• 한국방사선학회논문지
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• 제7권6호
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• pp.427-431
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• 2013

본 연구의 목적은 특발성 척추 측만증 환자를 대상으로 요가 운동 요법을 통하여 척추 측만각도 즉 요추 Cobb's angle의 정도를 분석하여 요가 운동 프로그램이 특발성 척추 측만연구에 어떠한 영향을 미치는지의 효과를 알아보는데 있다. 본 연구의 요가 운동 프로그램은 척추주변의 근육들의 지나친 긴장을 풀고 이완된 근육은 수축운동을 통하여 유연성과 탄력을 회복하여 운동 시 주동근과 길항근의 균형을 맞추고 협력근과의 조화로운 상태가 척추측만에 도움될 것으로 판단하여 골반운동과 척추 비틀기 운동을 중심으로 실시하였다. 실험대상은 광주광역시 소재 C병원에서 특발성 척추 측만증 진단을 받은 여자 중학생을 대상으로 하여, 요가 운동 프로그램으로 주5일, 1일 60분, 12주간 실시하여 요가 운동프로그램이 특발성 척추 측만증 변화에 미치는 영향을 알아보고자 실시하였다. 실험 전, 후 방사선을 통하여 요추의 Cobb's angle을 측정하여 효과를 검증하였다. 첫째, 요가 및 척추 전문가와 함께 연구하여 동작을 추축하였다. 둘째, 개발된 척추측만증에 대한 요가 운동 프로그램을 특발성 척추 측만증을 갖고 있는 여중생에게 12주간 실시하였다. 셋째, 특발성 척추 측만증에 대한 요가 운동 프로그램에 대한 타당성과 효과를 검증하였다. 그 결과 운동 전보다 5도가 통계적으로 유의하게 감소하여 (p=0.006)특발성 척추 측만증이 개선되었다.

• 대한한의학회지
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• 제38권2호
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• pp.61-72
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• 2017

Objectives: The effects of Gamiondam-tang (GMODT) co-administration within 5min on the pharmacokinetics (PK) of tamoxifen were observed as a process of the comprehensive and integrative medicine, combination therapy of tamoxifen with GMODT to achieve synergic pharmacodynamics and reduce toxicity on the breast cancer. Methods: After 50mg/kg of tamoxifen treatment, GMODT 100mg/kg was administered within 5min. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of GMODT treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen (Tmax, Cmax, AUC, $t_{1/2}$ and $MRT_{inf}$) were analysis as compared with tamoxifen single administered rats using noncompartmental pharmacokinetics data analyzer programs. Results: Co-administration with GMODT induced increased trends of plasma tamoxifen concentrations to 1hr after end of administration, and then showed decreased trends of plasma tamoxifen concentrations, and especially significant (p<0.05) increases of plasma tamoxifen concentrations were demonstrated at 0.5hr after end of co-administration with GMODT and also related significant (p<0.05) decreases of $AUC_{0-inf}$ and $MRT_{inf}$ as compared with tamoxifen single formula treated rats, at dosage levels of tamoxifen 10 mg/kg and GMODT 100 mg/kg within 5 min, in this experiment. Conclusion: Based on the results of the present study, it is considered that single co-administration GMODT within 5min significantly inhibited the oral bioavailability of tamoxifen through variable influences on the absorption and excretion of tamoxifen, can be influenced on the toxicity or pharmacodynamic of tamoxifen.

• KSBB Journal
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• 제23권2호
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• pp.109-117
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• 2008

