• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.43 no.3
• /
• pp.122-134
• /
• 2020

As globalization has been progressed, companies faced a situation in which it was difficult to secure global competitiveness only with their internal management systems. To overcome this, Supply Chain Management (SCM) emerged, which optimizes the whole supply chain process from suppliers to demand companies. In this study, it was analyzed that the effects of customer integration among the integration factors of SCM, and market orientation among the strategic orientations on management performances such as non-financial performance and financial performance through a mediating role of flexibility. At this time, it was analyzed whether CEO's support has a moderating effect on the influence of the market orientation. As a result of analysis, the customer integration was found to have an indirect effect on the non-financial performance and the financial performance through the flexibility. The market orientation was found to have a direct effect on the non-financial performance and at the same time, indirectly affected it through the flexibility. In addition, it was shown that more the level of CEO's support, higher the influence of the market orientation. This moderating effect had an indirect effect on the financial performance. Based on the above findings, various implications for improving management performance were proposed. This study suggests that investments in computerization such as ERP and smart factories can improve supply chain management performance and ultimately improve customer satisfaction and financial performance.

• Journal of the Korea Fashion and Costume Design Association
• /
• v.19 no.3
• /
• pp.193-206
• /
• 2017

The Seongsu handmade shoes street consists of subsidiaries, leather shoe manufacturers, and shoe stores associated with the business as a domestic shoe business cluster. Since its development in the 1980s, the shoe industry has been a center of shoe manufacturing but since the 2000s, it has lacked a fully developed environment, a uniform distribution system, market-oriented brand, marketing and design, and also suffers from an aging workforce. Seoul officials and Seongsu-dong small business owners must overcome these difficulties through town enterprise development, brand creation and marketing co-promoting composition of the characterization and distance, but the situation is still insignificant. The purpose of this study is to determine the actual situation as targeted at small merchant handmade shoes Seongsu-dong Street, to determine the factors in the problem, and to propose substantial improvements for Seongsu handmade shoes street. This study was a survey of street sales outlets in Seongsu handmade shoes street in Seoul. The spatial extent of the study was to set up the scope by reference to the directions given through the Seongsu handmade shoes street site. To build infrastructure facilities and distribution systems for the betterment of handmade shoes Seongsu-dong street, it is important to gain a competitive edge through a specialized industry such as a marketing strategy to establish branding as a specialized company. Shoemakers should also seek their own activation measures in areas such as training professionals, universities and corporate projects for joint participation in the ongoing development of new content. To pioneer the domestic and international sales channels, it is important to broaden the sales infrastructure. These areas will ultimately enable a significant contribution to strengthening national competitiveness.

• The Journal of the Korean dental association
• /
• v.53 no.1
• /
• pp.28-35
• /
• 2015

To overcome shortcoming of autogeneous, allogenic, xenogenic and alloplastic bone grafts, various growth factors related to bone regeneration have been identified and developed. Among them, rhBMP-2 is regarded as the most potent osteoinductive growth factor and it can trigger the differentiation of mesenchymal stem cells to osteogenic cells for accelerated new bone formation And several commercial products of rhBMP-2 are available in Korea. It is applied to maxillary sinus augmentation, guided bone regeneration and preservation of extraction socket. In this review, the development, action mechanism and clinical applications of rhBMP-2 will be described.

• Journal of the Korean Geotechnical Society
• /
• v.27 no.7
• /
• pp.69-79
• /
• 2011

Laboratory tests are generally used to determine the input parameters for the selected constitutive models controlling various stress and drainage conditions, but have disadvantages in that the tests are performed on the samples obtained from the bore hole which are prone to be disturbed by various factors such as the tube penetrations, sample preparations and storage. To overcome these disadvantages, it is necessary to understand the effect of disturbance on the stiffness of the sample, especially the normally consolidated clays which are generally considered as soft clays. Therefore, in this study triaxial tests are performed on the normally consolidated kaolinite to evaluate the sample disturbance effects on the stiffness and to determine the field representative input parameters. The stress path results show that the shear and coupling modulus degradation patterns with strain are affected seriously by the disturbance. However, the strengths of the normally consolidated kaolinite are little influenced by the disturbance.

