• Journal of Korean Medical classics
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• v.23 no.3
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• pp.81-101
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• 2010

The results of researching Jang's use of herb remedies through his book "Uihakchungjungchamseorok(醫學衷中參西錄)" are as follows. 1. Jang Seoksun's medicine is based on "Hwangjenaegyeong(黃帝內經)", "Sanghanron(傷寒論)", "Sinnongbonchogyeong(神農本草經)". And through constant study he brought to perfection his own unique medical theory. 2. He introduced Western medicine, and united it with traditional Chinese medicine. He perfected the Chinese-Western medical theory, by Chungjungchamseo(衷中參西) which means 'roots in traditional Chinese medicine, reference in Western medicine'. 3. He thought Onbyeong(溫病) was not an independent category of disease, but included it into the category of Sanghan(傷寒). So he used modified prescription of "Sanghanron(傷寒論)" to treat Onbyeong(溫病). 4. He expanded the category of remedy uses by using various compounds, such as minerals and animal compounds. He has also developed substitute remedies.

• Herbal Formula Science
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• v.12 no.1
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• pp.29-77
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• 2004

After this study: I report the following result from it. 1. Beriberi is defined as sensory or motor disorder of leg with a painful-swelling and pyrexia. If it progress severely, the disease transmits to heart and cause numbness of the lower abdomen, vomiting, anorexia, palpitation, chest distress and confusion. 2. The external etiologic factors of Beriberi are wind-toxic pathogen, dampness, improper diet and climate sickness, the internal etiologic factors are deficiencies of the kidney, both Gi and blood and original vital energy. 3. The treatment of Beriberi is free-going of blockage, because it is a blocked disease. 4. Danggwiy-juntongtang and Ganghwar-dochetang is the most in the order of frequency of use. Mahwang-juagyongtang, Banha-juagyongtang, Daehwang-juagyongtang, Shinbi-juagyongtang are used in sequence. 5. The prescriptions of Beriberi are made up of the herbs that clear heat, for example, Ganghwar, Changchul, Mahwang and Bangpung, and the herbs that reinforces Gi, for example, Insam and Bakchul.

• Journal of Haehwa Medicine
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• v.10 no.2
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• pp.73-81
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• 2002

In the literal study of anti-tumor effects of Jakeumjung. the results were as follows. 1. Jakeumjung is a traditional oriental medical prescription which is composed of Cremastare appeniculatae tuber, Euphorbiae pekinensis radix, Toosendan fructus, Chinensis galla, Moschus, Realgar and Cinnabaris. 2. Jakeumjung is applied to patients by administering or external application. When it is administered for patients, pertinent dose is 0.6~1.5g twice or three times per one day. When it is applied by external application, we melt it by water or vinegar and apply it to patients. 3. Effects of Jakeumjung are expelling toxin and pestilence, counteracting pathogen and relieving stagnation, detumescence and stopping pain. So it is used for detoxification from ancient. In recent, it is often used for cancer such as breast cancer, pancreatic cancer, epigastric cancer, acute leukemia, lymphoma, thymus cancer and skin cancer. 4. From the various experiments, Jakeumjung has been proved to have antifungal and antitumor effects. It inhibits and kills L7212, L1210 cells of leukemia. Especially, it acts in S stage of cell period. 5. Jakeumjung includes mineral medicines such as Realgar, Cinnabaris. So if we execute progressive study for anticancer effects and safety, the boundary of oriental medicine of using mineral medicines for cancer therapy will magnify in the future.

• The Journal of Korean Medicine
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• v.20 no.3 s.39
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• pp.3-8
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• 1999

This study was carried out to investigate the dose of prescription in Shanghanlun. To this end, literature research and a survey of several herbal medicines have been done. As a result, the weight of 1 liang (兩) is determined to be about 15g. Furthermore, we find that Jung-Kyung Jang, who compiled Shang-hanlun, used a great quantity of herbal medicines to treat critical conditions of iIInesses. Therefore application of Shang-hanIun s prescriptions according to the various conditions of patients must have changed the quantity of dosage.

• Herbal Formula Science
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• v.12 no.1
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• pp.105-121
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• 2004

This report describes the studies as follows through the research into the data of Fructus Forsythiae main blended prescriptions from Dongeuybogam. Through investigation on prescriptions from Dongeuybogam with Fructus Forsythiae as an ingredient, the following conclusions were reached. 1. All kinds of infection in a boil and the malignant tumor recorded the largest number of clinical frequency of the prescriptions in therapeutic use when Fructus Forsythiae was taken as a principle medicine. 2. The prescriptions are compounded with Fructus Forsythiae as a principle medicine can apply to eye disease, nose and ear disease, throat disease, trauma, the malignant tumor, skin disease, dental disease and heat pathogenic disease. 3. Various pathogenic factors such as wind-heat, heat, fire, wind, qi, poison, cold are put to practical use. 4. The dosage of Fructus Forsythiae is 2bun(about 0.75 gram) to 3jeon(about 11.25 gram), however 1joen(about 3.75 gram) has been taken the most for clinical application. 5. With examination the formulae of presciptions containing Fructus Forsythiae, I found the basic prescriptions as well as the medicines are in conjunction with Fructus Forsythiae and the theoretic grounds of formula in combining Fructus Forsythiae as a group of medicine for prescription through this research.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1192-1195
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• 2008

