• 한국가금학회:학술대회논문집
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• 한국가금학회 2000년도 제17차 정기총회 및 학술발표
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• pp.36-53
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• 2000

Five experiments were conducted to investigate the effects of antioxidants(Santoquin and Oxiban) using fresh or oxidized fat on the performance of broiler chicks. Day-old broiler chicks (except for Experiment 5 in which 6-d-ol birds were given experimental diets for 10 d) were fed diets containing fresh or oxidized fat (animal-vegetable fat blend in Experiments 1, 4, and 5 and corn oil in Experiments 2 and 3) with or without graded concentrations of Santoquin (0,250, 500 ppm in Experiments 1 and 2 and 0, in Experiment 4 and 400 ppm with 0.1% lipase in Experiment 5) of 2wk. In all experiments, birds fed fresh fat gained more weight, had better feed/gain, together with higher AME$_{n}$ and apparent fat digestibility (Experiments 1 and 2) than birds fed oxidized fat(P<0.05). There was no interaction among fat sources and antioxidants on the performance of chicks in any experiment. In Experiment 3, Santoquin more than 200 ppm resulted in a reduction in weight gain and feed intake(P<0.05). The livers of chicks fed oxidized fat in Experiments 2 and 5 had higher malondialdehyde (MDA) values (P<0.05) Chicks fed oxidized fat with 250 ppm Santoquin in Experiment 2 had lower liver MDA values, although this situation did not occur in Experiments 1, 4, and 5. These results indicate that antioxidant supplements can alleviate most deleterious effects of feeding oxidized fat and that supplementation of Santoquin more than 200 ppm has a negative effect on the performance of broiler chicks.s.

• Journal of Nutrition and Health
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• 제33권5호
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• pp.502-506
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• 2000

Effects of powdered siho(bupleuri radix) on serum and liver lipid composition and antioxidative capacity were investigated in rat fed high oxidized fat. Sixty male Sprague-Dawley rats weighing 161.25$\pm$2.51g were blocked into four groups according to body weight and raised seven weeks with basal diet(normal group), basal diet and 10% oxidized fat(control group), basal diet, 10% oxidized fat and 2% powdered siho(2% powdered siho group) and basal diet, 10% oxidized fat and 3% powdered siho(3% powdered siho group). Feed intake, body weight gain and feed efficiency were not significantly different among oxidized fat diet groups. The values of total cholesterol and triglyceride in plasma and liver showed no significantly different(p>0.05) in the oxidized fat diet groups. Plasma HDL-cholesterol showed atendency to increase in powdered siho diet groups. The values of thiobarbituric acid in plasma and liver were lower in the powdered siho diet groups than control group. Plasma GOT and GPT activity showed a tendence to decrease in powdered siho groups. Liver glutathione peroxidase activity showed a tendence to increase in powdered siho diet groups. Thus, it seems that powdered siho had some antioxidative elements.

• 대한약침학회지
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• 제7권3호
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• pp.37-46
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• 2004

Effects of Boonsimgieum aqua-acupuncture at $Naegweun(HP_6)$ and $Taecheung(LV_3)$ on liver and plasma lipid composition and antioxidative capacity were investigated in rat fed high oxidized fat. Concentrations of plasma triglyceride, total cholesterol and LDL-cholesterol showed a tendency to increase in the high oxidized fat diet group. However these values showed a tendency to decease in aqua-acupuncture groups. HDL-cholesterol showed no significantly different in all the treatment groups. Liver total cholesterol values showed a high in control group, however other treatment groups showed no significantly different. Liver triglyceride concentration showed a high value in control group and $Naegweun(HP_6)$ aqua-acupuncture group showed lower value than $Taecheung(LV_3)$ aqua-acupuncture group. Plasma GOT and GPT values showed a tendency to increase in high oxidized fat diet group. However aqua-acupuncture groups showed a lower values than control group. The concentration of TBARS in liver and plasma showed a high values in high oxidized fat diet group, however these values showed a tendency to decrease in aqua-acupuncture group. Glutathione peroxidase, superoxide dismutase and catalase activity values showed a low values in high oxidized fat diet group, however these values showed a tendency to increase in aqua-acupuncture groups and in aqua-acupuncture groups, these values showed no significantly different.