담자균류의 버섯은 대부분 영양생장단계의 균사체와 포자를 형성하는 생식생장단계인 자실체로 나누어진다. 그러나 자연산 상황버섯은 자연계에서의 분포수가 극히 적어 그 자실체를 얻기 어려우며, 이러한 희귀성으로 인해 매우 고가로 거래되고 있다. 1990년대 중반 상황버섯은 균사체 배양기술과 인공재배법이 확립된 후 농가에서 대량생산되기 시작하였으며, 이에 따라 상황버섯의 유효성분을 이용한 기능성 식품 및 의약품의 개발이 활발하였다. 그러나 인공재배법에 의한 상황버섯 추출물은 자연산 추출물의 항암 및 효능면에서 차이를 나타내고 있어, 자연산 자실체와 같은 수준에서의 약효를 나타내기 위한 인공배양기술과 고농도 유효성분을 획득하기 위한 추출법이 핵심기술로 대두되었고, 인공배양된 상황버섯과 자연산의 다각도적인 약효 비교에 관한 연구가 아직까지 진행되고 있다. 따라서 상황버섯의 유효성분이 높게 함유된 저렴한 추출물이 생산될 수 있는 기반 기술들이 기능성 음료용수, 식품 및 의약품으로 개발에 중요한 핵심기술로 떠오르고 있다. 국내 상황버섯 기능성 식품의 시장은 상황버섯의 효능에 대한 인지 증대, 웰빙열풍을 의한 건강 음료에 대한 선호도 증대 등으로 인해 향후에도 10% 이상의 높은 성장률을 보일 것으로 예상된다. 현재는 중소기업들이 주로 활동하고 있어 마케팅 및 유통의 한계로 인해 시장이 크게 확대되고 있지 않으나, 사업매력도가 긍정적으로 평가되고 있어 대기업에서도 상황버섯을 이용한 기능성 식품 시장에의 진출을 모색하고 있다.

• 대한예방한의학회지
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• 제21권2호
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• pp.127-137
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• 2017

Objectives : In our previous study, single co-administration GMODT within 5 min significantly inhibited the oral bioavailability of tamoxifen through variable influences on the absorption and excretion of tamoxifen. Therefore, the object of this study was to elucidate the possible effects on the pharmacokinetics of tamoxifen after single oral co-administration of GMODT with 2.5 hr-intervals. Methods : After 50 mg/kg of tamoxifen treatment, GMODT 100 mg/kg was administered with 2.5 hr-intervals. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of GMODT treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen (Tmax, Cmax, AUC, $t_{1/2}$ and $MRT_{inf}$) were analysis as compared with tamoxifen single administered rats. Results : Two-half hr-interval co-administration with GMODT induced variable changes on the plasma tamoxifen concentrations as compared with tamoxifen single treated rats, and especially significant (p<0.05) increases of plasma tamoxifen concentrations were demonstrated at 0.5 (199.61%) and 1 hr (101.06%) after end of co-administration with GMODT, and also related significant (p<0.05) decreases of $t_{1/2}$ (-39.54%) and $MRT_{inf}$ (-43.94%) as compared with tamoxifen single formula treated rats, at dosage levels of tamoxifen 50 mg/kg and GMODT 100 mg/kg with 2.5 hr-intervals, in this experiment. Conclusions : According to the results, GMODT critically decreased on the oral bioavailability of tamoxifen through variable influences on the absorption and excretion of tamoxifen. Hence, the co-administration of GMODT and tamoxifen should be avoided in the comprehensive and integrative medicine, combination therapy of tamoxifen with GMODT on the breast cancer.

• Journal of Acupuncture Research
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• 제37권1호
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• pp.49-58
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• 2020

Background: This study aimed to investigate the clinical effectiveness of treatment of Korean medicine on superior labrum anterior to posterior (SLAP) lesions. Methods: A total of 55 inpatients diagnosed with SLAP lesions by magnetic resonance imaging, were investigated from May 1^st, 2014 to May 31^st, 2019 at Haeundae Jaseng Hospital of Korean Medicine. The patients were sorted by gender, age, causing factor, illness duration, period of hospitalization, SLAP lesion type, complications, and treatments. Treatments included acupuncture, pharmacopuncture, Chuna therapy, herbal treatment, and physiotherapy. After treatment, the Numeric Rating Scale, Shoulder Pain and Disability Index, and European Quality of Life 5-Dimension questionnaire were used to evaluate treatment effect. Results: There were more males than females in this study (1:0.83). Patients were more likely to be in their 50s (38.18%), have an unknown etiology (70.91%), and be in the subacute disease stage (41.82%). According to the SLAP lesion type, most of the inpatients had Type 2 lesions (69.09%). For inpatients diagnosed with SLAP lesions, the mean shoulder numeric rating scale score decreased from 5.55 ± 0.90, to 4.07 ± 1.18 (p < 0.001), the mean Shoulder Pain and Disability Index score decreased from 50.35 ± 18.36, to 39.90 ± 19.34 (p < 0.001), and the mean European quality of life 5-dimension index increased from 0.70 ± 0.16, to 0.75 ± 0.13 (p < 0.01) after treatment. Conclusion: Treatment of Korean medicine effectively decreased pain and increased the quality of life of the patients with SLAP lesions in this study.