• Journal of Navigation and Port Research
• /
• v.34 no.3
• /
• pp.221-228
• /
• 2010

As container traffic is increasing, the introduction of mega-vessel has had a significant impact on the ports and terminals business. This movement of container shipping has led to intensely competitive environment among ports, so substantial pressures to develop new container ports or to expand existing ones, have been grown. However, it requires a huge investment, especially cost and time, to overcome environmental, geographical and financial restrictions generated from developing a port. This study addressed the Mobile Harbor, the new concept of marine logistics system as an alternative strategy. We performed an economic analysis on the introduction of the Mobile Harbor in coastal transport sector and also a sensitivity analysis to examine the effects of changing factors related on the economic evaluation. We have examined the value and application of Mobile Harbor as a preliminary study, which may contribute to further studies on the Mobile Harbor.

• The KIPS Transactions:PartB
• /
• v.10B no.5
• /
• pp.503-508
• /
• 2003

Since surgical treatment of the spine should overcome neurological compromises, the operative procedures need to be carefully planned and carried out with high degree of precision. Percutaneous vertebroplasty is a surgical procedure that was introduced for the treatment of compression fracture of the vertebrae. This procedure includes puncturing vertebrae and filling with polymethylmethacrylate (PMMA). Recent studies have shown that the procedure could provide structural reinforcement for the osteoporotic vertebrae while being minimally invasive and safe with immediate relief of pain. However, failures of treatment due to excessive PMMA volume injection have been reported as one of complications in vertebroplasty. It is believed that the control of PMMA volume is one of the most critical factors that can reduce the incidence of complications. Therefore, clinical success of vertebroplasty can be dependent on the volume of PMMA injection for a given patient. In this study, the optimal volume of PMMA injection for vertebroplasty was predicted based on the image analysis of a given patient.

• Genomics & Informatics
• /
• v.12 no.4
• /
• pp.195-202
• /
• 2014

Metabolic syndrome (MetS) is a complex disorder related to insulin resistance, obesity, and inflammation. Genetic and environmental factors also contribute to the development of MetS, and through genome-wide association studies (GWASs), important susceptibility loci have been identified. However, GWASs focus more on individual single-nucleotide polymorphisms (SNPs), explaining only a small portion of genetic heritability. To overcome this limitation, pathway analyses are being applied to GWAS datasets. The aim of this study is to elucidate the biological pathways involved in the pathogenesis of MetS through pathway analysis. Cohort data from the Korea Associated Resource (KARE) was used for analysis, which include 8,842 individuals (age, $52.2{\pm}8.9years$ ; body mass index, $24.6{\pm}3.2kg/m^2$). A total of 312,121 autosomal SNPs were obtained after quality control. Pathway analysis was conducted using Meta-analysis Gene-Set Enrichment of Variant Associations (MAGENTA) to discover the biological pathways associated with MetS. In the discovery phase, SNPs from chromosome 12, including rs11066280, rs2074356, and rs12229654, were associated with MetS (p < $5{\times}10^{-6}$), and rs11066280 satisfied the Bonferroni-corrected cutoff (unadjusted p < $1.38{\times}10^{-7}$, Bonferroni-adjusted p < 0.05). Through pathway analysis, biological pathways, including electron carrier activity, signaling by platelet-derived growth factor (PDGF), the mitogen-activated protein kinase kinase kinase cascade, PDGF binding, peroxisome proliferator-activated receptor (PPAR) signaling, and DNA repair, were associated with MetS. Through pathway analysis of MetS, pathways related with PDGF, mitogen-activated protein kinase, and PPAR signaling, as well as nucleic acid binding, protein secretion, and DNA repair, were identified. Further studies will be needed to clarify the genetic pathogenesis leading to MetS.