• 한국식품영양과학회지
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• 제32권6호
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• pp.926-930
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• 2003

솔잎분말이 과산화지질을 급여한 횐쥐의 혈장 및 간장지질구성과 항산화능에 미치는 영향을 검토했다. 일일 식이섭취량은 정상군을 비롯한 과산화지질처리군 모두에서 유의한 차이를 나타내지 않았다. 일일체중증가율 및 식이효율은 과산화지질처리군 모두가 정상군보다 높았으나, 대조군과 솔잎처리군 간에는 유의한 차이를 나타내지 않았다. 혈장 총콜레스테롤량은 과산화지질처리에 의해 증가하였으나, 솔잎 처리에 의해 감소되었다. 혈장 HDL-cholesterol량은 솔잎처리군에서 높은 경향을 나타내었다. 혈장 중성지질량은 처리군간에 유의한 차이를 나타내지 않았다. 간장의 총콜레스테를량과 중성지질량은 과산화지질처리군에서 증가하였으나, 솔잎처리에 따른 유의한 차이는 볼 수 없었다. 혈장 및 간장내 TBARS량과 혈장 GOT 및 GPT의 활성치는 과산화지질처리군에서 증가하였으나, 솔잎처리에 의해 감소되었다(p<0.05). 간장 glutathione peroxidase 활성치는 솔잎처리에 의해 증가하는 경향을 보였으나, 대조군과 유의한 차이를 나타내지는 않았다(p>0.05).

• 동아시아식생활학회지
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• 제15권6호
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• pp.675-686
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• 2005

It is known that appropriate exercise changes body composition and improves coronary artery disease. This study was undertaken to evaluate the relationships between aerobic exercise, body composition, and the blood lipid levels in the middle-aged women(33 to 54 years old). The 57 subjects were divided into two groups based on their exercise: the aerobic exercise group(A group: 44) which performed at about $60\%$ of $VO_2max$ during over 6 months and the sedentary one(S group: 13). The percentages of body fat waist/hip ratio(WHR), body mass, and lean body mass of two groups were measured and compared in serum HDLC level and oxidized LDL level, the two most effective factors of coronary artery disease. The subjects in A group showed the lower percentages of body fat and WHR, when compared with the ones in S group. The body mass and lean body mass of A group subjects were higher than those of S group subjects. The serum HDL-C level$(58.6\pm12.7mg/mL)$ was significantly higher for A than S group subjects.(p<0.05) The sem ox-LDL level $(6.64\pm4.11Eu/mL)$ for A group subjects was lower than S group ones. The fat mass showed significantly positive correlations with atherogenic index(AI)(r=0.301, p<0.05), and with blood glucose levels(r=0.334, p<0.05). Also the WHR whowed significantly positive correlations with LDL-C levels(r=0.277, p<0.05), and with AI(r=0.466, p<0.01). In summary, the subjects in A group have the lower percentages of body fat and WHR, when compared with the ones in S group. Also, A group subject showed a tendency that exercise enhances serum HDL-C levels and decreases oxidized LDL levels. And aerobic exercise showed positive results which change body composition and improve blood lipid levels. There were significantly positive correlations among the percentages of body fat At and blood glucose level. These results suggest that moderately intensive exercise is a significant factor in reducing coronary artery disease.

