• Journal of Periodontal and Implant Science
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• v.48 no.5
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• pp.284-294
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• 2018

Purpose: Epithelial barrier dysfunction is involved in the pathophysiology of periodontitis and oral lichen planus. Estrogens have been shown to enhance the physical barrier function of intestinal and esophageal epithelia, and we aimed to investigate the effect of estradiol (E2) on the regulation of physical barrier and tight junction (TJ) proteins in human oral epithelial cell monolayers. Methods: HOK-16B cell monolayers cultured on transwells were treated with E2, an estrogen receptor (ER) antagonist (ICI 182,780), tumor necrosis factor alpha ($TNF{\alpha}$), or dexamethasone (Dexa), and the transepithelial electrical resistance (TER) was then measured. Cell proliferation was measured by the cell counting kit (CCK)-8 assay. The levels of TJ proteins and nuclear translocation of nuclear factor $(NF)-{\kappa}B$ were examined by confocal microscopy. Results: E2 treatment increased the TER and the levels of junctional adhesion molecule (JAM)-A and zonula occludens (ZO)-1 in a dose-dependent manner, without affecting cell proliferation during barrier formation. Treatment of the tight-junctioned cell monolayers with $TNF{\alpha}$ induced decreases in the TER and the levels of ZO-1 and nuclear translocation of $NF-{\kappa}B$. These $TNF{\alpha}-induced$ changes were inhibited by E2, and this effect was completely reversed by co-treatment with ICI 182,780. Furthermore, E2 and Dexa presented an additive effect on the epithelial barrier function. Conclusions: E2 reinforces the physical barrier of oral epithelial cells through the nuclear ER-dependent upregulation of TJ proteins. The protective effect of E2 on the $TNF{\alpha}-induced$ impairment of the epithelial barrier and its additive effect with Dexa suggest its potential use to treat oral inflammatory diseases involving epithelial barrier dysfunction.

• Journal of Korean society of Dental Hygiene
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• v.14 no.6
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• pp.859-869
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• 2014

Objectives: The purpose of this study was to examine the subjective oral health awareness, oral health knowledge, oral health behavior and OHIP-14 in industrial workers. Methods: A self-reported questionnaire was filled out by 243 workers in Jeonbuk May 7 to June 10, 2014. Except incomplete answers, 230 data were analyzed. The questionnaire consisted of general characteristics of the subjects(sex, age, career, marital status, abd family), oral health recognition characteristics(oral health attention, subjective oral health status, and oral health concern), oral health knowledge, oral health behavior, and oral health related quality of life. The instrument was 14 questions od OHIP-14 including functional restriction(2 questions), physical pain(2 questions), psychological discomfort(2 questions), physical ability decease(2 questions), psychological function decease(2 questions), social activity decrease (2 questions), and social discomfort(2 questions). Cronbach's alpha was 0.949 in this study and it was reliable. Results: Oral health interests showed that 57.8% of the workers had concern for oral health interests and 50.4% perceived that their subjective oral health was moderate status. 55.6% of the workers answered that their oral health status was very worried. Women had more knowledge about the oral health. Those who were in fifties tended to have more knowledge of oral health than the other age groups. Those who had more concern for oral health included female workers, married workers, and workers above 21 years. The concern for oral health made the workers keep good oral health. Higher score of OHIP-14 means good oral health. Conclusions: Good oral health-related quality of life is proportional to continuous management of oral health and subjective oral health status. It is necessary to develop the tailored oral health education program for the workers.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.5 no.2
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• pp.96-99
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• 2009

Macroglossia is a tongue pathology of multiple etiology as systemic disease like cerebral palsy and Down syndrome etc. It can cause abnormal oral conditions including anterior open bite or dyspnea by changing occlusion and oral habits. So many handicapped children who have macroglossia need to get surgery of large tongue to improve esthetics, function, and treatment stability. The purpose of this report is to evaluate 2 patients, one has cerebral palsy and the other lymphangioma, who have experience of glossectomy with review of literature.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.40 no.2
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• pp.91-95
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• 2014

