• 한국약용작물학회지
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• 제13권4호
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• pp.138-140
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• 2005

천문동 (Asparagus cochinchinesis (Lour.) Merr.)의 기내생장과 증식의 가능성을 검토하기 위하여 신초의 유기, 생장 및 발근에 적합한 배지, 식물생장조절제, 배양온도를 검정한 결과를 요약하면 다음과 같다. MS 기본배지에 3.0 mg/l BA 처리시 신초의 유기 및 생장이 가장 양호하였으며 MS 기본배지에 0.5 mg/l IBA 처리가 발근에 가장 효과적이었고 기내배양 온도는 $23{\sim}25^{\circ}C$가 적합하였다.

• 동아시아식생활학회지
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• 제15권6호
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• pp.700-706
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• 2005

We are concerned about how to apply the theories of oriental medicine appropriately, which direction should it be taken, and how it should be developed. And it is believed to be essential for the government to make efforts to set a standard and laws to validate the medicinal effects and process of the assessment so that the systematic development can be encouraged, and to prepare guidance for the food development for national health improvement Ihis study was peformed to provide basic data that predict the usefulness of oriental medicinal herbs to remove the dampness through diuresis for excess syndrome obesity with oriental diet therapy cuisine(Yak-Sun). Five oriental medicininal herbs, Coix lachryma-jobi L, Atractylodes lancea DC., Ligusticum wallichii F., Angelica sinensis D., Zingiber officinale R. were collected and made into mixing extracts(OMCE). And we examined the effects of OMCE on body weight serum glucose, insulin and lipid profile improvement in rats fed high fat diets. Sprague-Dawley rae(230-250 g) were randomly divided into five groups : basal diet(normal diet control group, NCG), only high fat diet(High fat control group, HCG), high fat diet and supplemented with 25mg/100g body weight 50mg/100g body weight 75mg/100g body weight by OMCE(HLG, HMG, HHG). These experimental diets were fed for 6 weeks. The OME fed groups decreased more significantly in weight serum glucose insulin and lipids than the high fat control group did. These results imply that the OMCE can be used as a safe and clinically applicable ingredients for diet called Yaksun of excess syndrome obesity in human.

• 동아시아식생활학회지
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• 제13권3호
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• pp.176-184
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• 2003

This experiment was planned to develop a functional supplements by food resources to prevent and lessen the bad effects caused by the environmental pollution such as bad food, air, water and heavy metals exposed to people these days. As for Its primary stage, the nutrient profile and sensory characteristics of the duck-extract were evaluated in this study. The duck-extract was formulated by the mixture of bone and internal organs of ducks and 6 medicinal herbs which were able to be used as foods and known to help the excretion and the repression of the poison inside the body for a long time. As we compared the six medicinal herbs mentioned above to the vegetable herbs, the nutrient profile of the medicinal herbs were superior to the vegetable herbs. The duck-extract was composed of protein 49.92%, carbohydrate 37.02%, dietary fiber 20.99%, lipid 7.60% and ash 5.46%. The ratio of Ca to P was 1 : 1.4, which was a suitable ratio for absorption, the contents of Na and K were low and those of micro-elements such as Fe, Mn, Zn and Cu high compared to other meat extracts. The essential amino acids accounted for 30.91% of total amino acids. The result of sensory evaluation was better in overall preferences than the ones which are already in the market. From these results, the nutrient profile of the duck-extract was estimated to be able to supply enough nutrients to the people whose nutritional balance was destroyed these days. This study also showed the effective way of using duck-extract and its application to the oriental medicine.

• 생명과학회지
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• 제20권6호
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• pp.922-928
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• 2010

한방 생약재로부터 안전하면서도 신규의 항혈전제를 개발하기 위해, 현재 국내에서 유통되고 있는 국내 및 국외산 한방 생약재 33종을 대상으로 40종의 에탄올 추출물을 조제하고, 이들의 thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (aPTT)을 평가하였다. 생약재중 중국산은 28종으로 대부분이 국외산이었으며, 부위별로는 종자 및 뿌리 부위가 19종을 차지하였다. 평균 수분함량은 $6.85{\pm}2.26%$, 평균 추출율은 $5.27{\pm}4.25%$를 나타내었다. 조제된 시료의 TT평가 결과, 사인(중국), 고본, 팔각향, 계지, 당삼, 계혈등, 행인, 오배자, 괄루근 및 포황에서 우수한 트롬빈 저해활성을 확인하였으며, 다양한 농도에서 평가 결과 계혈등, 행인, 팔각향, 계지, 오배자 추출물 순으로 트롬빈 저해능이 강력함을 확인하였다. PT 평가 결과 오배자, 계혈등, 행인에서, aPTT 평가결과 오배자 및 계혈등에서 우수한 항혈전능을 확인하였다. 한편 추출물의 인간적혈구 용혈활성을 평가한 결과, 계혈등, 팔각향, 계지, 오배자 추출물은 $500\;{\mu}g/ml$ 농도에서도 용혈활성이 없음을 확인하여 이들 4종을 최종 선정하였다. 본 연구결과는 이미 대량생산이 확립된 한방생약제로부터 우수한 항혈전제 개발이 가능함을 제시하고 있으며, 트롬빈 및 혈장 응고 인자에 대한 특이 저해제 개발이 가능함을 제시하고 있다.

