• The Korean Journal of Physiology and Pharmacology
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• v.25 no.4
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• pp.365-374
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• 2021

The mammalian target of rapamycin (mTOR) plays a role in various cellular phenomena, including autophagy, cell proliferation, and differentiation. Although recent studies have reported its involvement in nociceptive responses in several pain models, whether mTOR is involved in orofacial pain processing is currently unexplored. This study determined whether rapamycin, an mTOR inhibitor, reduces nociceptive responses and the number of Fos-immunoreactive (Fos-ir) cells in the trigeminal nucleus caudalis (TNC) in a mouse orofacial formalin model. We also examined whether the glial cell expression and phosphorylated p38 (p-p38) mitogen-activated protein kinases (MAPKs) in the TNC are affected by rapamycin. Mice were intraperitoneally given rapamycin (0.1, 0.3, or 1.0 mg/kg); then, 30 min after, 5% formalin (10 μl) was subcutaneously injected into the right upper lip. The rubbing responses with the ipsilateral forepaw or hindpaw were counted for 45 min. High-dose rapamycin (1.0 mg/kg) produced significant antinociceptive effects in both the first and second phases of formalin test. The number of Fos-ir cells in the ipsilateral TNC was also reduced by high-dose rapamycin compared with vehicle-treated animals. Furthermore, the number of p-p38-ir cells the in ipsilateral TNC was significantly decreased in animals treated with high-dose rapamycin; p-p38 expression was co-localized in microglia, but not neurons and astrocytes. Therefore, the mTOR inhibitor, rapamycin, reduces orofacial nociception and Fos expression in the TNC, and its antinociceptive action on orofacial pain may be associated with the inhibition of p-p38 MAPK in the microglia.

• Journal of the Korean Society of Radiology
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• v.5 no.3
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• pp.111-120
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• 2011

A purpose of study is to develop optimization and radiation dose exposure reference level by measuring actual radiation dose in condition of quality control of mammography equipment for 39 clinics. The result were as follows. First, we measured T-test separating radiology from general clinic. According to the test, mAs was measured at average 78.58 mAs; radiology at 80.16 mAs and general clinic at 77.22 mAs. And, kerma rate was measured at average 7.71 mGy/mR; radiology at 8.94 mGy/mR and general clinic at 6.66 mGy/mR. HVL was measured at average 0.42 mmAl; radiology at 0.40 mmAl and general clinic at 0.43 mmAl. Average glandular dose was measured at average 1.14 mGy; radiology at 1.09 mGy and general clinic at 1.19 mGy. Second, we measured value of mAs, HVL, processing method and so on dividing two groups. And, we compared and analyzed average value measured using T-test. As a result, there was significance level in SID(P<0.05). There was significance level in mAs(P<0.05). Because processor was measured at 1.00 mGy and CR at 1.17 mGy according to the processing method of radiology. Third, according to the correlation analysis, radiology had significance level between average glandular dose and mAs and general clinic had significance level between average glandular dose and SID(P<0.05). Forth, as a result of regression analysis, mAs affected 22.7%t of average glandular dose and SID affected 21.7% of average glandular dose, which had significance level(P<0.05). And, mAs affected 29.0% of average glandular dose in radiology and SID affected 29.1% of average glandular dose in general clinic, which was most influential.

• Journal of the Optical Society of Korea
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• v.13 no.3
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• pp.335-340
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• 2009

Ultrashort pulse laser drilling of polycarbonate track-etched membrane (pTEM) material was used to fabricate a mouse embryo cell trapping device. Holes with a diameter of $2{\mu}m$ to $5{\mu}m$ were fabricated on a $10{\mu}m$ thick membrane using a femtosecond laser with a 150 fs pulse width and 775 nm wavelength and multiple-pulse irradiation. In cell trapping tests, the overall cell occupancy of the machined holes in the fabricated pTEM was found to be more than 80%. The results of a single pulse and multiple pulse irradiation were compared in terms of the surface quality. It was generally found that a single pulse with high energy was less desirable than irradiation with multiple pulses of lower energy.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09b
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• pp.1041-1042
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• 2006

High heat-resistant Al-Fe-V-Si and Al-Fe-V-Si-X rapidly solidified powder metallurgy (RS P/M) alloys have been developed under well-controlled high purity argon gas atmosphere. The $Al_{90.49}Fe_{6.45}V_{0.68}Si_{2.38}$ (at. %) RS P/M alloy exhibited high elevated-temperature strength exceeding 300 MPa and good ductility with elongation of 6 % at 573 K. Reduction of $H_2O$ partical pressure in P/M processing atmosphere led to improvement in mechanical properties of the powder-consolidated alloys under elevated-temperature service conditions. Ti addition to the Al-Fe-V-Si conduced to enhancement of the strength at room temperature. The tensile yeild strength and ultimate strenght were 545 MPa and 722 MPa, respectively.

• Proceedings of the Korea Information Processing Society Conference
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• 2008.11a
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• pp.1393-1396
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• 2008

P2P프로그램에 대한 연구는 정보공유 및 성능 향상을 초점으로 많은 연구가 진행되어 왔다. 그러나 P2P프로그램의 정보유출 문제에 대한 원인분석 및 대응방안에 대한 연구는 미비한 실정이다. 일본은 2004년부터 P2P프로그램을 통한 정보유출 사건이 빈번히 발생하고 있다. 이와 같은 이유로 본 연구는 일본의 P2P프로그램을 통한 정보유출 현황, 원인, 대응방안을 연구했다. 정보유출 현황을 조사하기 위해 정보유출에 관련된 언론기사를 수집했고, 일본 P2P프로그램으로부터 유출되고 있는 정보를 30개월간 수집했다. 정보유출 원인을 이해하고 대응방안을 파악하기 위해서 일본 P2P프로그램의 사용현황, 정보유출 사례, 정보유출 원인, 일본 정부·기관·기업·군의 대응방안을 조사하고 분석했다. 유출된 정보를 수집한 결과 개인 신상정보, 기업, 관공서, 군 등의 내부 자료를 수집할 수 있었으며, 유출 정보로 인한 사회적 심각성을 이해할 수 있었다. 또한 일본 민·관·군의 정보유출 대응방안이 실효성을 거두고 있는가를 검증하기위해서 유출정보를 지속적으로 수집하였다. 그 결과 대응방안 적용 시점부터 유출정보가 급격히 감소했음을 확인했다. 이러한 연구 결과는 타 국가의 P2P프로그램을 통한 정보유출 대응방안수립에 도움이 될 것이다.

