• 한국임상수의학회지
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• 제33권6호
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• pp.332-339
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• 2016

Polycaprolactone (PCL) scaffold have been developed as an alternative to natural donor tissue to repair a large osteochondral defect. The objective of this study is to evaluate efficacy and biocompatibility of bilayer PCL scaffold implanted for osteochondral repair in rabbit. Twenty-two male New Zealand White rabbits were used in this animal experiment. Rabbits were divided into three groups. Experimental surgery was carried out under general anesthesia. Osteochondral defects (5 mm diameter and 5 mm deep) were made in the center of the patellar groove using a 5 mm diameter biopsy punch. In group I (3D plotting) and group II (salt-leaching), the scaffold was implanted using the press-fitted technique into the defect. In control group, after osteochondral defect was created, the defect was left without implant. After four and eight weeks, rabbits were sacrificed and the defects were evaluated by macro -and microscopical methods. There were not found animal death and severe inflammatory evidence during the experimental periods. There were no significant differences between the experimental groups in gross evaluation. However the group I scored significantly higher than group II at 8 weeks in histological evaluation (P < 0.05). The 3-D plotting PCL scaffold was more suitable method for reconstruction of osteochondral defect than a salt-leaching PCL scaffold.

• 대한족부족관절학회지
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• 제24권2호
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• pp.55-60
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• 2020

Among the various surgical treatment methods for osteochondral lesions of the talus, autologous osteochondral transplantation (AOT) is a useful procedure in cases of a large defect, subchondral cyst, and failed primary bone marrow stimulation procedure. Although bone marrow stimulation alone may not regenerate the damaged plate sufficiently, AOT has the advantage of being able to replace the subchondral bone plate and cartilage with a new one at a same time. Nevertheless, postoperative cyst formation or pain may persist and donor site morbidity is still a limitation of AOT.

• 대한족부족관절학회지
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• 제17권2호
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• pp.154-160
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• 2013

The treatment of open, traumatic intraarticular injuries to the metatarsophalangeal joint with severe articular comminution and cartilage defect of metatarsal head is a challenge to the foot surgeon. We report the joint reconstruction treating the injured joint by autogenic costal osteochondral graft with satisfactory outcome.

• 대한정형외과스포츠의학회지
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• 제4권1호
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• pp.12-17
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• 2005

슬관절의 연골 결손에 대한 치료로 여러가지 방법이 시행되어 왔는데, 기존의 방법들은 치 유된 결손 부위가 섬유연골로 덮히는 것으로 알려져 있다. 최근 시행되는 자가 골연골 이식술과 자가 연골세포 이식술은 결손 부위가 대부분 초자연골로 덮힌다고 알려져 있다. 이 논문에서는 자가 골연골 이식술의 기초적 연구, 적응증, 수술 기법, 수술 후 결과를 기술하고자 한다.

• 대한관절경학회지
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• 제12권3호
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• pp.147-153
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• 2008

슬관절의 연골 결손에 대한 치료로 여러가지 방법이 시행되어 왔는데, 기존의 방법들은 치유된 결손 부위가 섬유연골로 재생되는 것으로 알려져 있다. 최근 시행되는 자가 골연골 이식술과 자가 연골세포 이식술은 결손 부위가 대부분 초자연골로 재생된다고 알려져 있다. 이 논문에서는 자가 골연골 이식술의 기초적 연구, 적응증, 수술 기법, 수술 후 결과를 기술하고자 한다.

• 대한족부족관절학회지
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• 제24권2호
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• pp.48-54
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• 2020

Osteochondral lesion of the talus (OLT) is a broad term used to describe an injury or abnormality of the talar articular cartilage and adjacent bone. Various terms are used to describe this clinical entity, including osteochondritis dissecans, osteochondral fractures, and osteochondral defects. Several treatment options are available; the choice of treatment is based on the type and size of the defect and the treating clinician's preference. Arthroscopic microfracture (a bone marrow stimulation technique) is a common and effective surgical strategy in patients with small lesions or in those in whom non-operative treatment has failed. This study had the following aims: 1) to review the historical background, etiology, and classification systems of OLT; 2) to describe a systematic approach to arthroscopic bone marrow stimulation for OLT; and 3) to determine the characteristics that are useful for assessing osteochondral lesions, including age, size, type (chondral, subchondral, cystic), stability, displacement, location, and containment of the lesion.

• Hip & pelvis
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• 제34권3호
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• pp.177-184
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• 2022

This study aimed to analyse the initial results of five patients with symptomatic osteochondral lesions (OCL) and femoroacetabular impingement (FAI) who were treated successfully with osteochondral autologous transfer (OAT) and femoral neck osteochondroplasty (OCP) through surgical dislocation of the hip. Five patients with FAI and OCL of the femoral head who underwent surgery between 2015-2018 were studied retrospectively. All patients had a grade IV OCL, and the median defect size was 2 cm2 (interquartile range [IQR], 2-2). At the final follow-up, the modified Harris hip score showed a median value of 94 (IQR, 91-95) (P=0.04). Pain evaluation using the visual analogue scale showed a median value of 1 (IQR, 1-2) (P=0.04). Adequate graft union and healthy formation of the chondral surface were observed by magnetic resonance imaging. Although the procedure is demanding, the combination of OAT and femoral neck OCP appears to be an effective alternative in young patients.