• Advances in Traditional Medicine
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• 제9권1호
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• pp.1-13
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• 2009

Medicinal herbs are significant source of synthetic and herbal drugs. In the commercial market, medicinal herbs are used as raw drugs, extracts or tinctures. Isolated active constituents are used for applied research. For the last few decades, phytochemistry (study of plants) has been making rapid progress and herbal products are becoming popular. According to Ayurveda, the ancient healing system of India, the classical texts of Ayurveda, Charaka Samhita and Sushruta Samhita were written around 1000 B.C. The Ayurvedic Materia Medica includes 600 medicinal plants along with therapeutics. Herbs like turmeric, fenugreek, ginger, garlic and holy basil are integral part of Ayurvedic formulations. The formulations incorporate single herb or more than two herbs (poly-herbal formulations). Medicinal herb contains multitude of chemical compounds like alkaloids, glycosides, saponins, resins, oleoresins, sesquiterpene, lactones and oils (essential and fixed). Today there is growing interest in chemical composition of plant based medicines. Several bioactive constituents have been isolated and studied for pharmacological activity. R. cordifolia is an important medicinal plant commonly used in the traditional and Ayurvedic system of medicine for treatment of different ailments. This review illustrates its major constituents, pharmacological actions substantiating the claims made about this plant in the traditional system of medicine and its clinical applications.

• 대한본초학회지
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• 제24권4호
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• pp.31-37
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• 2009

Objectives : The rapid progress seen in the Chinese medical and pharmaceutical industries since the mid.Ming Dynasty, and the resulting surge in demand for medicinal herbs led to the emergence of dedicated medicinal herb markets. A representative example was the medicinal herb market of Qizhou (today's Anguo) in Hebei Province. This paper examines various factors that contributed to the transformation and growth of Qizhou into and as a major medicinal herb market of China. Methods : Along with the examination of geographical factors, this study attempts to link the development of Qizhou as a center for medicinal herbs trade with legends related to the Medicine Lord Temple (Yao Wang Miao), a local shrine dedicated to the mythical Medicine Kings. Results : The main argument of this study is that although the emergence of Qizhou as China's largest marketplace for medicinal herbs was significantly helped by its proximity to Beijing, a huge source of demand, as well as its convenient location easily accessible from all parts of the country, and the large herbal production from surrounding areas, the single.most important contributing factor was the body of legends attributing to this city a magical healing energy. Conclusions : The example of Qizhou may also suggest that in pre.modern eras, legends related to supernatural healing power, associated to a city or town, were as important contributing factors to its emergence and growth as a dedicated medicinal herb market as its location or ease of access.

• 동아시아식생활학회지
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• 제18권1호
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• pp.104-110
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• 2008

This research was designed and implemented to evaluate how the composition of yaksuncha can affect the health of individuals suffering from diet-related diseases such as obesity and hyperlipidemia by prescribing Yaksun as a nutritional supplement with daily meals. The yaksunucha was prepared as Koekac, Sansa, Heshouwu and Woolong tea and the tea's effects on serum lipids and oxidative stress were evaluated by clinical procedures. The yaksuncha significantly increased HDL-cholesterol and decrease of LDL-cholesterol concentrations in serum. It also had significant effects on decreasing oxidative stress and homocystein levels. The physical characteristics of the yaksunucha were also examined, showing. Brix, pH and titratable acidity values of 1.4, 5.50 and 0.05% respectively. It is thought that scientific and objective evaluations were completed on the components of the yaksuncha prescription. Thus one can concluded that the components could be applied not only in the form of tea, but also various food. The data derived from this study provides basic information that will aid in the application of oriental medicinal resources to other foods as well as facilitate the study of medicinal herbs within the field of functional food research, which already draws sizable attention worldwide.

