• Journal of Energy Engineering
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• v.8 no.2
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• pp.224-232
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• 1999

Latent heat storage system using micro-encapsuled phase change material is effective method for floor heating of house and building. The temperature profile in capsule block and flow rate of hot water are important parameters for the development of heat storage system. In the present study, a mathematical model based on 3-D, non-steady state, Navier-Stokes equations, scalar conservation equations and turbulence model ($\kappa$-$\varepsilon$), is used to predict the temperature profiles in capsule and the velocity vectors in hot water pipe. The multi-block grids and fine grids embedding are used to join the circle in hot water pipe and square in capsule block. The phase change process of the capsule is quite complex not only because the size of phase change material is very small, but also because phase change material is mixed with the cement to form thermal storage block. In calculation, it's assumed that the phenomena of phase change is limited only the thermal properties of phase change material and the change of boundary is not happened in capsule. The purpose of this study is to calculate the temperature profiles in capsule block and velocity vectors in hot water pipe using the numerical calculation. Two kinds of thermal boundary condition were considered, the first (case 1) is the adiabatic condition for the both outside surfaces of the wall, the second (case 2) is the case in which one surface is natural convection with atmosphere and another surface is adaibatic. Calculation results are shown that the temperature profile in capsule block for case 1 is higher than that for case 2 due to less heat loss in adaibatic surface. Specially, in the domain of near Y=0, the difference of temperature is greater in case 1 than in case 2. The detailed experimental data of capsule block on the temperature profile and the thermal properties such as specific heat and coefficient of heat transfer with the various temperature are required to predict more exact phenomena of heat transfer.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6391-6395
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• 2012

Background: Ovarian cancer is ranked as the fifth most common cause of cancer death in women. In Malaysia, it is the fourth most common cancer in females. CA125 has been the tumor marker of choice in ovarian cancer but its diagnostic specificity in early stages is only 50%. Hence, there is a critical need to identify an alternative tumor marker that is capable of detecting detect ovarian cancer at an early stage. HE4 is a new tumor marker proposed for the early diagnosis of ovarian cancer and disease recurrence. Currently, none of the normal ranges of HE4 quoted in the literature are based on data for a multiethnic Asian population. Therefore, the aim of this study was to determine reference intervals for HE4 in an Asian population presenting in University Malaya Medical Centre, a tertiary reference hospital. Materials and Methods: 300 healthy women were recruited comprising 150 premenopausal and 150 postmenopausal women, aged from 20-76 years. All women were subjected to a pelvic ultrasonograph and were confirmed to be free from ovarian pathology on recruitment. Serum HE4 levels were determined by chemiluminescent microparticle immunoassay (CMIA, Abbott Architect). The reference intervals were determined following CLSI guidelines (C28-A2) using a non-parametric method. Results: The upper limits of the $95^{th}$ percentile reference interval (90%CI) for all the women collectively were 64.6 pmol/L, and 58.4 pmol/L for premenopausal) and 69.0 pmol/L for postmenopausal. The concentration of HE4 was noted to increase with age especially in women who were more than 50 years old. We also noted that our proposed reference limit was lower compared to the level given by manufacturer Abbott Architect HE4 kit insert (58.4 vs 70 pmol/L for premenopausal group and 69.0 vs 140 pmol/L in the postmenopausal group). The study also showed a significant difference in HE4 concentrations between ethnic groups (Malays and Indians). The levels of HE4 in Indians appeared higher than in Malays (p<0.05), while no significant differences were noted between the Malays and Chinese ethnic groups. Conclusions: More data are needed to establish a reference interval that will better represent the multiethnic Malaysian population. Probably a larger sampling size of equal representation of the Malay, Chinese, Indians as well as the other native ethnic communities will give us a greater confidence on whether genetics plays a role in reference interval determination.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6101-6104
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• 2012