The posttraumatic complications of jaw fractures related to jaw function and facial deformity include nonunion, malunion, malocclusion, temporomandibular joint dysfunction and facial asymmetry. This report presents cases referred to our department for revision of malunion and malocclusion following inadequate reduction of jaw fractures. Three patients with posttraumatic malocclusions caused by malunion were treated with a LeFort I osteotomy in one case and re-fracture in two cases. All of the patients exhibited stable results without further complications (e.g., malunion or malocclusion). Accurate preoperative diagnosis and proper anatomical reduction of the fracture segments are essential to preventing post-surgical malunion and malocclusion.

• Journal of Oral Medicine and Pain
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• v.23 no.3
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• pp.271-276
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• 1998

The purpose of the pilot study was to know the relationship between halitosis and oral hygine, to examine the difference of the positon of the straw to be placed in the oral cavity by using Halimeter. Fourteen persons that has good health condition without halitosis were participated in this pilot study. They were treated twice prophylaxis and then they had not tooth brushing during two weeks. After two weeks, they were examied to gingival index, plaque index, VSC valuses. The obtained results were as follosws : 1. No significant difference of VSC values were observed during two weeks withoiut tooth brushing. But significant difference of gingival index, plaque index were observed. It was suggested that halitosis was not caused by only plaque, complex reasons(salivary function, stress etc) maybe caused halitosis. 2. Here were significant reduction of VSC values as the depth of plastic straw into the oral cavity decreased (p<0.05)

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.49 no.3
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• pp.148-151
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• 2023

Schwannomas are benign tumors originating from myelinating cells constituting nerve sheaths but rarely contain cellular elements of the nerve. The authors encountered a 47-year-old female patient with a schwannoma on the anterior mandibular ramus arising from the buccal nerve, measuring 3 cm×4 cm. Surgical resection was performed with preservation of the buccal nerve via microsurgical dissection. After one month, the sensory function of the buccal nerve was recovered without complications.

• Journal of Periodontal and Implant Science
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• v.41 no.2
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• pp.79-85
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• 2011

Purpose: The aim of this study was to obtain objective and standardized information on masticatory function and patient atisfaction following second molar single implant therap. Methods: Twenty adult patient, who had restored second molar single implants more than 1 month before the study, were enrolled in this stud. All patients received a chewing test using peanuts before and after insertion of the implant prosthesi, with a questionnaire and visual analogue scale (VAS) to evaluate the effect of second molar single implant therap. Results: his study obtained standardized information on the masticatory function objectively (e.g., P, R, $X_{50}$) before (Pre-insertion) and after insertion (Post-insertion) of the implant prosthesis. Masticatory performance (P) after insertion of the implant prosthesis significantly increased from $67.8{\pm}9.9$ to $84.3{\pm}8.5$% (P<0.0001). With the implant prosthesis, the P value increased by 24%. The masticatory efficiency index (R) of Post-insertion is higher than that of Pre-insertion (P<0.0001). With the implant prosthesis, the R value increased by 29%. The median particle size ($X_{50}$) of Post-insertion is lower than that of Preinsertion (P<0.0001). More than 90% of the patients were satisfied with the second molar single implant therapy from a functional point of view. Conclusions: These findings indicate that a second molar single implant can increase masticatory function.

