• The Korean Journal of Physiology and Pharmacology
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• v.22 no.4
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• pp.447-456
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• 2018

Angiotensin-(1-9) [Ang-(1-9)], generated from Ang I by Ang II converting enzyme 2, has been reported to have protective effects on cardiac and vascular remodeling. However, there is no report about the effect of Ang-(1-9) on pulmonary hypertension. The aim of the present study is to investigate whether Ang-(1-9) improves pulmonary vascular remodeling in monocrotaline (MCT)-induced pulmonary hypertensive rats. Sprague-Dawley rats received Ang-(1-9) ($576{\mu}g/kg/day$) or saline via osmotic mini-pumps for 3 weeks. Three days after implantation of osmotic mini-pumps, 50 mg/kg MCT or vehicle were subcutaneously injected. MCT caused increases in right ventricular weight and systolic pressure, which were reduced by co-administration of Ang-(1-9). Ang-(1-9) also attenuated endothelial damage and medial hypertrophy of pulmonary arterioles as well as pulmonary fibrosis induced by MCT. The protective effects of Ang-(1-9) against pulmonary hypertension were inhibited by Ang type 2 receptor ($AT_2R$) blocker, but not by Mas receptor blocker. Additionally, the levels of LDH and inflammatory cytokines, such as $TNF-{\alpha}$, MCP-1, $IL-1{\beta}$, and IL-6, in plasma were lower in Ang-(1-9) co-treated MCT group than in vehicle-treated MCT group. Changes in expressions of apoptosis-related proteins such as Bax, Bcl2, Caspase-3 and -9 in the lung tissue of MCT rats were attenuated by the treatment with Ang-(1-9). These results indicate that Ang-(1-9) improves MCT-induced pulmonary hypertension by decreasing apoptosis and inflammatory reaction via $AT_2R$.

• Korean Journal of Veterinary Research
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• v.56 no.4
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• pp.215-221
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• 2016

Due to the shortage of the fingerling/juvenile mud loach, Misgurnus mizolepis in Korea, these fish have been imported from China. However, the mortality rate during and after their transportation is very high. In this study, we examined various physiological and histological parameters to evaluate the effect of salt treatment on the survival and recovery of mud loaches in holding farms during the quarantine process. Glucose, osmolality, $Na^+$, $Cl^-$, and histological changes were assessed for three different salinities. Non-treated fish (control 0.0%) exhibited lower levels of osmolality, and $Na^+$ and $Cl^-$ concentrations compared with those kept in solar salt solution (0.5% and 1.0%). Glucose levels in control fish were higher than those in fish exposed to 0.5% and 1.0% solar salt solution. Histologically, control fish showed thinner epidermis of skin, branchial hyperplasia and lamellar fusion with an abundance of eosinophilic granule cell-like cells. After solar salt solution treatment, damaged gill structures in the fish almost recovered within 5 days. The present study demonstrates that mud loaches transported from China suffer from skin and gill damage and physiological dysfunction which may increase the mortality and morbidity. Moreover, saline treatment might alleviate the stress responses and ionic/osmotic imbalances, and help heal gill damage.

• Preventive Nutrition and Food Science
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• v.22 no.3
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• pp.231-236
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• 2017

Fermented kale juices using four types of lactobacilli were produced in the present study. After 48 h of fermentation time, viable cell counts of all ferments reached an above $10^9CFU/mL$. The viability of the ferments after cold storage in the refrigerator for 4 weeks showed $10^8CFU/mL$ in all ferments. Among four types of fermented kale juices, the ferment of Lactobacillus acidophilus IFO 3025 indicated a good nutritional composition, including neutral sugar ($1,909.76{\mu}g/mL$), reducing sugar ($564.00{\mu}g/mL$, P<0.05), and protein contents ($160.06{\mu}g/mL$, P<0.05). The results of mineral composition analysis had the highest potassium value in all ferments ($854.16{\sim}895.07{\mu}g/mL$), particularly in the ferment of Lactobacillus brevis FSB-1 (P<0.001), which is necessary to sustain osmotic pressure, prevention of high blood pressure, and protein synthesis. Moreover, calcium, phosphorus, and magnesium contents related to bone health were generally sufficient in all ferments. Consequently, in this study, fermented kale juices may be suggested as a healthy fermented beverage with essential nutrients. However, the acceptability of the fermented kale juice to the Korean taste should be further investigated with a trained taste panel to determine whether inoculated fermentation could be an option for the consumers.

