Browse > Article

Prevention effect of Sunkiwhajung-tang, a prescription, on the gastric ulcer induced by indomethacin in rats  

Kim Sang Chan (Department of Pharmacology, College of Oriental Medicine, Kyungsan University)
Lee Dong En (Department of Pharmacology, College of Oriental Medicine, Kyungsan University)
Kwon Young Kyu (Department of Physiology, College of Oriental Medicine, Kyungsan University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 326-337 More about this Journal
Abstract
In order to evaluate the prevention effect of Sunkiwhajung-tang (SWT) which has been used as a traditional prescription for the treatment of digestive disease in Korea on the gastric ulcer induced by indomethacin in rats, the changes of number and size of ulcerative lesions, parietal, chief, Grimelius and Serotonin-positive cells in the peri-ulcerative tissues were detected with histological examinations of ulcerative and peri-ulcerative lesions after oral injections of SWT extracts (125, 250 and 500 mg/kg, respectively). SWT prevented to a great extent the expected indomethacin-induced elevation in hemorrhagic ulcerative lesions, the number and size of ulcerative lesions, and the number of parietal cell, chief cell, Grimelius-positive cells and Serotonin-positive cells in the peri-ulcerative lesions in a dose dependent manner. These results provide a story evidence that SWT produced an protective effect on gastric ulcer induced by indomethacin. Determination of the specific mechanisms involved in the protective effect of SWT on the gastric ulcer will require additional study.
Keywords
Sunkiwhajung-tang(順氣和中湯); gastric ulcer; indomethacin;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Changes in gastroduodenal 5-hydroxytryptamine-containing cells induced by dehydroleucodine. /
[ Penissi, A.;Mariani, L.;Souto, M.;Guzman, J.;Piezzi, R. ] / Cells Tissues Organs   DOI
2 Serotonin-containing EC cells in normal human gastric mucosa and in gastritis. Immunohistochemical, electron microscopic and autoradiographic studies. /
[ Ito, H.;Yokozaki, H.;Tokumo, K.;Nakajo, S.;Tahara, E. ] / Virchows Arch. A Pathol. Anat. Histopathol.   DOI
3 Comparative studies of serotonin-like immunoreactive cells in the digestive tract of vertebrates. /
[ El-Salhy M.;Winder E.;Lundqvist M. ] / Biomedical Res.   DOI
4 Immunohistochemical investigation of gastrin-producing cells (G cells). Estimation of antral density, mucosal distribution, and total mass of G cells in resected stomachs from patients with peptic ulcer disease. /
[ Stave R.;Brandtzaeg P. ] / Scand. J. Gastroenterol.   DOI
5 Difference between the effect of acute and chronic surgical vagotomy on the cytoprotective action of atropine against indomethacin-induced mucosal lesions on the gastrointestinal tract in rats. /
[ Karadi, O.;Bodis, B.;Szabo, I.;Rumi, G.;Mozsik, G. ] / J. Physiol. Paris   DOI
6 SU-840, a novel synthetic flavonoid derivative of sophoradin, with potent gastroprotective and ulcer healing activity. /
[ Brzozowski, T.;Konturek, S. J.;Kwiecien, S.;Pajdo, R.;Drozdowicz, D.;Sliwowski, Z.;Muramatsu, M. ] / J. Physiol. Pharmacol.
7 Effect of ebrotidine on ethanol-induced gastric mucosal damage in the rat. Comparative study with other H2-receptor antagonists. /
[ Palop, D.;Romero, A.;Villamayor, F.;Conejo, L.;Sacristan, A.;Ortiz, J. A. ] / Arzneimittelforschung
8 Gastric chief cell mass in duodenal ulcer. /
[ Perasso, A.;Testino, G.;Ansaldi, F. ] / Acta. Gastroenterol. Latinoam
9 Microcirculatory disturbance in indomethacin-induced intestinal ulcer. /
[ Miura, S.;Suematsu, M.;Tanaka, S.;Nagata, H.;Houzawa, S.;Suzuki, M.;Kurose, I.;Serizawa, H.;Tsuchiya, M. ] / Am. J. Physiol.
10 The effects of hange-shashin-to on gastric function in comparison with sho-saiko-to. /
[ Kase, Y.;Yuzurihara, M.;Iizuka, S.;Ishige, A.;Komatsu, Y. ] / Biol. Pharm. Bull.   DOI
11 A possible mechanism for the gastric mucosal protection by oren-gedoku-to (OGT), a traditional herbal medicine. /
[ Takase, H.;Imanishi, K.;Miura, O.;Yumioka, E. ] / Jpn. J. Pharmacol.   DOI
12 Comparative study of the effect of wei-yan-ning and furazolidone in the treatment of gastritis and gastric ulcer caused by pyloric Campylobacter. /
[ Zhang, B. M.;Song, X. R. ] / Zhong Xi Yi Jie He Za Zhi
13 /
[ 공정현 ] / 國譯 萬病回春
14 A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol-and indomethacin-induced gastric lesions in the rat. /
[ Chandranath, S. I.;Bastaki, S. M.;Singh, J. ] / Clin. Exp. Pharmacol. Physiol.   DOI
15 A silver nitrate staning for <TEX>$\alpha$</TEX>2-cells in human pancreatic islets. /
[ Grimelius L. ] / Acta. Soc. Med. Upsal.
