Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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SUPPRESSION BY CHLOROPHYLL, BUT PROMOTION BY CHLOROPHYLLIN, OF COLON CARCINOGENESIS IN THE FISHER 344 RAT

  • Blum, Carmen A. (Linus Pauling Institute, Oregon State University) ;
  • Xu, Meirong (Linus Pauling Institute, Oregon State University) ;
  • Orner, Gayle A. (Linus Pauling Institute, Oregon State University) ;
  • Diaz, G.Dario (Linus Pauling Institute, Oregon State University) ;
  • Li, Qingjie (Linus Pauling Institute, Oregon State University) ;
  • Bailey, George S. (Dept. of Environmental and Molecular Toxicology, Oregon State University) ;
  • Dashwood, Roderick H. (Dept. of Environmental and Molecular Toxicology, Oregon State University)
  • Published : 2001.10.01
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Abstract

The carcinogens 2-amino-3-methylimidazo［4, 5-f］quinoline (IQ) and 1, 2-dimethylhydrazine (DMH) induce colon tumors in the Fisher 344 rat that contain mutations in Ctnnbl, the gene for b-catenin, but the pattern of mutation differs from that found in human colon cancers. In both species, mutations affect the glycogen synthase kinase 3$\beta$ (GSK-3$\beta$) consensus region of $\beta$-catenin, but whereas they directly substitute critical Ser/Thr phosphorylation sites in human colon cancers, the majority of mutations cluster around Ser$_{33}$ in the rat tumors.(omitted)d)

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