• Journal of the Korean Institute of Landscape Architecture
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• v.33 no.1 s.108
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• pp.109-120
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• 2005

This landscape design proposal was presented to a design competition for Osong Biohealth Technopolis Institute of Cheongwon Gun Chung Cheong Buk Do which was held by Ministry of Health and Welfare in March 2004. The site is located in. Osong Li, Kang Wei Myun, Cheonwon Gun, Chung Cheong Buk Do and has an area of $402,600m^2$. The judging criteria for landscape design set by the client could be articulated as follows: an environment friendly design respecting the surrounding environment, a functionally efficient site plan by clustering buildings with similar uses, a site plan having 'front yard' by locating buildings in rear areas toward existing 'groves'. The proposal set the main design concept of this project as 'clustering'. By doing that, existing grades and plants can be saved, buildings with similar uses can be clustered, huge 'front yard' as a symbolic image of this project can be achieved, and finally many small open spaces for everyday life can be designed accordingly.

• Journal of Conservation Science
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• v.35 no.1
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• pp.41-49
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• 2019

This study analyzes the material characteristics of stone tools of the Paleolithic period excavated from the Osong site, located at the project site for the creation of the Osong 2nd Life Science Complex, and estimates the provenance of the stone materials. Because the stones had been buried for a long time, their surfaces had become heavily weathered yellow or yellowish-brown, and the magnetic susceptibility values varied from 0 to 15(${\times}10^{-3}SI$). The excavated stone tools were rocks with various magnetic susceptibility values that could not be specified. Five stone tools subjected to destructive analysis were divided into two groups, one with a value of 1-3(${\times}10^{-3}SI$) and the other with a value of 5-9(${\times}10^{-3}SI$), both based on visible characteristics. The results of the thin-section analysis showed that most of the stone tools were basaltic rocks comprising plagioclase, quartz, and pyroxene, and some had iron content as high as 20 wt.%. These findings and the present geological map suggest that the stone tools were not made from the surrounding rocks because there are no areas containing basaltic rocks surrounding Bongsan-ri in Osong-eup. Andesite and tuff are distributed along with basaltic rocks in the Doan-myeon area in Jeongpyeong-gun, Chungcheongbuk-do Province, but the distance from the excavation site is too far. To determine whether this region is actually related to the provenance of the raw rock, it is necessary to conduct additional field surveys and comprehensive and precise analyses.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.113-118
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• 2021

Chitosan is a polysaccharide derived from chitin by deacetylation. Chitosan is non-toxic, biodegradable, and biocompatible, so that it can be used in wide variety of medical applications such as wound healing and antimicrobial biomaterials. It also used as dermal fillers due to its ability to inject with liquid formulations. For investigation on in vivo distribution of these chitosans, Bolton-Hunter-conjugated chitosan (Chitosan-BH) was synthesized by the reaction between the primary amino group of chitosan and N-hydroxysuccinimide ester group of Bolton-Hunter reagent. Then Chitosan-BH was radiolabeled with ¹²⁵I (Chitosan-BH-¹²⁵I) using a Chloramine-T method. The effects of each radiolabeling step on the radiolabeling yield of the final product were tested. The results showed that purification step had significant effects on the radiolabeling yield of the final product. Finally, SPECT/CT images were obtained to evaluate in vivo uptake of the radiolabeled chitosan (Chitosan-BH-¹²⁵I) in several organs. The highest uptake was found in the site of injection at 21 days post-injection. The results of this study suggest that chitosan is expected to be useful for biomaterials of dermal fillers.

• The Korean Journal of Quaternary Research
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• v.24 no.1
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• pp.25-33
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• 2010

Holocene vegetation and climate changes were assumed on the basis of pollen records from Wonpyeong Trench II-3 of the Osong archaeological site, Cheongju, Chungbuk Province, Korea. An organic matter beared in coarse sediments appeared to be low throughout the succession. Although an occurrence of pollen grains is not high, some dominant and principal taxa may indicate vegetation changes response to climate changes in central inland area of the Korean Peninsula. The age determination can be estimated with indirect way by comparing with previous age-controlled pollen studies. It is assumed that the former last glacial conifer forests had been changed into open mixed conifers and deciduous broadleaved forest during the early Holocene period. Warmer and more humid climate conditions, during the mid-Holocene, might have allowed the hardwoods including deciduous- and evergreen-broadleaved trees, and warm-preferring pine tree to flourish. Subsequently, the former forests were replaced by mixed of conifer and deciduous broadleaved forest owing to deterioration of climate conditions during the late Holocene. Human activity is also detected by agricultural indicators, such as buckwheat and large pollen grains comparable to corn, in upper most pollen profile. During this time, the forests in studied area were primarily affected by human disturbance rather than natural environment.

• Journal of Conservation Science
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• v.34 no.6
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• pp.481-492
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• 2018

We conducted TL/OSL dating for the earthenware kilns in the Bongsan-ri archaeological site, Osong, which was occupied from the late nineteenth to the late twentieth century. With the SAR-TL/OSL method, paleodose was determined from the equivalent dose during the burial period($ED_{burial}$), the background dose($ED_{BG}$), the fading correction factor(f), and the overestimation correction factor(C). The annual dose rates and their provenance were evaluated from the measurement of natural radionuclides $^{238}U$, $^{232}Th$, and $^{40}K$. Because the comprehensive absolute age was provided by combining the resulting TL/OSL and radiocarbon data, we concluded that, for the absolute chronology of a modern archaeological site, TL/OSL dating and radiocarbon dating must be carried out together and summed. The construction and occupation of earthenware kilns in the Bongsan-ri site had changed from stage I (No.5, 6 kilns), to stage II (No.1, 2, 3 kilns), to stage III (No.4) in chronological order. When Bayesian statistics were applied, we found that the absolute ages of occupation for stages I, II, and III correspond to AD $1910{\pm}23$, AD $1970{\pm}10$, and AD $1987{\pm}4$. These results were in good agreement with the archaeological context or chronology.

