• Animal Bioscience
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• 제35권7호
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• pp.1048-1058
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• 2022

Objective: The present study was to investigate the extraction conditions of dietary fiber from dried cassava pulp (DCP) and cassava distiller's dried grains (CDG) under different NaOH concentrations, and the Fourier transform infrared (FTIR) was used to determine the dietary fiber components. Methods: The dried samples (DCP and CDG) were treated with various concentrations of NaOH at levels of 2%, 4%, 6%, and 8% using a completely randomized design with 4 replications of each. After extraction, the residual DCP and CDG dietary fiber were dried in a hot air oven at 55℃ to 60℃. Finally, the oven dried extracted dietary fiber was powdered to a particle size of 1 mm. Both extracted dietary fibers were analyzed for their chemical composition and determined by FTIR. Results: The DCP and CDG treated with NaOH linearly or quadratically or cubically (p<0.05) increased the total dietary fiber (TDF) and insoluble fiber (IDF). The optimal conditions for extracting dietary fiber from DCP and CDG were under treatment with 6% and 4% NaOH, respectively, as these conditions yielded the highest TDF and IDF contents. These results were associated with the FTIR spectra integration for a semi-quantitative analysis, which obtained the highest cellulose content in dietary fiber extracted from DCP and CDG with 6% and 4% NaOH solution, respectively. The principal component analysis illustrated clear separation of spectral distribution in cassava pulp extracted dietary fiber (DFCP) and cassava distiller's dried grains extracted dietary fiber (DFCDG) when treated with 6% and 4% NaOH, respectively. Conclusion: The optimal conditions for the extraction of dietary fiber from DCP and CDG were treatment with 6% and 4% NaOH solution, respectively. In addition, FTIR spectroscopy proved itself to be a powerful tool for fiber identification.

• International Journal of Computer Science & Network Security
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• 제22권5호
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• pp.294-302
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• 2022

Detection of fake news is a complex and a challenging task. Generation of fake news is very hard to stop, only steps to control its circulation may help in minimizing its impacts. Humans tend to believe in misleading false information. Researcher started with social media sites to categorize in terms of real or fake news. False information misleads any individual or an organization that may cause of big failure and any financial loss. Automatic system for detection of false information circulating on social media is an emerging area of research. It is gaining attention of both industry and academia since US presidential elections 2016. Fake news has negative and severe effects on individuals and organizations elongating its hostile effects on the society. Prediction of fake news in timely manner is important. This research focuses on detection of fake news spreaders. In this context, overall, 6 models are developed during this research, trained and tested with dataset of PAN 2020. Four approaches N-gram based; user statistics-based models are trained with different values of hyper parameters. Extensive grid search with cross validation is applied in each machine learning model. In N-gram based models, out of numerous machine learning models this research focused on better results yielding algorithms, assessed by deep reading of state-of-the-art related work in the field. For better accuracy, author aimed at developing models using Random Forest, Logistic Regression, SVM, and XGBoost. All four machine learning algorithms were trained with cross validated grid search hyper parameters. Advantages of this research over previous work is user statistics-based model and then ensemble learning model. Which were designed in a way to help classifying Twitter users as fake news spreader or not with highest reliability. User statistical model used 17 features, on the basis of which it categorized a Twitter user as malicious. New dataset based on predictions of machine learning models was constructed. And then Three techniques of simple mean, logistic regression and random forest in combination with ensemble model is applied. Logistic regression combined in ensemble model gave best training and testing results, achieving an accuracy of 72%.

• Genomics & Informatics
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• 제19권4호
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• pp.38.1-38.7
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• 2021

Kawasaki disease (KD) is an acute pediatric vasculitis that affects genetically susceptible infants and children. To identify coding variants that influence susceptibility to KD, we conducted whole exome sequencing of 159 patients with KD and 902 controls, and performed a replication study in an independent 586 cases and 732 controls. We identified five rare coding variants in five genes (FCRLA, PTGER4, IL17F, CARD11, and SIGLEC10) associated with KD (odds ratio [OR], 1.18 to 4.41; p = 0.0027-0.031). We also performed association analysis in 26 KD patients with coronary artery aneurysms (CAAs; diameter > 5 mm) and 124 patients without CAAs (diameter < 3 mm), and identified another five rare coding variants in five genes (FGFR4, IL31RA, FNDC1, MMP8, and FOXN1), which may be associated with CAA (OR, 3.89 to 37.3; p = 0.0058- 0.0261). These results provide insights into new candidate genes and genetic variants potentially involved in the development of KD and CAA.

