• 한국사회정책
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• v.24 no.1
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• pp.239-275
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• 2017

The purpose of this study is to explore what social workers experience and how they experience the needs of Meritocracy in the social welfare organization in the neoliberalism.. Therefore, in-depth interviews were conducted with 18 social workers, and I analyzed Colaizzi(1978) in a phenomenological method through collected research materials. As a result, the analysis is integrated in a total of four essential themes. According to the research results, the meritocracy - oriented phenomenon in the social welfare organization was 'paradox of Meritocracy'. Participants were buried in creating "nominal performance without any effectiveness" based on effectiveness and efficiency. Clients were instrumentalized in performance; moreover, they lost contact points with the field. Above all, there was "a reorganization of practices" that contradicted the original values of practice, in which the quality deterioration of service and the connection between organizations were weakened. In addition, the implementation of accountability of social welfare organization, which was intended by Meritocracy, has become a criterion for external evaluation, and the challenge of uncertain result has left a "rigid accountability without discretion." While participants were devoted to making a nominal performance, they failed to be guaranteed by the distinct characteristics of social welfare group. They experienced lost pride of the practitioner in the reality which contained the value of social welfare. However, in spite of this paradox of Meritocracy, participants demonstrated flexibility in order to preserve the original value and reached "a compromise with reality in the identity conflict." Based on the results of the research, I presented the discussion and policy directions.

• Genomics & Informatics
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• v.17 no.4
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• pp.38.1-38.6
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• 2019

DNA methylation is a relatively stable epigenetic modification that can regulate and stabilize gene expression patterns and hence establish cell identity. Because metabolic intermediates are key factors of DNA methylation and demethylation, perturbations in metabolic homeostasis can trigger alterations in cell-specific patterns of DNA methylation and contribute to disease development, including type 2 diabetes (T2D). During the past decade, genome-wide DNA methylation studies of T2D have expanded our knowledge of the molecular mechanisms underlying T2D. This review summarizes case-control studies of the DNA methylome of T2D and discusses DNA methylation as both a cause and consequence of T2D. Therefore, DNA methylation has potential as a promising T2D biomarker that can be applied to the development of therapeutic strategies for T2D.

• Mycobiology
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• v.28 no.4
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• pp.171-176
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• 2000

We have cloned a ${\alpha}-COP$ homolog, ancop, from Aspergillus nidulans by colony hybridization of chromosome specific library using ${\alpha}-COP$ homologous fragment as a probe. The probe DNA was amplified with degenerated primers designed by comparison of conserved region of the amino acid sequences of Saccharomyces cerevisiae ${\alpha}-COP$, Homo sapiens HEP-COP, and Drosophila melanogaster ${\alpha}-COP$. Full length cDNA clone was also amplified by RT-PCR. Comparison of genomic DNA sequence with cDNA sequence obtained by RT-PCR revealed 7 introns. Amino acid sequence similarity search of the anCop with other ${\alpha}-COPs$ gave an overall identity of 52% with S. cerevisiae, 47% with human and bovine, 45% with Drosophila and Arabidopsis. In upstream region from the transcription start site, a putative TATA and CAAT motif were also identified.

• Journal of the Korean Society of Marine Environment & Safety
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• v.6 no.2
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• pp.57-66
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• 2000

The argument about enlarging or limiting the function of the Korea Maritime Police. Agency (KMPA) has been and will be repeated. In this paper, the author highlights the internal and external issues facing KMPA, stemming partly from deficiencies of its struggles for advancement of the organization and partly from shortcomings of political support far it. And he urges KMPA to change the organizational culture for maintaining its identity and characteristics as a lead maritime agency by practising a scientific management system for maximizing cost-effectiveness of its administrative resources. In addition, he also suggests that KMPA adopt the Total Quality Management System for quality improvements in services and greater efficiency in its organizational structure to meet the future competition in the changing political and legal environment. he concludes by providing a 6-point vision statement for KMPA from the standpoint of favoring enlarging the function of KMPA.