• Advances in nano research
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• 제12권3호
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• pp.301-317
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• 2022

Many studies have shown that Mg-Nd-Zn-Zr (abbreviated as JDBM) alloy has good biocompatibility and biodegradability as well as promotion of cell adhesion, proliferation and differentiation, and Wnt/β-catenin signaling pathway may play a unique role in joint tissue by controlling the function of chondrocytes, osteoblasts and synoviocytes. However, it is not clear whether the JDBM alloy induces osteochondral repair through Wnt/β-catenin signaling pathway. This study aims to verify that JDBM alloy can repair osteochondral defects in rats, which is realized by Wnt/β-catenin signaling pathway. In this study, the osteochondral defect model of the right femoral condyle non-weight-bearing area in rats was established and randomly divided into three groups: Control group, JDBM alloy implantation group and JDBM alloy implantation combined with signaling pathway inhibitor drug ICRT3 injection. It was found that after JDBM alloy implantation, the bone volume fraction (BVF) became larger, the bone trabeculae were increased, the relative expression of osteogenesis gene Runx2, Bmp2, Opn, Ocn and chondrogenesis gene Collagen II, Aggrecan were increased, and the tissue repair was obvious by HE and Masson staining, which could be inhibited by ICRT3.

• 대한관절경학회지
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• 제5권2호
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• pp.99-103
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• 2001

목적 : 이번 전향적 연구의 목적은 슬관절의 연골 결손 환자의 치료로서 자가 골연골 이식술을 시행한 후 이차 관절경을 시행하여 관찰하는 것이다. 재료 및 방법 : 슬관절의 연골 결손의 치료로 자가 골연골 이식술이 시행된 40명의 환자 중 14면에서 이차 관절경이 시행되었다. 환자들의 연령은 $17\~59$세로, 평균 연령은 34세였다. 수술 전 14명 중 11명에게서 자기 공명영상을 시행하여 9면에서 연골 결손이 관찰되었으나 관절경술상 전례에서 연골결손을 확인하였다. 연골 결손의 부위는 대퇴골 내과가 7명, 활차 부위가 4명, 대퇴골 외과가 3명이었다. 연골 결손의 크기는 평균 $13\times10mm$, 최소 $5\times10mm$, 최대 $22\times20mm$이었다. 사용된 골연골의 갯수는 1개를 사용한 경우 8명, 2개가 3명, 3개가 2명, 5개가 1명이었다. 결과 : 수술 후 추적 관찰은 평균 21개월이었다. 대부분의 경우 수술 후 6개월에 이차 관절경을 시행하였다. 시행한 환자의 $86\%$에서 이식된 연골의 경도가 주변의 연골과 같았으며, $93\%$의 환자에서 주변 연골과 잘 융화된 것을 관찰할 수 있었다. 결론 : 자가 골연골 이식술을 자가 골연골 이식술은 슬관절의 연골결손의 치료의 한 방법으로 사용될 수 있을 것으로 생각된다.

• 대한족부족관절학회지
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• 제10권2호
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• pp.133-139
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• 2006

Purpose: To evaluate the results of mosaicplasty and microfracture after surgical treatments for symptomatic osteochondral lesion of talus (OLT) by second-look arthroscopy. Materials and Methods: 7 cases of mosaicplasty and 7 cases of microfracture were reviewed who undertook second-look arthroscopy at 6 months or one year after undertaking mosaicplasty or microfracture for OLT between December 2004 and October 2005. The mean age at first operation was 43.6 years (Range, 20-59) (Mosaicplasty; 43.9 years, Microfracture; 43.4 years). The mean size of cartilage defect was $15.0{\times}7.7\;mm$ in mosaicplasty and $7.1{\times}6.6\;mm$ in microfracture. Clinical outcomes were evaluated by Freiburg ankle score. Cartilage healing state was evaluated by Insall's classification for chondromalasia during second-look arthroscopy. Results: By the Freiburg ankle score, 9 ankles (6 in mosaicplasty, 3 in microfracture) had excellent and 5 (1 in mosaicplasty, 4 in microfracture) had good results at the times of second-look arthroscopy. By Insall's classification, consistency of the osteochondral grafts and congruity between grafts and native cartilage (Grade I) were shown in 9 (6 ankles in mosaicplasty, 3 ankles in microfracture), a fissuring (Grade II) in one ankle of mosaicplasty, a fasciculation (Grade III) in one ankle of microfracture, and partial exposure of subchondral bone (Grade IV) in 3 ankles of microfractures. Conclusion: Mosaicplasty was more excellent in consistency and hardness of cartilage than microfracture. In some cases of microfracture, cartilage healing was incomplete at 6 months postoperatively, so second-look arthroscopy is necessary to identify. If incomplete cartilage healing was shown, additional procedure such as microfracture or mosaicplasty was needed.