• 대한한의학회지
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• 제17권2호
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• pp.58-72
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• 1996

I. PURPOSE AND SIGNIFICANCE OF RESEARCH The presentation of research direction for compositive study and application of oriental medicine is urgently demanded. Since there is few investigation for the interest in basic and clinical field of oriental medicine, and we hope that compositive study and concentrative research between instruction in college and local clinics is established by this research. II. RESEARCH CONTENT ${\cdot}$ Analysis of survey in basic field of oriental medicine as instruction curriculum. ${\cdot}$ Analysis of survey in clinical field of oriental medicine as the classification of disease. III. RESULT The result of investigation shows that the most interested field is acupuncture and moxibustion in clinical field and diagnostics in basic field of oriental medicine. And oriental medicinal clinic doctors are concerned about prescription and a newly-developed techniques such as new acupuncture therapy, new machines. They hope that a study of oriental medicine in clinical field be accomplished with the special clinics as leader. According to the previous results, we can work out the foundation of compositive study and concentrative research between instruction in college and local clinics, and on this ground it is considered that we can grope for the presentation of research direction of local clinics.

• 동국한의학연구소논문집
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• 제6권2호
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• pp.109-133
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• 1998

근래 들어 악성종양의 발병률은 점점 상승하고 있으며 소화기암은 전체 악성종양중 높은 발생빈도를 보이는 질병으로 한의학계에서도 치료를 위해 많은 연구를 하고 있다. 소화기암의 증후와 치료에 관하여 열격, 반위(反胃), 적취(積聚), 장독(臟毒)을 위주로 명(明) 청대(淸代)까지의 역대(歷代) 문헌(文獻)을 통해 고찰(考察)한 결과 이는 복강내 악성종양과 증후에 있어서 유사성을 나타내며 치료는 초기에는 거사법(祛邪法)을, 중기에는 공보겸시(攻補兼施)를, 후기에는 부정법(扶正法)을 위주로 하는 것으로 나타났다. 역대 문헌에서는 이에 대한 처방구성을 다양하게 언급하여 향후 소화기암 치료에 응용할 수 있을 것으로 사료(思料)된다.

• 혜화의학회지
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• 제16권1호
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• pp.31-40
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• 2007

Hominis placenta have been studied as herbal acupuncture because of it's limitation of use. The properties of Hominis placenta are warm and supplement of Jeong-Hyeol, Jin-Ki and I thought that Hominis placenta have various effectiveness. So I considered Hominis placenta in Dong-Eui-Bo-Gam which is famous comprehensive korean traditional medical book. Hominis placenta was mentioned parts of Sin, Chung, Hwa, Heo-Ro, Bu-In and most of them are mentioned in Heo-Ro part. As a source book, Eui-Hak-Ib-Mun was used the most. Prescription used in various parts as mental disease, forgetfulness, tuberculosis, fever, various malnutrition disease, sterility, but it's basic principle action is all supplement of Heo-Ro. In management of Hominis placenta, most useing method is heating with steam and most of additional medicinal stuffs had action of supplying Eum, Yang, Ki, Hyeol in composition of prescription.

• 동의생리병리학회지
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• 제17권2호
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• pp.560-567
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• 2003

Antimetastatic effects of Agaricus mixed prescription (AMP) were studied in the respect of blood-borne metastasis. For this aim, cytotoxicity against various cancer cells and normal cells, Chicken Chorioallantoic membrane (CAM) assay, cancer cell adhesion assay, platelet aggregation assay, pulmonary colonization, life span of S-180 implanted mice, and cytokine release assay were evaluated, respectively. The results were summarized as follows; AMP did not exert any cytotoxicity against all cell lines with IC50 of 25mg/ml on B16BL6. AMP disrupted formation of CAM at 1mg/ml. AMP was suppressive in adhesion assay of B16BL6. AMP also inhibited tumor induced platelet aggregation. In pulmonary colonization assay by B16BL6, the number of colonies in the lungs was significantly decreased in sample group than in control group. In animal study with S-180, the life span of AMP treated group was extended than that of control group. IL-12 was effectively increased in AMP treated group in cytokine release assay. Taken together, AMP can be possibly applied to cancer or metastasis.

• 한국한의학연구원논문집
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• 제9권2호
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• pp.95-105
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• 2003

Kami-honghwa-tang(KH-19) is a prescription for reducing the side effect of radiotherapy. In this study, safety of KH-19 was evaluated by GLP guideline of Korea Food and Drug Administration. In acute oral toxicity study on rat, transient inhibition of weight increase was shown, but change in general symptom was not detected. No dead animal was observed up to 5,000 mg/kg in both male and female animals. In acute oral toxicity study on Beagle dog, transient vomiting, diarrhea, anorexia, and weight reduction was observed. However, no dead animal was observed up to 2,000 mg/kg in both male and female animals.

