• Parasites, Hosts and Diseases
• /
• v.44 no.4 s.140
• /
• pp.313-320
• /
• 2006

In an effort to characterize, on the molecular scale, the Acanthamoeba initially isolated from the cornea of an amoebic keratitis patient associated with overnight-wear orthokeratology lens in Korea, we conducted mitochondrial DNA restriction fragment length polymorphism, 18S rDNA sequencing, and drug sensitivity analyses on the isolate (KA/PE1). The patient was treated with polyhexamethylene biguanide, chlorhexidine and oral itraconazole, which resulted in resolution of the patient's ocular inflammation. The majority of the molecular characteristics of the KA/PE1 were determined to be identical, or quite similar, to those of A. castellanii Ma strain, which had been isolated also from amoebic keratitis. The risk of Acanthamoeba keratitis as a potential complication of overnight orthokeratology is briefly discussed.

• Medical Lasers
• /
• v.10 no.4
• /
• pp.229-237
• /
• 2021

Background and Objectives To assess the effectiveness of overnight orthokeratology (OK) in myopia using a new contact lens design over a one-month wearing period. Materials and Methods Participants were required to have myopia between -3.00 and -7.50D and astigmatism ≤ 2.00 D to participate in the study. The participants underwent OK with the White OK lens^® (Interojo, Pyungtek, Korea), which has a 6-curve lens design. Participants were assessed at weeks 1, 2, and 4 using slit-lamp bio-microscopy, and tested for refraction, uncorrected distance visual acuity, and corneal topography. Success was defined as achieving a Logarithm of the Minimum Angle of Resolution (logMAR) ≤ 0.1. Results A total of 46 eligible subjects with a mean age of 23.11 ± 7.89 years were recruited. Baseline logMAR was 1.18 ± 0.30 and a consistent decrease in logMAR was observed from week 1 to week 4. The success rate was 95.35% at week 4. The mean sphere significantly decreased from a mean pre-fitting value of -4.58 ± 1.28 D to a mean value of -0.65 ± 0.69 D at week 4 (p < 0.0001). Statistically significant corneal flattening was detected during keratometry at week 4. Conclusion Overnight OK with the White OK lens is effective for the correction of moderate and high myopia with astigmatism over a one-month wearing period.

• Journal of Korean Clinical Health Science
• /
• v.8 no.1
• /
• pp.1386-1397
• /
• 2020

Purpose: To examine the effectiveness of various treatments; bifocal spectacles, orthokeratology, atropine, and time spent in outdoors; in slowing down the myopia progression for Asian adolescents (6-18age). Methods: The research focused on examining the most effective treatment in controlling myopia based on the literature sources that have been published. Through meta-analysis of various research papers that already has been done in this field, a lot of data was collected. For each treatment, the difference in axial length and spherical equivalent over time was measured and recorded. To quantitatively record the difference, both axial length and spherical equivalent was determined by value of control group value of treatment group. The paper compared the effectiveness of each treatment based on the data that was measured. Results: Adolescents who chose to spend time outdoors in order to slow down myopia progression had axial length difference of 0.03 mm and spherical equivalent difference of 0.17 D. Adolescents that used atropine had axial length difference of 0.36 mm and spherical equivalent difference of 0.92 D. Bifocal spectacle resulted in axial length difference of 0.21 mm and spherical equivalent difference of 0.59 D, and for orthokeratology 0.23 mm and 0.04 D, respectively. Axial length wise, myopia was most controlled by the atropine since there was a greatest difference between the group that got the treatment and the group that did not have the treatment. According to the spherical equivalent difference data, myopia was most controlled by atropine. Conclusion: Atropine showed the most effective result in controlling myopia among the four treatment. Again, compared to other three treatment, using atropine appeared to have greatest ability in slowing down myopia progression since adolescents who were treated with atropine had greatest difference from adolescents in the control group that had the same condition but didn't get the treatment. However, every treatment was only used for 2 or 3 years which is quite short time period to measure the long term effect of the four treatments. Also, since atropine is a pharmaceutical method to control myopia, it may harm adolescents' eyes compared to optical or environmental treatment.