• 한국자원식물학회지
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• 제17권3호
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• pp.323-330
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• 2004

금앵자 추출물이 과산화지 질을 급여한 횐 쥐의 혈장 및 간장지질구성과 항산화능에 미치는 영향을 검토했다 혈장 총 콜레스테롤 량은 과산화지질 첨가군 모두가 정상군보다 증가하였으나, 금앵자 추출물 첨가에 의해 하락하였다. 혈장HDL-cholesterol량은 금앵자 첨가군이 대조군 보다 높은 경향을 나타내었다. 혈장 중성지질량은 정상군과 금앵자 첨가군은 유의한 차이를 나타내지 않았으며, 대조군 보다 낮은 수치를 보였다. 간장의 총 콜레스테롤 량은 전 처리군에서 유의한 차이를 나타내지 않았으며, 중성지질 량은 정상군과 금앵자 첨가군은 유의한 차이를 나타내지 않았으며, 대조군 보다 낮은 수치를 보였다 혈장내 TBARS량은 정상군과 금앵자군은 유의한 차이를 나타내지 않았으며, 대조군 보다 낮은 수치를 보였다. 간장내 TBARS량은 과산화지질 첨가에 의해 증가하였으나, 금앵자 첨가에 의해 하락했다. 혈장 GOT 및 GPT의 활성치는 관산화지질 첨가군에서 증가하였으나, 금앵자처리에 의해 하락했다(P＆lt;0.05). 간장 GSH-Px, SOD 및 CAT활성치는 금앵자처리에 의해 증가하는 경향을 보였다.

• 한국자원식물학회지
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• 제18권2호
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• pp.343-350
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• 2005

미나리즙이 과산화지질과 알코올을 급여한 흰쥐의 지질구성, 간장기능과 항산화능에 미치는 영향을 검토했다. 혈장 총콜레스테롤량은 과산화지질과 알코올을 급여한 처리군 모두가 정상군보다 증가하였다. 그러나 미나리즙 처리군들은 대조군보다 낮았다. 혈장HDL-cholesterol량은 미나리즙 처리군들이 대조군에 비하여 높은 값을 나타냈으며, 정상군과 유의한 차이를 나타내지 않았다. 혈장 Triglyceride량은 과산화지질과 알코올을 급여한 처리군 모두가 정상군 보다 증가하였으나, 미나리즙을 처리한 군이 대조군 보다 낮은 값을 보여, 하락하는 경향을 보였다. 간장의 총콜레스테롤량 및 Triglceride량은 대조군이 가장 높은 값을 나타내었으며, 정상군과 미나리즙 처리군간에는 유의한 차이를 나타내지 않았다. 혈장 및 간장의 TBARS량은 정상군과 미나리즙 처리군은 유의한 차이를 나타내지 않았으며, 대조군 보다 낮은 수치를 보였다. 혈장 GOT 및 GPT의 활성치는 과산화지질과 알코올의 급여에 의해 증가하였으나, 미나리즙 처리에 의해 하락했다(P<0.05). 간장 GSH-Px, SOD 및 CAT활성치는 미나리즙 처리에 의해 증가하였다.

• Korean Journal of Acupuncture
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• 제26권2호
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• pp.109-126
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• 2009

Objectives: To investigate the effects of Chrysanthemum indicum L. pharmacopuncture on lipids, antioxidant capacity and anti-inflammation in rats fed high-fat diet. Methods: Hyperlipidemic rats induced by high-fat diet were divided into 5 groups: no treatment control (normal, n=8), high-fat diet only control (control, n=8), high-fat diet and Chrysanthemum indicum L. pharmacopuncture at CV4 group (TI, n=8), high-fat diet and Chrysanthemum indicum L. pharmacopuncture at CV17 group (TII, n=8), and high-fat diet and Chrysanthemum indicum L. pharmacopuncture at EX-HN3 group (TIII, n=8). They were given pharmacopuncture accordingly every other day for two weeks followed by analyses of lowering lipids effects, oxidative capacity and anti-inflammatory effects. Results: Compared with the control, pharmacopuncture groups showed significantly decreased plasma total cholesterol (TC), liver thiobarbituric acid reactive substance (TBARS), catalase, glutathione peroxidase, neutrophils, monocytes, plasma and liver IL-$1{\beta}$, and plasma and liver IL-6. In other parameters including plasma and liver triglyceride, liver TC, LDL-cholesterol, HDL-cholesterol, liver TBARS, supraoxide dismutase, total protein, albumin, blood cell analysis, plasma and liver TNF-$\alpha$, and IL-10, there was no significant difference between control and pharmacopuncture groups. No clear acupoint-specificity was observed. Conclusions: Chrysanthemum indicum L. pharmacopuncture may improve control of hyperlipidemia.