• Food Science of Animal Resources
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• v.35 no.2
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• pp.149-155
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• 2015

The combined effects of smoking and boiling on the proximate composition, technological quality traits, shear force, and sensory characteristics of the Korean traditional boiled loin were studied. Cooking loss, processing loss, and shear force were lower in the smoked/ boiled samples than those in the control (without smoking treatment) (p<0.05). The results showed that the boiled loin samples between the control and treatment did not differ significantly in protein, fat, or ash contents, or pH values (p>0.05). The treated samples had higher score for overall acceptability than the control (p<0.05). Thus, these results show that the Korean traditional boiled loin treated with smoking for 60 min before boiling had improved physicochemical properties and sensory characteristics.

• Journal of Microbiology and Biotechnology
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• v.19 no.10
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• pp.1184-1190
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• 2009

A thermostable extracellular $\beta$-mannanase from the culture supernatant of a fungus Aspergillus niger gr was purified to homogeneity. SDS-PAGE of the purified enzyme showed a single protein band of molecular mass 66 kDa. The $\beta$-mannanase exhibited optimum catalytic activity at pH 5.5 and $55^{\circ}C$. It was thermostable at $55^{\circ}C$, and retained 50% activity after 6 h at $55^{\circ}C$. The enzyme was stable at a pH range of 3.0 to 7.0. The metal ions $Hg^{2+}$, $Cu^{2+}$, and $Ag^{2+}$ inhibited complete enzyme activity. The inhibitors tested, EDTA, PMSF, and 1,10-phenanthroline, did not inhibit the enzyme activity. N-Bromosuccinimide completely inhibited enzyme activity. The relative substrate specificity of enzyme towards the various mannans is in the order of locust bean gum>guar gum>copra mannan, with $K_m$ of 0.11, 0.28, and 0.33 mg/ml, respectively. Since the enzyme is active over a wide range of pH and temperature, it could find potential use in the food-processing industry.

• Proceedings of the Korea Information Processing Society Conference
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• 2014.11a
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• pp.1183-1186
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• 2014

Our research is different form traditional to have some large LED screen grouping together to constitute multi-vision technique. In this paper, we purpose a method of using k-path diffusion method to build connect between the devices and find an optimal data transmission path. In second half of this paper, through practical application, we using this technique transmitting data successfully and achieving a simple Multi-vision effect. This technique possess smart devices and Wifi P2P's features, these features improve system's dynamic and decentralized processing ability make our technique has high scalability.

• Proceedings of the Korea Information Processing Society Conference
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• 2014.04a
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• pp.858-860
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• 2014

최근 영상처리 기법과 하드웨어의 발달로 의학 분야에서는 질병의 진단에 다양한 영상 시스템을 활용하고 있다. 특히 OCT 기술은 인체조직의 고해상도 이미지 획득과 혈류속도 측정을 동시에 할 수 있어 의료분야에 다양하게 적용이 가능하여 많은 관심을 받고 있다. 이에 더욱더 선명한 OCT 영상을 획득하기 위해 다양한 알고리즘과 필터를 사용함에 따라 빠른 프로세스 처리가 요구되고 있는 실정이다. 본 논문에서는 듀얼 코어 이상급의 CPU 를 탑재한 시스템에서 데이터 처리 모듈과 렌더링 모듈을 트리플 버퍼를 통해 비동기식으로 멀티스레드화 하였고, GPU 기반의 병렬처리를 통한 데이터 처리를 하여 속도를 향상시켰다. 이에 광학 카메라 촬영 시 선명한 실시간 OCT 영상을 확인할 수 있었다.

• Journal of Animal Science and Technology
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• v.52 no.3
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• pp.229-236
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• 2010

Effect of molasses addition to complete calf starter (CCS) and the following pellet processing was evaluated with 12 Holstein-Friesian (HF) calves (7-14 d old with $42\;{\pm}\;5.5\;kg$ average BW), with 6 calves (replicate) per treatment. The CCS was formulated with 65% concentrate calf starter and 35% local corn fodder. On the CCS, molasses was added either 5% (M5) or 10% (M10), then the mixture was pelleted and fed to the calves for 7 weeks. Molasses addition, regardless of addition level, improved (p<0.05) both the durability and hardness of the pellet which contains 35% of high fibrous local corn fodder. Upon feeding to calves, the feed intake and daily gain were numerically higher with 5% molasses addition compared to 10% molasses addition. Blood VFA level was remarkably higher (p<0.01) in calves fed M10 than calves fed M5. There was no difference (p>0.05) in blood glucose level between M5 and M10. Length and number of papillae were not different (p>0.05) by the addition levels of molasses. However, there was one exception in number of papillae at caudo-dorsal sac which were higher (p<0.05) number in M5 than M10 calves. Considering the quality of CCS pellet, calf performance and rumen development, there was no additional benefit of 10% molasses addition compared to 5%. From the results of this study, 5% molasses addition could be recommended for local farmer when they utilize local corn fodder to make CCS for HF calves in Indonesia.