• 제목/요약/키워드: Oral function

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미취학 아동의 치아우식증과 식습관 및 간식섭취와의 관계 (A study on the correlation between the dental caries and dietary habits and snack intake of pre-school children)

  • 강현숙;정정화
    • 한국치위생학회지
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    • 제10권2호
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    • pp.345-359
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    • 2010
  • Objectives : The purpose of this study was to correlation between the index of dental caries in primary teeth and the habits of diet and snack which are expected to influence on the index. The subjects of this study were 165 parents of the children who visited a pediatric dental hospital located in Gyeong-gi do from Jun. 15th to Sep. 26th, 2009, and the self-report questionnaire survey was performed. Methods : A questionnaire used in a previous study was revised and completed for this study and it consisted of 15 items on general characteristic, nine items on dietary habit, and five items on snack intake habit. The collected data was analyzed using SPSS program and findings are as follows Results : 1. The index of dental caries in primary teeth by ages was that children of four years old has 4~5 with 27.5%, children of five years old has 2~3 and 4~5 with 33.3% and children of six years old has 1 and 8~9 with 25.6%, showing a statistically significant(${\chi}^2$=37.72, p<.01). 2. The frequency of brushing teeth was found to have statistically significant negative correlation with the number of primary teeth with dental caries (${\chi}^2$=61.20, p<.001). 3. The frequency of taking snack was found to have statistically significant positive correlation with the number of primary teeth with dental caries (${\chi}^2$=51.42, p<.001). 4. The desirability of dietary habit was found to have statistically significant negative correlation with the number of primary teeth with dental caries (${\chi}^2$=36.51, p<.001). 5. The frequency of taking biscuit was found to have statistically significant positive correlation with the number of primary teeth with dental caries (${\chi}^2$=67.74, p<.001). 6. The frequency of taking bread was found to have statistically significant positive correlation with the number of primary teeth with dental caries (${\chi}^2$=29.63, p<.01). 7. The frequency of taking caramel and candy was found to have statistically significant positive correlation with the number of primary teeth with dental caries (${\chi}^2$=38.85, p<.001). 8. The frequency of taking soft drinks was found to have statistically significant positive correlation with the number of primary teeth with dental caries (${\chi}^2$=52.92, p<.001). 9. The frequency of taking ice-creams was found to have statistically significant positive correlation with the number of primary teeth with dental caries (${\chi}^2$=75.07, p<.001). Conclusions : Those findings show that the children with undesirable dietary habit and higher frequency of taking snack have higher index of dental caries in primary teeth, therefore, it is considered that the regular brushing teeth and establishment of desirable dietary habit are very important for keeping health oral cavity. It is recommended that the continuous concern and repeated learning are needed in house and group of rearing infants so that the children take foods of fruits which have function of self-purification than the food of carbohydrates which has high adhesion and level of sweetness.

부자(附子)의 경구투여(經口投與)가 RAT의 척수손상(脊髓損傷)에 미치는 영향(影響) 및 비교(比較) (The Effects of Radix aconiti on the Contraction of Rat's Spinal Cord Injury)

  • 이건목;김경식;이강창
    • Journal of Acupuncture Research
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    • 제15권2호
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    • pp.105-116
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    • 1998
  • Purpose In this study, We observed the recovery process in the ability to move in the hind limbs of the rats whose spinal cord injuries were treated by Radix acouniti(RA). The purpose of this study is to see the effects of Radix acouniti(RA) water extract on the contraction of rat's spinal cord injury. Procedure First, the rats were subjected to hemisectional spinal cord injuries by a scalpel blade. Those rats, then, were divided into three groups: Sham operated rats group and the experimental group, which received the Radix acouniti(RA) water extract, and the control group, which had no treatment. Their recovery in the ability to walk was observed by the Open Field Test (OFT) for 14 days after the injuries. Method The OFT was applied at four points: the hip, knee, ankle joint, and the tail. Each joint was given a movement rating of from 0 to 3, depending on the amount of movement. A movement rating of 0 designates no movement, a 1 designates slight movement, a 2 designates increased movement, and a 3 designates active movement. Slight movement is defined as a joint displaying less than or equal to 30% of that joint range, increased movement is displaying less than or equal to 60% of that joint's range, and active movement is greater than or equal to 90% of that joint's range. Tail movement is also graded on a scale of 0 to 3. A rating of 0 indicates that the tail is down 100% of the time, one of 1 indicates that the tail is down more than 10%, one of 2 shows that the tail is down less than 50% but more than 10% of the time, and one of 3 shows that the tail is down less than 10% of the time. All four ratings were added together and then averaged to arrive at a single score. Results The sham group which did not go through spinal cord injuries showed near normal results on all 3 joints and tail from right after the operation, which one would expect. The RA oral application group showed more effective recovery of movememt function than the control group around 4 days after the spinal cord injuries. However, after 14 days, both groups displayed almost the same degree of movement recovery. The results of this study are summarized as follows: 1. After 14days the spinal cord injuries, movement was recovered in sham operated group, control group, and experimented group in the hip, the knee, the tail and then the ankle of rats, in that order. 2. Around 7 days after the spinal cord injuries, the experimental group proved the effectiveness of the therapy in terms of movement recovery. 3. The level of ALT, ALP, AST in RA treated group was slightly increased. 4. The level of BUN and creatinine in RA treated group was slightly increased. The above results indicate that RA therapy at an early stage can bring about better movement recovery in patients with spinal cord injuries from traffic accidents or industrial disasters. But there is apparent side effect of RA on clinical, therefore the study on this should be continued.