• 한방안이비인후피부과학회지
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• 제29권2호
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• pp.12-32
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• 2016

Objectives : The objective of this study is to develop the strategies of the psoriasis clinical trials guideline on Korean medicine by comparison between Clinical guidelines and domestic and foreign clinical trials papers of psoriasis on Korean medicine. Methods : This study is based on analysis of papers on Clinical trials guidelines, Clinical practice guideline and clinical trials about Korean medicine. The papers were searched from Pubmed, Medline, Oasis(Oriental Medicine Advanced Searching Integrated System), Korean Traditional Knowledge Portal and Google portal database. Results : A total 8 Clinical practice guidelines and 2 Clinical trials guidelines were found. Moreover, there were 15 foreign papers about clinical trials and 29 internal articles about case studies. They suggested the diagnostic strategy, classification, effective outcome measure, severity measure, precaution of combination therapy, precaution and treatment period of clinical trials, safety evaluation, patterns of Korean Medicine, clinical specific features on psoriasis.Conclusions : The criteria of every item to provide the clinical trials guideline using Korean medicine on psoriasis were developed by apply the results. If we accumulate the more clinical articles on Korean medicine, it will be great help to develop the reliable standard of that guideline.

• 생명과학회지
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• 제17권11호
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• pp.1492-1496
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• 2007

CD40L를 발현하는 KU812세포와 CD40를 발현하는 항원 특이적 B 세포의 배양을 통해 IgE 클라스 스위치가 유도된다. 본 연구자는 체외면역법에 의해 건강인의 말초혈액을 이용하여 쌀 알레르겐 특이적 IgM 항체를 생성하는 B 세포주를 수립하였다. 본 연구에서는 KU812세포에 의한 쌀 알레르겐 특이적 IgE 항체의 유도를 시도하였다. 배양 전, 쌀 알레르겐 특이적 B 세포주, RA9G11과 PMA와 ionomycin을 6시간 처리하여 활성화된 KU812세포에서 CD40와 CD40L 발현량을 flow cytomerty를 통화여 각각 확인하였다. RA9G11세포와 활성화된 KU812세포는 높은 수준의 CD40와 CD40L를 각각 발현하였다. 쌀 알레르겐 특이적 IgE항체 합성 유도를 위해, 여러 가지 농도의 IL-4 존재하에, RA9G11세포와 활성화된 KU812세포를 12일 동안 배양하였다. IgE 정상영역의 mRNA 발현량과, 쌀 알레르겐 특이적 IgE 항체 생성 세포가 모든 조건에서 확인되었으며, 특히 50U의 L-4 농도 하에서 같은 비율의 RA9G11과 활성화된 KU812세포를 배양했을 때, IgE 합성이 가장 높았다. 따라서 활성화된 KU812세포에 의한 쌀 알레르겐 특이적 IgE 합성은 알레르기 질환의 치료 및 예방에 관한 연구에 기여할 것으로 사료된다.

• 한국병원경영학회지
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• 제8권2호
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• pp.70-92
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• 2003

The main objective of this paper is to investigate the factors affecting organizational citizenship behavior of hospital employees, and based on the investigation, to suggest some implications for effective human resources management of hospitals. For this purpose, physical therapists were selected as the subject of the research. Using their individual characteristics, job characteristics, professionalism and group cohesiveness as the variables affecting organizational citizenship behavior, an empirical model was constructed and tested. A survey was conducted through structured and self-administered questionnaire for the physical therapists working at hospitals of Busan-Kyongnam area, and data from 240 therapists were utilized in the final analysis. Major results of the empirical analysis are as follows: First, perception on professionalism and the degree of organizational citizenship behavior were higher for male, older, relatively more-educated and higher-grade employees. It is necessary to develope some measures to educate and motivate the employees who are in lower state of professionalism and organizational citizenship behavior. Second, among the individual characteristics, need for growth was found to have significant, positive influence on professionalism and group cohesiveness, but no direct effect on organizational citizenship behavior. On the other hand, extroversion had direct, positive effect on organizational citizenship behavior, as well as on professionalism and group cohesiveness. This result suggests that personnel selection and personality education should be conducted carefully. Third, job characteristics appeared to have very large, positive effect on professionalism, but not directly on organizational citizenship behavior. Fourth, professionalism was found to have very large, positive influence on group cohesiveness and direct, positive effect on organizational citizenship behavior. This implies that enhancing professionalism of physical therapists can strengthen organizational citizenship behavior in hospitals, and hence top management should actively support the programs for job re-design, skill education and quality improvement to enhance professionalism of their employees. Fifth and last, as an intervening factor, group cohesiveness appeared to have the largest, direct, positive effect on organizational citizenship behavior. It is, therefore, important for top management to improve group cohesiveness by exploring ways toward greater harmony and solidarity among the members of physical therapy department.