• Journal of The Korean Ophthalmological Society
• /
• v.59 no.11
• /
• pp.1009-1016
• /
• 2018

Purpose: To assess the effect on axial elongation and associated factors between spectacles and of orthokeratology lens (OK) wearing in children with mild to moderate myopia. Methods: A total of one hundred subjects, ranging in age from 6 to 13 years, and with mild to moderate myopia no more than -4.50 diopters in spherical equivalent, visited our clinic from 2013 to 2015. The OK group (75 eyes) and the spectacles group (64 eyes) were compared and analyzed on the axial elongation and associated factors. Results: In the OK group, axial length was elongated in 1 year period with a mean increase of $0.24{\pm}0.29mm$. In spectacles group, axial length was elongated in 1 year period with a mean increase of $0.42{\pm}0.20mm$. The statistically significant suppression of axial elongation was observed in OK group compared to the spectacles group (Mann-Whitney U test, p < 0.05). For OK group, the age of starting OK (Pearson's correlation, r = -0.481, p < 0.05) was the only influencing factor on axial elongation, which had negative correlation with axial elongation. In spectacles group, the age of starting spectacles had negative correlation with axial elongation (Pearson's correlation, r = -0.462, p < 0.05) and baseline spherical equivalent, spherical diopter, cylindrical diopter from manifest refraction had positive correlation with axial elongation. Comparison of axial elongation in orthokeratology lens group and spectacles group by age groups (6 to 9 years [28 eyes], 9 to 13 years [47 eyes]), 9 to 13 years of orthokeratology lens group had the stronger suppression of axial elongation (Mann-Whitney U test, p < 0.05). Conclusions: The OK effectively suppresses axial elongation compared to the spectacles. Although the patients are in age from 9 to 13 years, the axial elongation was effectively suppressed.

• Journal of Korean Ophthalmic Optics Society
• /
• v.13 no.4
• /
• pp.65-73
• /
• 2008

Purpose: The purpose of this study is to investigate the effect of age in the response to long-term overnight orthokeratology (OK) lens wearing. Methods: Among volunteers, ninety-five healthy subjects who had no eye diseases and could wear OK contact lens at least for 8 hours every day were divided into three groups children, youngsters and young adults. Unaided logMAR visual acuity, refractive error, apical corneal radius, corneal asphericity and central corneal thickness were measured with different period; before and after one day, one week, two weeks, one month, three months and six months of OK lens wear. Paired student t-test, ANOVA analysis and Pearson correlation were used with a critical p value of 0.05 for statistical analysis. Results: All groups showed statistically significant (p<0.001) improvement in unaided visual acuity, a trend for flattening in the apical corneal radius, decrease in central corneal thickness and less prolate after OK lens wear. The child group showed significantly rapid change (p<0.001) in visual acuity, and apical corneal radius showed that they reached the targeted refractive change earlier compared with youngster and adult groups. The visual effect of OK lens was significantly related with the change in central corneal thickness after long-term OK lens wear, especially in child and youngster group, and central corneal thickness were highly correlated with the targeted refractive change. Conclusions: Visual acuity change is statistically correlated with the central corneal thickness change, which is highly correlated with targeted refractive change in the long-term orthokeratology and younger lens wearers showed a rapid response to OK lens wear, suggesting a reduced epithelial response with increasing age. The results found this study extends our understanding and development in the long-term orthokeratology.

• Journal of Korean Ophthalmic Optics Society
• /
• v.14 no.3
• /
• pp.7-15
• /
• 2009

Purpose: To investigate the corneal recovery after discontinuing orthokeratology (OK) lenses wear in children for long-term period. Methods: Among the OK lens wearers who wear over 8 months and showed successful refractive correction, 25 subjects were selected who want to discontinue the OK lenses. Uncorrected visual acuity, refractive correction, corneal curvature (Sim K), central corneal thickness and corneal eccentricity were measured during the OK lens wearing period and after discontinuation for 1 month. Results: Uncorrected visual acuity and corneal shape had remodeled significantly during the OK lens wear and recovered significantly during the first week of discontinuation. Uncorrected visual acuity and refractive correction had achieved full recovery 2 weeks after discontinuation of lens wear and were highly correlated with the changes in corneal thickness. But corneal shape recovered slowly, eccentricity had recovered fully after 1 month and corneal curvature and central thickness had not been achieved full recovery until 1 month after discontinuation. Conclusions: Recovery of after longterm use of OK lens is rapid for refractive change, but slow for corneal curvature and central thickness that to refit the contact lenses, practitioners need patience.