• Genomics & Informatics
• /
• v.6 no.3
• /
• pp.153-156
• /
• 2008

Complex diseases such as stroke and cancer have two or more genetic loci and are affected by environmental factors that contribute to the diseases. Due to the complex characteristics of these diseases, identifying candidate genes requires a system-level analysis of the following: gene ontology, pathway, and interactions. A database and user interface, termed StrokeBase, was developed; StrokeBase provides queries that search for pathways, candidate genes, candidate SNPs, and gene networks. The database was developed by using in silico data mining of HGNC, ENSEMBL, STRING, RefSeq, UCSC, GO, HPRD, KEGG, GAD, and OMIM. Forty candidate genes that are associated with cerebrovascular disease were selected by human experts and public databases. The networked cerebrovascular disease gene maps also were developed; these maps describe genegene interactions and biological pathways. We identified 1127 genes, related indirectly to cerebrovascular disease but directly to the etiology of cerebrovascular disease. We found that a protein-protein interaction (PPI) network that was associated with cerebrovascular disease follows the power-law degree distribution that is evident in other biological networks. Not only was in silico data mining utilized, but also 250K Affymetrix SNP chips were utilized in the 320 control/disease association study to generate associated markers that were pertinent to the cerebrovascular disease as a genome-wide search. The associated genes and the genes that were retrieved from the in silico data mining system were compared and analyzed. We developed a well-curated cerebrovascular disease-associated gene network and provided bioinformatic resources to cerebrovascular disease researchers. This cerebrovascular disease network can be used as a frame of systematic genomic research, applicable to other complex diseases. Therefore, the ongoing database efficiently supports medical and genetic research in order to overcome cerebrovascular disease.

• KDI Journal of Economic Policy
• /
• v.26 no.1
• /
• pp.71-104
• /
• 2004

This paper explores the empirical performances of the workout companies with special interests in the effectiveness of corporate reorganizing tools on their revitalization. In the empirical analysis it considers the criteria of success or failure in restructuring from both creditors' and debtors' perspectives. The key results are summarized as follows. First, the initial conditions on the debt structure of the workout companies are significantly related to the revitalization from both creditors' and debtors' point of view. Second, the debt restructuring instruments are insignificant in the success of corporate turnarounds while the debt-to-equity conversion has been a relatively effective tool. Third, the self-restructuring efforts, employment downsizing and governance reshuffling do not affect the performances significantly. The higher importance of initial conditions than corporate restructuring efforts may imply that Korean corporate workouts serve better to the needs of creditor financial institutions which are to maximize debt recovery and of the government which is to overcome financial crisis.

• The Journal of Fisheries Business Administration
• /
• v.30 no.1
• /
• pp.1-29
• /
• 1999

When the international fisheries order changes following the UN Law of the Sea, the new regional fisheries order is forming among East North Asian states and era of Economic Zones is really coming. In those changes of foreign and domestic fisheries environment, to maintain sustainable growth of the industry in 21st century the North East Asian states plot adjustments to fisheries management, such as introduction of the TAC system and others. The TAC seems to be an appropriate systematic response especially because traditional functions of fisheries management have already demonstrated their limits in regards to fisheries sustainable development. Introduction of the TAC to the North East Asian fisheries not only resolves the inability of traditional fisheries management to develop the industry consequently, but also strengthens the EEZ and existing marine management systems. However, the TAC was born by thewestern industrial mentality, still contains persistent mistakes and is difficult to change. Therefore, its introduction to and implication in North East Asian region might cause numerous problems. From this point of view, introduction of the TAC system will disregard peculiarities of North East Asian fisheries, so main efforts should be concentrated on improving the functions of existing system via consecutive step-by-step approach. In addition, the TAC should be grafted into the existing fisheries system through cooperative management system, creating stable systematic ground and considering scientific and fisheries motives. Especially, TAC system, unlike the traditional fisheries' management system, is scientific, being systematically developed one, and needs to be gradually installed, considering its systematic character. Therefore, the TAC should better be introduced by systematic and scientific approaches, paying more attention to strengthening the existing fisheries system, but not immediately and in the form it is right now. Concluding, introduction of the TAC can not be made considering the outward factors deriving from the UN Law of the Sea without corrections.'h overcome limitations and ineffectiveness of traditional fisheries, most efforts should be concentrated on basic revision of 21st centuries' fisheries and strengthening the functions of traditional fisheries aimed to develop the leading business of marine industries.