Korean Journal of Oriental Medicine (한국한의학연구원논문집)

Korean Institute of Oriental Medicine (한국한의학연구원)
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Acute Oral Toxicity Study of Kami-honghwa-tang

가미홍화탕의 단회 경구 투여 독성 연구

  • Sung, Hyun-Jea (Choongju Oriental Hospital, College of Oriental Medicine, Semyung University) ;
  • Moon, Geun-Ah (Korea Institute of Oriental Medicine) ;
  • Ryoo, Choong-Ryeol (College of Oriental Medicine, Dongshin University) ;
  • Yoon, Yoo-Sik (Choongju Oriental Hospital, College of Oriental Medicne, Semyung University)
  • 성현제 (세명대학교 한의과대학 충주한방병원) ;
  • 문근아 (한국한의학연구원) ;
  • 유충렬 (동신대학교 한의과대학) ;
  • 윤유식 (세명대학교 한의과대학 충주한방병원)
  • Published : 2003.12.30
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Abstract

Kami-honghwa-tang(KH-19) is a prescription for reducing the side effect of radiotherapy. In this study, safety of KH-19 was evaluated by GLP guideline of Korea Food and Drug Administration. In acute oral toxicity study on rat, transient inhibition of weight increase was shown, but change in general symptom was not detected. No dead animal was observed up to 5,000 mg/kg in both male and female animals. In acute oral toxicity study on Beagle dog, transient vomiting, diarrhea, anorexia, and weight reduction was observed. However, no dead animal was observed up to 2,000 mg/kg in both male and female animals.

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