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Bone regeneration in oral and maxillofacial field using rhBMP-2  

Hwang, Soon Jung (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Park, Min-Woo (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Park, Jae bong (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Park, Hyun Soo (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Paek, Seung-Jun (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Sul, Hee-Kyung (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Lee, Kyung jin (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Hong, Dong-Hwan (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Publication Information
The Journal of the Korean dental association / v.53, no.1, 2015 , pp. 28-35 More about this Journal
Abstract
To overcome shortcoming of autogeneous, allogenic, xenogenic and alloplastic bone grafts, various growth factors related to bone regeneration have been identified and developed. Among them, rhBMP-2 is regarded as the most potent osteoinductive growth factor and it can trigger the differentiation of mesenchymal stem cells to osteogenic cells for accelerated new bone formation And several commercial products of rhBMP-2 are available in Korea. It is applied to maxillary sinus augmentation, guided bone regeneration and preservation of extraction socket. In this review, the development, action mechanism and clinical applications of rhBMP-2 will be described.
Keywords
rhBMP-2; carrier; alveolar bone; oral and maxillofacial bone regeneration;
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1 Triplett RG, Nevins M, Marx RE, Spagnoli DB, Oates TW, Moy PK, et al: Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation. J Oral Maxillofac Surg 67: 1947-1960, 2009   DOI
2 Lee YM, Shin SY, Kim JY, Kye SB, Ku Y, Rhyu IC: Bone reaction to bovine hydroxyapatite for maxillary sinus floor augmentation: histologic results in humans. Int J Periodontics Restorative Dent 26: 471-481, 2006
3 de Freitas RM, Susin C, Spin-Neto R, Marcantonio C, Wikesjo UM, Pereira LA, Marcantonio E Jr. Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP-2/ACS or autogenous bone grafts: a proof-of-concept randomized clinical trial. J Clin Periodontol. 40:968-75, 2013   DOI
4 Carter TG, Brar PS, Tolas A, Beirne OR. Off-label use of recombinant human bone morphogenetic protein-2(rhBMP-2) for reconstruction of mandibular bone defects in humans. J Oral Maxillofac Surg. 66:1417-25, 2008   DOI
5 Herford AS, Boyne PJ. Reconstruction of mandibular continuity defects with bone morphogenetic protein-2(rhBMP-2). J Oral Maxillofac Surg. 66:616-24, 2008   DOI
6 Herford AS, Boyne PJ, Rawson R, Williams RP: Bone morphogenetic protein-induced repair of the premaxillary cleft. J Oral Maxillofac Surg 65: 2136-2141, 2007   DOI
7 Pradel W, Lauer G: Tissue-engineered bone grafts for osteoplasty in patients with cleft alveolus. Ann Anat 194: 545-548, 2012   DOI
8 Neovius E, Lemberger M, Docherty Skogh AC, Hilborn J, Engstrand T: Alveolar bone healing accompanied by severe swelling in cleft children treated with bone morphogenetic protein-2 delivered by hydrogel. J Plast Reconstr Aesthet Surg 66: 37-42, 2013   DOI
9 Fiorellini JP, Howell TH, Cochran D, Malmquist J, Lilly LC, Spagnoli D, Toljanic J, Jones A, Nevins M. Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation. J Periodontol. 76:605-13, 2005   DOI
10 Chrastil J, Low JB, Whang PG, Patel AA. Complications associated with the use of the recombinant human bone morphogenetic proteins for posterior interbody fusions of the lumbar spine. Spine(Phila Pa 1976) 38:E1020-E1027, 2013.
