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Kami-bang-pung-tong-sung-san is Involved in Protecting Neuronal Cells from Cytotoxic Insults  

Na Young Cheul (Department of Pathology, College of Oriental Medicine, Daejeon University)
Nam Gung Uk (Department of Neurophysiology, College of Oriental Medicine, Daejeon University)
Lee Yong Koo (Department of Western Internal Medicine, College of Oriental Medicine, Daejeon University)
Kim Dong Hee (Department of Pathology, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.1, 2004 , pp. 265-273 More about this Journal
Abstract
KBPTS is the fortified prescription of Bang-pung-tong-sung-san (BPTS) by adding Spatholobi Clulis and Salviae Miltiorrzae Radix. BPTS prescription has been used in Qriental medicine for the treatments of vascular diseases including hypertension, stroke, and arteriosclerosis, and nervous system diseases. Yet, the overall mechanism underlying its activity at the cellular levels remains unknown. To investigate the protective role of KBPTS on brain functions, noxious stimulations were applied to neurons in vitro and in vivo. KBPTS pretreatment in cultured cortical neurons of albino ICR mice rescued death caused by AMPA, NMDA, and kainate as well as by buthionine sulfoximine (BSO) and ferrous chloride (Fe/sup 2+/) treatments. Furthermore, KBPTS promoted animal's recovery from coma induced by a sublethal dose of KCN and improved survival by a lethal dose of KCN. To examine its physiological effects on the nervous system, we induced ischemia in the Sprague-Dawley rat's brain by middle cerebral artery (MCA) occlusion. Neurological examination showed that KBPTS reduced the time which is required for the animal after MCA occlusion to respond in terms of forelimb and hindlimb movement$. Histological examination revealed that KBPTS reduced ischemic area and edema rate and also protected neurons in the cerebral cortex and hippocampus from ischemic damage. Thus, the present data suggest that KBPTS may play an important role in protecting neuronal cells from external noxious stimulations.
Keywords
Kami-bang-pung-tong-sung-san; neuron; neurotoxicity; middle cerebral artery (MCA) occlusion; hippocampus; cerebral cortex; rat;
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