• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2010년도 춘계 학술발표회
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• pp.862-870
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• 2010

This thesis has been researched on optimized design method for the total cross section of embankment considering the fact that the size of embankment cross section is directly related with economic efficiency when dam designing. In general, embankment cross section of fill dam is either determined by cohesion and angle of internal friction, a strength parameter of embankment materials or by permeability of embankment. Therefore the size of embankment cross section depending on strength parameter of embankment materials was determined by using MIDAS-GTS program through stress-seepage coupled analysis at the time of fill dam design. As a result, determination of embankment cross section was more affected by the size of central core and permeability rather than by slope stability by shear strength and it was revealed that in case of embankment height being over 20m, stability against infiltration and slope action could be secured only when embankment slope is at least over 1:2.5. In addition, it was also revealed that in case of making the size of central core exceeding specification standard, total cross section of embankment could be reduced considerably and at the time of embankment design, adequate size and appropriateness of embankment cross section could be determined with referring the table suggested by this study.

• Korean Chemical Engineering Research
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• 제55권3호
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• pp.287-295
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• 2017

Using nanotechnology, magnetic nanoparticles of iron oxide were produced via co-precipitation method and followed modification with organic compounds. In the next step, functionalized monomer was provided via coupling ${\beta}$-cyclodextrine and allylamine onto modified magnetic nanoparticles. These nanoparticles were used to establish the adsorption rate of celecoxib. Magnetic nanoparticles are modified by (3-mercaptopropyl)trimethoxysilane. Nano-adsorbent was characterized by analytical and spectroscopic methods, such as Fourier transform infrared spectroscopy, elemental analysis, thermo-gravimetric analysis, and transmission electron microscopy (TEM). Laboratory parameters, such as the kinetics of adsorption isotherms, pH, reaction temperature and capacity were optimized. Finally, by using this nano-adsorbent in the optimized condition, extraction of celecoxib from biological samples as urine, drug matrix and blood plasma was carried out by high performance liquid chromatography with sensitivity and high accuracy.

• 한국주조공학회지
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• 제31권6호
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• pp.336-341
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• 2011

Recently, aluminium usage in the automobile industry has been increased cause of its lightweight. The aluminium has a melting-solidification process in producing line and another melting process was needed in manufacturing process. Two times of melting process for making ingot and casting not only makes the loss of time and money but contaminates the air with Sox, Nox. For this reason, the holding furnace with laminated adiabatic material was developed. This holding furnace can deliver the molten aluminium directly to the industry needing molten aluminium. Recent holding furnace has above $15^{\circ}C/h$ of cooling rate and that causes solidification of molten aluminium. The ANSYS software was used to analysis the heat transfer. The adiabatic materials were laminated with optimized arrangement and holding furnace shape was changed with optimized modelling by ANSYS analysis for reducing the cooling rate of molten aluminium in holding furnace.

• 생명과학회지
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• 제15권1호
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• pp.136-140
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• 2005

다양한 라세믹 에폭사이드 기질에 대한 입체선택적 가수분해 반응을 촉매하는 epoxide hydrolase 활성을 측정할 수 있는 미생물 세포 기반의 자외선 활성 분석법을 최적화하였다. 2.5 mg/ml의 세포 농도에서도 비교적 쉽게 흡광도 변화량을 인식할 수 있는 흡광도 범위인 0.5 이상을 얻을 수 있고, 반응 동력학 분석에도 응용할 수 있었다. 기존의 GC, HPLC 분석 법 보다 분석 시간을 줄일 수 있으며, 효소를 별도로 분리$\cdot$정제하지 않고 미생물 세포 자체의 epoxide hydrolase활성 분석이 가능하므로 상업적 특성이 우수한 epoxide hydrolase을 가진 미생물을 효율적으로 선별하는데 응용될 수 있을 것으로 기대된다.

• 환경생물
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• 제22권1호
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• pp.206-212
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• 2004

In an effort to develop the tools for monitoring the contamination of xenoestrogen in the aquatic environment of Korea, reverse transcription-polymerase chain reaction (RT-PCR) analysis of vitellogenin (VTG) mRNA expression were optimized in Synechogobius hastus. Based on the partial VTG cDNA sequence VTG mRNA level in livers from male fishes was analyzed by RT-PCR. As an internal control beta actin mRNA was amplified. 3 ${\mu}g$ of total RNA was reverse transcribed in 20 $\mu$l reaction using murine leukemia virus 〔MuLV〕 reverse transcriptase. Subsequent PCR using the 1 ${\mu}g$ of cDNA resulted in linear increase in PCR product of VTG in female liver cDNA from 10 to 30 cycles of amplification. On the contrary, in male, PCR product first detected at 28 cycles of amplification and linearly increased during 38 cycles of amplification, suggesting that male S. hastus expresses minute amount of VTG mRNA which is $2^{-18}$ equivalent of female. In conclusion, the optimized protocol of VTG mRNA expression in the liver of male S. hastus will be promising the environmental monitoring the xenoestrogen contamination in the western coast and estuaries in Korea.

