• Journal of Acupuncture Research
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• 제22권3호
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• pp.113-122
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• 2005

한약복합처방(韓藥複合處方)의 경구 투여 및 약침 병용 시술이 STZ에 의해 유발된 생쥐의 당뇨병에 미치는 영향에 확인한 결과 다음과 같은 결론을 얻었다. 1. 한약복합처방(韓藥複合處方)의 경구 투여 및 약침 병용 시술이 STZ에 의한 혈청 중 insulin 함량에는 변화를 나타내지 않았으나 혈청 중 glucose 함량은 감소시켰다. 2. 한약복합여방(韓藥複合濾方)의 경구 투여 및 약침 병용 시술이 STZ에 의해 상승된 혈청 중 triglyceride 함량을 유의하게 감소시켰으나 혈청 중 total cholesterol 함량에는 영향을 나타내지 못했다. 3. STZ 투여로 인해 혈청 내 지질과산화물의 함량이 증가되었으나 한약복합처방(韓藥複合處方)의 경구 투여 및 약침 병용 시술은 이에 영향을 미치지 못 하였다. 4. STZ에 의해 증가된 catalase활성이 한약복합처방(韓藥複合處方)의 경구 투여 및 약침 병용 시술에 의해 감소되었으나, GSH의 활성에는 유의한 변화가 나타나지 않았다.

• 대한한의정보학회지
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• 제18권1호
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• pp.64-77
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• 2012

Donguibogam, Korea's cultural heritage and traditional Oriental medicine book listed in the World Heritage three years ago, is indeed great in its importance and value. Korea's posterity has sought treatment methods through the medical book and their researches on that book have continued. However, it is rare to make the concrete analysis on the medicines for prescriptions recorded in the book. In this study, we reviewed "Ears" in the Section "Bodily Appearance" among the five chapters of Donguibogam, and analyzed the 55 types of prescriptions for ear diseases, the medical characteristics, tastes, prime classification of medical herbs, and acupunctural effects, and the dosage forms depending on prescriptions. For insect-entering ear diseases and 20 kinds of a single-medicine prescription also, the treatments are presented in the book, but we presented the texts only and excluded them in the analysis. We also excluded overlapping prescriptions and adding and reducing prescriptions of the 55 prescriptions, and thus classified the left 42 proscriptions by dosage form. As a result: 1. With respect to medical characteristics, the medicine with warm characteristics reached 9 types(40.9%), the highest rate, followed by the medicine with cold characteristics 8 types (36.4%). 2. Concerning medical tastes, the medicine with bitter taste included 12 types (54.5%), the medicine with sour taste 10 types (45.5%), and the medicine with sweet taste 7 types (31.8%). It was unusual that of the 22 medicines used for multipurpose, no medicine with the taste was found. 3. For the acupunctural effects, the medicine with acupuncture effects for spleen medirian reached 12 types in total (54.5%). On the contrary, the medicine with the effects for pericardium meridian reached only one (4.5%) among the total of 22 medicines. 4. In the dosage form of 42 prescriptions, powder medicine was 15 types (35.7%), and decoction medicine was 14 (33.3%). Powder, dedoction, and pill medicines accounted for 90.4% of the total medicine type. It was found that in particular, for ear diseases powder medicine was used more frequently than decoction medicine.

• 생약학회지
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• 제37권2호통권145호
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• pp.103-109
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• 2006

Advanced glycation end products (AGEs) formation plays an important role in the progression of diabetic complications. To develop effective herbal formulations with suppression of diabetic nephropathy, a common complication in diabetic patients, we evaluated inhibitory activities of KIOM-79, a new herbal prescription, on the formation of AGEs using in vitro and in vivo model systems. Effects of KIOM-79 on the expression of AGEs, RAGEs (receptor for Advanced glycation end products), type IV collagen and renal $TGF-{\beta}1$ mRNA was also examined in streptozotocon (STZ)-induced diabetic rats. STZ-induced diabetic rats were treated orally with KIOM-79 (250 and $500\;kg^{-1}$ once a day for 13 weeks). In vitro system KIOM-79 suppressed the formation of AGEs $(18.12\;{\mu}g/ml)$. In STZ-induced diabetic rats showing accumulation of AGE and RAGE, pathological examination revealed that KIOM-79 prevented AGE and RAGE deposition in the kidney. In STZ induced diabetic rats, the expansion of mesangial matrix and the glomerular tufts seemed to be larger than those in normal rats. Howεver, after administration with KIOM-79, mesangial metrix and glomerular volume were decreased, and overexpression of type IV collagen was also decreased. Overexpression of renal $TGF-{\beta}1$ mRNA was inhibited significantly. These results suggest that the KIOM-79 might be an effective herbal prescription to prevent or alleviate the progression of diabetic nephropathy.

