• Journal of Radiopharmaceuticals and Molecular Probes
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• v.3 no.2
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• pp.91-97
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• 2017

$^{18}F-THK-5351$ is a PET radiotracer to image the hyperphosphorylated tau fibrillar aggregates in human brain. This protocol describes the optimized radiosynthesis of $^{18}F-THK-5351$ using a commercial GE $TRACERlab^{TM}$ $FX_{FN}$ radiosynthesis module. $^{18}F-THK-5351$ was prepared by nucleophilic [$^{18}F$]fluorination from its protected tosylate precursors, (S)-(2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy] quinolone(THK-5352), at $110^{\circ}C$ for 10 min in dimethyl sulfoxide, followed by deprotection with 1 N HCl. The average radiochemical yield of $^{18}F-THK-5351$ was $31.9{\pm}6.7%$(decay-corrected, n = 10), with molar activity of $198.1{\pm}33.9GBq/{\mu}mol$($5.4{\pm}0.9Ci/{\mu}mol$, n = 10). The radiochemical purity was determined to be above 98%. The overall production time including HPLC purification is approximately 70 min. This fully-automated protocol is validated for clinical use.

• IEIE Transactions on Smart Processing and Computing
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• v.4 no.2
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• pp.115-125
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• 2015

This paper presents a Cuckoo search algorithm to secure adversaries misdirecting multi-hop routing in Mobile ad hoc networks (MANETs) using a robust Trust Predicated Routing Framework with an optimized cluster head selection. The clustering technique designed in this framework leads to efficient routing in MANETs. The heavy work load in the node causes an energy drop in cluster head, which leads to re-clustering of the group, and another cluster head is selected to avoid packet loss during data transmission. The problem in the re-clustering process is that the overall efficiency of the routing process is reduced and the processing time is increased. A Cuckoo search based optimization algorithm is proposed to solve the problem of re-clustering by selecting the secondary cluster head within the initially formed cluster group and eliminating the reclustering process. The proposed framework enables a node to select a reliable and secure route for MANET and the performance can be evaluated by comparing the simulated results with the AODV routing protocol, which shows that the performance of the proposed routing protocol are improved significantly.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.2
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• pp.687-708
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• 2017

The machine-to-machine (M2M) communication is featured by tremendous number of devices, small data transmission, and large uplink to downlink traffic ratio. The massive access requests generated by M2M devices would result in the current medium access control (MAC) protocol in LTE/LTE-A networks suffering from physical random access channel (PRACH) overload, high signaling overhead, and resource underutilization. As such, fairness should be carefully considered when M2M traffic coexists with human-to-human (H2H) traffic. To tackle these problems, we propose an adaptive Slotted ALOHA (S-ALOHA) and time division multiple access (TDMA) hybrid protocol. In particular, the proposed hybrid protocol divides the reserved uplink resource blocks (RBs) in a transmission cycle into the S-ALOHA part for M2M traffic with small-size packets and the TDMA part for H2H traffic with large-size packets. Adaptive resource allocation and access class barring (ACB) are exploited and optimized to maximize the channel utility with fairness constraint. Moreover, an upper performance bound for the proposed hybrid protocol is provided by performing the system equilibrium analysis. Simulation results demonstrate that, compared with pure S-ALOHA and pure TDMA protocol under a target fairness constraint of 0.9, our proposed hybrid protocol can improve the capacity by at least 9.44% when ${\lambda}_1:{\lambda}_2=1:1$and by at least 20.53% when ${\lambda}_1:{\lambda}_2=10:1$, where ${\lambda}_1,{\lambda}_2$ are traffic arrival rates of M2M and H2H traffic, respectively.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.11A
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• pp.1021-1033
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• 2008

In recent years, the growing interest in wireless sensor network has resulted in thousands of publications. Most of this research is concerned with delivering raw data such as temperature, pressure, or humidity. Recently, the focus of sensor network paradigm is changing for delivering multimedia contents. However, most existing routing protocols are not very practical for transmitting multimedia contents in resource constrained sensor networks. In this paper, we propose an optimized node-disjoint multi-path routing protocol for throughput enhancement and load balancing. We focused on how to allocate traffic to independent multiple end-to-end routes. Decentralized transmission using our node-disjoint multi-path routing scheme results in bandwidth aggregation and throughput enhancement. In addition, our scheme provides ways to remove link-joint routes for decreasing routing overhead.