• Genomics & Informatics
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• 제20권3호
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• pp.35.1-35.9
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• 2022

Microsatellites or simple sequence repeats are motifs of 1 to 6 nucleotides in length present in both coding and non-coding regions of DNA. These are found widely distributed in the whole genome of prokaryotes, eukaryotes, bacteria, and viruses and are used as molecular markers in studying DNA variations, gene regulation, genetic diversity and evolutionary studies, etc. However, in vitro microsatellite identification proves to be time-consuming and expensive. Therefore, the present research has been focused on using an in-house built java pipeline to identify, analyse, design primers and find related statistics of perfect and compound microsatellites in the seven complete genome sequences of coronavirus, including the genome of coronavirus disease 2019, where the host is Homo sapiens. Based on search criteria among seven genomic sequences, it was revealed that the total number of perfect simple sequence repeats (SSRs) found to be in the range of 76 to 118 and compound SSRs from 01 to10, thus reflecting the low conversion of perfect simple sequence to compound repeats. Furthermore, the incidence of SSRs was insignificant but positively correlated with genome size (R² = 0.45, p > 0.05), with simple sequence repeats relative abundance (R² = 0.18, p > 0.05) and relative density (R² = 0.23, p > 0.05). Dinucleotide repeats were the most abundant in the coding region of the genome, followed by tri, mono, and tetra. This comparative study would help us understand the evolutionary relationship, genetic diversity, and hypervariability in minimal time and cost.

• Earthquakes and Structures
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• 제22권2호
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• pp.185-201
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• 2022

Structural Health Monitoring (SHM) is used to provide reliable information about the structure's integrity in near realtime following extreme incidents such as earthquakes, considering the inevitable aging and degradation that occurs in operating environments. This paper experimentally investigates an integrated wireless sensor network (Wi-SN) based monitoring technique for damage detection in concrete structures. An effective SHM technique can be used to detect potential structural damage based on post-earthquake data. Two novel methods are proposed for damage detection in reinforced concrete (RC) building structures including: (i) Jerk Energy Method (JEM), which is based on time-domain analysis, and (ii) Modal Contributing Parameter (MCP), which is based on frequency-domain analysis. Wireless accelerometer sensors are installed at each story level to monitor the dynamic responses from the building structure. Prior knowledge of the initial state (immediately after construction) of the structure is not required in these methods. Proposed methods only use responses recorded during ambient vibration state (i.e., operational state) to estimate the damage index. Herein, the experimental studies serve as an illustration of the procedures. In particular, (i) a 3-story shear-type steel frame model is analyzed for several damage scenarios and (ii) 2-story RC scaled down (at 1/6th) building models, simulated and verified under experimental tests on a shaking table. As a result, in addition to the usual benefits like system adaptability, and cost-effectiveness, the proposed sensing system does not require a cluster of sensors. The spatial information in the real-time recorded data is used in global damage identification stage of SHM. Whereas in next stage of SHM, the damage is detected at the story level. Experimental results also show the efficiency and superior performance of the proposed measuring techniques.

• 한국전문물리치료학회지
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• 제30권2호
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• pp.136-143
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• 2023

Background: The International Classification of Functioning, Disability and Health (ICF) model, created by the World Health Organization, provides a theoretical framework that can be applied in the diagnosis and treatment of various disorders. Objects: Our research purposed to ascertain the relationship between structure/function, activity, and participation domain variables of the ICF and pain, pain-associated disability, activities of daily living (ADL), and quality of life in patients with chronic low back pain (LBP). Methods: Two-hundred patients with chronic LBP (mean age: 35.5 ± 8.8 years, females, n = 40) were recruited from hospital and community settings. We evaluated the body structure/function domain variable using the Numeric Pain Rating Scale (NPRS) and Roland-Morris disability (RMD) questionnaire. To evaluate the activity domain variable, we used the Oswestry Disability Index (ODI) and Quebec Back Pain Disability Scale (QBDS). For clinical outcome measures, we used Short-form 12 (SF-12). Pearson's correlation coefficient was used to ascertain the relationships among the variables (p < 0.05). All the participants with LBP received 30 minutes of conventional physical therapy 3 days/week for 4 weeks. Results: There were significant correlations between the body structure/function domain (NPRS and RMD questionnaire), activity domain (ODI and QBDS), and participation domain variables (SF-12), rending from pre-intervention (r = -0.723 to 0.783) and postintervention (r = -0.742 to 0.757, p < 0.05). Conclusion: The identification of a significant difference between these domain variables point to important relationships between pain, disability, performance of ADL, and quality in participants with LBP.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 추계학술대회
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• pp.443-444
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• 2021

정보 서비스에 대한 보안 위협은 갈수록 그 방법이 발전하고 있으며, 보안 위협으로 발생된 빈도와 피해도 증가하고 있다. 특히 조직 내부에서 발생하는 보안 위협이 크게 증가하고 있으며, 그 피해 규모도 크다. 이러한 보안 환경을 개선할 수 있는 방법으로 제로 트러스트 모델이 제안되었다. 제로 트러스트 모델은, 정보 자원에 접근하는 주체를 악의적 공격자로 간주한다. 주체는 식별 및 인증 과정을 통해 검증 후에 정보 자원에 접근할 수 있다. 그러나 초기 제안된 제로 트러스트 모델은 기본적으로 네트워크에 집중하고 있어, 시스템이나 데이터에 대한 보안 환경은 고려하지 않고 있다. 본 연구에서는 기존의 제로 트러스트 모델을 파일 시스템으로 확장한 제로 트러스트 기반 접근통제 메커니즘을 제안하였다. 연구 결과, 제안된 파일 접근통제 메커니즘은 제로 트러스트 모델 구현을 위해 적용될 수 있는 것으로 확인되었다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 추계학술대회
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• pp.588-590
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• 2022

