P into the stream. At point 2, the high amount of T-N indicates that the upper stream is contaminated by agricultural activity.

Analysis of the Differences in Healthy Behaviors of Adolescents by Regional Size and Related Factors (도시 규모 별 청소년의 건강생활 실천 차이와 관련 요인)

  • Chin, Young Ran;Yang, Sun-Yi
    • Journal of Korean Academy of Rural Health Nursing
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    • v.18 no.1
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    • pp.11-18
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    • 2023
  • Purpose: This study is to compare adolescents' health behaviors by city size and to propose regionally tailored health promotion. Methods: We analyzed the data from the 17th Youth Health Risk Behavior Online Survey, national widly performed in 2021. Multi-sample descriptive and linear regression analysis was performed by city size. Results: The frequency of fruit consumption in the last week was 2.88 in the rural area, which is lower than 2.98 and 3.05 in other cities (F=10.98, p<.001). The number of high-intensity physical activity days in the last week (7 days) was 2.90 days in the rural area, higher than 2.74 and 2.73 days in other cities (F=3.36, p=.038). The number of days smoking cigarettes in the last 30 days was 3.23 days in the rural area, higher than 3.08 and 3.02 days in other cities (F=3.41, p=.035). BMI was 22.01 in the rural area, which was higher than 21.57 and 21.61 in other cities (F=4.19, p=.015). Conclusion: School health offices in the rural area districts need to operate to manage lack of fruit intake, smoking, and weight management programs in association with local healthcare institutions.

A study on the Safety Awareness and Safety Practice Behavior of Adult Learners: Focusing on 「Civic Safety Culture College」 in Changwon City (성인학습자들의 안전의식과 안전생활실천 연구: 창원지역 「시민안전문화대학」 중심으로)

  • PARK, Sin-Young;EO, Yong-Sook
    • Journal of Fisheries and Marine Sciences Education
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    • v.27 no.6
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    • pp.1619-1627
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    • 2015
  • The purpose of this study was to examine the relationship between the safety awareness and safety practice behavior of adult learners who participated in "civic safety culture college" was held in Changwon city. We carried out a questionnaire survey that was targeted at 150 citizens, but 132 citizens were included finally. Data collected were analyzed with SPSS 21.0 statistical program. Analysis methods were t-test, one way ANOVA, Scheffe test, Pearsons correlation coefficient, and multiple linear regression. The results were as follows. First, safety awareness point was an average of 4.17 point which was higher levels. Area showing the highest safety awareness was fire safety. Safety practice behavior point was an over intermediate level of an average of 3.58 point. Second, safety practice behavior had statistically significant difference according to sex(t=2.58, p=.01), education(t=-2.57, p=.01), job(t=-1.96, p=.05), housing(t=3.65, p<.001). Third, there was a positive correlation between home safety awareness(r=.28, p<.001), traffic safety awareness(r=.37, p<.001), fire safety awareness(r=.37, p<.001), emergency care awareness(r=.45, p<.001) and safety practice behavior. Fourth, safety practice behavior was related to the emergency care awareness(${\beta}$=.34, p=.002), this factor accounted for 19.5% of the variability of the safety practice behavior. These results are expected to be very important baseline data for many different businesses and program development for strengthening of safety awareness and spreading of safety culture in Changwon city.

Evaluation of Insecticidal Activity of Plant Extracts against the Diamondback Moth, Plutella xylostella (Lepidoptera: Plutellidae) on Vegetable Plant (배추좀나방(Plutella xylostella)에 대한 식물추출물의 살충력 평가)

  • Choi, I-Jin;Kwon, Hyuk-Hyun;Lee, Han-Ho;Son, Hyoung-Gi;Hong, Sang-Kil;Kang, Jong-Woon;Park, Yu-Soon
    • Korean Journal of Plant Resources
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    • v.26 no.1
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    • pp.19-25
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    • 2013
  • This study focused on the usefulness of plant extracts for a city organic farm. Insecticidal activity of 8 plant species, plants crude extracts by ethanol and water, against third instar larvae (susceptible strain) of Plutella xylostella was evaluated in this study. Ethanol(25%) extracts of plant materials had better insecticidal activity than water extracts at the room temperature. Insecticidal activity were investigated by leaf disc spray method. Five plant extracts (Capsicum annuum, Chelidoniun majus, Leonurus sibiricus, Coptis japonica, Mentha piperascens) showed over 50% insecticidal activity to P. xylostella at the concentration of $1500mg{\cdot}L^{-1}$. Extract of C. annuum showed the highest insecticidal activity (83.3%) against P. xylostella. Phytotoxicity was not observed on Raphanus sativus and Brassica campestris with spray application. Seed germination and growth of two plants were not affected. Extract of C. japonica revealed 73.3% control efficacy against P. xylostella of R. sativus and showed 70% control efficacy against those of B. campestris, respectively, in plastic house. Insecticidal activity against various insects was observed in C. japonica extract as 87.4% for R. sativus and 74.3% for B. campestris in the field. These results suggested that extracts of C. annuum, C. japonica showed the highest insecticidal activity, and could be used as city farm insecticides for organic farming.

Factors Influencing Depression of Elderly Women in a Metropolitan City (일 대도시 여성노인의 우울에 영향을 미치는 요인)

  • Yang, Seung-Ae
    • Journal of Korean Public Health Nursing
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    • v.26 no.1
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    • pp.158-173
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    • 2012
  • Purpose: This study was conducted in order to investigate factors related to depression of elderly women in a Metropolitan city. Methods: Subjects included 118 elderly women older than 65 years of age. Structured questionnaires were used for data collection, and descriptive statistics, t-test, ANOVA, Pearson correlation coefficients, and hierarchical regression analysis were performed for data analysis. Results: A significant difference in depression was observed according to number of chronic diseases(F=4.963, p=.001). Significant factors influencing depression included number of chronic diseases (${\beta}$=.265, p<.01), cognitive function (${\beta}$=.290, p<.01), quality of sleep(${\beta}$=.212, p<.01), and nutritional state (${\beta}$=.161, p<.05). These factors explained 54.2% of the variance. Conclusion: Findings of this study suggest the need for development of nursing strategies to decrease the incidence of depression in elderly women.