• Journal of Information Technology Services
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• v.10 no.2
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• pp.163-176
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• 2011

In the current Internet environment, there may exist a number of independently-operating authentication systems even within a single organization, according to the service types and service providing entities. Current silo-style isolated authentication system model has revealed critical problems in the aspects of usability, cost-effectiveness, extensibility and flexibility, and privacy protection. Recently, several next generation authentication systems have been actively developed by leading industrial and standardization institutions. This paper firstly analyzes the problems of current Internet authentication system environments. And then, the underlying idea, operating procedures, and pros and cons of the newly developed next generation authentication systems are analyzed so as to provide the selection guidelines for the new authentication systems and drive further development directions for future Internet authentication systems.

• Journal of Families and Better Life
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• v.27 no.1
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• pp.107-125
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• 2009

This paper analyzes the life and culture contents of the primary Korean textbook for female marriage immigrants and investigates ways to improve the textbook organization in future. The study results are as follows: 1. The textbook must reflect the demands of female marriage immigrants as learners that need to adapt to Korean society. 2. The textbook needs to adopt a circulating disposition in organizing such life and culture contents that female marriage immigrants can obtain and utilize while living in diverse life environments 3. The textbook should also provide multi-cultural elements in order to help female marriage immigrants with the internalization of the complex identity between their home countries and Korea.

• Genomics & Informatics
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• v.14 no.1
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• pp.12-19
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• 2016

Neuropeptides produced from prohormones by selective action of endopeptidases are vital signaling molecules, playing a critical role in a variety of physiological processes, such as addiction, depression, pain, and circadian rhythms. Neuropeptides bind to post-synaptic receptors and elicit cellular effects like classical neurotransmitters. While each neuropeptide could have its own biological function, mass spectrometry (MS) allows for the identification of the precise molecular forms of each peptide without a priori knowledge of the peptide identity and for the quantitation of neuropeptides in different conditions of the samples. MS-based neuropeptidomics approaches have been applied to various animal models and conditions to characterize and quantify novel neuropeptides, as well as known neuropeptides, advancing our understanding of nervous system function over the past decade. Here, we will present an overview of neuropeptides and MS-based neuropeptidomic strategies for the identification and quantitation of neuropeptides.

• Journal of Microbiology
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• v.44 no.3
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• pp.311-319
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• 2006

Bud6p is a component of a polarisome that controls cell polarity in Saccharomyces cerevisiae. In this study, we investigated the role of the Candide albicans Bud6 protein (CaBud6p) in cell polarity and hyphal development. CaBud6p, which consists of 703 amino acids, had 37% amino-acid sequence identity with the Bud6 protein of S. cerevisiae. The homozygous knock-out of CaBUD6 resulted in several abnormal phenotypes, such as a round and enlarged cells, widened bud necks, and a random budding pattern. In hypha-inducing media, the mutant cells had markedly swollen tips and a reduced ability to switch from yeast to hypha. In addition, a yeast two-Hybrid analysis showed a physical interaction between CaBud6p and CaAct1p, which suggests that CaBud6p may be involved in actin cable organization, like Bud6p in S. cerevisiae. Taken together, these results indicate that CaBud6 plays an important role in the polarized growth of C. albicans.

• Journal of the Korean Home Economics Association
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• v.34 no.3
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• pp.1-8
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• 1996

These days, Home Economics in Korea is confronted with the inner argument about its identity and the outer pressure of re-organization caused by educational reformation. Fundamentally, these internal and external challenges to Home Economics arise from that Home Economics has not been fulfilling the needs of individuals and families due to weakening of integrate perspective, insufficient practice and conservative tendency of study. To get over the current problems and construct a new paradigm of Home Economics contributing to the requirements of new era, the following prerequisites might be fulfilled; \circled1 More active concern about surmounting the alienation that threatening the modern family life and self-actualization of individuals. \circled2 An endeavor to find a new family philosophy and patterns of family culture as the basis of community restoration that harmonize the traditions with changes. \circled3 An Effort to find a highter values that contribute to symbiosis and development of global community including all human beings, creatures and eco-system on the earth.

• Journal of Engineering Education Research
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• v.14 no.5
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• pp.67-74
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• 2011

The object of this study is to examine the process of the birth and transformation of civil engineering education as well as of modern civil engineers, called 'State noblesse', in the state engineer groups of France. For this, we will look into the background of founding the civil engineer corps and the civil engineering school, the transformation process of the civil engineering school into the applied school of Ecole Polytechnique, the activities of civil engineers in the industrialization process, and finally the organization and identity of the civil engineer group.