Background: Breast cancer accounts about one million from total annual ten million new diagnosed cases of neoplasia worldwide and is the main cause of death due to cancer in women. Tamoxifen is the most popular selective estrogen receptor modulator used in anti estrogen treatments. Tamoxifen must be converted into its metabolite endoxifen for biologic effects; this conversion process is catalysed by highly polymorphic cytochrome P450 2D6 (CYP2D6). This study surveyed copy number variation of the CYP2D6 gene and its possible correlation with Tamoxifen resistance in breast cancer patients. Methods: This case control study was performed on samples taken from 79 patients with breast cancer who used tamoxifen in Yazd and Tehran Cities, Iran. Real time reactions were conducted for 10 healthy samples using the comparative $C_t$ (Cycles threshold) method, each pair of genes being compared and samples with ratios around 1 were taken as control samples. Proliferation reactions were done by Real-Time PCR ABI Prism 7500. All registered data were transformed into SPSS 15 program and analyzed. Results: Efficiency of PCR for both CYP2D6 and ALB genes was 100%. From all 23 drug resistant patients 21.7% had one copy, 47.8% two copies and 30.4% had three copies. Also from all 56 drug sensitive patients, 26.8% had one copy, 51.8% two copies and 21.4% had three copies. The percentage of patients with one and two copies was similar between two groups but patients with three copies were more likely to belong to the drug resistant group more. Odd ratios for one and two copies were 0.759 and 0.853 respectively, indicating possible protective effects while that for three copies was 1.604. Conclusions: Based on our study there is no significant link between CYP2D6 gene copy numbers and tamoxifen resistance in women with breast cancer. But more studies considering other influencing factors appear warranted.

• Magazine of the Korea Concrete Institute
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• v.9 no.3
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• pp.127-135
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• 1997

In this study, the wedge splitting tcst (WST) was carried out for the fatigue wack growth behavior of concrete. Selected test variables were concrete compressive strength of 28, 60 and 118 MI%, and stress ratio with 2 levels (6. 13%). In oder to make the designed stress ratio, the maximum and thr minimum fatigue loading level were 75-85% and 5- 10% of ultimate static load, respectively. Fatigue testing was preceded by crack mout.h opening displacement (CMOI)) compliance calibration tcst, and then the fatigue crack growth was computed by crack lcngth vs. (lMOI) compliance relations acquisited by the CMOD compliance calibration technique. To evaluate thc validity of CMOD compliancc calibration techniquc, the crack length p~mlicted by this method was cornpard with the crack length by linear elastic fracture mechanics(LEFIbl) and dyeing test. On the basis of the experimental results, a LRFhl-based c.mpirica1 model for f'at,igue crack growth rate(da/dN-AKI relationships) was presented. The fat,igut. crack growth ratc increased with the strength of concwtc. It appcars that t.he da/tiN-AKI relationships was influenced by stress ratio, however, the effect is diminished with an increase of strength. The comparisons between CblOl) compliance calibration technique anti the other. methods gave the validity of' ('MOD compliance calibration technique for the LZXT.

• Korean Journal of Adult Nursing
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• v.13 no.1
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• pp.123-135
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• 2001