• Journal of Advanced Navigation Technology
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• v.12 no.4
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• pp.350-356
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• 2008

The recent networks are trending toward wireless networks. So wireless internet used to service of wired networks. But wireless networks can't show same performance of wired networks. Therefore, we are must concerned about Routing Protocol for improvement of a weak point of physical feature. But many researchers are not focusing on developing Routing Protocol. In this paper, we improve on AODV(Ad-hoc On-demand Distance Vector) for Wireless Mesh Networks. And it analyzed the result of simulation.

• The KIPS Transactions:PartD
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• v.10D no.7
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• pp.1197-1206
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• 2003

This paper describes the IPP (Internet Printing Protocol), a standard that makes network setup for printers potentially much easier and, not so incidentally, also user can print over the Internet and specifies an implementation of IPP client/server system. It allows the system administrator and operators to control IPP system users and printer devices. The focus of this effort is optimized capabilities the security features for authentication, authorization, and policies, also improved compatibility with existing WP devices. Finally this paper presents conclusions and further researches.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.8 no.2
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• pp.23-28
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• 2008

In this paper, we propose location-aided cooperative routing protocol (LACARP) for supporting power saving and stable route lifetime in mobile ad-hoc wireless sensor networks. The main ideas and features of the proposed routing protocol are as follows. First, the definition of the area of route search using location-based information to support power saving transmission. Second, the expect zone-based establishment of routing route within the area of route search. Third, the cooperative-aided transmission method. In the operation of data transmission over the established rout the datas are transmitted via both the established route and cooperative route aided by neighbor nodes. The performance evaluation using OPNET(Optimized Network Engineering Tool) shows the LACARP can improve the packet delivery ratio and power saving transmission efficiently.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.8 no.2
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• pp.29-34
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• 2008

In this paper, we proposed a system protocol for detecting injurious insect to support energy saving transmission in wireless bio sensor networks. The main ideas and features of the system are as follows. First, the route establishment method which is based on the energy efficiency and stability by using time-division tree structure. Second, multi-hop direction-based data gatering structure. In this structure, the selected fading method is used to transmit packet via the established tree structure for supporting power saving and route lifetime efficiently. Finally, we can get the node power saving and reduce transmission delay, thus network lifetime and efficiency are improved. The performance evaluation of the proposed protocol is via OPNET(Optimized Network Engineering Tool).

• The KIPS Transactions:PartC
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• v.13C no.6 s.109
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• pp.685-690
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• 2006

This paper compares the performance of the unicast routing protocol and the broadcast routing protocol in a small-sized wireless multi-hop network, such as home network. Normally, ad-hoc routing protocols are designed for general wireless multi-hop networks, not being said to be optimized for the small-sized ad hoc network. This paper compares some unicast routing protocols and optimal broadcast routing protocol, and shows the result. The result of the simulation says the broadcast routing protocol shows better performance than the ad-hoc routing protocols in the small-sired wireless multi-hop network. Especially, the result shows that the broadcast protocol has higher packet delivery ratio and lower packet latency than unicast routing protocols

• Korean Journal of Biological Psychiatry
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• v.18 no.4
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• pp.232-238
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• 2011

Objectives Optimized voxel based morphometry (VBM) has been increasingly applied to investigate differences in the brain morphology between a group of patients with mild cognitive impairment (MCI) and control subjects. Optimized VBM permits comparison of gray matter (GM) volume at voxel-level from the entire brain. The purpose of this study was to assess the regional GM volume change measured by optimized VBM in MCI subjects compared to controls. Methods Twenty patients with MCI and 20 control subjects with normal cognition were recruited for this study. We applied the optimized VBM protocol to the image data including study-specific template and the modulation of the data with the Jacobian determinants. GM volume differences between the MCI subjects and the control subjects and their correlations with the neuropsychological performances were investigated. Results Optimized VBM analysis revealed GM volume reduction in hippocampus, precentral gyrus, insula and parietal operculum in the MCI group compared to the control group (family wise error corrected p < 0.05). Korean version of the Consortium to Establish a Registry for Alzheimer's disease (CERAD-K) word list recall scores were significantly correlated with the GM volumes of hippocampus, precuneus and posterior cingulate in the MCI group (FWE corrected p < 0.05). Conclusions The results confirm previous findings of atrophic changes in medial temporal lobe and parietal lobe in the MCI group and suggest that these abnormalities may be related with cognitive decline and prognosis in patients with MCI.