• Journal of Korean society of Dental Hygiene
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• v.19 no.3
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• pp.351-362
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• 2019

Objectives: The study aimed to analyze the factors affecting the maturity of dental biofilm, which was assessed with quantitative light-induced fluorescence-digital(QLF-D), in a sample of Korean older adults. Methods: This cross-sectional study included 67 participants, aged 65 years and older. All participants completed a questionnaire and tests to measure their manual dexterity and handgrip strength, which are parameters that indicate hand function abilities. To evaluate dental biofilm maturity, 804 surfaces of six index teeth were imaged using QLF-D and then quantified as ${\Delta}R$ values. All data were collected from May 25, 2017 to April 30, 2018. The independent t-test, one-way analysis of variance, and step-wise multiple linear regression were performed to analyze the factors associated with the maturity of dental biofilm (${\Delta}R$). Results: The multivariate linear regression analysis revealed that the factor most strongly related to dental biofilm maturity(${\Delta}R$) was manual dexterity (${\beta}=-0.326$), followed by handgrip strength (${\beta}=-0.303$) and use of interdental cleaning devices (${\beta}=-0.283$) (p<0.05). Conclusions: Manual dexterity, handgrip strength, and use of interdental cleaning devices are factors that can predict dental biofilm maturity in adults aged 65 years or older. Therefore, the hand function of a patient should be evaluated first, before assessing the oral hygiene status of the patient or providing him/her with oral health education, and the dental hygienist should provide differentiated oral hygiene care depending on the patient's hand function ability. Finally, dental hygienists should help older adults to recognize the importance of auxiliary oral hygiene devices such as interdental brushes and keep motivating them to use the devices more frequently.

• Journal of Dental Anesthesia and Pain Medicine
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• v.23 no.3
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• pp.153-162
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• 2023

Background: Recent animal studies have suggested the role of GABA type A (GABA-_A) receptors in salivation, showing that GABA-_A receptor agonists inhibit salivary secretion. This study aimed to evaluate the effects of propofol (a GABA-_A agonist) on salivary secretions from the submandibular, sublingual, and labial glands during intravenous sedation in healthy volunteers. Methods: Twenty healthy male volunteers participated in the study. They received a loading dose of propofol 6 mg/kg/h for 10 min, followed by 3 mg/kg/h for 15 min. Salivary flow rates in the submandibular, sublingual, and labial glands were measured before, during, and after propofol infusion, and amylase activity was measured in the saliva from the submandibular and sublingual glands. Results: We found that the salivary flow rates in the submandibular, sublingual, and labial glands significantly decreased during intravenous sedation with propofol (P < 0.01). Similarly, amylase activity in the saliva from the submandibular and sublingual glands was significantly decreased (P < 0.01). Conclusion: It can be concluded that intravenous sedation with propofol decreases salivary secretion in the submandibular, sublingual, and labial glands via the GABA-_A receptor. These results may be useful for dental treatment when desalivation is necessary.

• Korean Journal of Schizophrenia Research
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• v.21 no.2
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• pp.74-80
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• 2018

Objectives : This study investigated whether long-acting injectable (LAI) paliperidone is different from its oral form in terms of the effect on cognitive function in schizophrenia spectrum and other psychotic disorders. Methods : We reviewed the medical records of patients in Seoul National University Bundang Hospital who were diagnosed as having schizophrenia and/or other psychotic disorders based on DSM-5 from 2016 to 2017. Seven patients were treated with oral paliperidone and 11 were treated with paliperidone palmitate. All patients underwent clinical and neuropsychological assessment, including the Korean version of the MATRICS Consensus Cognitive Battery (MCCB) at their first visit or within one month of their initial treatment. MCCB was repeated within three to 12 months after the initial assessment. Results : There was no significant difference between the two groups in most cognitive domains including speed of processing, attention and vigilance, working memory, verbal learning, visual learning and reasoning and problem solving domain. However, patients treated with paliperidone palmitate showed better improvement in social cognition domain than those taking oral paliperidone. The standardized values of social cognition domain scores had significantly improved over time in patients under paliperidone palmitate, demonstrating a significant time-by-group interaction. Conclusion : Our results show that long-acting injectable paliperidone could be helpful in some aspects of improving cognitive function in schizophrenia spectrum and other psychotic disorders. Further studies with other antipsychotics are necessary to generalize the results.