• 동의생리병리학회지
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• 제21권3호
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• pp.596-604
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• 2007

For countless time, many have been made in our oriental medicine. To understand such prescription and to use, we must study the monarch(jun), minister(chen), adjuvant(zou) and guide(shi) theory that is most of the prescription structure principle's the basis. The monarch is the center of the prescription. Two kind is greatly in the method to select the monarch, in the prescription. One method is that a medicinal herb of the high class of medical herb of the Sinnong's Classic becomes the monarch, and the other method is a medicinal herbs which there is most many qunantity in the prescription becomes the monarch. Additionally, a medicinal herbs name of a prescription name can become the monarch. The minister assist the monarch and this is a criteria of the prescription grouping with the monarch. The minister has close relation with the monarch. The adjuvant helps the monarch and the minister nature of drug or restains. So this makes the prescription effectiveness act accurately. The guide does the activity to help the harmony of the prescription and the activity to help the prescription to act in correct place. If we understand the monarch, minister, adjuvant and guide theory well, we have some advantage. The interpreting of the prescription comes to De easy. and, an application range of the prescription is enhanced. the increase and decrease of the medicinal herbs comes to be easy in the prescription. Finally that theory will be used for the principle to make new prescription.

• 대한본초학회지
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• 제26권1호
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• pp.111-117
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• 2011

Objectives : The present study was designed to investigate effects of mixed extract from korean medicinal herbs (MIX) on oxidation/reduction reaction-related and aging-related enzyme in vitro. Methods : We performed MTT assay, collagenase inhibition assay, elastase inhibition assay, tyrosinase inhibition assay, DPPH free radical scavenging assay, SOD-like activity and xanthine oxidase inhibition assay. Results : Recently, many studies have reported that elastin is also involved in inhibiting or repairing wrinkle formation, although collagen is a major factor in the skin wrinkle formation. The MIX showed 97% inhibition of collagenase activity, and 64% inhibition of elastase activity at 1 mg/ml concentration of MIX, next only to positive control, which indicate good efficacy for anti-wrinkle ingredient. Also it's treatment showed 34% inhibition of tyrosinase activity, to relate whitening effect, at the same dose of MIX. Antioxidant activities were determined by DPPH radical scavenging, xanthine oxidase (XO) inhibiting activity and SOD-like activity. Also these scavenging, XO-inhibiting and SOD-like activities were measured in 91%, 80%, and 63% inhibition, respectively, at a treated dose of 1 mg/ml, compare to control. Conclusions : These results suggest that possibility of mixed korean medicinal herbs as a functional ingredient for anti-wrinkle and whitening, anti-oxidation and anti-aging cosmetic formula.

• 한국한의학연구원논문집
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• 제3권1호
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• pp.67-83
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• 1997

In order to search for anti-influenza virus type A agents from Korean medicinal herbs, we selected 100 medicinal herbs, based on a review of the Korean traditional medicine books. Four of 100 Korean medicinal herbs, MM-40, MM-55, MM-63, MM-110, exhibited very strong anti-influenza virus activity. The fractions of four medicinal herbs, which had very strong anti-influenza virus activity, were tested for antiviral activity by means of Haemagglutination inhibition test(HTT), 40% MeOH fraction of MM-40, $H_2O$ fraction of MM-55, 20% fraction of MM-63 3nd $H_2O$ fraction of MM-110 had strong anti-influenza virus activity at the range of $78{\mu}g/ml$ to $156{\mu}g/ml$, 1.56mg/ml to 100mg/ml, 6.25mg/ml to 50mg/ml and $48.7{\mu}g/ml$ to $780{\mu}g/ml$, respectively. These results of HIT indicated that fractions of Korean medicinal herbs might inhibit either attachment of virus to cell surface receptor or penetration of virus into cell during the initial stage of infection. In the cytotoxicity of fractions against red blood cells, 40% MeOH fraction of MM-40, 20% fraction of MM-63 and $H_2O$ fraction of MM-110 showed cytotoxicity at the range of $78{\mu}g/ml$ to 10mg/ml, 50mg/ml to 100mg/ml and $195{\mu}g/ml$ to 100mg/ml, respectively, whereas $H_2O$ fraction of MM-55 did not show cytotoxicity. In order to establish influenza virus adapted animal model, influenza virus type A were passaged 3 and 4 times successively in Balb/c mouse. As a result, we had 4 HA unit titers on the 5 days of 3rd passages and 7 days of 4th passages after infection, respectively.