• Journal of the Korean Chemical Society
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• v.56 no.4
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• pp.468-472
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• 2012

Efficient one-pot microwave-assisted synthesis of various benzo-[1,4]-oxazinones via Smiles rearrangement is described. Treatment of 2-chloroacetamide, substituted 2-chlorophenols and cesium carbonate in MeO-PEG-OMe (2,000) as solvent afforded the corresponding benzo-[1,4]-oxazinones and 1H-pyrido[2,3-b][1,4]-oxazin-2-(3H)-one as moderate yield.

• Bulletin of the Korean Chemical Society
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• v.23 no.7
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• pp.931-932
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• 2002

• Proceedings of the Korean Society of Life Science Conference
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• 2005.09a
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• pp.66-66
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• 2005

• Bulletin of the Korean Chemical Society
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• v.34 no.2
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• pp.585-589
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• 2013

Optically active N-benzyl-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and N-benzyl-2-methyl-2H-benzo[b][1,4]thiazin-3(4H)-ones with potential synthetic and pharmacological interest were prepared via Smiles rearrangement in conventional as well as microwave irradiation conditions in one-pot from inexpensive (S)-2-chloropropionic acid. Most of the compounds displayed good inhibition against Gram positive bacteria and fungi in the antibiotic test.