• Journal of Korean Neurosurgical Society
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• v.58 no.1
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• pp.76-78
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• 2015

This report details a case of unexpected, severe post-operative cerebral edema following cranioplasty. We discuss the possible pathological mechanisms of this complication. A 50-year-old female was admitted to our department with sudden onset of stuporous consciousness. A brain computed tomography (CT) revealed a subarachnoid hemorrhage with intracranial hemorrhage and subdural hematoma. Emergency decompressive craniectomy and aneurysmal neck clipping were performed. Following recovery, the decision was made to proceed with an autologous cranioplasty. The cranioplasty procedure was free of complications. An epidural drain was placed and connected to a suction system during skin closure to avoid epidural blood accumulation. However, following the procedure, the patient had a seizure in the recovery room. An emergency brain CT scan revealed widespread cerebral edema, and the catheter drain was clamped. The increased intracranial pressure and cerebral edema were controlled with osmotic diuretics, corticosteroids, and antiepileptic drugs. The edema slowly subsided, but new low-density areas were noted in the brain on follow-up CT 1 week later. We speculated that placing the epidural drain on active suction may have caused an acute decrease in intracranial pressure and subsequent rapid expansion of the brain, which impaired autoregulation and led to reperfusion injury.

• Tribology and Lubricants
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• v.30 no.5
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• pp.247-255
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• 2014

Charged polymer chains, i.e., polyelectrolytes, are known to show superior aqueous lubricating properties compared to those of neutral polymer chains, especially in brush conformation. This is primarily because of the incorporation of a large amount of counterions within the polymer layers and the consequently increased osmotic pressure. However, this effect is active only when the polymer chains remain immobilized even under tribostress, which is not realistic for high-contact pressure tribological applications, especially when they are irreversibly immobilized on tribopair surfaces. In contrast, with free polymers, which can be included as surface-active additives in the base lubricant (water), long-term lubricating performance based on "self-healing" properties is readily expected. In order to assess whether the superior aqueous lubricating properties of polyelectrolyte chains are valid for free polymers too, this study reviews recent studies on the tribological properties of many charged biopolymer and synthetic copolymers at a nonpolar, hydrophobic interface. In contrast to the irreversibly immobilized polyelectrolyte chains, free polyelectrolyte chains show inferior aqueous lubricating properties compared to their neutral counterparts owing to charge accumulation and the consequently impeded surface adsorption on the nonpolar surface. Nevertheless, bovine submaxillary mucin (BSM), a representative biopolymer, shows a sufficiently effective surface adsorption and aqueous lubricating capabilities even at neutral pH without losing the polyanionic characteristics.

• Journal of Korean Society of Water and Wastewater
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• v.25 no.3
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• pp.399-405
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• 2011

In a desalination technology using RO membranes, chemical cleaning makes damage for membrane surface and membrane life be shortened. In this research cleaning technology using direct osmosis (DO) was introduced to apply it under the condition of high pH and high concentration of feed. When the high concentration of feed is injected to the concentrate side after release of operating pressure, then backward flow occurred from treated water toward concentrated for osmotic pressure. This flow reduces fouling on the membrane surface. Namely, flux of DO was monitored under pH 3, 5, 10 and 12 conditions at feed concentrations of NaCl 40,000 mg/L, 120,000 mg/L and 160,000 mg/L. As a result, DO flux in pH 12 increased about 21% than pH 3. DO cleaning was performed under the concentrate NaCl 160,000 mg/L of pH 12 during 20 minutes. Three kinds of synthetic feed water were used as concentrates. They consisted of organic, inorganic and seawater; chemicals of SiO2 (200 mg/L), humic acid (50 mg/L) sodium alginate (50 mg/L) and seawater. As a result, fluxes were recovered to 17% in organic fouling, 15% in inorganic fouling and 14% of seawater fouling after cleaning using DO under the condition of concentrate NaCl 160,000 mg/L of pH 12.