• 한방안이비인후피부과학회지
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• 제29권2호
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• pp.82-97
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• 2016

Objective : The aim of this study was to search and analyze the herbal combinations in formulas used to treat atopic dermatitis in Korean medicine. Methods : Articles on the atopy were searched for from among those registered on the OASIS up to December, 2015. After the articles were reviewed, information on both internal and external formulas for atopy was constructed. Then, the herbal combination in the formulas was analyzed by using frequency distribution, network analysis, and data mining. Results : The combination of 'Saposhnikovia Radix - Schizonepetae Spica' and 'Scutellariae Radix - Phellodendri Cortex ' was mostly used in both internal and external formulas to treat atopy in articles. By using the network analysis and data mining, twelve combinations including ' (Saposhnikovia Radix, Ponciri Fructus Pericarpium) - (Platycodi Radix, Schizonepetae Spica) ' were discovered. Five effective combinations were also searched for external formulas.Conclusions : This study could help researchers to analyze the formulas in various ways. Moreover, the herbal combination in atopy formulas could be used to search for atopy formulas in other databases or make a new prescription.

• 한국의사학회지
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• 제22권2호
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• pp.33-41
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• 2009

The objective of this article is to analysis of Acupuncture & Moxibustion Fix-a-day Method (AMFDM) shown in the acupuncture documents of the Chosun-Korea dynasty. Through such inquisition, The development process of AMFDM could be found. cross-comparison analysis of the contents of three medical books, Chim-Gu-Tek-Il-Pien-Zip(CGTIPZ), Dong-Eui-Bo-Gam(DEBG) and Chim-Gu-Gyung-Hum-Bang (CGGHB) of the Chosun-Korea dynasty. The development process of AMFDM of the three books is different from each other, depending on the purpose of writing books. But The three books contain common parts. It could be divided into three types, Simple-AMFDM, Extensive-AMFDM and Spirit-Existence-AMFDM. The development process of AMFDM of the Chosun-Korea dynasty has three steps. First, Integration and specialization phase in CGTIPZ. CGTIPZ sum many kind of AMFDMs up, and compare them to be specialized area. Second, Setting theory phase in DEBG. DEBG theorize AMFDM made of Spirit-Existence-AMFDM. Third, Practical use phase in CGGHB. CGGHB invented practical reinforcement to replace complicated ones.

• 동국한의학연구소논문집
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• 제2권1호
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• pp.167-176
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• 1993

The purpose of this study is to invesigate the effect of Yook-Gun-ja-Tang on the side effect of cyclophosphamide to splenical tissue in the rat. The experimental animal were divided into normal group, control group, sample group by way of method treatment of the drug. Each group was sacrificed and stained in accordance with the schedule and observed under light microscope. The results of this study were as follow : 1. After treatment of Yook-Gun-Ja-Tang, rat's weight and volume were more increased than normal group and control group. 2. The decrease of the numbers of the splenical tissue after administration of cyclophosphamide were recovered with prescription of the Yook-Gun-la-Tang ; The decreases of white pulp, red pulp, marginal zone, central artery were recovered. 3. Increased macrophages in red pulp of splenical tissue of rats with administration of cyclophosphamide were decreased after treatment of Yook-Gun-Ja-Tang. These results appeared to suggest that Yook-Gun-Ja-Tang might be effective on the: side effect of cyclophosphamide to splenical tissue of rat's and applied to the prescription for the recovery of the side effect of drug.

• 대한한의학원전학회지
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• 제24권6호
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• pp.101-110
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• 2011

There are not a few cases in Oriental medicine where a different prescription should be given to some of the patients whose symptoms are similar to each other. In other words, there might happen a misdiagnosis due to an extremely delicate difference in symptoms of the same diseases, causing a patient's condition to get worse or to be even on the brink of death. In such a context, the records in "WooJam JabJeo(愚岑雜著)" are worthwhile to do in-depth research on. Jang-Taegyung described his first-hand experience in major medical treatment very vivaciously during his ages between 25 and 42. Particularly, most of the prescriptions recorded in this book include not only his empirical prescriptions on the patients who life was almost on the brink of death but it also so plentifully contained the process of overcoming the side effect caused by other clinics' misdiagnosis; thus, that this book is drawing attention in that it could be indispensable materials not only in the research on medical history but also for clinical treatment. Particularly, as regards two cases of insanity, this book mentions the reason for using totally different prescription on one case from the other case even though the two cases had a similar symptom, through which we can acquire somewhat concrete experience in curing scenes though indirectly during the period of the Joseon Dynasty. We were able to get the result from the analysis of the two cases of insanity as follows: 1. WooJam, in treating the two cases of insanity due to the severe exacerbation of yang energy, managed to treat the one case by inducing a bowel movement and the other case by inducing urination. Such a different treatment seems to be greatly attributable to the constitutional factor of the two patients. Such an Oriental-medicine-based method of diagnosis and prescription as WooJam's is rarely found in Western medicine-i.e., that's why more thorough research on Oriental medicine is deeply required. 2. In case of the second patient, the patient arrived at insanity due to another clinic's treatment on perspiration on the patient with severe mouth thirst. This medical story once again highlights the importance of a diagnosis in today's Oriental medicine and at the same time it's a good example showing how big the side effect caused by the abuse of medicinal herbs is. The second patient's body fluids ran dry and finally his yang energy got exacerbated all the more due to the treatment by perspiration.

