• Allergy, Asthma & Immunology Research
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• v.10 no.6
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• pp.628-647
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• 2018

Purpose: Obesity is associated with metabolic dysregulation, but the underlying metabolic signatures involving clinical and inflammatory profiles of obese asthma are largely unexplored. We aimed at identifying the metabolic signatures of obese asthma. Methods: Eligible subjects with obese (n = 11) and lean (n = 22) asthma underwent body composition and clinical assessment, sputum induction, and blood sampling. Sputum supernatant was assessed for interleukin $(IL)-1{\beta}$, -4, -5, -6, -13, and tumor necrosis factor $(TNF)-{\alpha}$, and serum was detected for leptin, adiponectin and C-reactive protein. Untargeted gas chromatography time-of-flight mass spectrometry (GC-TOF-MS)-based metabolic profiles in sputum, serum and peripheral blood monocular cells (PBMCs) were analyzed by orthogonal projections to latent structures-discriminate analysis (OPLS-DA) and pathway topology enrichment analysis. The differential metabolites were further validated by correlation analysis with body composition, and clinical and inflammatory profiles. Results: Body composition, asthma control, and the levels of $IL-1{\beta}$, -4, -13, leptin and adiponectin in obese asthmatics were significantly different from those in lean asthmatics. OPLS-DA analysis revealed 28 differential metabolites that distinguished obese from lean asthmatic subjects. The validation analysis identified 18 potential metabolic signatures (11 in sputum, 4 in serum and 2 in PBMCs) of obese asthmatics. Pathway topology enrichment analysis revealed that cyanoamino acid metabolism, caffeine metabolism, alanine, aspartate and glutamate metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, pentose phosphate pathway in sputum, and glyoxylate and dicarboxylate metabolism, glycerolipid metabolism and pentose phosphate pathway in serum are suggested to be significant pathways related to obese asthma. Conclusions: GC-TOF-MS-based metabolomics indicates obese asthma is characterized by a metabolic profile different from lean asthma. The potential metabolic signatures indicated novel immune-metabolic mechanisms in obese asthma with providing more phenotypic and therapeutic implications, which needs further replication and validation.

• Korean Journal of Remote Sensing
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• v.11 no.3
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• pp.1-21
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• 1995

The characteristics of the Asian summer monsoon have been investigated for the periods of 1993/1994, the contrasting years in a view of the summer monsoon precipitation. In order to investigate the monsoon features over the eastern Asian monsoon region, the cloudiness(using the extensive data derived by the geostationary meteorological satellite), the condition of underlying surface including sea-surface temperature, and the summer rainfall are analyzed and some comparisons with 1993 and 1994 are also made and the characteristic differences are discussed. An analysis of the 2-degree latitude-longitude gridded 5-day mean high cloud amount data shows the detailed movement and persistence of the convective activities. In order to describe the spatial and temporal structures of the intraseasonal oscillation for the movement and evolution of the monsoon cloud, the extended empirical orthogonal fnction analysis with the twenty-day window size is used for the each year. Also, in order to find out the periodicity of the equatorial convective cluster, Fourier harmonic analysis is applied to the each year. The most prevailing intraseasonal oscillations of high cloud amount are 61 day mode and 15day mode in the equatorial and the subtropical oceans. However it was found that the most prevailing modes over the equatorial western Pacific and Indian Ocean were different for each year, hence raising the possibillity that the contrasting monsoon presipitation may be more fundamentally related to the interaction of intraseasonal oscillations and seasonal variation of convective activities over the lower latitude ocean.

• Ecology and Resilient Infrastructure
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• v.8 no.4
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• pp.253-265
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• 2021

In this study, crop cultivation filed was extracted by using Unmanned Aerial Vehicle (UAV) imagery and deep learning models to overcome the limitations of satellite imagery and to contribute to the technological development of understanding the status of crop cultivation field. The study area was set around Chungbuk Goesan-gun Gammul-myeon Yidam-li and orthogonal images of the area were acquired by using UAV images. In addition, study data for deep learning models was collected by using Farm Map that modified by fieldwork. The Attention U-Net was used as a deep learning model to extract feature of UAV in this study. After the model learning process, the performance evaluation of the model for corn cultivation extraction was performed using non-learning data. We present the model's performance using precision, recall, and F1-score; the metrics show 0.94, 0.96, and 0.92, respectively. This study proved that the method is an effective methodology of extracting corn cultivation field, also presented the potential applicability for other crops.