11 Leknes KN, Yang J, Qahash M, Polimeni G, Susin C, Wikesjo UM(2008). Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2: radiographic observations. Clin Oral Implants Res 19:1027-1033, 2008   DOI
12 Devine JG, Dettori JR, France JC, Brodt E, McGuire RA. The use of rhBMP in spine surgery: is there a cancer risk? Evid Based Spine Care J 3:35-41, 2012
13 de Lange GL, Overman JR, Farre-Guasch E, Korstjens CM, Hartman B, Langenbach GE, et al: A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model. Oral Surg Oral Med Oral Pathol Oral Radiol 117: 8-22, 2014   DOI
14 Chiapasco M, Di Martino G, Anello T, Zaniboni M, Romeo E: Fresh Frozen versus Autogenous Iliac Bone for the Rehabilitation of the Extremely Atrophic Maxilla with Onlay Grafts and Endosseous Implants: Preliminary Results of a Prospective Comparative Study. Clin Implant Dent Relat Res, 2013
15 Martuscelli R, Toti P, Sbordone L, Guidetti F, Ramaglia L, Sbordone C: Five-year outcome of bone remodelling around implants in the maxillary sinus: assessment of differences between implants placed in autogenous inlay bone blocks and in ungrafted maxilla. Int J Oral Maxillofac Surg, 2014
16 von Arx T, Cochran DL, Hermann JS, Schenk RK, Buser D: Lateral ridge augmentation using different bone fillers and barrier membrane application. A histologic and histomorphometric pilot study in the canine mandible. Clin Oral Implants Res 12: 260-269, 2001   DOI
17 Carragee EJ, Hurwitz EL, Weiner BK: A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J 11: 471-491, 2011   DOI
18 Bignon A, Chouteau J, Chevalier J, Fantozzi G, Carret JP, Chavassieux P, Boivin G, Melin M, Hartmann D. Effect of micro- and macroporosity of bone substitutes on their mechanical properties and cellular response. Journal of Materials Science: Materials in Medicine 14:1089-1097, 2003   DOI
19 Triplett RG, Nevins M, Marx RE, Spagnoli DB, Oates TW, Moy PK, et al: Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation. J Oral Maxillofac Surg 67: 1947-1960, 2009   DOI
20 Gutwald R, Haberstroh J, Stricker A, Ruther E, Otto F, Xavier SP, et al: Influence of rhBMP-2 on bone formation and osseointegration in different implant systems after sinus-floor elevation. An in vivo study on sheep. J Craniomaxillofac Surg 38: 571-579, 2010   DOI
21 Urist MR: Bone: formation by autoinduction. Science 150: 893-899, 1965   DOI
22 Carreira AC, Lojudice FH, Halcsik E, Navarro RD, Sogayar MC, Granjeiro JM: Bone morphogenetic proteins: facts, challenges, and future perspectives. J Dent Res 93: 335-345, 2014   DOI
23 Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, et al: Novel regulators of bone formation: molecular clones and activities. Science 242: 1528-1534, 1988   DOI
24 Kim RY, Oh JH, Lee BS, Seo YK, Hwang SJ, Kim IS. The effect of dose on rhBMP-2 signaling, delivered via collagen sponge, on osteoclast activation and in vivo bone resorption. Biomaterilas 35: 1869-1881, 2014   DOI
25 Bessho K, Konishi Y, Kaihara S, Fujimura K, Okubo Y, Iizuka T: Bone induction by Escherichia coli -derived recombinant human bone morphogenetic protein-2 compared with Chinese hamster ovary cell-derived recombinant human bone morphogenetic protein-2. Br J Oral Maxillofac Surg 38: 645-649, 2000   DOI
26 Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, et al: Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing. J Bone Miner Metab 27: 355-363, 2009   DOI
27 Kim IS, Lee EN, Cho TH, Song YM, Hwang SJ, Oh JH, et al: Promising efficacy of Escherichia coli recombinant human bone morphogenetic protein-2 in collagen sponge for ectopic and orthotopic bone formation and comparison with mammalian cell recombinant human bone morphogenetic protein-2. Tissue Eng Part A 17: 337-348, 2011
28 Jung RE, Glauser R, Scharer P, Hammerle CH, Sailer HF, Weber FE: Effect of rhBMP-2 on guided bone regeneration in humans. Clin Oral Implants Res 14: 556-568, 2003   DOI
29 Boyne PJ, Lilly LC, Marx RE, Moy PK, Nevins M, Spagnoli DB, et al: De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. J Oral Maxillofac Surg 63: 1693-1707, 2005   DOI