• Title/Summary/Keyword: Oxirane

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Optimization of Batch Production of Chiral Phenyl Oxirane by Response Surface Analysis (반응표면분석법을 이용한 광학활성 phenyl oxirane의 회분식생산 최적화)

  • 김희숙;박성훈;이은열
    • Journal of Life Science
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    • v.13 no.6
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    • pp.794-798
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    • 2003
  • Batch production of (S)-phenyl oxirane was investigated using epoxide hydrolase activity of Rhodosporidium toruloides SJ-4. Effect of reaction condition of asymmetric biohydrolysis of racemic phenyl oxirane was analyzed and optimized by response surface methodology. The optimal conditions of pH, temperature and DMSO cosolvent ratio were 7.4, $34^P\circ}C$, and 2.3%(v/v), respectively. The final yield was enhanced up to 67%, and reaction times required to reach 99% ee (enatiomeric excess) decreased down to 50% by response surface methodology Enantiopure (S)-phenyl oxirane with 100% enantiopurity and 24% yield (theoretical yield = 50%) was obtained from racemic substrate.

Production of Chiral Phenyl Oxirane by Rhodosporidium toruloides in Hollow-fiber Reactor (Rhodosporidium toruloides를 이용한 Hollow-fiber 반응기에서의 광학활성 Phenyl Oxirane 생산)

  • 김희숙;박성훈;이은열
    • Journal of Life Science
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    • v.13 no.6
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    • pp.788-793
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    • 2003
  • Production of chiral phenyl oxirane by Rhodosporidium toruloides SJ-4 was investigated. Racemic phenyl oxirane was kinetically resolved by enantioselective hydrolysis reaction by epoxide hydrolase of R. toruloides in two-phase hollow-fiber reactor system. Dodecane with high concentration of the racemic substrate passed through the lumen side and cell suspension was recirculated through the shell side of the hollow fiber reactor For the removal of phenyl-1, 2-ethandiol to reduce the product inhibition to biocatalysts, another hollow-fiber reactor was employed to extract the diol. Racemic phenyl oxirane up to 300 mM was enantioselectively resolved with high enantiopurity (>99% ee) in hollow-fiber reactor system.

Syntheses of Oxirane Carboxylic Acids as Hypoglycemic agents

  • 서영거;백소영;민경훈;신동윤;정재경
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1997.04a
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    • pp.75-75
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    • 1997
  • 뛰어난 혈당강하작용을 가지고 있는 oxirane carboxilic acid의 analogue 합성과 관련하여 oxirane carboxilic acid의 기본골격을 용이하게 형성할 수 있고 동시에 다앙한 관능기를 갖는 side chain을 도입할 수 있는 방법을 개발함으로써 다양한 유도체들을 합성하는데 이용하고자 함. 방법 및 결과 $\alpha$,$\beta$-unsaturated ester로부터 dioxirane을 이용한 직접적인 epoxidation을 통해서 보통의 방법으로는 얻기 어려운 oxirane carboxilic acid의 ester를 높은 수율로 합성할 수 있는 방법이 개발되었으며 특히 분자내에 cpoxide 존재하에서도 Mitsnobu 방법을 이용한 O-alkylation에 의해 aryl ether 결합을 형성할 수 있는 방법이 개발되었으며 이들 방법을 이용하여 다양한 유도체들을 합성하였다.

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Development of Recombinant Saccharomyces cerevisiae Expressing Epoxide Hydrolase for the Preparation of Chiral Phenyl Oxirane (광학활성 Phenyl Oxirane 제조용 유전자 재조합 생촉매 개발)

  • 이수정;이은정;김초희;이지원;김희숙;이은열
    • Journal of Life Science
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    • v.13 no.1
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    • pp.105-109
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    • 2003
  • Epoxide hydrolase (EH) gene from Aspergillus niger #33 was cloned from cDNA library generated by reverse transcriptase-polymerase chain reaction (RT-PCR). The nucleotide sequence analysis revealed that the deduced amino acid sequence was almost similiar to that of A. niger LCP521 previously reported. The cloned EH gene was transformed into Saccharomyces cerevisiae and expressed by addition of galactose. The recombinant S. cerevisiae showed hydrolytic activity toward racemic phenyl oxirane substrate based on chiral GC analysis, and can be used as a potential biocatalyst for the preparation of chiral phenyl oxirane.