• 동의생리병리학회지
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• 제23권6호
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• pp.1332-1340
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• 2009

Moxa-combustion therapy makes use of heat stimulus and chemicals result form when cauterize the skin with moxa cones to medical cares. Despite an extensive evidence-base guiding the selection of stimulation parameters and attributes of subject, little methodologically research regarding the attributes of moxa cautery in need to provide effective stimulation. To determine moxibustion's effects of the three different moxa cautery made by three different company(as A, B, C), the small intestinal motility in rats were observed after moxibustion at ST36. Under anesthesia, each intensities(1, 5, 10 times), two regions(left and right at ST36) and a quantity(as number of 1, 5, 10 times at once) were applied to the groups divided with sex. In each intensities groups, the A product made increase with 5, 10 times in male and female group. The B and C product made increase with 10 times in male group and the B product made increase with 1, 5, 10 times and the C product made increase with 5 times in female group. In two regions(left and right at ST36) groups, the A and C product made increase with 1(right), 5(right) times and the B product made increase with 1(left), 10(left), 10(right) times in male group. In female group, the A product made increase with 5(left), 5(right), 10(right) times and the B product made increase with 1(left), 10(left), 10(right) times and the C product made increase with 5(left), 10(left) times. In a quantity(as number of 1, 5, 10 times at once) groups, the A and B product did not show any changes but the C product made increase with a quantity of 10 times in male group. In female group, The B product made increase with a quantity of 1 times and the C product made increase with a quantity of 5 times, but the A product did not show any changes. Three different moxa cautery made by three different company made differents result in each group divided with sex. With these results, it was suggested that we should consider the a process of manufacture and moxa cautery's quality for the adequate value of moxibustion.

• Applied Microscopy
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• 제29권2호
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• pp.163-175
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• 1999

본 실험은 화상을 입은 생쥐에서 SQ의 치유 효과를 알아보기 위함에 있다. 실험군은 7개군으로 구분하였다; 대조군, 화상군, 그리고 화상을 입헌 후 SQ를 처치한 군. 대조군을 제외한 모든 군은 등 부위에 2도 화상을 입혔다. SQ를 처치한 모든 군은 하루에 한 번씩 10초 간격으로 순수한 SQ 3방울을 도포하였다. 화상 후 10일 동안 조직학적 및 미세구조적 변화를 광학 현미경과 전자현미경으로 관찰하였다. 광학현미경으로 관찰한 결과, 화상군의 표피층의 모든 부분은 SQ를 처치한 군보다 더 심한 상처를 입었다. SQ를 처치한 6째와 10일째 군에서, 기저층은 분화가 활발하였고, 가시층의 각화세포는 수적으로 매우 증가하였다. 전자현미경으로 관찰한 결과, SQ를 처치한 모든 군의 기저층에서 세포분열이 화상군에서보다 더 활발하게 나타났다. 특히, SQ를 처치한 10일군에서는 이상적인 결과를 얻을 수 있었다; 대조군보다 더 두꺼운 가시층과 많은 각화세포, 뚜렷한 세포간교, 그리고 멜라닌세포를 포함하는 튼튼한 기저층. 이와 같은 결과로 보아 SQ은 표피성장인자(EGF)를 활성화시키고, 유해산소의 제거 역할을 하며, 막계에 에너지원을 제공할 가능성이 있다. 이 실험의 결과는 SQ가 화상 치료에 특수한 효과가 있다고 사료된다.