The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Neuroprotective Effect of $NeuBo153^{\circledR}$ on Transient Focal Cerebral Ischemia in Rats

$NeuBo153^{\circledR}$의 중풍동물 모델에 대한 뇌신경 보호효과

  • Bu, Young-Min (Dept of Herbal Pharmacology, College of pharmacy, Woosuk University) ;
  • Oh, Se-Nam (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Hwang, Man-Ki (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Chung, Jin-Hee (Korea Institutue of Science and Technology of East Medicine, NeuMed Co. Ltd) ;
  • Lee, Dae-Hee (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Young-Mee (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Mi-Yon (Korea Institutue of Science and Technology of East Medicine, NeuMed Co. Ltd) ;
  • Kim, Zhen-Hwa (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Ho-Cheol (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University)
  • 부영민 (우석대학교 한약학과 본초학교실) ;
  • 오세남 (경희대학교 한의과대학 본초학교실) ;
  • 황만기 (경희대학교 한의과대학 본초학교실) ;
  • 정진희 (뉴메드 한의과학기술연구소) ;
  • 이대희 (경희대학교 한의과대학 본초학교실) ;
  • 박영미 (경희대학교 한의과대학 본초학교실) ;
  • 김미연 (뉴메드 한의과학기술연구소) ;
  • 김진화 (경희대학교 한의과대학 본초학교실) ;
  • 김호철 (경희대학교 한의과대학 본초학교실)
  • Published : 2006.06.30
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Abstract

Objectives : The purpose of the present study is to observe the neuroprotective effect of the $NeuBo153^{\circledR}$ on transient focal cerebral ischemia in rats. Methods : $NeuBo153^{\circledR}$ was made by mixing the herbs, mainly the root of Panax ginseng, the root of Rehmannia glutinosa and Poria cocos, the stem bark of Acanthopanax senticosus, the root of Scutellaria baicalensis and Mel, and heating for 96 hours. Transient Focal cerebral ischemia (2 h of ischemia, 22 h of reperfusion) was induced by intraluminal suture method with SD rats. Sensory motor function was tested by rotarod test, prehensile traction test, beam balance test and foot fault test at 24 h after ischemia. The brain slices were stained by 2% 2, 3, 5-triphenyltetrazolium chloride and the infarct volume was measured by graphic analyzer at 24 h after ischemia. Results : $NeuBo153^{\circledR}$ treated group did not show significant differences compared with vehicle treated group in body temperature. Oral administration of $NeuBo153^{\circledR}$ reduced brain infarct volume by 29.7% compared with vehicle treated group. $NeuBo153^{\circledR}$ also showed protective effects on sensory motor functional deficits. Conclusion : $NeuBo153^{\circledR}$ treatment reduced brain damage and improved functional deficits induced by MCAo. It showed neuroprotective effects even when treatment was relayed 2 h after injury. Further research is required to evaluating long term functional recovery am accurate therapeutic range and mechanisms.

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