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SUPPRESSION BY CHLOROPHYLL, BUT PROMOTION BY CHLOROPHYLLIN, OF COLON CARCINOGENESIS IN THE FISHER 344 RAT

  • Blum, Carmen A.;Xu, Meirong;Orner, Gayle A.;Diaz, G.Dario;Li, Qingjie;Bailey, George S.;Dashwood, Roderick H.
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.48-49
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    • 2001
  • The carcinogens 2-amino-3-methylimidazo[4, 5-f]quinoline (IQ) and 1, 2-dimethylhydrazine (DMH) induce colon tumors in the Fisher 344 rat that contain mutations in Ctnnbl, the gene for b-catenin, but the pattern of mutation differs from that found in human colon cancers. In both species, mutations affect the glycogen synthase kinase 3$\beta$ (GSK-3$\beta$) consensus region of $\beta$-catenin, but whereas they directly substitute critical Ser/Thr phosphorylation sites in human colon cancers, the majority of mutations cluster around Ser$_{33}$ in the rat tumors.(omitted)d)

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SUPPRESSION BY CHLOROPHYLL, BUT PROMOTION BY CHLOROPHYLLIN, OF COLON CARCINOGENESIS IN THE FISHER 344 RAT

  • Blum, Carmen A.;Xu, Meirong;Orner, Gayle A.;Diaz, G.Daria;Li, Qingjie;Bailey, George S.;Dashwood, Roderick H.
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10b
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    • pp.5-6
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    • 2001
  • The carcinogens 2-arnioo-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the Fisher 344 rat that contain mutations in Ctnnb1, the gene for b-catenin, but the pattern of mutation differs from that found in human colon cancers. in both species, mutations affect the glycogen synthase kinase 3$\beta$ (GSK-3$\beta$) consensus region of $\beta$-catenin, but whereas they directly substitute critical Ser/Thr phosphorylation sites in human colon cancers, the majority of mutations cluster around Ser$^{33}$ in the rat tumors.(omitted)

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Potential Prebiotic Properties of Whey Protein and Glycomacropeptide in Gut Microbiome

  • Bryna Rackerby;Hoang Ngoc M. Le;Avery Haymowicz;David C. Dallas;Si Hong Park
    • Food Science of Animal Resources
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    • v.44 no.2
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    • pp.299-308
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    • 2024
  • Proteins in whey have prebiotic and antimicrobial properties. Whey protein comprises numerous bioactive proteins and peptides, including glycomacropeptide (GMP), a hydrophilic casein peptide that separates with the whey fraction during cheese making. GMP has traditionally been used as a protein source for individuals with phenylketonuria and also has prebiotic (supporting the growth of Bifidobacterium and lactic acid bacteria) and antimicrobial activities. GMP supplementation may help positively modulate the gut microbiome, help treat dysbiosis-related gastrointestinal disorders and improve overall health in consumers.