16 /
[ Sternberger, L. A. ] / Immunocytochemistry
17 Secretory functions of the alimentary tract. /
[ Guyton, A. C.; Guyton, A. C.(Ed.) ] / Textbook of medical physiology
18 Changes in the intermediary glads of the gastric mucosa in peptic ulcer of different localization in morphometric interpretation. /
[ Azarenko, V. V.;Samsonov, V. A. ] / Arkh. Patol.
19 Chief cell mass after shot-term ranitidine treatment for duodenal ulcer. /
[ Testino, G. ] / Hepatogastroenterology
20 /
[ Banks, WJ ] / Applied veterinary histology
21 Anti-ulcer effect of the hot water extract of black tea (Camellia sinensis). /
[ Maity, S.;Vedasiromoni, J. R.;Ganguly, D. K. ] / J. Ethnopharmacol.   DOI
22 A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers. /
[ Amagase, K.;Okabe, S. ] / J. Physiol. Pharmacol.
23 Platelet-derived growth factor reverses the effects induced by NSAIDs on ulcer healing. /
[ Arceiz, E.;Lanas, A.;Ortego, J.;Sainz, R. ] / Eur. J. Gastroenterol. Hepatol.
24 Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats. /
[ Tsukimi, Y.;Nozue, C.;Okabe, S. ] / J. Gastroenterol. Hepatol.
25 Influence of prostaglandins, omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat. /
[ Inauen, W.;Wyss, P. A.;Kayser, S;Baumgartner, A.;Schurer-Maly, C. C.;Koelz, H. R.; Halter, F. ] / Gastroenterology
26 Alendronate induces gastric injury and delays ulcer healing in rodents. /
[ Elliott, S. N.;McKnight, W.;Davies, N. M.;MacNaughton, W. K.;Wallace, J. L. ] / Life Sci.
27 Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: protection by melatonin. /
[ Bandyopadhyay, D.;Biswas, K.;Bhattacharyya, M.;Reiter, R J.;Banerjee, R K. ] / Curr. Mol. Med.   DOI
28 Therapeutic effect of egualen sodium (KT1-32), a new antiulcer agent, on chronic gastritis induced by sodium taurocholate in rats. /
[ Mochizuki, S.;Matsumoto, M.;Wakabayashi, S.;Kosakai, K.;Tomiyama, A.;Kishimoto, S. ] / J. Gastroenterol.   DOI
29 Parietal cell hyperactivity is not due to Helicobacter pylori infection in patients with duodenal ulcer. /
[ Valenzuela, M.;Martin-Ruiz, J. L.;Cahallero-Plasencia, A M.;Alvarez-Cienfuegos, L.;Nogales, F. F.;Guilarte, J.; Pena, J. F. ] / Am. J. Gastroenterol.
30 Morphometric characteristics of fundal glands of the stomach in duodenal ulcer and pre-ulcer condition. /
[ Uspenskii, V. M. ] / Arkh. Patol.
31 Altered gastrin regulation in mice infected with Helicobacter felis. /
[ Dial, E. J.;Hall, L. R.;Romero, J. J.;Lechago, J.;Fox, J. G.;Lichtenberger, L. M. ] / Dig. Dis. Sci.   DOI
32 /
[ 何紹奇 ] / 現代中醫內科學
33 /
[ 李乾枸 ] / 中醫胃腸病學
34 /
[ 張介賓 ] / 景岳全書
35 태음조위탕의 궤양억제효능에 관한 연구 /
[ 박동언;김달래 ] / 사상의학회지
36 황기건종합이중탕이 항궤양 및 위장관 기능에 미치는 효과에 대한 실험적 연구 /
[ 성은미;백태현 ] / 대한한방내과학회지
37 가마귀비탕이 흰쥐의 위궤양에 미치는 영향 /
[ 백동진 ] / 한의학회지
38 Nitric oxide inhibitors ameliorate indomethacin-induced enteropathy in rats. /
[ Parasher, G.;Frenklakh, L.;Siddiqui, T.;Nandi, J.;Levine, R. A. ] / Dig. Dis. Sci.   DOI
39 Prostaglandin E prevents indomethacin-induced gastric and intestinal damage through different EP receptor subtypes. /
[ Kunikata T.;Araki H.;Takeeda M.;Kato S.;Takeuchi K. ] / J. Physiol.