A Study on the Polymerization of Energetic Poly(NEO) (에너지를 함유한 선 폴리머인 poly(NEO) 제조 공정 연구)

  • Cheun Young Gu;Kim Jin Seuk
    • Journal of the Korea Institute of Military Science and Technology
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    • v.7 no.2 s.17
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    • pp.109-117
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    • 2004
  • We synthesized energetic prepolymer(2-nitrato ethyl oxirane, NEO) for plastic-bonded explosive and measured its thermodynamic parameters. 2-Nitrato ethyl oxirane(NEO) as a monomer was synthesized from 4-butene-ol, the first-step was preparation of 1-nitrate-3-butene and second-step was synthesized 2-nitrate-ethyl oxirane from 1nitrate-3-butene and then polymerized by cationic ring opening polymerization. The unreacted monomer concentration was measured by GC. The thermodynamic parameters were obtained from the ceiling temperature(Tc) values of 1 mole monomer at each reaction temperature. We varied feed rate of monomer, concentration of initiator and monomer to control molecular weight and polydispersity of perpolymer(NEO). Number average molecular weight(Mn), polydispersity(PD), and glass transition temperature(Tg), viscosity of prepolymer(NEO) were 2000, 1.07, $-55^{\circ}C$ and 300 poise respectively.

Design and Synthesis of Novel Energetic Oxirane Monomers Containing a Molecular Explosive Moiety (분자화약 구조를 포함하는 옥시란계 에너지화 단량체의 설계 및 합성)

  • Shen, Yechen;Kwon, Younghwan;Kim, Jin Seuk
    • Journal of the Korea Institute of Military Science and Technology
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    • v.18 no.2
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    • pp.131-138
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    • 2015
  • Energetic monomers with new design concept were synthesized for energetic prepolymers. Novel energetic monomers consisted of ring-opening polymerizable oxirane and a molecular explosive moiety instead of small explosophores as energetic functional groups. According to the design concept, glycidyl dinitroazetidine (GDNAZ) and glycidyl nitroazetidinol(GNAZO) energetic monomers were synthesized, respectively, and characterized by NMR, EA and GC MS. Heat of formation and detonation performance were calculated by theoretical method to evaluate energy performance of these novel energetic monomers. The result revealed that GDANZ and GNAZO possessed high potential as new energetic monomers for synthesizing energetic prepolymers and binders in PBXs.

Quantum Mechanical Studies of the Structures and Reactions of oxiranes (Oxiranes의 구조와 반응에 관한 양자역학적 연구)

  • Shi Choon Kim
    • Journal of the Korean Chemical Society
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    • v.30 no.2
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    • pp.248-258
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    • 1986
  • The electronic structures and geometries of model substituted oxiranes, and carbonyl ylides containing cyano, methoxy and thiomethoxy substituents were investigated by MNDO-SCF-MO method. Stabilization and geometries caused by substituents, the ease of formation of carbonyl ylides from oxiranes and the reactivities of the cycloaddition of substituted carbonyl ylides were investigated.

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Colloidal-Chemical Parameters of Petroleum-collecting and Dispersing Surfactants Based on Vegetable Oil Acid Fractions and 2-(Chloromethyl) Oxirane

  • Asadov, Ziyafaddin H.;Ahmadova, Gulnara A.;Rahimov, Ravan A.;Mammadova, Khuraman A.
    • Journal of the Korean Chemical Society
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    • v.55 no.6
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    • pp.1012-1017
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    • 2011
  • Novel surfactants have been synthesized by catalytic chloropropoxylation reaction of carboxylic acid fractions of sunflower, olive, cottonseed, soya-bean, castor and corn oils with 2-(chloromethyl)oxirane. Colloidal-chemical parameters as well as petroleum-collecting and petroleum-dispersing capacities of the synthesized chloropropoxylate esters having heterochain of various lengths have been determined. Influence of carboxylic acid fractions composition and length of chloroxypropylene chain on petroleum-collecting and dispersing capacities has been revealed.