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Effects of Guemengja (Rosae Laevigatae Michx.) Extracts on Serum Lipid Composition and Antioxidative Capacity in Rats Fed High Oxidized Fat  

박영훈 (상지대학교 화학과)
이은 (상지대학교 생명산업학과)
임상철 (상지대학교 식물학과)
Publication Information
Korean Journal of Plant Resources / v.17, no.3, 2004 , pp. 323-330 More about this Journal
Abstract
Effects of Guemengja (Rosae Laevigatae Michx.) Extracts on serum and liver lipid composition and antioxidative capacity were investigated in rat fed high oxidized fat. Twenty eight male Sprague-Dawley rats weighing 159.35$\pm$2.17g were blocked into four groups according to body weight and raised seven weeks with basal diet (normal group, I), basal diet and 10% oxidized fat (control group, II), basal diet, 10% oxidized fat and 100mg/kgg Guemengja Extracts (100mg/kg Guemengja Extracts group, III) and basal diet, 10% oxidized fat and 200mg/kg Guemengja Extracts (200mg/kg Guemengja Extracts group, IV). The level of plasma total cholesterol and triglyceride showed a tendency to decrease, whereas the plasma HDL-cholesterol concentration revealed a tendency to increase in guemengja extracts groups. The level of liver total cholesterol showed no significantly different in all treatment groups, however the level of liver triglyceride showed a tendance to decrease in guemengja extracts groups. Thiobarbituric acid(TBARS) values in plasma and liver showed a tendence to decrease in guemengja extracts groups. The guemengja extracts samples have also decreased the plasma GOT and GPT activities, whereas they have increased the liver glutathione peroxidase, superoxide dismutase and catalase activity.
Keywords
catalase; cholesterol; glutathione peroxidase; superoxide dismutase; triglyceride; thiobarbituric acid;
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