선박에 대한 위치와 자세 공유는 다양한 변화가 있는 해상환경에서 안전한 항해와 효율적 운용을 도모하기 위한 아주 중요한 사항이다. 이를 위한 기술로 AIS(Automatic Identification System)가 대표적으로 활용이 되고 있다. 선박내 통신규약의 일종인 NMEA-0183을 통해 자함(ownship) 및 타선의 정보를 수집하여 항행에 큰 도움을 준다. 더 나아가 이 기술은 지상의 관제소 및 항공 영역에까지 공유되어 해상의 안전한 항행과 사고예방 및 대처용으로도 적극적으로 활용되고 있다. 이러한 AIS의 장점으로 인해 국제해사기구에 의해 국제여객선과 300톤 이상의 선박에 대해서는 AIS 탑재가 의무화된 상황이다. AIS는 장거리 송출을 위해 VHF(Very High Frequency) 밴드 영역을 사용하며, 이러한 특성으로 인해 타선의 정보를 모니터링하는 시스템에서는 필요 이상의 타깃들의 정보가 수집되고 표출이 되는 상황이다. 본 연구에서는 모니터링 시스템의 표출영역을 고려한 효율적인 AIS 데이터 추출 방안을 제시한다. 아울러, 이를 통해 결과적으로 모니터링 시스템의 처리 및 네트워크 부하를 감소시키고 타 체계의 타깃 정보와의 형평성 있는 표출을 유도한다.

• 한국수학교육학회지시리즈E:수학교육논문집
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• 제37권4호
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• pp.591-614
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• 2023

오래전부터 NCTM(National Council of Teachers of Mathematics)과 같은 수학교육기관에서 글쓰기는 필수적인 부분으로 언급해 왔다. 그리고 최근 교육부 조사에 따르면 코로나 시대 이후 기초학력 저하의 심각성을 보고하였다. 본 연구는 수학교육에서 수학 쓰기를 재정의하고, 현재 수학교육에서 제시되는 역량 중 과거부터 언급해 온 문제해결, 의사소통, 추론 영역을 중심으로 글쓰기의 역할과 그 중요성을 파악하는 것을 목적으로 하였다. 연구 결과에서 문제해결에서의 글쓰기는 인지적인 부분을 정리함으로써 개념과 방법을 습득할 수 있는 능력을 기를 수 있고, 의사소통에서의 글쓰기는 재인지 과정을 통해 자신감을 가질 수 있으며, 추론에서의 글쓰기는 단계적으로 어떤 부분이 부족한지를 스스로 파악할 수 있다. 특히, AI를 활용하는 미래 사회에서 수업 환경이 달라지는 만큼 쓰기를 통한 진위성 판단이나 올바른 쓰기 문화 정착을 위해 연구가 이루어질 필요가 있다.

• Genomics & Informatics
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• 제21권3호
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• pp.38.1-38.8
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• 2023

Non-small cell lung cancer (NSCLC) is an important cause of cancer-associated deaths worldwide. Therefore, the exact molecular mechanisms of NSCLC are unidentified. The present investigation aims to identify the miRNAs with predictive value in NSCLC. The two datasets were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed miRNAs (DEmiRNA) and mRNAs (DEmRNA) were selected from the normalized data. Next, miRNA-mRNA interactions were determined. Then, co-expression network analysis was completed using the WGCNA package in R software. The co-expression network between DEmiRNAs and DEmRNAs was calculated to prioritize the miRNAs. Next, the enrichment analysis was performed for DEmiRNA and DEmRNA. Finally, the drug-gene interaction network was constructed by importing the gene list to dgidb database. A total of 3,033 differentially expressed genes and 58 DEmiRNA were recognized from two datasets. The co-expression network analysis was utilized to build a gene co- expression network. Next, four modules were selected based on the Z_summary score. In the next step, a bipartite miRNA-gene network was constructed and hub miRNAs (let-7a-2-3p, let-7d-5p, let-7b-5p, let-7a-5p, and let-7b-3p) were selected. Finally, a drug-gene network was constructed while SUNITINIB, MEDROXYPROGESTERONE ACETATE, DOFETILIDE, HALOPERIDOL, and CALCITRIOL drugs were recognized as a beneficial drug in NSCLC. The hub miRNAs and repurposed drugs may act a vital role in NSCLC progression and treatment, respectively; however, these results must validate in further clinical and experimental assessments.