The purpose of this study is to analyze the structural pattern of nurses' pain management with patients who experience pain. As a research method, the Q methodology, which is useful for an objective view of a highly abstract concept, was applied. The data collecting activity of this study was from August, 21st, 2000 to November, 24th 2000. The Q-population, the previous thesis and a literature review were done. Questions about pain management by the nurse on the patients, caregivers, nursing students, doctors, nurses, and others were asked in documentary work and in-depth interviews. In all, 223 units of the Q-population were formed, and the last 35 units of the Q-population were extracted. The data on the P-sample was collected from 41 nurses who worked in the medical and surgical units of a hospital that belonges to C university in Seoul. The research results were constituted in 3 types. Type I was the 'pattern of judging by objectivity'. The statement on which most of the people highly agreed for those patterns was shown by 'If patients said that they are suffering from pain, we sufficiently performed an assessment about the etiology, location, duration and degree'. For type I, the same pain was found in different locations according to the patients, so the etiology of the pain should be identified first place. Since ways of coping are different according to pain etiology, it was thought that it is important to assess sufficiently the pain etiology, location, duration, and degree. Therefore, when patients complain of pain, the pain etiology should be identified and assessed; according to the result, pain management should be performed systematically. Type II was the 'pattern of accepting by subjectivity'. The statement on which most of the people highly agreed for those patterns was shown as 'If patients said that they are suffering from pain, the medical treatment should be performed rapidly and speedily.' For type II, when the patient complains of pain, treatment should be performed quickly in order to prevent the condition getting worse, and it is thought that activity is a reasonable duty. Further, by trying to show empathy after pain is admitted and by understanding and coping rapidly with the pain of patients, an attitude which matched the altruistic morals of nurses is being shown. Type III was the 'pattern of worrying about', and the statement on which most of the people highly agreed for those patterns was shown is 'When there is a pain, to help patients to tolerate the pain to the highest degree.' In type III, the pain is a subjective expression, so there is a difference according to every individual. Therefore, actually if there is no measurement of pain, it could be exaggerated so nurses should help patients to tolerate it to the utmost. Even if there is a way to remove pain without an analgesic drug, nurses were reluctant to perform pain management as they possibly could. Through these research results, pain management of nurses was classified in 3 types, and structural characteristics in each type were discovered. Based upon the characteristics according to the type, an individualized pain management intervention strategy should be established and the follow up work performed.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.24 no.1
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• pp.1-8
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• 1991

Population dynamics of Matted sole Limanda yokohamae($G{\"{U}}NTHER$) in Tokyo bay, Japan has been studied by virtual population analysis (VPA) for multi cohort and experimental fishing. Based on the biological data, the present parameters of the Limanda yekohamae stock at the Tokyo bay, Japan were estimated as follows: natural mortality coefficient(M) were 0.313 for male and 0.250 for female, terminal fishing mortality coefficient(F) were 2.190 for male, and 0.798 for female, rate of exploitation(E) was $30\%\;to\;50\%$. From the result of virtual population analysis for multi cohort, the population size were estimated from 3,5000,000 to 9,200,000 fishes, according to the result of experimental fishing, estimated stock size were 2,400,000 to 8,700,000 fishes. Stock size difference of the two methods were about two times in 1987, however, other years has been showed from 0.8 to 1.5 times. Both method has been showed same increase and decrease tendency of the c. p. u. e. and catches. From the isopleth diagram plot by Beverton and Holt's yield per recruit, the catches could be increase two times for female, 1.3 times for male than present aspects by the fishing management. And further, as reducing fishing effort, extension of mesh size and rising the length at first caputre, are reasonable in order to manage the stock at the optimum level.

• Korean journal of food and cookery science
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• v.7 no.4
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• pp.35-40
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• 1991

The sensory evaluation by Preference test revealed that the best Kongjook was obtained when the soymilk was prepared with eight-times of water to the volume of soybean. Based on the results, the ratios of soybean: rice: water (v/v/v) having 2:1:16($G_1$), 3:2:24($G_2$), 3:2:30($G_3$),and 4:3:32($G_4$), were chosen. The soaked rice was cooked with soymilk, Kongjook prepared from $G_2$ and $G_4$, showed the highes preference in eating quality and flavor, but the former had better quality in consistency and color, indicating that Kongjook from $G_2$ was the most preferable. The cooking time of soybean prior to the preparation of soymilk also showed that Kongjook prepared from $G_2$ had better preference than other samples regardless of the cooking times of soybean. The spreadability of Kongjook from $G_2$ determined with a line-chart method was 5.85.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.7
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• pp.913-921
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• 2019