• 한국해양공학회지
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• 제29권5호
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• pp.331-341
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• 2015

A degasser is a separation unit used in drilling to separate gas from the drilling mud. The degasser used in offshore drilling was developed at an early stage of drilling. Since its development, the design of the degasser’s internal structure has been optimized, with many limitations due to the restrictions of experimental and computational performance measurement methods. Despite the recent development of CFD technology for multiphase flow analysis, CFD has only been used in a limited way for degasser internal flow analysis and design optimization. In this study, a design optimization procedure for a degasser’s internal structure design was proposed, and CFD analyses of three types of internal structural designs were performed to evaluate the separation performance. The CFD result for each design type was used for the design optimization and, as the result, an optimized design is proposed.

• 한국기계가공학회지
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• 제19권1호
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• pp.108-113
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• 2020

Pinions are generally heavy and integrated with a shaft. Thus, fabricating a pinion is a material- and machining-intensive task characterized by low productivity. Contact of the output pinion with a sliding surface or a cloud contact causes loss of power because of friction. Consequently, the output pinion undergoes considerable wear and tear at its ends, which adversely affects the overall transmission efficiency of decelerators. To improve transmission efficiency and extend gear life, an optimum output pinion design is required. To this end, in this study, an output pinion for worm gear decelerators was designed and optimized by means of product verification through prototyping and performance evaluation to improve gear life and productivity. The optimized design was validated and subjected to structural analysis.

• 한국생산제조학회지
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• 제19권6호
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• pp.776-781
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• 2010

Optimum design of movable hydraulic crane's booms for weight reduction was performed in this study. Since the boom weight of the present used booms is very heavy, it is needed to make them lighter structure as possible as we can. Optimum design was performed for the booms by changing from the hexagonal cross section to triangular truss structure under the conditions, which are the allowable stress for the present cross section must be maintained, and the optimized weight must be minimized. CATIAV5 was used for stress analysis and design variables were established as the height and width of the triangular truss structure. As the results, it is found that the height of the truss structure is increased in proportion to the height of the booms and the maximum stress for optimal truss structure was obtained as 412MPa, which is lower than the allowable stress for the present hexagonal cross section. The optimized weight of the booms is reduced to about 19.88% comparing to the original weight.

• Investigative Magnetic Resonance Imaging
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• 제19권1호
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• pp.10-18
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• 2015

Background and Purpose: The association between the low emotional regulation and the brain structural change of major depressive disorder (MDD) has been proposed, but the voxel-based morphometry (VBM) studies on female MDD are rare. The purpose of the present study was to show the regional volume changes of gray matter (GM) in female patients with MDD by optimized VBM. Methods: To control subjects homogeneity, twenty female MDD patients and age, sex matched 21 normal controls were included for the VBM analysis. To identify the change of regional gray matter volume (GMV), the optimized VBM was performed with T1 MRIs. The amounts of gray/white matter and intracranial cavity volumes (ICV) were measured. The analysis of covariance (ANCOVA) and partial correlation analyses covariate with age and ICV were applied for VBM. Results: The age and ICV distributions were similar between the two groups. In the ANCOVA, the total GMV of MDD was smaller than that of normal controls. In the VBM, regional GMV was relatively decreased in the limbic system (amygdalae, ambient gyri, hippocampi heads, subiculum, posterior parahippocampal gyri, pulvinar nuclei, dorsal posterior cingulate gyri, and left pregenual cingulate gyrus). The lingual gyri, short insular gyri, right fusiform gyrus, and right inferior frontal gyrus were also showed decreased regional GMV. Conclusion: The results of this study indicate that the female MDD is mainly associated with the structural deficits of the limbic system and limbic system related cortices, which were known to the center of emotions.

• 한국정밀공학회지
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• 제19권1호
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• pp.43-47
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• 2002

The new core making method economizing the amount of core sand has been requested. The new method is that a core box is heated until it reaches reasonable temperature and then core sand with core binder is sprayed into the core box. Since inner temperature distribution have to be uniform in order to form uniform thickness of core, we studied inner temperature distribution of core box. First, we determined proper number of torches and optimized torch positions to minimize the average of absolute deviation(AVEDEV) of inner temperature. The results are as fellowed: 1. The number of torches that enables uniform inner temperature distribution about $300^{\circ}C$ is 25. 2. When $S_H$ and $S_V$ is 0.7, the torch positions are optimized and AVEDEV is 5.85.