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The Effect of Postural Yinyang Correction of Temporomandibular Joint for Temporomandibular Disorder

  • Lee, Seung-Jeong;Ryu, Hye-Min;Kim, Su-Gyeong;Park, Eun-Jin;Lim, Jae-Eun;Lee, Young-Jun;Song, Choon-Ho;Yoon, Hyun-Min;Kim, Cheol-Hong
    • Journal of Acupuncture Research
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    • 제35권3호
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    • pp.129-137
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    • 2018
  • Background: The purpose of this study was to determine the effect of Postural Yinyang correction of the temporomandibular joint (functional cerebrospinal therapy) on temporomandibular disorder. Methods: Medical records of 21 outpatients were reviewed who were diagnosed with temporomandibular joint disorder, unspecified (K0769) and treated at the Department of Acupuncture & Moxibustion, Dong-Eui University Korean Medicine Hospital from May $1^{st}$, 2017 to April $30^{th}$, 2018. Patients received more than 10 treatments of upper cervical manipulation and performed self-exercise therapy more than 3 times a day and wore an accurate balancing appliance in the oral cavity for more than 8 hours per day. To estimate the efficacy, visual analogue scale (VAS), numerical rating scale (NRS), maximum mouth opening (MMO), symptom intensity scale (SIS), max SIS (MSIS), symptom frequency scale (SFS), mandibular function impairment questionnaire (MFIQ) and 5-point Likert scale were used. Results: NRS and MSIS were significantly improved during each period. VAS, MMO, SIS, and SFS were significantly improved during each period, except the period from the $8^{th}$ to $10^{th}$ visit. MFIQ score was significantly improved during the period from the $1^{st}$ to $10^{th}$ visit. In the 5-point Likert scale, the results showed a high patient satisfaction with the treatment. Conclusion: These results showed that functional cerebrospinal therapy using an accurate balancing appliance, may be useful for reducing the symptoms of temporomandibular disorder.

$NeuBo153^{\circledR}$의 중풍동물 모델에 대한 뇌신경 보호효과 (Neuroprotective Effect of $NeuBo153^{\circledR}$ on Transient Focal Cerebral Ischemia in Rats)

  • 부영민;오세남;황만기;정진희;이대희;박영미;김미연;김진화;김호철
    • 대한본초학회지
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    • 제21권2호
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    • pp.151-158
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    • 2006
  • Objectives : The purpose of the present study is to observe the neuroprotective effect of the $NeuBo153^{\circledR}$ on transient focal cerebral ischemia in rats. Methods : $NeuBo153^{\circledR}$ was made by mixing the herbs, mainly the root of Panax ginseng, the root of Rehmannia glutinosa and Poria cocos, the stem bark of Acanthopanax senticosus, the root of Scutellaria baicalensis and Mel, and heating for 96 hours. Transient Focal cerebral ischemia (2 h of ischemia, 22 h of reperfusion) was induced by intraluminal suture method with SD rats. Sensory motor function was tested by rotarod test, prehensile traction test, beam balance test and foot fault test at 24 h after ischemia. The brain slices were stained by 2% 2, 3, 5-triphenyltetrazolium chloride and the infarct volume was measured by graphic analyzer at 24 h after ischemia. Results : $NeuBo153^{\circledR}$ treated group did not show significant differences compared with vehicle treated group in body temperature. Oral administration of $NeuBo153^{\circledR}$ reduced brain infarct volume by 29.7% compared with vehicle treated group. $NeuBo153^{\circledR}$ also showed protective effects on sensory motor functional deficits. Conclusion : $NeuBo153^{\circledR}$ treatment reduced brain damage and improved functional deficits induced by MCAo. It showed neuroprotective effects even when treatment was relayed 2 h after injury. Further research is required to evaluating long term functional recovery am accurate therapeutic range and mechanisms.

