• 한국멀티미디어학회논문지
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• 제11권12호
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• pp.1635-1648
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• 2008

The extraction of important features in cancer cell image analysis is a key process in grading renal cell carcinoma. In this study, we applied three-dimensional (3D) texture feature extraction methods to cell nuclei images and evaluated the validity of them for computerized cell nuclei grading. Individual images of 2,423 cell nuclei were extracted from 80 renal cell carcinomas (RCCs) using confocal laser scanning microscopy (CLSM). First, we applied the 3D texture mapping method to render the volume of entire tissue sections. Then, we determined the chromatin texture quantitatively by calculating 3D gray-level co-occurrence matrices (3D GLCM) and 3D run length matrices (3D GLRLM). Finally, to demonstrate the suitability of 3D texture features for grading, we performed a discriminant analysis. In addition, we conducted a principal component analysis to obtain optimized texture features. Automatic grading of cell nuclei using 3D texture features had an accuracy of 78.30%. Combining 3D textural and 3D morphological features improved the accuracy to 82.19%. As a comparative study, we also performed a stepwise feature selection. Using the 4 optimized features, we could obtain more improved accuracy of 84.32%. Three dimensional texture features have potential for use as fundamental elements in developing a new nuclear grading system with accurate diagnosis and predicting prognosis.

• Mass Spectrometry Letters
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• 제11권4호
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• pp.118-124
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• 2020

An analytical method was developed for hypoxia-inducible factor (HIF) stabilizers based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) sample preparation and liquid chromatography-high resolution mass spectrometry analysis. HIF stabilizers potentially enhance the performance of athletes, and hence, they have been prohibited. However, the analysis of urinary HIF stabilizers is not easy owing to their unique structure and characteristics. Hence, we developed the QuEChERS preparation technique for a complementary method and optimized the pH, volume of extraction solvent, and number of extractions. We found that double extraction with 1% of formic acid in acetonitrile provided the highest recovery of HIF stabilizers. Moreover, the composition of the mobile phase was also optimized for better separation of molidustat and IOX4. The developed method was validated in terms of its precision, detection limit, matrix effect, and recovery for ISO accreditation. To the best of our knowledge, this is the first demonstration of the application of the QuEChERS method, which is suitable as a complementary analytical method, in antidoping.

• Bulletin of the Korean Chemical Society
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• 제31권5호
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• pp.1361-1367
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• 2010

A series of O,O-dialkyl-1-phenoxyacetoxy-1-methylphosphonate analogues (1~22) as a new class of potent inhibitors of pyruvate dehydrogenase were synthesized and 3D-QSARs (three dimensional qantitative structure-activity relationships) models on the pre-emergency herbicidal activity against the seed of cucumber (Cucumus Sativa L.) were derived and discussed quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indeces analysis (CoMSIA) methods. The statistical values of CoMSIA models were better predictability and fitness than those of CoMFA models. The inhibitory activities according to the optimized CoMSIA model I were dependent on the electrostatic field (41.4%), the H-bond acceptor field (26.0%), the hydrophobic field (20.8%) and the steric field (11.7%). And also, it was found that the optimized CoMSIA model I with the sensitivity to the perturbation ($d_q{^{2'}}/dr^2{_{yy'}}$ = 0.830) and the prediction ($q^2$ = 0.503) produced by a progressive scrambling analyses were not dependent on chance correlation. From the results of graphical analyses on the contour maps with the optimized CoMSIA model I, it is expected that the structural distinctions and descriptors that subscribe to herbicidal activities will be able to apply new an herbicide design.

• Journal of Electrical Engineering and Technology
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• 제11권3호
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• pp.781-789
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• 2016

Busbar has been used as electric conductor within extra high voltage (EHV) gas insulated switchgear (GIS), which makes EHV GIS higher security, smaller size and lower cost. However, the main fault of GIS is overheating of busbar connection parts, circuit breaker and isolating switch contact parts, which has been already restricting development of GIS to a large extent. In this study, a coupled magneto-flow-thermal analysis is used to investigate the thermal properties of GIS busbar in steady-state. A three-dimensional (3-D) finite element model (FEM) is built to calculate multiphysics fields including electromagnetic field, flow field and thermal field in steady-state. The influences of current on the magnetic flux density, flow velocity and heat distribution has been investigated. Temperature differences of inner wall and outer wall are investigated for busbar tank and conducting rod. Considering the end effect in the busbar, temperature rise difference is compared between end sections and the middle section. In order to obtain better heat dissipation effect, diameters of conductor and tank are optimized based on temperature rise simulation results. Temperature rise tests have been done to validate the 3-D simulation model, which is observed a good correlation with the simulation results. This study provides technical support for optimized structure of the EHV GIS busbar.