• Korean Journal of Agricultural Science
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• v.6 no.1
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• pp.15-20
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• 1979

In order to determine the effects of different degrees of moisture stress on germination of various plant species, hundred seeds of six vegetables and six turfgrasses were germinated in petri dishes on filter papers moistened with water-mannitol solutions of 0, 2, 4, 8, 10, and 12 atmosphere osmotic concentration (degrees of moisture stress). The percentages and rates of germination of all species tested were generally decreased with: increase in moisture stress. Chinese cabbage and cucumber were quite resistant to physiological drought as the germination was not appreciably affected until moisture stress exceeded 10 atmosphere. However, increase in moisture stress decreased germination affecting most seriously tomato, carrot and squash. Weeping lovegrass, Italian ryegrass and perennial ryegrass germinated well at 10 atmosphere but the germination of Kentucky bluegrass, meadow fescue and orchardgrass was greatly reduced by increasing osmotic pressure. The result indicates that it may be possible to select drought resistant species and varieties by their ability to germinate in osmotic solutions.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.3 no.1
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• pp.35-38
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• 1973

The authors have interpreted one patient's full mJuth intra-oral films, oblique- lateral film of the left mandible and orthopantomograph which revealed 6 radicular and 1 residual cysts. As a results of interpretation of these serial films, we have drawn following conclusions: 1. Radicular cyst arose from the cell rests contained in an apical granuloma which was sequel to advanced pulpitis due to dental caries. 2. Residual cyst was developed from remaining cell rests after the extraction of a tooth with such a radicular cyst or apical dental granuloma. 3. Cyst grew in size by absorption of fluid into cystic cavity due to difference in osmotic pressure between the cystic fluid and adjacent tissue fluid.

• Korean Journal of Microbiology
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• v.9 no.4
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• pp.149-154
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• 1971

Effect pf gibberellic acid (GA) on the growth rate, respiratory activity and solute uptake of Chlorella cells were measured and their correlation were discussed. Growth rate and respiratory activity of the algal cells are enhanced considerably by very samll amount (50 ppm) of GA treatment although they are suppressed by relatively higher concentration more than 100 ppm. Phosphate uptake of the algal cells, however, decreased even though lower concentration of GA is applied. Thereforem it is inferred that the growth enhancement of the algae by GA is not due to the increase of the permeability of the algal cells but expansion growth owing to the increase of osmotic pressure caused by the increase of hydrolase activity of the algae.

• Journal of Nutrition and Health
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• v.28 no.9
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• pp.834-845
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• 1995

This study was conducted in order to establish an in vitro method simulating the physiological function of fibers along the large intestine of humans. Commercial fibers including guar gum, apple pectin, citrus pectin, CM-cellulose, alginic acid and $\alpha$-cellulose, and dietary fiber residues obtained from rice bran, barley, soybean, Korea cabbage, apple, tangerine and sea mustard were employed to determine the water-holding capacity, weight of hydrated residue and fiber content after anaerobic fermentation using human fecal inoculum for 24 hours, followed by dialysis under osmotic suction pressure. The weight of hydrated residue in commercial fibers was in the decreasing order of CM-cellulose > alginic acid, $\alpha$-cellulose > apple pectin, citrus pectin > guar gum and that in food fiber residues was in the decreasing order of rice bran, sea mustard > soybean > tangerine, Korean cabbage > barley > apple. It was demonstrated that the larger the weight of hydrated residue was, the more the weight of human stool increased. Consequently this in vitro method can be used as a preceeding test before undertaking animal or human experiment to predict the physiological effects of fiber residues from diverse food samples as well as commercially refined fibers.