• 한방비만학회지
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• 제16권2호
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• pp.85-91
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• 2016

목적: 본 연구는 황금추출물이 과산화지질을 장기간 급여한 흰쥐의 지질대사, 산화반응 및 전염증성 cytokine의 생산에 미치는 영향을 검토하기 위해 수행되었다. 방법: 10주 동안 흰쥐에게 과산화지질을 과량으로 급여하여 생체 내에 과잉의 지질을 축적시킨 후, 황금추출물을 6주간 급여하였다. 그 후, 각 처리군별로 지질대사, 산화반응 및 전염성 cytokine의 생산에 미치는 영향을 조사했다. 결과: 혈액 내 유리지방산, 총지질, 총콜레스테롤, low density lipoprotein-cholesterol과 간장 내 총지질, 총콜레스테롤이 황금추출물 처리군에서 하락했다. 혈액 및 간장의 thiobarbituric acid 농도가 황금추출물 처리군에서 하락했다. 간장 내 항산화효소들(glutathione peroxidase, liver catalase, liver superoxide dismutase)의 활성치가 황금처리군에서 상승하였다. 전염증성 cytokine(interleukin $[IL]-1{\beta}$, tumor necrosis $factor-{\alpha}$, IL-6)의 농도는 황금추출물 처리군에서 하락했다. 반면에 IL-10의 농도는 황금추출물 처리군에서 증가했다. 결론: 이상의 결과들을 종합해 보면, 황금 추출물은 과산화지질을 급여한 비만쥐의 지질대사, 항산화반응 및 항염증반응에 긍정적인 효과를 나타내었음을 인식시켜 준다.

• 운동영양학회지
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• 제16권2호
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• pp.113-122
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• 2012

This study assessed the amount of energy consumed and fat deposition after endurance training in order to review the effect of 4-week endurance exercise on resting metabolic rate of a mouse during and after exercise and the effect of exercise. A total of 19 seven-week-old ICR male mice were used as the study subject. Those mice were divided into sedentary group (Sed) and trained group (Tr) after a week of environment adaption. The Tr group was trained with endurance exercise five times a week for four weeks. Weight and the amount of food intake were daily weighed and resting metabolic rate and metabolic rate after exercise were assessed before starting exercise and on the fourth week after training. Metabolic rate during exercise were measured four weeks after training. At the end of breeding period, statistically significant difference was shown in weights of trained and sedentary groups (p < 0.05). During a resting period, no significant difference was shown in oxygen intake, respiratory exchange ratio, and the amount of carbohydrate and fat oxidized. Moreover, no significant difference was shown in excess post-exercise oxygen consumption (EPOC) of an hour period after training. In contrast, the maximal oxygen uptake (VO₂ max) was approximately 11.1% higher in trained group after training compare to before. However, there was no significant difference in respiratory exchange ratio and carbohydrate and fat oxidization. During exercise, oxygen uptake, carbon dioxide production, and respiratory exchange ratio in energy metabolism during exercise showed no significant difference. However, significant difference was exhibited in the amount of fat oxidized in both groups. Summing up those results, endurance exercise could be concluded to be effective in weight control. However, weight loss is thought to be resulted from increase in fat oxidization during exercise unlike the conclusion made from previous studies where weight loss is prominently influenced by energy metabolism during a resting period and increased fat oxidation during post-exercise recovery. All experimental procedures were carried out at the Animal Experiment Research Center of Konkuk University. This study was conducted in accordance with the ethical guidelines of the Konkuk University Institutional Animal Care and Use Committee.