• Steel and Composite Structures
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• 제25권1호
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• pp.117-126
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• 2017

The component method is an analytical approach for investigating the moment-rotation relationship of steel connections. In this study, the component method was improved from two aspects: (i) load analysis of mechanical model; and (ii) combination of spring elements. An optimized component method with more reasonable component models, spring arrangement position, and boundary conditions was developed using finite element analysis. An experimental testing program in two major-axis and two minor-axis connections under symmetrically loading was carried out to verify this method. The initial rotational stiffness obtained from the optimized component method was consistent with the experimental results. It can be concluded that (i) The coupling stiffness between column and beam flanges significantly affects the effective height of the tensile-column web. (ii) The mechanical properties of the bending components were obtained using an equivalent t-stub model considering the bending capacity of bolts. (iii) Using the optimized mechanical components, the initial rotational stiffness was accurately calculated using the spring system. (iv) The characteristics of moment-rotation relationship for beam to column connections were effectively expressed by the SPRING element analysis model using ABAQUS. The calculations are simpler, and the results are accurate.

• 대한조선학회 특별논문집
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• 대한조선학회 2015년도 특별논문집
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• pp.50-55
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• 2015

Application of newly conceptualized Anti-Splash Devices designed for COT vent pipes were studied on a P/V valve located on the upper deck of an oil carrier vessel. Anti-Splash devices are used in the shipbuilding industry in order to avoid oil overflow and spray accidents caused by excess pressure and vacuum condition in the cargo oil tanks. These conditions are caused by the transverse and longitudinal sloshing forces that arise from ship motion during sea voyages. The main issue with existing Anti-Splash device model is flux at the outlet of the Anti-Splash Device, and so, new conceptual models for the Anti-Splash device were developed and compared to existing Anti-Splash device model using CFD analysis. Transient analysis was used to capture the flow and velocity of each model and a comparative analysis was performed between old and new-concept models. This data was used to determine the optimal design parameters in order to develop an optimized Anti-Splash Device. A Factory acceptance test was performed on the new-concept models in order to verify the performance and efficiency against their design requirements and other criterion. The final step performed was to apply the optimized Anti-Splash Device models for COT vent pipes to an actual vessel and verify performance through a seawater cargo operation during a sea voyage as per the ship owner's request. The patent for the aforementioned device was obtained by the Korean Intellectual property Office dated Dec. 18th,2014.

• 정보처리학회논문지D
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• 제13D권4호
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• pp.463-476
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• 2006

R-tree는 일반적으로 트리 노드의 크기를 디스크 페이지의 크기와 같게 함으로써 I/O 성능이 최적화 되도록 구현한다. 최근에는 주메모리 환경에서 CPU 캐시 성능을 최적화하는 R-tree의 변형이 개발되었다. 이는 노드의 크기를 캐시 라인 크기의 수 배로 하고 MBR에 저장되는 키를 압축하여 노드 하나에 더 많은 엔트리를 저장함으로써 성능을 높였다. 그러나, 디스크 최적 R-tree와 캐시 최적 R-tree의 노드 크기 사이에는 수십-수백 바이트와 수-수십 킬로바이트라는 큰 차이가 있으므로, I/O 최적 R-tree는 캐시 성능이 나쁘고 캐시 최적 R-tree는 디스크 I/O 성능이 나쁜 문제점을 가지고 있다. 이 논문에서는 CPU 캐시와 디스크 I/O에 모두 최적인 R-tree, PR-tree를 제안한다. 캐시 성능을 위해 PR-tree 노드의 크기를 캐시 라인 크기보다 크게 만든 다음 CPU의 선반입(prefetch) 명령어를 이용하여 캐시 실패 횟수를 줄이고, 트리 노드를 디스크 페이지에 낭비가 적도록 배치함으로써 디스크 I/O 성능도 향상시킨다. 또한, 이 논문에서는 PR-tree에서 검색 연산을 수행하는데 드는 캐시 실패 비용을 계산하는 분석 방법을 제시하고, 최적의 캐시와 I/O 성능을 보이는 PR-tree를 구성하기 위해, 가능한 크기의 내부 단말 노드, 중간 노드를 갖는 PR-tree 생성하여 성능을 비교하였다. PR-tree는 디스크 최적 R-tree보다 삽입 연산은 3.5에서 15.1배, 삭제 연산은 6.5에서 15.1배, 범위 질의는 1.3에서 1.9배, k-최근접 질의는 2.7에서 9.7배의 캐시 성능 향상이 있었다. 모든 실험에서 매우 작은 I/O 성능 저하만을 보였다.