40 TFF/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. /
[ Farrell, J. J.;Taupin, D.;Koh, T. J.;Chen, D.;Zhao, C. M.;Podolsky, D. K.;Wang, T. C. ] / J. Clin. Invest.   DOI
41 Protective effect of mannitol, glucose-fructose-sucrose -maltose mixture, and natural honey hyperosmolar solutions against ethanol-induced gastric mucosal damage in rats. /
[ Gharzouli, K.;Gharzouli, A.;Amira, S.;Khennouf, S. ] / Exp. Toxicol. Pathol.   DOI
42 Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage. /
[ Natale, G.;Lazzeri, G.;Blandizzi, C.;Gherardi, G.;Lenzi, P.;Pellegrini, A.;Del Tacca, M. ] / Toxicol. Appl. Pharmacol.   DOI
43 Permissive role of neutrophils in pathogenesis of indomethacin-induced gastric lesions in rats. /
[ Suzuki K.;Araki H.;Komoike Y.;Takeuchi K. ] / Med. Sci. Monit.
44 Mechanisms involved in enteropathy induced by administration of nonsteroidal antiinflammatory drugs (NSAIDs). /
[ Yamagiwa, S.;Yoshida, Y.;Halder, R. C.;Weerasinghe, A.;Sugahara, S.;Asakura, H.;Abo, T. ] / Dig. Dis. Sci.   DOI
45 Gastric mucosal cellular changes induced by indomethacin (NSAID) in male albino rats. /
[ Sagar, V.;Ahamed, R. N. ] / Indian. J. Exp. Biol.
46 /
[ 박경아;이원택;박미경;이종은 ] / 조직화
47 /
[ Ross MH;Romrell LJ;Kaye, GI ] / Histology a text and atlas
48 /
[ Jones, T.J.;Hunt, R.D. ] / Veterinary pathology
49 /
[ Lee, S. K.;Chi, J. G. ] / Color atlas of pathology
50 Effect of the antiulcer polysaccharide fraction from Bupleurum falcatum L. on the healing of gastric ulcer induced by acetic acid in rats. /
[ Matsumoto, T.;Sun, X. B.;Hanawa, T.;Kodaira, H.;Ishii, K.;Yamada, H. ] / Phytother. Res.
51 The antiulcer activity of Garcinia cambogia extract against indomethacin- induced gastric ulcer in rats. /
[ Mahendran, P.;Vanisree, A J.;and Shyamala Devi, C. S. ] / Phytother. Res.   DOI
52 Effect of Piper Iongum Linn, Zingiber officianalis Linn and Ferula species on gastric ulceration and secretion in rats. /
[ Agrawal, A K.;Rao, C. V.;Sairam, K.;Joshi, V. K.;Goel, R. K. ] / Indian J. Exp. Biol.
53 Investigations on the protective action of Condonopsis pilosula (Dangshen) extract on experimentally-induced gastric ulcer in rats. /
[ Wang Z.T.;Du Q.;XU G.J.;Wang R.J.;Fu D.Z.;Ng T.B. ] / Gen. Pharmacal.   DOI
54 Effects of a polysaccharide fraction from the roots of Bupleurum falcatum L. on experimental gastric ulcer models in rats and mice. /
[ Sun, X. B.;Matsumoto, T.;Yamada, H. ] / J. Pharm. Pharmacol.   DOI
55 Therapeutic effect of Oren-gedoku-to extract on stress-induced acute gastric mucosal lesions in rats. /
[ Ohta, Y.;Kobayashi, T.;Nishida, K.;Nagata, M.;Ishiguro, I. ] / Phytother. Res.   DOI
56 Preventive effect of Oren-gedoku-to(Huanglian-Jie-Du-Tang) extract on the development of stress-induced acute gastric mucosal lesions in rats. /
[ Ohta, Y.;Kobayashi, T.;Nishida, K.;Sasaki, E.;Ishiguro, I. ] / J. Ethnopharmacol.   DOI
57 Protective effects of Hange-shashin-to on water-immersion restraint stress-induced gastric ulcers. /
[ Li, J.;Takeda, H.;Inazu, M.;Hayashi, M.;Tsuji, M.;Ikoshi, H.;Takada, K.;Matsumiya, T. ] / Methods Find Exp. Clin. Pharmacol.   DOI
58 Effect of Saiboku-to, an Oriental Herbal Medicine, on gastric lesion induced by restraint water-immersion stress or by ethanol treatment. /
[ Yuzurihara, M.;Ikarashi, Y.;Kase, Y.;Torimaru, Y.;Ishige, A.;Maruyama, Y. ] / J. Pharm. Pharmacol.   DOI
59 Gastrin, gamma-endorphin and somatostatin cells of the stomach and duodenum in patients with duodenal ulcer treated with dalargin. /
[ Zverkov, L. V.;Vinogradov. V. A.;Bulgakov, S. A..;Smagin, V. G.;Shcherbakova, N. V. ] / Ter. Arkh.
60 Effects of 4-(4-bromophenyl)-2-methyl-1,2,3,4-tetrahydroiso-quinoline hydrochloride on acute gastric lesions, acid secretion in rats and on some hemodynamic parameters in cats. Methods Find. /
[ Atanassova, R.;Petkov, O.;Ivanov, C.;Valchanova, N.;Bozhikov, M. ] / Exp. Clin. Pharmacol.