• The Korean Journal of Physiology and Pharmacology
• /
• v.14 no.6
• /
• pp.377-384
• /
• 2010

The present study examined whether metformin treatment prevents isoporterenol-induced cardiac hypertrophy in mice. Chronic subcutaneous infusion of isoproterenol (15 mg/kg/24 h) for 1 week using an osmotic minipump induced cardiac hypertrophy measured by the heart-to-body weight ratio and left ventricular posterior wall thickness. Cardiac hypertrophy was accompanied with increased interleukin-6 (IL-6), transforming growth factor (TGF)-${\beta}$, atrial natriuretic peptide (ANP), collagen I and III, and matrix metallopeptidase 2 (MMP-2). Coinfusion of metformin (150 mg/kg/24 h) with isoproterenol partially inhibited cardiac hypertrophy that was followed by reduced IL-6, TGF-${\beta}$, ANP, collagen I and III, and MMP-2. Chronic subcutaneous infusion of metformin did not increase AMP-activated protein kinase (AMPK) activity in heart, although acute intraperitoneal injection of metformin (10 mg/kg) increased AMPK activity. Isoproterenol increased nitrotyrosine levels and mRNA expression of antioxidant enzyme glutathione peroxidase and metformin treatment normalized these changes. These results suggest that metformin inhibits cardiac hypertrophy through attenuating oxidative stress.

• The Journal of Korean Orthopaedic Ultrasound Society
• /
• v.8 no.1
• /
• pp.11-15
• /
• 2015

A subperiosteal ganglion is a very rare benign soft tissue tumor characterized by mucoid degeneration and cyst formation within the periosteum, which may results in cortical erosion. When evaluating a periosteal mass in out-patient clinic, ultrasonography can be used to define the location and cystic nature of the subperiosteal ganglion. A 48 years old woman had two month history of the protruding mass over the anteromedial aspect of right proximal tibia. Ultrasonography was used for the diagnosis of the subperiosteal ganglion in out-patient clinic and mass was excised uneventfully. We report the case of a subperiosteal ganglion of the proximal tibia with literature review.

• The Journal of Korean Orthopaedic Ultrasound Society
• /
• v.8 no.1
• /
• pp.16-20
• /
• 2015

Glomus tumors are rare benign neoplasm commonly found in the subcutaneous layer on nail bed that arises from a neuromyoarterial glomus. Histologically, they are classified into three group; solid glomus tumor, glomangioma, and glomangiomyoma which is the most uncommon. Unlike other type, glomangiomyomas have rarely been described in the nail bed. Although glomus tumors are often diagnosed primarily by their characteristic clinical symptoms, imaging modalities, such as ultrasonography and magnetic resonance imaging can be helpful. We present a rare case of a recurrent subungal glomangiomyoma that diagnosed by ultrasonography and treated with surgical excision.

• The Journal of Korean Orthopaedic Ultrasound Society
• /
• v.7 no.2
• /
• pp.127-131
• /
• 2014

Skeletal muscles which are the largest part of human body may develop pain and dysfunction. The myofascial pain syndrome that has trigger points as a unique characteristic is a major cause of morbidity. Trigger points are focal, hyperirritable painful areas located in a taut band of skeletal muscle. They produce local area pain and a referred pattern pain and often accompany chronic joint dysfunction. Various modalities are used to inactivate trigger points in myofascial pain syndrome. Trigger-point injection has been shown to be one of the most effective treatment modality to provide prompt relief of symptoms. This review article presents general concept of myofascial pain syndrome and technique of trigger point injection.

• The Journal of Korean Orthopaedic Ultrasound Society
• /
• v.7 no.2
• /
• pp.132-137
• /
• 2014

We can test for small structures located at the surface layer as high resolution ultrasonic techniques and small probes were developed. Accordingly ultrasound became a useful tool in the diagnosis and treatment of wrist diseases. It is important to understand the anatomical structures and apply clinical features as well as these technical aspects when using ultrasound. The purpose of this article is to evaluate the usefulness and approach of ultrasound about typical diseases according to the area of the wrist pain.

• The Journal of Korean Orthopaedic Ultrasound Society
• /
• v.1 no.1
• /
• pp.40-49
• /
• 2008

Hip joint is one of the most deeply located joint in human body. Moreover, most clinical symptoms of various hip diseases are vague and confusing. In these reasons, the imaging modalities of hip have been extensively studied and developed. From a plain radiograph to more complex MR arthrography, various techniques are now available. In this brief review, the long and short of imaging modalities and clinical examples of common hip diseases will be introduced. The most important significance of diagnostic imaging is its clinical relevance. It is because when we know the characteristics of the imaging modalities and the disease itself, the optimal approach to a patient can be achieved, but when we do not know, the expensive images can only be a meaningless picture.

• The Journal of Korean Orthopaedic Ultrasound Society
• /
• v.1 no.1
• /
• pp.50-57
• /
• 2008

The anatomy which is the systemic understanding of a structure and the physical examinations which is the functional assessment of its role comprise the fundamental capability for a clinician providing medial care to the knee. This article provides the basic anatomy of the bones, meniscus, anterior and posterior cruciate ligaments, medial and lateral collateral ligaments, muscles, medial and lateral 3 layer concept, anterior and posterior aspect of the knee, bursae around the knee, and the physical examinations of the meniscus, medial and lateral collateral ligament, anterior and posterior cruciate ligament with posterolateral corner. The conceptual and systemic understanding of the anatomy and the physical examinations of the knee would be a compass or lighthouse for the physician providing medical care to the knee.

• The Journal of Korean Orthopaedic Ultrasound Society
• /
• v.1 no.1
• /
• pp.58-63
• /
• 2008

Mechanism of the peroneal tendon dislocation is mainly the ankle trauma and commonly caused by severe peroneal tendon contraction at ankle dorsiflexion state. Peroneal tendon tears are frequently combined in recurrent dislocation. The peroneal tendon dislocation from the fibula groove can be confirmed with ultrasound scanning. Recurrent dislocation needs surgical treatment and usually gains good clinical outcome with fibula groove deepening procedure. Tibialis anterior tendon rupture is frequently found in old age but active patients who had tendency of tendon weakness due to chronic tendon attrition, repeated steroid injection, diabetic tendinopathy or inflammatory arthropathy.

• The Journal of Korean Orthopaedic Ultrasound Society
• /
• v.1 no.1
• /
• pp.10-13
• /
• 2008

Purpose: To evaluate the efficiency of needling and injection technique without steroid for symptomatic calcific tendinitis of the shoulder. Material and Methods: We chose 12 symptomatic calcific tendinitis patients, whose ages ranged from 35 to 64. Procedure ware dry needling and injection of prolotherapic agent near the lesion. Results: All the case revealed prominent improvement without limitation of shoulder function, especially in active painful stage. Conclusion: Sonographic injection technique for calcific tendinitis would be one of the good modality not only for symptomatic relieve but also good functional recovery.

• The Journal of Korean Orthopaedic Ultrasound Society
• /
• v.1 no.1
• /
• pp.14-17
• /
• 2008

Meniscal extrusion is defined as a distance of 3 mm or more between the peripheral border of the meniscus and the edge of the tibial plateau on the coronal plane, associated with degeneration or tear of meniscus, effusion, osteophyte, osteoarthritis. There are many advantages of ultrasonography, including cost, dynamic real-time assessment. We evaluated a patient with anteromedial mass of the knee by ultrasonography, which was proved to be the extrusion of medial meniscus. We report a case of extrusion of medial meniscus evaluated by ultrasonography with review of the related literatures.