• 한국임상수의학회지
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• 제19권3호
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• pp.357-359
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• 2002

Male pseudohermaphrodites is one of abnormalities of phenotypic sex and have an XY chromosome constitution and testes, but the internal or external genitalia are to some degree those of a female. We surveyed one case which were referred in Veterinary Medical Teaching Hospital of Seoul National University. When patient was purchased, its phenotype was entirely female that have female external genitalia. However, from the age of 6 months, clitoris was gradually increased to Os clitoris, and patients showed male behavior. Critical clinical sign was trauma of protruded Os clitoris. In radiographic and ultrasonographic examination, he had normal vagina and urinary bladder. In chromosome examination, he had an XY chromosome constitution. This case was performed removal of Os clitoris and ovariohysterectomy.

• 한국임상수의학회지
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• 제27권1호
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• pp.83-87
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• 2010

양성자(Hermaphroditism)는 사람과 동물에서 매우 드물게 발생단계의 이상으로 발생한다. 한국에서 개의 양성자 발생 보고는 6 사례가 있으며 그들 모두가 American Cocker Spaniel 품종이었다. 본 연구자들은 진돗개에서 발생한 양성자 사례를 발견하고 그 특징 분석과 병리조직학적 연구 및 분자생물학적 성별감별 연구를 수행하였다. 본 사례연구를 통하여 os clitoris와 ovotestes를 가지며 암컷 성을 가진 양성자 진돗개를 최초로 확인하고 보고하는 바이다.

• 한국수정란이식학회지
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• 제23권2호
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• pp.119-125
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• 2008

A 3-month-old American Cocker spaniel was presented at the Veterinary Teaching Hospital, Chungbuk National University, for examination of urinary tract after dissection of vaginal mass at local clinic before 10 days. Clinical examination of the affected bitch revealed a normal sized vulva in a normal anatomical position with a grossly enlarged clitoris, which contained an os clitoris. On examinations of the genital gland, there were testis, epididymis, ductus deferens and uterus. The histology of both gonads was primarily testis. Seminiferous tubules were divided into many parts by fibrous connective tissue. A small number of spermatogonia was present, but large numbers of Leydig's cells were existed. A normal female karyotype (78, XX) was detected in metaphase spreads obtained from cultured peripheral lymphocytes. Y chromosome specific sequences were not detected in genomic DNA by PCR. After 27 months, the os clitoris was larger than 3-month-old dog and os bone was more calcified than young age. Combining the results of cytogenetic, molecular genetic and histological examinations, the dog was diagnosed as a female hermaphrodite with Sry-negative XX sex reversal.

• 한국임상수의학회지
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• 제29권5호
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• pp.422-426
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• 2012

3세령 코커 스파니엘 개가 질의 종괴를 평가하기 위해서 내원하였다. 이 종괴는 방사선 상에서 음경골이 있는 음핵이 확인 되었다. 생식선과 확장된 음핵의 제거를 보호자에게 추천하였다. 수술적으로 제거하는 동안 정관과 자궁 둘 다 관찰 되었으며, 난소가 있어야 할 곳에서 정소형태의 생식선이 관찰 되었다. 조직병리학적인 평가에서 정상적인 자궁과 고환과 부고환조직, 정관이 확인 되었다. 핵형분석에서는 정상적인 암컷의 염색체 (78, XX)를 보였고, PCR에서 Sry 가 나타나지 않았다. 이 결과들을 바탕으로 본 환축은 Sry-negative XX 성전환으로 진단되었다.