Objective: The objectives of this study were to compare identified informative regions through two genome-wide association study (GWAS) approaches and determine the accuracy and bias of the direct genomic value (DGV) for milk production traits in Korean Holstein cattle, using two genomic prediction approaches: single-step genomic best linear unbiased prediction (ss-GBLUP) and Bayesian Bayes-B. Methods: Records on production traits such as adjusted 305-day milk (MY305), fat (FY305), and protein (PY305) yields were collected from 265,271 first parity cows. After quality control, 50,765 single-nucleotide polymorphic genotypes were available for analysis. In GWAS for ss-GBLUP (ssGWAS) and Bayes-B (BayesGWAS), the proportion of genetic variance for each 1-Mb genomic window was calculated and used to identify informative genomic regions. Accuracy of the DGV was estimated by a five-fold cross-validation with random clustering. As a measure of accuracy for DGV, we also assessed the correlation between DGV and deregressed-estimated breeding value (DEBV). The bias of DGV for each method was obtained by determining regression coefficients. Results: A total of nine and five significant windows (1 Mb) were identified for MY305 using ssGWAS and BayesGWAS, respectively. Using ssGWAS and BayesGWAS, we also detected multiple significant regions for FY305 (12 and 7) and PY305 (14 and 2), respectively. Both single-step DGV and Bayes DGV also showed somewhat moderate accuracy ranges for MY305 (0.32 to 0.34), FY305 (0.37 to 0.39), and PY305 (0.35 to 0.36) traits, respectively. The mean biases of DGVs determined using the single-step and Bayesian methods were $1.50{\pm}0.21$ and $1.18{\pm}0.26$ for MY305, $1.75{\pm}0.33$ and $1.14{\pm}0.20$ for FY305, and $1.59{\pm}0.20$ and $1.14{\pm}0.15$ for PY305, respectively. Conclusion: From the bias perspective, we believe that genomic selection based on the application of Bayesian approaches would be more suitable than application of ss-GBLUP in Korean Holstein populations.

• The Journal of the Korea Contents Association
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• v.21 no.4
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• pp.359-369
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• 2021

This study aims to investigate pre-service primary English teachers' perceptions of multicultural education. For this study, the researchers surveyed 63 pre-service teachers at a national university of education using an online survey. A quantitative method is used in order to collect and analyze data. The results revealed the following: First, pre-service primary English teachers stand at a considerably high level in their overall understanding of elementary students and clearly recognize the necessity of multicultural education in school. Second, concerning the difference that the personal variables of gender, grade, and major make in the subjects' perception of English education based on multicultural education, grade showed no statistically significant difference, but gender and major are responsible for a slight difference. Third, an analysis was made of the correlation between the subjects having or not having received multicultural education and the personal variables of gender, grade, and major, yielding the following results: Gaining or not gaining multicultural education does not correlate with gender, but does significantly with grade and major.

• Nutrition Research and Practice
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• v.17 no.4
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• pp.682-697
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• 2023

BACKGROUND/OBJECTIVES: Tibetan tea is a kind of dark tea, due to the inherent complexity of natural products, the chemical composition and beneficial effects of Tibetan tea are not fully understood. The objective of this study was to unravel the composition of Tibetan tea using knowledge-guided multilayer network (KGMN) techniques and explore its potential antioxidant and hypolipidemic mechanisms in mice. MATERIALS/METHODS: The C57BL/6J mice were continuously gavaged with Tibetan tea extract (T group), green tea extract (G group) and ddH2O (H group) for 15 days. The activity of total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in mice was detected. Transcriptome sequencing technology was used to investigate the molecular mechanisms underlying the antioxidant and lipid-lowering effects of Tibetan tea in mice. Furthermore, the expression levels of liver antioxidant and lipid metabolism related genes in various groups were detected by the real-time quantitative polymerase chain reaction (qPCR) method. RESULTS: The results showed that a total of 42 flavonoids are provisionally annotated in Tibetan tea using KGMN strategies. Tibetan tea significantly reduced body weight gain and increased T-AOC and SOD activities in mice compared with the H group. Based on the results of transcriptome and qPCR, it was confirmed that Tibetan tea could play a key role in antioxidant and lipid lowering by regulating oxidative stress and lipid metabolism related pathways such as insulin resistance, P53 signaling pathway, insulin signaling pathway, fatty acid elongation and fatty acid metabolism. CONCLUSIONS: This study was the first to use computational tools to deeply explore the composition of Tibetan tea and revealed its potential antioxidant and hypolipidemic mechanisms, and it provides new insights into the composition and bioactivity of Tibetan tea.