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비증후군성 부분 무치증 환자에서 PAX9 유전자 돌연변이 (A Novel PAX9 Mutation in a Family with Non-Syndromic Oligodontia)

  • 이예지;신터전;현홍근;김정욱;이상훈;김영재
    • 대한소아치과학회지
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    • 제43권3호
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    • pp.299-305
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    • 2016
  • 본 연구는 서울대학교 치과병원 소아치과에 내원한 부분 무치증 환자를 대상으로 질환의 원인이 될 수 있는 돌연변이를 규명하고, 그 역할에 대하여 고찰하고자 하였다. 다수의 영구치 결손을 주소로 서울대학교 치과 병원에 내원 한 7세 여아와 어머니를 대상으로 구강검진 및 파노라마 방사선 촬영을 진행하였다. 연구 동의서를 받고, 유전자 검사를 위한 채혈을 시행하였다. PAX9 유전자의 모든 exon에 대해 특이적인 primer를 이용하여 중합효소 연쇄반응을 시행하였으며, 해당 산물을 정제하고 염기서열분석을 진행하였다. 결과는 NCBI Gene Bank와 대조하여 해당 영역의 돌연변이를 조사하였다. 7세 환아는 총 11개의 영구치 결손이 관찰되었으며, 어머니는 총 19개의 영구치 결손이 관찰되었다. 치아 결손 외에 손톱, 모발, 피부, 땀샘과 연관 된 다른 결함은 관찰되지 않았다. 유전자 분석 결과, PAX9의 exon 2 영역에서 nonsense mutation(c.184G>T, $p.Glu62^*$)을 확인하였으며, 대상자 모두에서 이형접합 돌연변이로 관찰되었다. 해당 돌연변이의 결과로 exon 2 내에서 전사 종결이 일어나게 되며, 발현 된 단백질은 정상 단백질에 비하여 280개의 아미노산이 짧은 상태로 발현된다고 추측할 수 있다. 결손된 부분은 paired box domain 및 DNA binding site 등 해당 단백질의 기능에 있어서 필수적인 영역을 포함하고 있으므로, 부분 무치증을 유발했을 가능성이 높다. 또는 해당 돌연변이의 전사체가 nonsense-mediated decay system(NMD system)에 의하여 분해됨으로써 haploinsufficiency를 유발하여 부분 무치증의 원인으로 작용했을 것으로 사료된다.

골결손과 치주질환 유도 후 성견 절치의 실험적 함입이동시 치주조직의 반응 (PERIODONTAL RESPONSE FOLLOWING APPLICATION OF INTRUSIVE FORCES TO THE INCISORS WITH BONE LOSS AND PERIODONTAL DISEASE IN ADULT DOGS)

