Browse > Article

Disorder of Sexual Development in a Cocker Spaniel Dog: Sry-negative XX Sex Reversal  

Lee, Sung-Lim (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University)
Maeng, Geun-Ho (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University)
Kim, Na-Hyun (Department of Pathobiology, College of Veterinary Medicine, Konkuk University)
Park, Ki-Tae (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University)
Lee, Hee-Chun (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University)
Lee, Jae-Hoon (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University)
Publication Information
Journal of Veterinary Clinics / v.29, no.5, 2012 , pp. 422-426 More about this Journal
Abstract
A 3-year-old Cocker spaniel was presented for evaluation because of a mass protruding from the vulva. This mass confirmed the presence of an internal bone in clitoris on the radiography. We recommended to the owner of the surgical removal of the gonads and uterus as well as the excision of the enlarged clitoris and os clitoris. The dog had gonads in the region of where the ovaries were located and presented what appeared to be a bicornate uterus and ductus deferens. Histological analysis revealed a morphologically normal uterus and two testes with their epididymis and ductus deferens. Karyotyping revealed a normal female chromosome constitution (78, XX), and polymerase chain reaction (PCR) identified the absence of Sry. Based on these findings, the patient was diagnosed with Sry-negative XX sex reversal.
Keywords
XX sex reversal male; hermaphrodites; Sry-negative; dog;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Meyers-Wallen VN, Patterson DF. XX sex reversal in the American cocker spaniel dog: phenotypic expression and inheritance. Hum Genet 1988; 80: 23-30.   DOI   ScienceOn
2 Meyers-Wallen VN, Schlafer D, Barr I, Lovell-Badge R, Keyzner A. Sry-negative XX sex reversal in purebred dogs. Mol Reprod Dev 1999; 53: 266-273.   DOI   ScienceOn
3 Patel M, Dorman KS, Zhang YH, Huang BL, Arnold AP, Sinsheimer JS, Vilain E, McCabe ER. Primate DAX1, SRY, and SOX9: evolutionary stratification of sex-determination pathway. Am J Hum Genet 2001; 68: 275-280.   DOI   ScienceOn
4 Pereira ET, de Almeida JC, Gunha AC, Patton M, Taylor R, Jeffery S. Use of probes for ZFY, SRY, and the Y pseudoautosomal boundary in XX males, XX true hermaphrodites, and an XY female. J Med Genet 1991; 28: 591-595.   DOI
5 Rota A, Cucuzza AS, Iussich S, Delorenzi L, Parma P. The case of an Sry-negative XX male Pug with an inguinal gonad. Reprod Domest Anim 2010; 45: 743-745.
6 Sarafoglou K, Ostrer H. Clinical review 111: familial sex reversal: a review. J Clin Endocrinol Metab 2000; 85: 483-493.   DOI   ScienceOn
7 Selden JR, Moorhead PS, Koo GC, Wachtel SS, Haskins ME, Patterson DF. Inherited XX sex reversal in the cocker spaniel dog. Hum Genet 1984; 67: 62-69.   DOI   ScienceOn
8 Buijtels JJ, de Gier J, van Haeften T, Kooistra HS, Spee B, Veldhuis Kroeze EJ, Zijlstra C, Okkens AC. Minimal external masculinization in a SRY-negative XX male Podenco dog. Reprod Domest Anim 2009; 44: 751-756.   DOI   ScienceOn
9 Christensen BW. Disorders of sexual development in dogs and cats. Vet Clin North Am Small Anim Pract 2012; 42: 515-526.   DOI   ScienceOn
10 de la Chapelle A. The etiology of maleness in XX men. Hum Genet 1981; 58: 105-116.   DOI
11 Ergun-Longmire B, Vinci G, Alonso L, Matthew S, Tansil S, Lin-Su K, McElreavey K, New MI. Clinical, hormonal and cytogenetic evaluation of 46, XX males and review of the literature.: J Pediatr Endocrinol Metab 2005; 18: 739-748.
12 Jang G, Byeon YE, Kim MK, Koo OJ, Lee BC. Analysis of SRY-negative XX true Hermaphroditism in an English Cocker Spaniel. J Vet Clin 2008; 25: 221-223.
13 Kang JT, Kim HJ, Oh HJ, Hong SG, Park JE, Kim MJ, Kim MK, Jang G, Kim DY, Lee BC. SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer. J Vet Sci 2012; 13: 211-213.   DOI   ScienceOn
14 Koopman P, Gubbay J, Vivian N, Goodfellow P, Lovell- Badge R. Male development of chromosomally female mice transgenic for Sry. Nature 1991; 351: 117-121.   DOI   ScienceOn
15 Kuiper H, Bunck C, Gunzel-Apel AR, Drogemuller C, Hewicker-Trautwein M, Distl O. SRY-negative XX sex reversal in a Jack Russell Terrier: a case report. Vet J 2005; 169: 116-117.   DOI   ScienceOn
16 Matsuu A, Hashizume T, Kanda T, Nagano M, Sugiyama A, Okamoto Y, Hikasa Y. A case of persistent Mullerian duct syndrome with sertoli cell tumor and hydrometra in a dog. J Vet Med Sci 2009; 71: 379-381.   DOI   ScienceOn
17 Meyers-Wallen VN. Genetics of sexual differentiation and anomalies in dogs and cats. J Reprod Fertil Suppl 1993; 47: 441-452.