• Journal of Genetic Medicine
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• v.14 no.1
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• pp.8-17
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• 2017

Purpose: Pulse wave velocity (PWV) is an indicator of arterial stiffness, and is considered a marker of vascular damage. However, a genome-wide association study analyzing single nucleotide polymorphisms (SNPs) associated with brachial-ankle PWV (baPWV) has not been conducted in healthy populations. We performed this study to identify SNPs associated with baPWV in healthy populations in Korea. Materials and Methods: Genomic SNPs data for 2,407 individuals from three sites were analyzed as part of the Korean Genomic Epidemiologic Study. Without replication samples, we performed multivariable analysis as a post hoc analysis to verify the findings in site adjusted analysis. Healthy subjects aged between 40 and 70 years without self-reported history or diagnosis of hypertension, diabetes, hyperlipidemia, heart disease, cerebrovascular disease and cancer were included. We excluded subjects with a creatinine level >1.4 mg/dL (men) and 1.2 mg/dL (women). Results: In the site-adjusted association analysis, significant associations (P<$5{\times}10^{-8}$) with baPWV were detected for only 5 SNPs with low minor allele frequency. In multivariable analysis adjusted by age, sex, height, body mass index, mean arterial pressure, site, smoking, alcohol, and exercise, 11 SNPs were found to be associated (P<$5{\times}10^{-8}$) with baPWV. The 5 SNPs (P<$5{\times}10^{-8}$) linked to three genes (OPCML, PRR35 and RAB40C) were common between site-adjusted analysis and multivariable analysis. However, meta-analysis of the result from three sites for the 11 SNPs showed no significant associations. Conclusion: Using the recent standard for genome-wide association study, we did not find any evidence of significant association signals with baPWV.

• Journal of KIBIM
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• v.8 no.4
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• pp.41-48
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• 2018

Recent technological improvements have made abundant changes in construction industry. In specific, some technical applications, such as Building Information Modeling (BIM) opens up many possibilities. Some studies have articulated the use of BIM and its advantages in construction, but most of them are theoretical, not practical. This study is to provide an insight to such obstacles in BIM research. By investigating a real project that could utilize BIM in planning and construction phases, the authors try to investigate a possible outline of advantages in BIM implementation. The study area was set to a railway construction site in South Korea. The site covers a multiple railway tracks, stations, telecommunication facilities, infrastructure facilities, railway structures, and so numerous. In the site, the authors have identified 12 errors in 7 projects that could be prevented if BIM was utilized before the construction.

• The Korean Journal of Quaternary Research
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• v.21 no.2
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• pp.1-3
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• 2007

• Mass Spectrometry Letters
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• v.12 no.3
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• pp.66-75
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• 2021

Interleukin-4 (IL-4) and IL-13 are cytokines secreted by immune cells. Cytokines induce the proliferation of macrophages or promote the differentiation of secretory cells. The initiation and progression of allergic inflammatory diseases, such as asthma, are dependent on cytokines acting through related receptor complexes. IL-4 and IL-13 are N-glycoproteins. Glycan structures in glycoproteins play important roles in protein folding, protein stability, enzymatic function, inflammation, and cancer development. Therefore, the glycan structure of IL-4 and IL-13 needs to be elucidated in detail for the development of effective therapies. We report the first attempt to characterize the site-specific N-glycosylation of recombinant IL-4 and IL-13 via liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. The tandem mass spectra of intact N-glycopeptides were identified using the Integrated GlycoProteome Analyzer (I-GPA) platform, which can automatically and rapidly analyze multiple N-glycopeptides, including their glycan composition and amino acid sequences. The recombinant IL-4 and IL-13 were identified with amino acid sequence coverages of 84% and 96%, respectively. For IL-4, 52 glycoforms on one N-glycosylation site were identified and quantified. In IL-13, 232 N-glycopeptides from three N-glycosylation sites were characterized, with the site Asn52 being the most extensively glycosylated (~80%). The complex glycans were the most abundant glycan on IL-4 and IL-13 (~96% and 91%, respectively), and the biantennary glycans were the most abundant in both recombinant IL-4 and IL-13 proteins.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.31 no.6
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• pp.339-346
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• 2018

An Industry Foundation Classes(IFC), which is a data schema developed focusing on architecture, is being expanded to civil engineering structures. However, it is difficult to create an information model based on extended IFC since the BIM software cannot provide support functions. To manage a railway track based on the extended IFC, this paper proposed a method to create an alignment-centered separated railway track model and convert it to an extended IFC-based information model. First, railway track elements have been classified into continuous and discontinuous structures. The continuous structures were created by an alignment-based software, and discontinuous structures were created as independent objects through linkage of the discretized alignment. Second, a classification system and extended IFC schema for railway track have been proposed. Finally, the semantic information was identified by using the property of classification code and user interface. The availability of the methods was verified by developing an extended IFC-based information model of the Osong railway site.