  • 황현식;박양수;최홍란
    • 대한치과교정학회지
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    • 제28권3호
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    • pp.431-440
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    • 1998
  • 치주질환에 이환된 성인환자에서 상악전치의 치간공간과 아울러 정출이 발생된 경우 기능 및 심미의 회복을 위해서는 함입이동이 필요하다. 본 연구는 골하치주낭 즉, 수직적 골결손이 있는 절치의 함입이동시 치주조직 반응을 살펴보기 위하여 시행되었다. 상악 좌우 측절치에 골결손과 함께 치주질환을 유발시킨 성견 4마리를 실험대상으로 하여 양측 모두에 치주수술을 시행하고 결손부 최하방 치근면에 notch를 형성 한 2주후 우측 제2측절치는 4주간 함입이동 후 4주간 보정을 시행한 실험측으로, 좌측 제2측절치는 구강위생관리만 시행한 대조측으로 사용한 바 조직소견을 통하여 다음과 같은 결론을 얻었다. 1. 함입이동없이 치주수술만 시행한 대조측의 조직소견은 치주낭 깊이의 감소를 보였으나 notch 부위부터 치주낭 기저부까지 긴 접합상피 상태를 보였으며 신생백악질이 형성된 일부에서만 결합조직 부착의 양상이 보였다. 2. 함입이동을 시행한 실험측은 대조측에 비하여 상피부착이 줄어든 반면 보다 넓은 신생 결합조직 부착 소견을 나타내었다. 3. 대조측과는 달리 실험측 notch근처의 결합조직내에는 다수의 세포가 관찰되었으며, 신생 백악질 생성 역시 대조측보다 많이 관찰되었다. 이상의 결과는 치주질환으로 인하여 정출된 치아에서도 철저한 염증조절과 구강위생이 유지되고 적절한 크기의 힘에 의하여 순수한 함입이동이 적용된다면 바람직한 치료결과가 가능함을 시사하였다.

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부분 무치악 환자에서 마그네슘 이온주입 임플란트의 성공률에 대한 전향적 임상연구 (The success rate of Mg-incorporated oxidized implants in partially edentulous patients: a prospective clinical study)

  • 최수정;유정호;이규복;김진욱
    • 대한치과보철학회지
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    • 제50권3호
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    • pp.176-183
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    • 2012
  • 연구 목적: 부분 무치악 환자에서 Mg titanate implant (M Implant system, Shinhung, Korea)의보철 후 1년간의 방사선사진을 이용한 변연골 흡수량과 Osstell$^{(R)}$을 이용한 임플란트 안정성 평가 결과를 분석하여 임상적인 성공률에 대해 알아보고자 한다. 연구 재료 및 방법: 38명의 환자에 79개의 임플란트를 식립하여 보철 후 1년 동안 변연골 흡수량, 임플란트의 동요도, 임플란트 식립 위치에 따른 분포 및 성공률, 보철 전후에 따른 성공률을 분석했다. 결과: 변연골의 흡수량은 보철물 장착 후 1년간의 평가에서 상악에서는 평균 1.537 mm, 하악에서는 평균 1.172 mm의 변연골 흡수가 관찰되었으며, 전체적인 상하악의 평균 변연골 흡수량은 1.255 mm로 관찰되었다. 수술 후 시간이 경과함에 따라 ISQ값은 미약하게 감소하였다가 증가하는 경향을 보였으나, 상악과 하악 모두에서 식립 당일 이후 예비 인상일, 최종 보철물의 장착일과 주기적인 평가 기간 동안 ISQ값의 큰 증가나 감소를 나타내지는 않았다. 성공률은 상악에서의 94.12%였고, 하악에서의 98.39%였다. 결론: 본 실험의 결과로 미루어 Mg titanate implant는 임상적으로 양호한 결과를 보여주었다.

실패한 고정성 임플란트 보철물을 제거 후 임플란트 융합 가철성 국소의치로 전환 치료한 증례 (A conversion to implant assisted removable partial denture in failed fixed implant prosthesis of mandible: A case report)

  • 진승리;정창모;윤미정;허중보;이현종;이소현
    • 대한치과보철학회지
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    • 제58권2호
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    • pp.161-168
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    • 2020
  • 임플란트 고정성 보철물의 실패는 과도한 교합스트레스와 같은 생역학적인 요인과 세균 감염, 염증과 같은 생물학적인 요인으로 인하여 일어난다. 임플란트 합병증으로 인한 문제가 해결되지 않고 악화되어 심한 골흡수가 일어난 임플란트는 제거되어야 하며, 제거 후 잔존 치아와 잔존 임플란트 및 잔존 치조제를 고려하여 새로운 치료를 계획해야 한다. 본 증례의 환자는 하악 무치악부에 약 10년 전 식립한 하악 고정성 임플란트 보철물 중 일부를 임플란트 주위염으로 인하여 제거하게 되었다. 추가 임플란트 재식립을 위한 잔존 치조골의 상태를 재평가 하고 소수의 임플란트를 추가 식립 후 임플란트 서베이드 크라운을 지대치로 하는 임플란트 융합 가철성 국소의치로 최종 치료하였다. 이를 통해 실패 이후 저작기능을 다시 회복하고 구강위생 관리에 유리한 조건으로 전환하였기에 이를 보고하고자 한다.