• 동의생리병리학회지
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• 제24권3호
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• pp.367-372
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• 2010

The purpose of this study is to make a basis of in vivo or clinical study about alopecia. We investigated the prescriptions of alopecia by researching oriental medicine literature. We found the prescriptions used for alopecia. And we surveyed the frequency and classification of the herbs used for alopecia. The results of this study were recorded as follows. The most frequently used single herbs in the prescriptions were Angelicae Gigantis Radix(當歸), Glycyrrhizae Radix(甘草), Poria(茯笭), Paeoniae Radix Alba(白芍藥). Herbs specifically frequently used in the prescriptions of alopecia were as follows. Polygoni Multiflori Radix(何首烏), Rehmanniae Radix(生地黃), Cuscutae Semen(菟絲子), Bupleuri Radix(柴胡), Scutellariae Radix(黃芩), Viticis Fructus(蔓荊子), Aconiti Iateralis Preparata Radix(附子). Herbs frequently used were classified by property. The result was as follows. (()-The number of herbs) 補益藥(32), 解表藥(18), 淸熱藥(15) 收澀藥(9), 活血祛瘀藥(8), 利水滲濕藥(8).

• 동의생리병리학회지
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• 제17권2호
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• pp.326-337
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• 2003

In order to evaluate the prevention effect of Sunkiwhajung-tang (SWT) which has been used as a traditional prescription for the treatment of digestive disease in Korea on the gastric ulcer induced by indomethacin in rats, the changes of number and size of ulcerative lesions, parietal, chief, Grimelius and Serotonin-positive cells in the peri-ulcerative tissues were detected with histological examinations of ulcerative and peri-ulcerative lesions after oral injections of SWT extracts (125, 250 and 500 mg/kg, respectively). SWT prevented to a great extent the expected indomethacin-induced elevation in hemorrhagic ulcerative lesions, the number and size of ulcerative lesions, and the number of parietal cell, chief cell, Grimelius-positive cells and Serotonin-positive cells in the peri-ulcerative lesions in a dose dependent manner. These results provide a story evidence that SWT produced an protective effect on gastric ulcer induced by indomethacin. Determination of the specific mechanisms involved in the protective effect of SWT on the gastric ulcer will require additional study.

• 대한한의학방제학회지
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• 제10권2호
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• pp.159-188
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• 2002

The purpose of this study was to reseach the effect of Daehwanggamchoeumja(大黃甘草飮子) and its component groups on diabetes, free radicals, and antioxidants system in Alloxan-induced diabetic rats. The experimental group was divided into three groups: Daehwanggamchoeumja(DG), and its components groups, Gamdutang (Gamcho&Daedu; DG-I) and Daehwanggamchotang(DG-2). The results were obtained as follows: 1. In the study of effect on diabetic metabolic dysfunction(Glucose, Triglyceride, Total Cholesterol, HDL Cholesterol, Total Protein, Albumin, Creatine, BUN), only DG has a significant effect. 2. In the study on free radical scavenging effect in vitro(the suppressing effect on peroxidation of linoleic acid on concentration, the scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system, inhibitory effect on lipid peroxidation reaction by hydroxy radical in $H_2O_2Fe^{2-}$system, and the effect on Nitrate reductase activity), DG and DG-2 have more effect than DG-l relatively. 3. In the study on antioxidants system in vivo(The level of serum LPO, The level of hepatic LPO, Catalase, GSH, GST), only DG has a significant effect. These results suggest that Daehwanggamchoeumja(大黃甘草飮子) has an effect on diabetes, peroxidative damage by free radical, so it seems to be useful to prevent and treat diabetes. The mechanisms of these are supposed to be involved in antioxidant and three drugs' cooperative synergy effect.

• 의료법학
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• 제7권2호
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• pp.331-364
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• 2006

Medical supplies have contradiction of efficacy and side effect to the various diseases together. Therefore, people have tried to reduce the side effects and also provide various methods to cope with any damages from the medicine quickly. In the case of accidents by medical supplies, the victim can be protected with advantage by the Product Liability Law rather than the Torts. The limit of Product Liability Law's application depends on whether medical supplies belong to the product or not. According to Product Liability Law, the product should be processed. Therefore, medical supplied should be processed to be the category of product. It can be said that the medical supplies in pharmacy, Chinese medicine, medical herbs, biological medicine manufactures, blood manufactured medicine, cord blood, hemopoietic progenitior cell and stem cell belongs to the manufactured products. The mixture by the prescription of doctor or preparation of pharmacist can be recognized as the product because prescription or preparation is a manufacturing act. Therefore, applying Product Liability Law to manufacturer, doctor or pharmacist would achieve the goal which is protecting the victims extensively.

• 대한한의학방제학회지
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• 제17권1호
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• pp.75-83
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• 2009

Objective : The purpose of this study is to indicate of problems in statistical analysis method of "The Korean Journal of oriental Medical Prescription" and we will be proposed the useful application of the statistical analysis method. Methods : In this paper, we were analysed statistical analysis methodology from published journal articles "The Korean Journal of Oriental Medical Prescription" December, year 2000 to December, year 2008. We were investigated of problems in application of structured analysis methods those journal articles that including statistical analysis techniques and analysis methods. Results : 1. A random allocation of the experimental group and control groups are important factors in the planning process of statistical analysis. However, there are less explanation those journal articles. 2. There are no consideration in specimen size that there will be considerate by the level of significance and statistical test. 3. Many article authors were confused between parametric methods and non-parametric methods that they were applied parametric statistical analysis methods although inapplicable sample size. 4. There were applied the parametric methods consists of t-test instead non-parametric methods in the comparison of average intergroup relations. 5. There were less understanding posterior analysis and were confused with t-test. Conclusion : Our goal was to outline the key methods with a brief discussion of problems(statistical analysis methods), avenues for solutions. we recommend authors to use an appropriate statistical analysis methods for obtaining a more cautions results.