• 대한교통학회지
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• 제24권2호
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• pp.19-30
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• 2006

본 연구는 일반국도의 통행특성을 고려한 지점검지기의 적정설치지점 선정을 다루고 있다. 일반국도에서의 ITS 구축은 활발히 진행되고 있으나. 자료수집 구간에서의 통행시간 추정 신뢰도에 가장 큰 영향을 미치고 있는 지점검지기의 설치지점에 관해 적절한 기준이 제시되지 못하고 있는 실정이다. 따라서 본 연구에서는 일반국도의 구간 통행시간의 추정을 위해 대표성을 확보할 수 있는 지점검지기의 적정설치지점을 선정하여 제시하고자 한다 이를 위하여 GPS 프로브 차량과 지점검지기를 이용하여 대상지역의 통행특성을 수집하고, 지점속도와 구간통행시간의 상관분석을 통하여 적정설치지점을 선택한다. 분석결과 일반국도의 구간별 적정설치지점의 특성은 다음과 같다. 첫째. 구간 통행시간과 지점 속도와의 상관관계는 구간의 시점에서부터 높아지다가 일정시점이 지나서는 낮아지는 U자형 형태를 보이고 있다. 둘째. 최적설치지점은 분석구간마다 상이하게 존재하나, 대부분 구간연장을 기준으로 중류부 및 중 하류부에 존재한다. 셋째, 구간의 적정설치지점은 구간의 중류부에서 하류부로 넘어가는 지점이 적절하며, 일반적으로 자료수집 구간 연장을 기준으로 시점부로부터 $55{\sim}60%$가 되는 지점이다. 넷째, 종단경사는 적정설치지점과 관련하여 중요한 결정인자가 되며, 종단경사가 큰 경우에 있어서 검지기의 설치는 배제되어야 한다. 끝으로, 본 연구의 결과를 토대로 한 지점검지기의 현장적용을 통해, 정보제공 구간내 통행시간 추정 및 예측력의 개선을 기대한다.

• Journal of Nutrition and Health
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• 제51권1호
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• pp.73-86
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• 2018

본 연구는 선형계획법을 이용하여 현재의 식품섭취패턴에서 크게 벗어나지 않으면서 영양섭취기준을 충족하는 한국 성인의 최적 식품섭취패턴을 설계하였고, 주요 결과는 다음과 같다. 식품품목별 실제섭취량과 최적섭취량을 비교하였을 때 실제섭취량보다 최적섭취량이 높게 나타나 영양섭취기준을 충족하기 위해서 현재보다 섭취량을 더 늘릴 필요가 있는 식품품목으로 모든 집단에서 공통적으로 채소류, 50 ~ 64세 남성을 제외한 집단에서 우유 유제품류인 것으로 나타났다. 50 ~ 64세를 제외한 여성에서는 채소류, 우유 유제품류 이외에도 과일류도 섭취량을 더 높여야 하는 식품품목으로 나타났다. 모든 남성 집단과 19 ~ 29세를 제외한 여성 집단에서 김치의 최적섭취량이 실제 섭취량보다 낮게 나타나 김치는 덜 섭취해야 하는 식품품목인 것으로 파악되었다. 또한 조미료에 대해서는 모든 집단에서 공통적으로 최적섭취량이 0 g으로 산출되었다. 이에 선형계획법을 이용해서 설계한 최적 식품섭취패턴에서 조미료의 최적섭취량이 실생활에서 실현 불가능한 0 g으로 산출되었기 때문에 설계한 최적 식품섭취패턴의 실현성을 높이기 위해서는 나트륨의 목표섭취량을 실제섭취량이 고려된 보다 현실적인 기준으로 재설정할 필요가 있다.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 1997년도 추계학술대회논문집; 한국과학기술회관; 6 Nov. 1997
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• pp.370-376
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• 1997

A Simplified Finite Element Method(FEM) model has been developed for the Exhaust System. For the verification of the usage of the developed model , Natural Frequencies, Mode Shapes and Frequency Response Function have been compared between numerical analysis and experimental result. It shows that the developed numerical model also can be utilized to prove the Stress distribution of the Exhaust System if it can be adopted for the vibration analysis adequately.