Sipjeondaebo-tang has been traditionally prescribed a medicine as a restorative. In this study, we investigated the acute toxicity about water-extracted Sipjeondaebo-tang. Thirty rats completed 14 days of oral Sipjeondaebo-tang at the respective doses of 0(control group), 2000 and 5000 mg/kg. We observed survival rates, general toxicity, change of body weight and autopsy. To be confirmed the data for the toxicity and safety problems of oriental medicine prescription. Compared with the control group, we could not find any toxic alteration in all treated groups (2000 and 5000 mg/kg). LD50 of Sipjeondaebo-tang was over 5000 mg/kg and it is very safe to SD rats.

• The Journal of Korean Medical History
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• v.17 no.2
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• pp.99-110
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• 2004

This study makes SoGanEum(疎肝飮), which is included in YoYak(要略) [JangBuPyoBonHeoSil MaekYakChongBang (臟腑標本虛實脈藥摠方)], its object. It elucidates the origin of this prescription from Chinese medical texts, and examines the characteristics shown in the process of reception through Joseon's exemplary medical texts.

• Journal of Sasang Constitutional Medicine
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• v.15 no.1
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• pp.12-26
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• 2003

1. Purpose This study is intend to catch DongMu(東武)'s viewpoint of Chobongeun Soyangin prescription. 2. Method Through Comparing Chongeun Soyangin prescriptions and medications on those of DongEuiBoGam(東醫寶鑑), DongyiSooseBowon Gabobon and DongyiSooseBowon Sinchukbon, we can find DongMu(東武)'s viewpoint of Sasang Constitutional Medicine. 3. Results 1) The same Hi prescriptions between DongEuiBoGam(東醫寶鑑) and Chobongeun Soyangin are not entirely identical. 2) GamCho(甘草), GaengMi(粳米) and Sagunja(使君子) were used in the Chobongeun Soyangin prescriptions. that means DongMu(東武)'s viewpoint of Sasang Constitutional Medicine was not entirely established. 3) PaedockSan(敗毒散), VukmijihwangTang(六味地黃湯) and BaekhoTang(白虎湯) were representative prescriptions in the Chobongeun Soyangin prescriptions. And that prescriptions were connected to DongyiSooseBowon Sinchukbon. 4) The same kind medications which were record on DongEuiBoGam(東醫寶鑑) and Chobongeun Soyangin are eighteen. And that medications are the structural principle of Chobongeun Soyangin prescriptions.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.1
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• pp.265-273
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• 2004

KBPTS is the fortified prescription of Bang-pung-tong-sung-san (BPTS) by adding Spatholobi Clulis and Salviae Miltiorrzae Radix. BPTS prescription has been used in Qriental medicine for the treatments of vascular diseases including hypertension, stroke, and arteriosclerosis, and nervous system diseases. Yet, the overall mechanism underlying its activity at the cellular levels remains unknown. To investigate the protective role of KBPTS on brain functions, noxious stimulations were applied to neurons in vitro and in vivo. KBPTS pretreatment in cultured cortical neurons of albino ICR mice rescued death caused by AMPA, NMDA, and kainate as well as by buthionine sulfoximine (BSO) and ferrous chloride (Fe/sup 2+/) treatments. Furthermore, KBPTS promoted animal's recovery from coma induced by a sublethal dose of KCN and improved survival by a lethal dose of KCN. To examine its physiological effects on the nervous system, we induced ischemia in the Sprague-Dawley rat's brain by middle cerebral artery (MCA) occlusion. Neurological examination showed that KBPTS reduced the time which is required for the animal after MCA occlusion to respond in terms of forelimb and hindlimb movement$. Histological examination revealed that KBPTS reduced ischemic area and edema rate and also protected neurons in the cerebral cortex and hippocampus from ischemic damage. Thus, the present data suggest that KBPTS may play an important role in protecting neuronal cells from external noxious stimulations.

• Korean Journal of Oriental Medicine
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• v.16 no.1
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• pp.1-9
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• 2010

Lee Gyujun put forward Buyang as core medical tenet, which has been one of the prominent medical theories since around the first decade in the 20th century. He wrote two major medical books except for small kinds: Somundaeyo(素問大要) and Uigamjungma(醫鑑重磨). Until recently, studies on that theory have tended to focus on examining Somundaeyo. However, study on Uigamjungma is equally as important and is to be done as that on Somundaeyo. This is because the former is rather clinically oriented as the latter is theoretical so that the two is twins of one medical theory, in other words the other side of a coin. There are four versions of Uigamjungma editions: the first edition in 1922 by wooden block; one with annotation and Korean translation by Park Heesung; one edited and manually transcribed by Lee Wonse(李元世); and Daesung publisher's in 2000. Lee Gyujun revised medical theories, prescription, and herbology extracted not only from Donguibogam(東醫寶鑑) as well known wide, but also from Bangyakhappyeon(方藥合編) and Gyengakjeonse(景岳全書), based on the Buyang Theory(扶陽論).