• Journal of Korean Clinical Health Science
• /
• v.3 no.2
• /
• pp.372-377
• /
• 2015

Purpose: The aim of this study is to compare total high order aberrations between surgery which uses TransPRK and general laser assisted sub-epithelial keratomileusis. Methods: The patients who had general laser assisted sub-epithelial and TransPRK laser assisted sub-epithelial by visiting ophthalmic clinic in Ulsan from January 2014 to August 2014 was researched. Results: When comparing total high order aberrations before and after operation, it was found that total high order aberration in general laser assisted sub-epithelial group increased to $0.222{\pm}0.078{\mu}m$ from $0.074{\pm}0.019{\mu}m$ while that in TransPRK assisted sub-epithelial group increased to $0.179{\pm}0.045{\mu}m$ from $0.076{\pm}0.032{\mu}m$. When comparing the increment in total high order aberrations between two groups after surgery, it was found that the increments of TransPRK assisted sub-epithelial group were statistically smaller than that of general laser assisted sub-epithelial group (p<0.05). Conclusions: This study made a comparative analysis of total high order aberrations between general laser assisted sub-epithelial and TransPRK assisted sub-epithelial which was introduced recently and the result showed a significant difference. The findings of this study suggest that TransPRK assisted sub-epithelial can be used widely in simply improving eye sight and quality of vision by reducing an increase in high order aberration caused by orthokeratology surgery. It is expected that TransPRK assisted sub-epithelial will be helpful for improving the understanding quality of eye sight which occurs by several methods of vision correction surgery.

• Journal of Korean Ophthalmic Optics Society
• /
• v.12 no.2
• /
• pp.1-12
• /
• 2007

Object of this research is to estimate the effect of myopia correction and safety on reverse geometry contact lens fitting in school children. This research include 53(106eyes) schoolchildren among 7 to 18 years who has low to moderate myopia(-1.00D~-5.00D) and prescribed reverse geometry contact lens for purpose on orthokeratology between January to July 2004 and had 3months full follow up examination. They were tested for slit lamp examinations, BUT(Break up time), direct ophthalmoscopy, retinoscopy, uncorrected visual acuity, best corrected visual acuity, autorefraction, autokeratometry and corneal topography in each examination(1day, 1week, 2weeks, 1, 2, and 3months) of before-and-after lens wearing to find out the effect of myopic correction and side effect. The results came out as follow. The average of uncorrected visual acuity was $0.0938{\pm}0.378$ before lens wear and $0.3136{\pm}0.283$ after 1day lens wear, and there was fast improvement after 1week($0.7925{\pm}0.301$) and little improvement after 2weeks period but still they shows better uncorrected visual acuity(p<0.01). The result of this study, the reverse geometry lens is very useful to correct refractive error and control the progression of myopia temporally among low to moderate myopic patient. The side effects were relatively rare but further study should be necessary with long term lens wear effect on eye health. For the lens prescription, the clinical fitting process had higher rate of success with consideration of eccentricity and corneal topography.

• Journal of Korean Ophthalmic Optics Society
• /
• v.18 no.3
• /
• pp.271-277
• /
• 2013

Purpose: The purpose was to study the corneal refractive power changes associated with the wearing of everted silicone hydrogel soft lenses. Methods: The corneal refractive power and corneal astigmatism were measured using corneal topographer (CT-1000, Shin-nippon Co., Japan) for checking change of corneal refractive power and objective refractive error was measured by auto-refractometer (Natural vision-K 5001, Shin-nippon Co., Japan). We measured at baseline and 1 week after lens wearing. Results: The correcting of corneal refractive power could be effective in low myopia. It's more effective to the higher power of greatest meridian of cornea and the more corneal astigmatism. 73% of subjects' refractive error was decrease less than 1 D and 17% of the subjects had an reverse effect (increase) occurs. The reduction of objective refractive error was more effective when cornea refractive power was great or corneal astigmatism was much. Conclusions: Pressure which the everted silicone hydrogel lens to the cornea could be caused. It occurred as the degrees of corneal power, corneal astigmatism and objective refractive error differences. Selection of an appropriate subject is important considering difficulty of changing the parameters of the lens.