화학적 발암원의 조직 특이성 암유발기전 - DMBA와 NMU의 선택적 유암 발생기전을 중심으로 (Molecular Basis of Organospecific Carcinogensis by Chemical Carcinogens-Study with Breast Cancer Specific Carcinogens: DMBA as an Indirect-Acting carcinogen and NMU as a Direct-Acting cancinogen.)

  • 박종영;김승원;박상철
    • 한국환경성돌연변이발암원학회지
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    • 제9권1호
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    • pp.1-12
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    • 1989
  • 특정 발암원의 조직특이성 암유발기전을 연구하기 위하여 DMBA의 구강투여 또는 NMU의 동맥주입에 의하여 유암이 유도되는 실험모델을 대상으로 선택하였다. 본 실험에서는 화학적 발암원의 유암유발기전에 미치는 숙주인 흰쥐의 연령효과를 아울러 비교분석하였으며, 특히 발암원의 조직내 활성화, 불활화 및 해독 그리고 DNA 손상과 수성등의 변화를 구명하였다. 유암의 발생율은 1년생 흰쥐보다 생후 50일 흰쥐에서 현저하게 높았다. 특정조직의 선택적 발암기전을 설명하는 기전의 일환으로 조직 DNA의 특정 발암원에 의한 공유결합성 지표(covalent binding index, CBI)를 발암원의 활성화 기전 지표로는 cytochrome P450의 함량을 반면 불확화의 지표로는 glutathione S-transferase와 peroxide의 활성을 비교하였다. 조직의 CBI는 생후 50일군의 유선조직이 DMBA나 NMU에 대하여 간조직보다 유의하게 높았으며 시험관내 CBI 실험에서는 생후 50일군 유선조직의 microsome 분획의 발암원 활성화능이 보다 높음을 관찰하였다. 또한 T.C.D.D. 의존성 cytochrome P450 함량도 생후 50일군에서 가장 높았다. 그러나 불활화 효소들은 연령 변화에 따라 유의한 변화를 보여주지 않았다. 상기의 결과들은 DMBA나 NMU와 같은 발암물질이 특정조직, 특히 유선조직에 생후 50일군에서 유암을 선택적으로 유발하는 기전은 표적 조직의 높은 발암원 활성화능, 낮은 불활화등 그리고 효율이 낮은 DNA 수선능이 연계적으로 작동함으로써 이루어지고 있음을 보여주고 있다.

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Incidence of Adverse Effects and Discontinuation Rate between Patients Receiving 250 Micrograms and 500 Micrograms of Roflumilast: A Comparative Study

  • Joo, Hyonsoo;Han, Deokjae;Lee, Jae Ha;Rhee, Chin Kook
    • Tuberculosis and Respiratory Diseases
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    • 제81권4호
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    • pp.299-304
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    • 2018
  • Background: Roflumilast is the only approved oral phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease (COPD) in patients with chronic bronchitis and a history of frequent exacerbations. The purpose of this study was to examine the incidence of adverse effects associated with roflumilast treatment in a real-world setting. Further, we compared the incidence of adverse effects and the discontinuation rate among patients receiving different doses. Methods: We identified all outpatients diagnosed with COPD at Seoul St. Mary's Hospital between May 2011 and September 2016 and retrospectively reviewed their medical records. Roflumilast was prescribed to patients in doses of $500{\mu}g$ and $250{\mu}g$. Results: A total of 269 COPD patients were prescribed roflumilast in our hospital during the study period. Among them, 178 patients were treated with $500{\mu}g$ and 91 patients were treated with $250{\mu}g$. The incidence of adverse effects was 38.2% in the $500{\mu}g$ group and 25.3% in the $250{\mu}g$ group (p=0.034). The discontinuation rate of roflumilast was 41.6% (n=74) in the $500{\mu}g$ group and 23.1% (n=21) in the $250{\mu}g$ group (p=0.003). When adjusted by age, sex, smoking status, and lung function, $500{\mu}g$ dose was significantly associated with the discontinuation of roflumilast (odds ratio, 2.87; p<0.001). Conclusion: There was a lower incidence of adverse effects and discontinuation among patients treated with $250{\mu}g$ compared with $500{\mu}g$ dose. Further studies regarding the optimal dose of roflumilast are required.