The Effect of Yook-Gun-Ja-Tang on The Side-Effect of Cyclophosphamide to The Spleen in The Rat

육군자탕(六君子湯)이 Cyclophosphamide로 손상(損傷)된 비장조직(脾臟組織)의 회복(恢復)에 미치는 영향(影響)

The purpose of this study is to invesigate the effect of Yook-Gun-ja-Tang on the side effect of cyclophosphamide to splenical tissue in the rat. The experimental animal were divided into normal group, control group, sample group by way of method treatment of the drug. Each group was sacrificed and stained in accordance with the schedule and observed under light microscope. The results of this study were as follow : 1. After treatment of Yook-Gun-Ja-Tang, rat's weight and volume were more increased than normal group and control group. 2. The decrease of the numbers of the splenical tissue after administration of cyclophosphamide were recovered with prescription of the Yook-Gun-la-Tang ; The decreases of white pulp, red pulp, marginal zone, central artery were recovered. 3. Increased macrophages in red pulp of splenical tissue of rats with administration of cyclophosphamide were decreased after treatment of Yook-Gun-Ja-Tang. These results appeared to suggest that Yook-Gun-Ja-Tang might be effective on the: side effect of cyclophosphamide to splenical tissue of rat's and applied to the prescription for the recovery of the side effect of drug.