• Ecology and Resilient Infrastructure
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• v.8 no.2
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• pp.88-96
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• 2021

In surface image velocimetry, a wide area of a river is photographed at an angle to measure its velocity, inevitably causing image distortion. Although a distorted image can be corrected into an orthogonal image by using 2D projective coordinate transformation and considering reference points on the same plane as the water surface, this method is limited by the uncertainty of changes in the water level in the event of a flood. Therefore, in this study, we developed a tilt image correction technique that corrects distortions in oblique images without resetting the reference points while coping with changes in the water level using the geometric relationship between the coordinates of the reference points set at a high position the camera, and the vertical distance between the water surface and the camera. Furthermore, we developed a distortion correction method to verify the corrected image, wherein we conducted a full-scale river experiment to verify the reference point transformation equation and measure the surface velocity. Based on the verification results, the proposed tilt image correction method was found to be over 97% accurate, whereas the experiment result of the surface velocity differed by approximately 4% as compared to the results calculated using the proposed method, thereby indicating high accuracy. Application of the proposed method to an image-based fixed automatic discharge measurement system can improve the accuracy of discharge measurement in the event of a flood when the water level changes rapidly.

• Translational and Clinical Pharmacology
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• v.25 no.2
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• pp.67-73
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• 2017

Glimepiride, a third generation sulfonylurea, is an antihyperglycemic agent widely used to treat type 2 diabetes mellitus. In this study, an untargeted urinary metabolomic analysis was performed to identify endogenous metabolites affected by glimepiride administration. Urine samples of twelve healthy male volunteers were collected before and after administration of 2 mg glimepiride. These samples were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and then subjected to multivariate data analysis including principal component analysis and orthogonal partial least squares discriminant analysis. Through this metabolomic profiling, we identified several endogenous metabolites such as adenosine 3', 5'-cyclic monophosphate (cAMP), quercetin, tyramine, and urocanic acid, which exhibit significant metabolomic changes between pre- and posturine samples. Among these, cAMP, which is known to be related to insulin secretion, was the most significantly altered metabolite following glimepiride administration. In addition, the pathway analysis showed that purine, tyrosine, and histidine metabolism was affected by pharmacological responses to glimepiride. Together, the results suggest that the pharmacometabolomic approach, based on LC-MS/MS, is useful in understanding the alterations in biochemical pathways associated with glimepiride action.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.6
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• pp.14-18
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• 2019

The conductivity of a semiconductor is primarily determined by the carriers. To achieve higher conductivity, the number of carriers should be high, and an energy trap level is created so that the carriers can cross the forbidden zone with low energy. Carriers have a crystalline binding structure, and interfacial mismatching tends to make them less conductive. In general, high-concentration doping is typically used to increase mobility. However, higher conductivity is also observed in non-orthogonal conjugation structures. In this study, the phenomena of higher conductivity and higher mobility were observed with space charge limiting current due to tunneling phenomena, which are different from trapping phenomena. In an atypical structure, the number of carriers is low, the resistance is high, and the on/off characteristics of capacitances are improved, thus increasing the mobility. ZTO thin film improved the on/off characteristics of capacitances after heat treating at $150^{\circ}C$. In charging and discharging tests, there was a time difference in the charge and discharging shapes, there was no distinction between n and p type, and the bonding structure was amorphous, such as in the depletion layer. The amorphous bonding structure can be seen as a potential barrier, which is also a source of space charge limiting current and causes conduction as a result of tunneling. Thus, increased mobility was observed in the non-structured configuration, and the conductivity increased despite the reduction of carriers.

• Tunnel and Underground Space
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• v.29 no.3
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• pp.172-183
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• 2019

The generalized Hoek-Brown (GHB) failure criterion developed by Hoek et al. (2002) is a nonlinear function which defines a stress condition at failure of rock mass. The relevant strength parameter values are systematically determined using the GSI value. Since GSI index is a value quantifying the condition of in-situ rock mass, the GHB criterion is a practical failure condition which can take into the consideration of in-situ rock mass quality. Considering that most rock mechanics engineers are familiar with the linear Mohr-Coulomb criterion and that many rock engineering softwares incorporate Mohr-Coulomb criterion, the equations for the equivalent friction angle and cohesion were also proposed along with the release of the GHB criterion. The proposed equations, however, fix the lower limit of the minor principal stress range, where the linear best-fitting is performed, with the tensile strength of the rock mass. Therefore, if the tensile stress is not expected in the domain of analysis, the calculated equivalent friction angle and cohesion based on the equations in Hoek et al. (2002) could be less accurate. In order to overcome this disadvantage of the existing equations for equivalent friction angle and cohesion, this study proposes the analytical formula which can calculate optimal equivalent friction angle and cohesion in any minor principal stress interval, and verified the accuracy of the derived formula.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.30 no.3
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• pp.229-235
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• 2019