• 대한한의학회지
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• 제21권4호
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• pp.159-173
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• 2000

Objectives : First, to restore reliability of oriental prescriptions that are effective against incurable diseases, Second, in the short term, to secure the validity of traditional remedies with the help of accumulated data and in the long term, develop new therapeutic methods and prescriptions in order to broaden its aspect in the field of medicine. Third, to maintain predominance on oriental therapeutic methods and put it into practical use based upon the results obtained by this paper. Methods : In the primary sub-thesis(herbalogical analytic methods applied on unknown oriental prescriptions), models of analytic method and in gathering information that could be put into practice are being revised In the secondary sub-thesis(method in gathering and analysing in dealing with oriental prescription), several statistical approaches and analysis on data that has been gathered are being revised. In the tertiary sub-thesis(research on legal guarantee of the offerer rights), an alternative scheme that covers the limitations of the legislative content in dealing with offerer rights is being revised Results : This research has revealed several problems, including those which were foreseen, in proceeding with the project. The prospect of the involvement of the medical personnel engaging in the field of oriental medicine was remarkably bright. Given the condition that the project will proceed as it follows, unknown oriental prescriptions and remedies which have been particularly ignored will eventually play an important role in clinical practice. Conclusions : It is clear to everyone that these oriental remedies will remain ignored by the public unless they gain popularity. Strict verifications on these oriental remedies are definitely needed in order to overcome this limitation. Finally, it should provide a momentum in the field of medicine in gaining popularity to the public.

• 대한본초학회지
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• 제24권4호
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• pp.17-23
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• 2009

Objectives : This study aimed to provide basic data for future policies regarding the expansion of health insurance, through investigating the current status of Oriental herbal medicine insurance as perceived by the public. Methods : Questionnaire was developed through literature searches, in-depth interviews, item generation and item reduction. The questionnaires were further refined by a focus group. 221 surveys were retrieved from the general public. Results : The in-depth interviews, reveal that the public is aware of the various forms of Oriental herbal medicine formulas, except for the use of mixture of which are soluble granules covered by insurance. The public awareness of the soluble granules turned out to be so low that enhanced awareness of it is required. The public identified decoctions as the most preferred formula as well as the most effective formulas out of all Oriental herbal medical formulas. They also suggested that it should be the first to be included when the insurance policy expands in the future. The public had frequent experienced not choosing Oriental herbal prescription due to the high cost. Insurance coverage of Oriental herbal prescription is much needed. The public indicated that they will make frequent visits to the KMD if the insurance covers Oriental herbal prescriptions. Conclusions : The current status quo of Oriental herbal medicine insurance showed that the public identified decoctions as the most preferred, most effective and the top priority to be covered by insurance.

• 대한한방소아과학회지
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• 제13권2호
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• pp.125-137
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• 1999

The common cold is the most common pediatric infectious disease, and the incidence is higher in early childhood than in any other period of life. Treatment of the common cold is largely symptomatic. Thus treatment of oriental medicine for the common cold is very effective and safe. We studied 81 children suffering from common cold Oriental Medicine Hospital in Kyunghee University, and analyzed age, sex, season, clinical manifestation, complications, prescription. The results were as follows: 1. Age and sex distribution of children from 1 to 3 was 37.1%, 3 to 6 was 34.6%, over 6 was 24.7%, male to female ratio was 1.31 : 1 2. Frequency of affection per year, from 3 to 5 was 30.9%, 6 to 9 was 29.6%, over 10 was 27.2%, below 3 was 4.9% 3. Frequency of seasons giving rising to common cold, winter was 40.7%, spring and autumn were 16%, summer was 1.2%. 4. Frequency of complications, empyema and rhinitis were 38.3%, asthma was 21%, pneumonia was 16%, atopic dermatitis was 7.4%. 5. Frequency of Clinical manifestation, cough and sputum were 45.7%, high fever and sore throat were 27.2%, complex symptom was 25.9%. 6. Frequency of prescription, BoAh-Tang-gami(補兒湯加味)was 27.2% BangPungHaeDoc-Tang(防風解毒湯)was 11.1 %, GamiGinHae-Tang (加味鎭咳湯)was 11.1%.