The implementation of an in-band full-duplex wireless communication system is demonstrated in this study. In the analog/RF domain, the self-interference(SI) signal is reduced using a separate antenna for the transmitter and receiver paths, and most of the SI signal is canceled in the digital domain. A software defined radio(SDR) is used to implement the in-band full-duplex wireless communication system. The USRP X310 device uses transmitting and receiving antennas. By adjusting the gain of the transmitting and receiving ends of the SDR device, the magnitude of the SI signal entering the receiving antenna, and the size of the received signal from the outside, are both set to -64 dB. To verify the in-band full-duplex wireless communication performance, the source data is image and orthogonal frequency-division multiplexing is used for modulation. A WiFi standard frame with a carrier frequency of 2.67 GHz and bandwidth of 20 MHz is used. In the received signal, the SI signal is canceled by digital signal processing and the SI signal is attenuated by up to 34 dB. OFDM demodulation was impossible when the SI signal was not removed. However, the bit error rate is reduced to $2.63{\times}10^{-5}$ when the SI signal is attenuated by 34 dB, and no error is detected in the 100 Mbit data output as a result of passing through the Viterbi decoder.

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.1
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• pp.161-171
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• 2021

This paper presents the findings of a comparative study on minimum weight design and sensitivity evaluation using different experimental design methods for the structural design of an active-type deck support frame (DSF) developed for the float-over installation of an of shore plant topside. The thickness sizing variables of the structural members of a passive-type DSF were considered the design factors, and the output responses were defined using the weight and strength performances. The design of the experimental methods applied in the comparative study of the minimum weight design and the sensitivity evaluation were the orthogonal array design, Box- Behnken design, and Latin hypercube design. A response surface method was generated for each design of the experiment to evaluate the approximation performance of the design space exploration according to the experimental design, and the accuracy characteristics of the approximation were reviewed. Regarding the minimum weight design, the design results, such as numerical costs and weight minimization, of the experimental design for the best design case, were evaluated. The Box- Behnken design method showed the optimum design results for the structural design of the passive-type DSF.

• Animal Bioscience
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• v.35 no.11
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• pp.1675-1688
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• 2022

Objective: Pregnant Nelore heifers (n = 417) were used to evaluate the effects of supplementation with monensin-molasses multinutrient block (B) during pre and/or postpartum on reproductive and progeny performance. Methods: Heifers were allocated in four treatments: i) CC: heifers received control supplement (C) in loose meal form (0.06% of body weight [BW] offered daily before and after parturition; n = 108); ii) CB: received C before parturition and B (0.07% of BW offered weekly after parturition; n = 117); iii) BC: received B before and C after parturition (n = 103) and iv) BB: received B before and after parturition (n = 89). During pre and postpartum periods, concentration of metabolites/hormones and cow/calf performance was evaluated over time. Cows were synchronized twice for fixed timed artificial insemination (FTAI) using an estradiol/progesterone-based protocol. Data was analyzed by orthogonal contrasts (C). Results: B increased pregnancy at first FTAI (p = 0.04) and overall pregnancy rate (C1: CC vs BB+BC+CB; p = 0.05). Supplemented cows had greater body condition score (BCS) only at parturition (D0; p = 0.04) and at D40 (p = 0.02). B increased BW (p = 0.03), glucose concentrations (p = 0.01) and subcutaneous fat thickness (p = 0.03) only at D40. Concentrations of insulin were higher in supplemented cows (p = 0.008). Calves born by cows supplemented before and after parturition (C2: BB vs BC+CB) were heavier at 80 (p<0.001), 120 (p<0.001), 170 (p = 0.002) and 210 (p = 0.02) days old. Conclusion: Regardless of period of treatment, block supplementation increased pregnancy at first FTAI and overall pregnancy rate. Additionality, block supplementation during both pre and postpartum periods improved progeny weight until weaning. Block supplementation can be a tool to optimize fertility and calf performance in Nelore primiparous cows.